| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alla El-Din Hamid Sayed, Tomomi Watanabe-Asaka, Shoji Oda, Hiroshi Mitan. Apoptosis and morphological alterations after UVA irradiation in red blood cells of p53 deficient Japanese medaka (Oryzias latipes). Journal of photochemistry and photobiology. B, Biology. vol 161. 2017-03-07. PMID:27203565. |
apoptosis and morphological alterations after uva irradiation in red blood cells of p53 deficient japanese medaka (oryzias latipes). |
2017-03-07 |
2023-08-13 |
Not clear |
| Alla El-Din Hamid Sayed, Tomomi Watanabe-Asaka, Shoji Oda, Hiroshi Mitan. Apoptosis and morphological alterations after UVA irradiation in red blood cells of p53 deficient Japanese medaka (Oryzias latipes). Journal of photochemistry and photobiology. B, Biology. vol 161. 2017-03-07. PMID:27203565. |
these results suggested that uva exposure induced both p53 dependent and independent apoptosis and morphological alterations in red blood cells but less sensitive to uva than wild type in medaka fish. |
2017-03-07 |
2023-08-13 |
Not clear |
| Yoon Hee Chung, Daejin Ki. RIP kinase-mediated ROS production triggers XAF1 expression through activation of TAp73 in casticin-treated bladder cancer cells. Oncology reports. vol 36. issue 2. 2017-03-06. PMID:27349281. |
the p53 family protein p73 plays an important role in apoptosis induced by chemotherapeutic drugs. |
2017-03-06 |
2023-08-13 |
Not clear |
| Yehong Liu, Puye Yang, Na Chen, Shumei Lin, Min Li. Effects of recombinant human adenovirus-p53 on the regression of hepatic fibrosis. International journal of molecular medicine. vol 38. issue 4. 2017-03-06. PMID:27572658. |
the tumor suppressor protein p53 is a transcription factor that is involved in cell proliferation, cell cycle regulation, apoptosis and dna repair. |
2017-03-06 |
2023-08-13 |
human |
| Yehong Liu, Puye Yang, Na Chen, Shumei Lin, Min Li. Effects of recombinant human adenovirus-p53 on the regression of hepatic fibrosis. International journal of molecular medicine. vol 38. issue 4. 2017-03-06. PMID:27572658. |
taken together, these findings suggest that ad-p53 promotes apoptosis and inhibits the proliferation of hscs in a time‑ and dose-dependent manner by modulating the expression of p53, tgf-β1 and α-sma. |
2017-03-06 |
2023-08-13 |
human |
| Zhen Zhang, Lei Yang, Lei Lei, Rongping Chen, Hong Chen, Hua Zhan. Glucagon-like peptide-1 attenuates advanced oxidation protein product-mediated damage in islet microvascular endothelial cells partly through the RAGE pathway. International journal of molecular medicine. vol 38. issue 4. 2017-03-06. PMID:27574116. |
apoptosis, cell viability and reactive oxygen species (ros) production were examined, the expression levels of p53, bax, receptor for advanced glycation end-products (rage) and nad(p)h oxidase subunit were determined, and the activity of nad(p)h oxidase, caspase-9 and caspase-3 was also determined. |
2017-03-06 |
2023-08-13 |
Not clear |
| Zhen Zhang, Lei Yang, Lei Lei, Rongping Chen, Hong Chen, Hua Zhan. Glucagon-like peptide-1 attenuates advanced oxidation protein product-mediated damage in islet microvascular endothelial cells partly through the RAGE pathway. International journal of molecular medicine. vol 38. issue 4. 2017-03-06. PMID:27574116. |
the results revealed that aopps increased the expression of rage, p47phox and p22phox; induced nad(p)h oxidase-dependent ros generation, increased p53 and bax expression, enhanced the activity of caspase-9 and caspase-3, and induced cell apoptosis. |
2017-03-06 |
2023-08-13 |
Not clear |
| Tomoyuki Koguchi, Chizu Tanikawa, Jinichi Mori, Yoshiyuki Kojima, Koichi Matsud. Regulation of myo-inositol biosynthesis by p53-ISYNA1 pathway. International journal of oncology. vol 48. issue 6. 2017-03-06. PMID:27035231. |
in response to various cellular stresses, p53 exerts its tumor suppressive effects such as apoptosis, cell cycle arrest, and senescence through the induction of its target genes. |
2017-03-06 |
2023-08-13 |
Not clear |
| Muthuraman Pandurangan, Gansukh Enkhtaivan, Doo Hwan Ki. Anticancer studies of synthesized ZnO nanoparticles against human cervical carcinoma cells. Journal of photochemistry and photobiology. B, Biology. vol 158. 2017-03-03. PMID:26985734. |
the mrna expression of apoptotic gene p53 and caspase 3 was up-regulated following zno nanoparticle exposure, which confirms the occurrence of apoptosis at the transcriptional level. |
2017-03-03 |
2023-08-13 |
human |
| Qingqing Wang, Yiran Ao, Kai Yang, Hong Tang, Dan Che. Circadian clock gene Per2 plays an important role in cell proliferation, apoptosis and cell cycle progression in human oral squamous cell carcinoma. Oncology reports. vol 35. issue 6. 2017-03-03. PMID:27035749. |
