| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huimin Shi, Aiqing Zhang, Yanfang He, Min Yang, Weihua Ga. Effects of p53 on aldosterone-induced mesangial cell apoptosis in vivo and in vitro. Molecular medicine reports. vol 13. issue 6. 2017-04-06. PMID:27109859. |
furthermore, the ratio of mc apoptosis and the p53 expression level were significantly increased following ald exposure, compared with the control group. |
2017-04-06 |
2023-08-13 |
rat |
| Huimin Shi, Aiqing Zhang, Yanfang He, Min Yang, Weihua Ga. Effects of p53 on aldosterone-induced mesangial cell apoptosis in vivo and in vitro. Molecular medicine reports. vol 13. issue 6. 2017-04-06. PMID:27109859. |
the present study hypothesized that ald may directly contribute to the occurrence of mc apoptosis via p53, which may participate in ald-induced renal injury. |
2017-04-06 |
2023-08-13 |
rat |
| Hui Yang, Jia Deng, Yingying Jiang, Jiao Chen, Xianzheng Zeng, Zhiyang He, Xiaojuan Jiang, Zhuoning Li, Chunling Jian. Emulsified isoflurane treatment inhibits the cell cycle and respiration of human bronchial epithelial 16HBE cells in a p53-independent manner. Molecular medicine reports. vol 14. issue 1. 2017-04-06. PMID:27176636. |
the expression levels of p53, p21, sco1, sco2 and tp53‑induced glycolysis and apoptosis regulator (tigar) were detected by reverse transcription‑quantitative polymerase chain reaction and western blotting. |
2017-04-06 |
2023-08-13 |
human |
| Bin Liu, Yufeng Shi, Wending Peng, Qingyu Zhang, Jie Liu, Nianping Chen, Runzhi Zh. Diosmetin induces apoptosis by upregulating p53 via the TGF-β signal pathway in HepG2 hepatoma cells. Molecular medicine reports. vol 14. issue 1. 2017-04-06. PMID:27176768. |
diosmetin induces apoptosis by upregulating p53 via the tgf-β signal pathway in hepg2 hepatoma cells. |
2017-04-06 |
2023-08-13 |
human |
| Maryam Jalayeri, Afshin Pirnia, Elaheh Poorazizi Najafabad, Ali Mohammad Varzi, Mohammadreza Gholam. Evaluation of alginate hydrogel cytotoxicity on three-dimensional culture of type A spermatogonial stem cells. International journal of biological macromolecules. vol 95. 2017-04-05. PMID:27984148. |
after one month of encapsulation and culture in dmem culture medium containing 10ng/ml gdnf, cells were removed from hydrogel and were examined for viability, cell morphology and structure, cytotoxicity and expression of apoptosis genes fas, p53, bax, bcl2, caspase3 by staining with trypan blue, scanning electron microscopy, ldh test, and real time pcr, respectively. |
2017-04-05 |
2023-08-13 |
mouse |
| Hai-Yan Wang, Hai-Zhong Yu, Sheng-Mou Huang, Yu-Lan Zhen. p53, Bcl-2 and cox-2 are involved in berberine hydrochloride-induced apoptosis of HeLa229 cells. Molecular medicine reports. vol 14. issue 4. 2017-04-04. PMID:27601129. |
p53, bcl-2 and cox-2 are involved in berberine hydrochloride-induced apoptosis of hela229 cells. |
2017-04-04 |
2023-08-13 |
human |
| Hai-Yan Wang, Hai-Zhong Yu, Sheng-Mou Huang, Yu-Lan Zhen. p53, Bcl-2 and cox-2 are involved in berberine hydrochloride-induced apoptosis of HeLa229 cells. Molecular medicine reports. vol 14. issue 4. 2017-04-04. PMID:27601129. |
the effects of berberine hydrochloride on the apoptosis of hela229 cells was detected by immunofluorescence and flow cytometry, and the mrna expression levels of p53, b‑cell lymphoma 2 (bcl‑2) and cyclooxygenase‑2 (cox‑2) were analyzed by reverse transcription-quantitative polymerase chain reaction. |
2017-04-04 |
2023-08-13 |
human |
| Hai-Yan Wang, Hai-Zhong Yu, Sheng-Mou Huang, Yu-Lan Zhen. p53, Bcl-2 and cox-2 are involved in berberine hydrochloride-induced apoptosis of HeLa229 cells. Molecular medicine reports. vol 14. issue 4. 2017-04-04. PMID:27601129. |
in conclusion, berberine hydrochloride inhibited the proliferation and induced apoptosis of hela229 cells, potentially via the upregulation of p53 and the downregulation of bcl‑2 and cox‑2 mrna expression levels. |
2017-04-04 |
2023-08-13 |
human |
| Z-W Fei, M-K Qiu, X-Q Qi, Y-X Dai, S-Q Wang, Z-W Quan, Y-B Liu, J-M O. Oxymatrine suppresses proliferation and induces apoptosis of hemangioma cells through inhibition of HIF-1a signaling. International journal of immunopathology and pharmacology. vol 28. issue 2. 2017-04-04. PMID:25816398. |
moreover, omt in vitro inhibited proliferative activities and induced cell apoptosis and cycle arrest in g0/g1 phase in ha cells with decreased expression of hif-1a, vegf, bcl-2, and cyclind1, and increased expression of p53. |
2017-04-04 |
2023-08-13 |
human |
| Jia Song, Jing Zhang, Jiang Sha. Knockdown of CUL4A inhibits invasion and induces apoptosis in osteosarcoma cells. International journal of immunopathology and pharmacology. vol 28. issue 2. 2017-04-04. PMID:26055549. |
in vitro, silencing of cul4a gene inhibited os cell proliferation and invasion, and induced cell apoptosis, followed by increased expression of p27 and p53 and decreased expression of mmp-2. |
2017-04-04 |
2023-08-13 |
human |
