| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chao Meng, Linlin Song, Juan Wang, Di Li, Yanhong Liu, Xiaoguang Cu. Propofol induces proliferation partially via downregulation of p53 protein and promotes migration via activation of the Nrf2 pathway in human breast cancer cell line MDA-MB-231. Oncology reports. vol 37. issue 2. 2017-04-11. PMID:28035403. |
cell apoptosis, caspase-3 activity, and western blot analysis for p53 and nrf2 protein were also assessed. |
2017-04-11 |
2023-08-13 |
human |
| Zhihong Liu, You Lu, Yingmin Xiao, Yipin L. Upregulation of miR-21 expression is a valuable predicator of advanced clinicopathological features and poor prognosis in patients with renal cell carcinoma through the p53/p21‑cyclin E2‑Bax/caspase-3 signaling pathway. Oncology reports. vol 37. issue 3. 2017-04-11. PMID:28184919. |
meanwhile, the overexpression of mir-21 not only increased cell proliferation, inhibited apoptosis and reduced caspase-3 activity in the a-498 cells, but also suppressed p53, cdkn1a p21, cyclin e2 and bax protein expression in the a-498 cells. |
2017-04-11 |
2023-08-13 |
human |
| Chemotherapy Efficacy Is Dependent upon p53 Dynamics. Cancer discovery. vol 6. issue 6. 2017-04-11. PMID:27125550. |
drug-induced apoptosis occurs after cells reach a p53 threshold level, which increases over time. |
2017-04-11 |
2023-08-13 |
Not clear |
| Chun-Qiu Dai, Ting-Ting Luo, Shi-Cheng Luo, Jia-Qi Wang, Sheng-Ming Wang, Yun-Hu Bai, Yan-Ling Yang, Ya-Yun Wan. p53 and mitochondrial dysfunction: novel insight of neurodegenerative diseases. Journal of bioenergetics and biomembranes. vol 48. issue 4. 2017-04-10. PMID:27422544. |
if stress or damage is irreversible, p53 will translocate to mitochondria, leading into apoptosis or necrosis. |
2017-04-10 |
2023-08-13 |
Not clear |
| Xin Hu, Jing Wang, Yu Xia, Mihereguli Simayi, Syed Ikramullah, Yuanbing He, Shihong Cui, Shuang Li, Qimanguli Wushoue. Resveratrol induces cell cycle arrest and apoptosis in human eosinophils from asthmatic individuals. Molecular medicine reports. vol 14. issue 6. 2017-04-07. PMID:27779703. |
in addition, resveratrol was observed to arrest cell cycle progression in g1/s phase by increasing the protein expression levels of p53 and p21, and concurrently reducing the protein expression levels of cdk2, cyclin a and cyclin e. furthermore, resveratrol treatment significantly induced apoptosis in eosinophils, likely through the upregulation of bim and bax protein expression levels and the downregulation of bcl‑2 protein expression. |
2017-04-07 |
2023-08-13 |
human |
| Dan Jiang, Lingyao Wang, Tong Zhao, Zhaoyu Zhang, Renxia Zhang, Jingji Jin, Yong Cai, Fei Wan. Restoration of the tumor-suppressor function to mutant p53 by Ganoderma lucidum polysaccharides in colorectal cancer cells. Oncology reports. vol 37. issue 1. 2017-04-07. PMID:27878254. |
in addition, western blot assay and in vitro cell-free apoptosis assay suggested that the activation of mutant p53 was effective in both a transcriptional-dependent and -independent pathway. |
2017-04-07 |
2023-08-13 |
Not clear |
| L Manta, N Suciu, O Toader, R M Purcărea, A Constantin, F Pop. The etiopathogenesis of uterine fibromatosis. Journal of medicine and life. vol 9. issue 1. 2017-04-07. PMID:27974911. |
proliferative effects of estrogen and progesterone may be exercised through proinflammatory factors (tnf alpha), growth factors (igf1, igf2, tgfbeta3 and betafgf) or inhibitors of apoptosis (p53 suppression). |
2017-04-07 |
2023-08-13 |
Not clear |
| Kai Liu, Dongdong Lin, Yabo Ouyang, Lijun Pang, Xianghua Guo, Shanshan Wang, Yunjin Zang, Dexi Che. Amphiregulin impairs apoptosis-stimulating protein 2 of p53 overexpression-induced apoptosis in hepatoma cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 3. 2017-04-07. PMID:28351301. |
