| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mei-Juan Zhou, Fang-Zhi Chen, Han-Chun Chen, Xin-Xing Wan, Xi Zhou, Qian Fang, Dian-Zheng Zhan. ISG15 inhibits cancer cell growth and promotes apoptosis. International journal of molecular medicine. vol 39. issue 2. 2017-03-16. PMID:28035359. |
however, these effects were significantly diminished when p53 was knocked down, suggesting that the effects of inhibitory effects of isg15 on hela cell growth and the induction of apoptosis were p53-dependent. |
2017-03-16 |
2023-08-13 |
Not clear |
| Ziliang Zhou, Lijie Zhou, Fangfang Jiang, Binghui Zeng, Changbo Wei, Wei Zhao, Dongsheng Y. Downregulation of miR-222 Induces Apoptosis and Cellular Migration in Adenoid Cystic Carcinoma Cells. Oncology research. vol 25. issue 2. 2017-03-16. PMID:28277192. |
previous studies have shown that mir-222 targets the p53 upregulated modulator of apoptosis (puma) to regulate cell biological behavior in some human malignancies. |
2017-03-16 |
2023-08-13 |
human |
| Judit Varga, Judit Bátor, Gergő Nádasdi, Zita Árvai, Renáta Schipp, József Szeberény. Partial Protection of PC12 Cells from Cellular Stress by Low-Dose Sodium Nitroprusside Pre-treatment. Cellular and molecular neurobiology. vol 36. issue 7. 2017-03-15. PMID:26626595. |
the partial inhibition of apoptosis was accompanied by reduced phosphorylation of certain proteins (such as stress-activated protein kinases, the p53, and the eif2α proteins), decreased caspase activation, and less intense internucleosomal dna fragmentation. |
2017-03-15 |
2023-08-13 |
rat |
| Xiaojin Ning, Tao Tao, Jianhong Shen, Yuteng Ji, Lili Xie, Hongmei Wang, Ning Liu, Xide Xu, Chi Sun, Dongmei Zhang, Aiguo Shen, Kaifu K. The O-GlcNAc Modification of CDK5 Involved in Neuronal Apoptosis Following In Vitro Intracerebral Hemorrhage. Cellular and molecular neurobiology. vol 37. issue 3. 2017-03-14. PMID:27316643. |
we showed that cdk5 was dynamically modified with o-glcnac in response to neuronal activity and that glycosylation represses cdk5-dependent apoptosis by impairing its association with p53 pathway. |
2017-03-14 |
2023-08-13 |
Not clear |
| Atif Zafar, Swarnendra Singh, Imrana Nasee. Cytotoxic activity of soy phytoestrogen coumestrol against human breast cancer MCF-7 cells: Insights into the molecular mechanism. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 99. 2017-03-14. PMID:27913286. |
dna damage leads to p53 up-regulation which directs the cell cycle arrest at g1/s phase and promotes caspase-dependent apoptosis of mcf-7 cells. |
2017-03-14 |
2023-08-13 |
human |
| Zhihai Wang, Kui Liao, Wenqi Zuo, Xueliang Liu, Zhili Qiu, Zhitao Gong, Chuan Liu, Quan Zeng, Yi Qian, Liang Jiang, Youquan Bu, Suling Hong, Guohua H. Depletion of NFBD1/MDC1 Induces Apoptosis in Nasopharyngeal Carcinoma Cells Through the p53-ROS-Mitochondrial Pathway. Oncology research. vol 25. issue 1. 2017-03-14. PMID:28081741. |
nfbd1, a signal amplifier of the p53 pathway, is vital for protecting cells from p53-mediated apoptosis and the early phase of dna damage response under normal culture conditions. |
2017-03-14 |
2023-08-13 |
mouse |
| Zhihai Wang, Kui Liao, Wenqi Zuo, Xueliang Liu, Zhili Qiu, Zhitao Gong, Chuan Liu, Quan Zeng, Yi Qian, Liang Jiang, Youquan Bu, Suling Hong, Guohua H. Depletion of NFBD1/MDC1 Induces Apoptosis in Nasopharyngeal Carcinoma Cells Through the p53-ROS-Mitochondrial Pathway. Oncology research. vol 25. issue 1. 2017-03-14. PMID:28081741. |
however, n-acetyl cysteine (nac) and downregulation of p53 expression could partially reverse the apoptosis caused by the loss of nfbd1. |