we found that in the tca8113 cells, after per2 downregulation, the mrna expression levels of cyclin a2, b1 and d1, cdk4, cdk6 and e2f1 were significantly increased (p<0.05), the mrna expression levels of p53, p16 and p21 were significantly decreased (p<0.05), cell proliferation was significantly higher (p<0.05), apoptosis was significantly lower (p<0.05) and the number of cells in the g1/g0 phase was significantly decreased (p<0.05). |
2017-03-03 |
2023-08-13 |
human |
| Li Gao, Lei Yu, Chun-Ming Li, Ying Li, Bao-Lin Jia, Bin Zhan. Karyopherin α2 induces apoptosis in tongue squamous cell carcinoma CAL-27 cells through the p53 pathway. Oncology reports. vol 35. issue 6. 2017-03-03. PMID:27109484. |
karyopherin α2 induces apoptosis in tongue squamous cell carcinoma cal-27 cells through the p53 pathway. |
2017-03-03 |
2023-08-13 |
human |
| Xiao-Lan Li, Jianbiao Zhou, Zit-Liang Chan, Jing-Yuan Chooi, Zhi-Rong Chen, Wee-Joo Chn. PRIMA-1met (APR-246) inhibits growth of colorectal cancer cells with different p53 status through distinct mechanisms. Oncotarget. vol 6. issue 34. 2017-03-02. PMID:26452133. |
prima-1met (apr-246) is a methylated derivative and structural analog of prima-1 (p53 re-activation and induction of massive apoptosis). |
2017-03-02 |
2023-08-13 |
human |
| Xiao-Lan Li, Jianbiao Zhou, Zit-Liang Chan, Jing-Yuan Chooi, Zhi-Rong Chen, Wee-Joo Chn. PRIMA-1met (APR-246) inhibits growth of colorectal cancer cells with different p53 status through distinct mechanisms. Oncotarget. vol 6. issue 34. 2017-03-02. PMID:26452133. |
however, prima-1met induces robust apoptosis only in crc cells with mutant p53. |
2017-03-02 |
2023-08-13 |
human |
| Atsuko Nakatsuka, Makoto Matsuyama, Satoshi Yamaguchi, Akihiro Katayama, Jun Eguchi, Kazutoshi Murakami, Sanae Teshigawara, Daisuke Ogawa, Nozomu Wada, Tetsuya Yasunaka, Fusao Ikeda, Akinobu Takaki, Eijiro Watanabe, Jun Wad. Insufficiency of phosphatidylethanolamine N-methyltransferase is risk for lean non-alcoholic steatohepatitis. Scientific reports. vol 6. 2017-03-02. PMID:26883167. |
pemt exerted inhibitory effects on p53-driven transcription by forming the complex with clathrin heavy chain and p53, and pemt-/- mice fed hfhs diet demonstrated prominent apoptosis of hepatocytes. |
2017-03-02 |
2023-08-13 |
mouse |
| Young June Kim, Tae-Hyun Kim, Minjeong Kim, Min Ju Kim, Hae-Won Kim, Hosup Shi. Complete reduction of p53 expression by RNA interference following heterozygous knockout in porcine fibroblasts. In vitro cellular & developmental biology. Animal. vol 52. issue 7. 2017-03-02. PMID:27142766. |
tumor suppressor p53 plays a critical role in the regulation of cell cycle and apoptosis in mammals. |
2017-03-02 |
2023-08-13 |
mouse |
| Rajib Majumder, Samudra Prosad Banik, Suman Khowal. AkP from mushroom Termitomyces clypeatus is a proteoglycan specific protease with apoptotic effect on HepG2. International journal of biological macromolecules. vol 91. 2017-03-02. PMID:27180294. |
augmentation of apoptosis was attributed to up-regulation of p53 and bax protein expression succeeded by caspase-3 activation. |
2017-03-02 |
2023-08-13 |
Not clear |
| Wei Chang, Wei He, Pei-Pei Li, Sha-Sha Song, Ping-Fan Yuan, Jing-Tao Lu, Wei We. Protective effects of Celastrol on diethylnitrosamine-induced hepatocellular carcinoma in rats and its mechanisms. European journal of pharmacology. vol 784. 2017-03-02. PMID:27181068. |
meanwhile, celastrol suppressed the expression of the protein mdm2, activated the intrinsic mitochondrial apoptosis pathway induced by p53, inhibited anti-apoptotic bcl-2 and bcl-xl, induced the pro-apoptotic bax, cytochrome c, parp and caspases. |
2017-03-02 |
2023-08-13 |
rat |
| Fu-Jen Huang, Wen-Hsiung Cha. Effects of ochratoxin a on mouse oocyte maturation and fertilization, and apoptosis during fetal development. Environmental toxicology. vol 31. issue 6. 2017-03-01. PMID:25504763. |
furthermore, ota upregulated the levels of p53 and p21 in blastocyst cells derived from ota-pretreated oocytes, indicating that such cells undergo apoptosis via p53-, p21-, and caspase-3-dependent regulatory mechanisms. |
2017-03-01 |
2023-08-13 |
mouse |
| Dan He, Jinnan Xiang, Baojie Li, Huijuan Li. The dynamic behavior of Ect2 in response to DNA damage. Scientific reports. vol 6. 2017-03-01. PMID:27074761. |
ect2 knockdown did not affect foci localization of γh2ax, topbp1, or brca1, or activation of atm, yet it impeded p53 ser15 phosphorylation and activation, and resulted in defects in apoptosis and activation of s and g2/m checkpoints in response to dna damage. |
2017-03-01 |
2023-08-13 |
mouse |
| M P de Morais, R F Curado, K S F E Silva, K K V O Moura, J T Arrud. Male idiopathic infertility and the TP53 polymorphism in codon 72. Genetics and molecular research : GMR. vol 15. issue 4. 2017-02-28. PMID:27819720. |
this suggests that the p53 gene (tp53) is important for apoptosis regulation during spermatogenesis, and may be associated with male infertility. |
2017-02-28 |
2023-08-13 |
mouse |