| Yang-Yang Han, Jiang-Jiang Tang, Rong-Fang Gao, Xin Guo, Ming Lei, Jin-Ming Ga. A new semisynthetic 1-O-acetyl-6-O-lauroylbritannilactone induces apoptosis of human laryngocarcinoma cells through p53-dependent pathway. Toxicology in vitro : an international journal published in association with BIBRA. vol 35. 2017-04-04. PMID:27262408. |
the results of p53 knockdown suggest that caspase-mediated apoptosis induced by abl-l was in p53-dependent pathway on hep-2 cells. |
2017-04-04 |
2023-08-13 |
human |
| Guen Tae Kim, Se Hee Lee, Young Min Ki. Torilis japonica extract-generated intracellular ROS induces apoptosis by reducing the mitochondrial membrane potential via regulation of the AMPK-p38 MAPK signaling pathway in HCT116 colon cancer. International journal of oncology. vol 49. issue 3. 2017-04-03. PMID:27314881. |
our results show that not only does tje regulate the ampk/p38 signaling pathway, but it induces apoptosis in cells in which p53 has been knocked down using sirna. |
2017-04-03 |
2023-08-13 |
Not clear |
| Bi Liu, Ming Lei, Tao Hu, Fei Yu, De-Ming Xiao, Hao Kan. Inhibitory effects of SRT1720 on the apoptosis of rabbit chondrocytes by activating SIRT1 via p53/bax and NF-κB/PGC-1α pathways. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 36. issue 3. 2017-04-03. PMID:27376802. |
with the srt1720 concentration increasing, the chondrocyte viability increased, the apoptosis rate decreased, the protein expression levels of sirt1 and pgc-1α and the mrna expression levels of type ii collagen and aggrecan increased ({ptp}<0.05), and the expression levels of p53, nf-κb and bax decreased (p<0.05). |
2017-04-03 |
2023-08-13 |
rabbit |
| Ying Zhang, Yuan-Yuan Wu, Fu-Yuan Qiao, Wan-Jiang Zen. Association between p53 polymorphism at codon 72 and recurrent spontaneous abortion. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 36. issue 3. 2017-04-03. PMID:27376811. |
p53 gene plays an important role in apoptosis, which is necessary for successful invasion of trophoblast cells. |
2017-04-03 |
2023-08-13 |
Not clear |
| Min Shi, Liang Ma, Li Zhou, Ping F. Renal Protective Effects of 17β-Estradiol on Mice with Acute Aristolochic Acid Nephropathy. Molecules (Basel, Switzerland). vol 21. issue 10. 2017-04-03. PMID:27763560. |
in the mice kidney tissue and human renal proximal tubule cells (hk-2 cells), e2 both attenuated aa-induced cell apoptosis and downregulated the expression of phosphor-p53 (ser15), p53, and cleaved-caspase-3. |
2017-04-03 |
2023-08-13 |
mouse |
| Min Shi, Liang Ma, Li Zhou, Ping F. Renal Protective Effects of 17β-Estradiol on Mice with Acute Aristolochic Acid Nephropathy. Molecules (Basel, Switzerland). vol 21. issue 10. 2017-04-03. PMID:27763560. |
this study highlights that e2 exhibited protective effects on the renal injury of acute aan in male mice by reducing rtec apoptosis, which might be related to inhibiting the p53 signaling pathway. |
2017-04-03 |
2023-08-13 |
mouse |
| Georgiana Gabriela Petrică-Matei, Florin Iordache, Răzvan Hainăroşie, Marinela Bosta. Characterization of the tumor cells from human head and neck cancer. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 57. issue 2 Suppl. 2017-04-03. PMID:27833973. |
the aim of the present study was to evaluate the expression of p53 protein, the apoptosis process and the cell cycle parameters in the cell cultures of head and neck carcinoma obtained from fragments of tumor excised from patients. |
2017-04-03 |
2023-08-13 |
human |
| Georgiana Gabriela Petrică-Matei, Florin Iordache, Răzvan Hainăroşie, Marinela Bosta. Characterization of the tumor cells from human head and neck cancer. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 57. issue 2 Suppl. 2017-04-03. PMID:27833973. |
using elisa assay and flow cytometry methods we analyzed the p53 protein expression, distribution of the cell cycle phases and the level of apoptosis in the tumor cells which were immediately isolated from the tumor fragments, as well as in the ones that were subsequently passed in culture several times. |
2017-04-03 |
2023-08-13 |
human |
| Alejandro Parrales, Tomoo Iwakum. p53 as a Regulator of Lipid Metabolism in Cancer. International journal of molecular sciences. vol 17. issue 12. 2017-04-03. PMID:27973397. |
the tumor suppressor p53 is a transcription factor that controls the expression of proteins involved in cell cycle arrest, dna repair, apoptosis, and senescence. |
2017-04-03 |
2023-08-13 |
Not clear |
| Fangrong Zhang, Min Li, Yujie Su, Jianping Zhou, Wei Wan. A dual-targeting drug co-delivery system for tumor chemo- and gene combined therapy. Materials science & engineering. C, Materials for biological applications. vol 64. 2017-03-31. PMID:27127046. |
regulation of gene expression using p53 is a promising strategy for treatment of numerous cancers, and chemotherapeutic drug dichloroacetate (dca) induces apoptosis and growth inhibition in tumor, without apparent toxicity in normal tissues. |
2017-03-31 |
2023-08-13 |
mouse |