2017-03-14 |
2023-08-13 |
mouse |
| Yinghua Li, Zhengfang Lin, Mingqi Zhao, Tiantian Xu, Changbing Wang, Huimin Xia, Hanzhong Wang, Bing Zh. Multifunctional selenium nanoparticles as carriers of HSP70 siRNA to induce apoptosis of HepG2 cells. International journal of nanomedicine. vol 11. 2017-03-13. PMID:27462151. |
moreover, se@pei@sirna exhibited enhanced cytotoxic effects on cancer cells and triggered intracellular reactive oxygen species, and the signaling pathways of p53 and akt were activated to advance cell apoptosis. |
2017-03-13 |
2023-08-13 |
human |
| Yu-Chiang Hung, Tai-Long Pan, Wen-Long H. Roles of Reactive Oxygen Species in Anticancer Therapy with Salvia miltiorrhiza Bunge. Oxidative medicine and cellular longevity. vol 2016. 2017-03-13. PMID:27579153. |
danshen may enhance tnf-α-induced apoptosis, upregulate caspase-3, caspase-8, caspase-9, endoplasmic reticulum stress, p21, p53, bax/bcl-2, dr5, and amp-activated protein kinase, or activate the p38/jnk, mitogen-activated protein kinase, and fasl signaling pathways. |
2017-03-13 |
2023-08-13 |
human |
| Jiansen Li, Xiangqian Zheng, Ming Gao, Jingzhu Zhao, Yigong Li, Xiangrui Meng, Biyun Qian, Jiafeng L. Suberoyl bis-hydroxamic acid activates Notch1 signaling and induces apoptosis in anaplastic thyroid carcinoma through p53. Oncology reports. vol 37. issue 1. 2017-03-13. PMID:28004113. |
suberoyl bis-hydroxamic acid activates notch1 signaling and induces apoptosis in anaplastic thyroid carcinoma through p53. |
2017-03-13 |
2023-08-13 |
human |
| Kou-Dong Zhang, Lin-Rong Tong, Shui-Ming Wang, Rui-Yun Peng, Hai-Dong Huang, Yu-Chao Dong, Xing-Xing Zhang, Qiang Li, Chong Ba. Apoptosis of Lewis Lung Carcinoma Cells Induced by Microwave via p53 and Proapoptotic Proteins Chinese medical journal. vol 130. issue 1. 2017-03-13. PMID:28051018. |
apoptosis of lewis lung carcinoma cells induced by microwave via p53 and proapoptotic proteins microwave therapy is a minimal invasive procedure and has been employed in clinical practice for the treatment of various types of cancers. |
2017-03-13 |
2023-08-13 |
Not clear |
| Gunjan Sharma, Nishant Kumar Rana, Priya Singh, Pradeep Dubey, Daya Shankar Pandey, Biplob Koc. p53 dependent apoptosis and cell cycle delay induced by heteroleptic complexes in human cervical cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 88. 2017-03-13. PMID:28110188. |
p53 dependent apoptosis and cell cycle delay induced by heteroleptic complexes in human cervical cancer cells. |
2017-03-13 |
2023-08-13 |
human |
| Gunjan Sharma, Nishant Kumar Rana, Priya Singh, Pradeep Dubey, Daya Shankar Pandey, Biplob Koc. p53 dependent apoptosis and cell cycle delay induced by heteroleptic complexes in human cervical cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 88. 2017-03-13. PMID:28110188. |
our studies demonstrate that anticancer property of these two complexes was due to induction of apoptosis through p53 mediated pathway as well as arrest of cells in g2/m phase of cell cycle. |
2017-03-13 |
2023-08-13 |
human |
| Youying Tu, Eunhye Kim, Ying Gao, Gary O Rankin, Bo Li, Yi Charlie Che. Theaflavin-3, 3'-digallate induces apoptosis and G2 cell cycle arrest through the Akt/MDM2/p53 pathway in cisplatin-resistant ovarian cancer A2780/CP70 cells. International journal of oncology. vol 48. issue 6. 2017-03-10. PMID:27082635. |
the p53 protein played an important role in tf3-induced apoptosis and g2 cell cycle arrest. |
2017-03-10 |
2023-08-13 |
Not clear |
| Razmik Mirzayans, Bonnie Andrais, Piyush Kumar, David Murra. The Growing Complexity of Cancer Cell Response to DNA-Damaging Agents: Caspase 3 Mediates Cell Death or Survival? International journal of molecular sciences. vol 17. issue 5. 2017-03-09. PMID:27187358. |
thus, activation of the p53 signaling pathway by ionizing radiation and other dna-damaging agents hinders apoptosis and triggers growth arrest (e.g., through premature senescence) in some genetic backgrounds; such growth arrested cells remain viable, secrete growth-promoting factors, and give rise to progeny with stem cell-like properties. |
2017-03-09 |
2023-08-13 |
human |
| Qiong Wu, Xi Wang, Jing Liu, Jiyue Zheng, Yang Liu, Yumei Li, Fang Su, Weili Ou, Rui Wan. Nutlin-3 reverses the epithelial-mesenchymal transition in gemcitabine-resistant hepatocellular carcinoma cells. Oncology reports. vol 36. issue 3. 2017-03-08. PMID:27430152. |
nutlin-3, a small molecule regulator of the tumor suppressor p53, targets the interaction between p53 and murine double minute 2 (mdm2) thereby promoting stabilization of p53 and subsequent p53‑dependent induction of apoptosis and cell cycle arrest. |
2017-03-08 |
2023-08-13 |
Not clear |
| Hui Liu, Feihu Chen, Ling Zhang, Qing Zhou, Shuyu Gui, Yuan Wan. A novel all-trans retinoic acid derivative 4-amino‑2‑trifluoromethyl-phenyl retinate inhibits the proliferation of human hepatocellular carcinoma HepG2 cells by inducing G0/G1 cell cycle arrest and apoptosis via upregulation of p53 and ASPP1 and downregulation of iASPP. Oncology reports. vol 36. issue 1. 2017-03-08. PMID:27177208. |
a novel all-trans retinoic acid derivative 4-amino‑2‑trifluoromethyl-phenyl retinate inhibits the proliferation of human hepatocellular carcinoma hepg2 cells by inducing g0/g1 cell cycle arrest and apoptosis via upregulation of p53 and aspp1 and downregulation of iaspp. |
2017-03-08 |
2023-08-13 |
human |
| Hui Liu, Feihu Chen, Ling Zhang, Qing Zhou, Shuyu Gui, Yuan Wan. A novel all-trans retinoic acid derivative 4-amino‑2‑trifluoromethyl-phenyl retinate inhibits the proliferation of human hepatocellular carcinoma HepG2 cells by inducing G0/G1 cell cycle arrest and apoptosis via upregulation of p53 and ASPP1 and downregulation of iASPP. Oncology reports. vol 36. issue 1. 2017-03-08. PMID:27177208. |
the expression levels of murine double minute 2 (mdm2), apoptosis stimulating proteins of p53 (aspp), cell cycle- and apoptosis-associated proteins were detected by western blotting. |
2017-03-08 |
2023-08-13 |
human |
| Hui Liu, Feihu Chen, Ling Zhang, Qing Zhou, Shuyu Gui, Yuan Wan. A novel all-trans retinoic acid derivative 4-amino‑2‑trifluoromethyl-phenyl retinate inhibits the proliferation of human hepatocellular carcinoma HepG2 cells by inducing G0/G1 cell cycle arrest and apoptosis via upregulation of p53 and ASPP1 and downregulation of iASPP. Oncology reports. vol 36. issue 1. 2017-03-08. PMID:27177208. |
consequently, atpr exerted a better inhibitory effect on the proliferation of hepg2 cells than atra through increased expression of p53 and aspp1 and downregulation of iaspp, thereby resulting in g0/g1 cell cycle arrest and apoptosis. |
2017-03-08 |
2023-08-13 |
human |
| b' Iva Poto\\xc4\\x8dnjak, Robert Domitrovi\\xc4\\x8. Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K/Akt activation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 98. issue Pt B. 2017-03-07. PMID:27825756.' |
cp intoxication induced apoptosis and inhibition of the cell cycle in kidneys by increasing the expression of p53 and bax and suppressing bcl-2 and cyclin d1 expression. |
2017-03-07 |
2023-08-13 |
mouse |