amphiregulin impairs apoptosis-stimulating protein 2 of p53 overexpression-induced apoptosis in hepatoma cells. |
2017-04-07 |
2023-08-13 |
Not clear |
| Kai Liu, Dongdong Lin, Yabo Ouyang, Lijun Pang, Xianghua Guo, Shanshan Wang, Yunjin Zang, Dexi Che. Amphiregulin impairs apoptosis-stimulating protein 2 of p53 overexpression-induced apoptosis in hepatoma cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 3. 2017-04-07. PMID:28351301. |
hepg2 cells) by enhancing the transactivation activity of p53, but long-term aspp2 overexpression fails to induce more apoptosis since activation of the epidermal growth factor/epidermal growth factor receptor/sos1 pathway impairs the pro-apoptotic role of aspp2. |
2017-04-07 |
2023-08-13 |
Not clear |
| Kai Liu, Dongdong Lin, Yabo Ouyang, Lijun Pang, Xianghua Guo, Shanshan Wang, Yunjin Zang, Dexi Che. Amphiregulin impairs apoptosis-stimulating protein 2 of p53 overexpression-induced apoptosis in hepatoma cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 3. 2017-04-07. PMID:28351301. |
moreover, blocking soluble amphiregulin with a neutralizing antibody also significantly increased apoptotic cell death of hepg2 cells due to treatment with methyl methanesulfonate, cisplatin, or a recombinant p53 adenovirus, suggesting that the function of amphiregulin involved in inhibiting apoptosis may be a common mechanism by which hepatoma cells escape from stimulus-induced apoptosis. |
2017-04-07 |
2023-08-13 |
Not clear |
| Paweł Szymański, Paulina Olszewska, Elżbieta Mikiciuk-Olasik, Antoni Różalski, Agnieszka Maszewska, Łukasz Markiewicz, Magda Cuchra, Ireneusz Majstere. Novel tetrahydroacridine and cyclopentaquinoline derivatives with fluorobenzoic acid moiety induce cell cycle arrest and apoptosis in lung cancer cells by activation of DNA damage signaling. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 3. 2017-04-07. PMID:28351316. |
treatment of cells with the compounds increased phosphorylation and accumulation of p53 that regulate cell cycle as well as apoptosis. |
2017-04-07 |
2023-08-13 |
human |
| Jishu Quan, Yong Li, Meihua Jin, Dunfu Chen, Xuezhe Yin, Ming Ji. Suppression of p53-inducible gene 3 is significant for glioblastoma progression and predicts poor patient prognosis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 3. 2017-04-07. PMID:28351326. |
p53-inducible gene 3, a downstream molecule of the tumor suppressor p53, has been found involved in apoptosis and oxidative stress response. |
2017-04-07 |
2023-08-13 |
Not clear |
| Ziyi Zhao, Changjin Chen, Junzhi Lin, Wentong Zeng, Juan Zhao, Yindan Liang, Qinrui Tan, Chao Yang, Hui L. Synergy between von Hippel-Lindau and P53 contributes to chemosensitivity of clear cell renal cell carcinoma. Molecular medicine reports. vol 14. issue 3. 2017-04-06. PMID:27485825. |
further analysis indicated that co‑expression of vhl and p53 inhibited cell proliferation by completely inhibiting the cell cycle at the g0/g1 phase, and promoted apoptosis following treatment with adm or sunitinib. |
2017-04-06 |
2023-08-13 |
Not clear |
| Ziyi Zhao, Changjin Chen, Junzhi Lin, Wentong Zeng, Juan Zhao, Yindan Liang, Qinrui Tan, Chao Yang, Hui L. Synergy between von Hippel-Lindau and P53 contributes to chemosensitivity of clear cell renal cell carcinoma. Molecular medicine reports. vol 14. issue 3. 2017-04-06. PMID:27485825. |
these findings demonstrated that vhl and p53 act synergistically in the regulation of cell proliferation and apoptosis in ccrcc. |
2017-04-06 |
2023-08-13 |
Not clear |
| Ziyi Zhao, Changjin Chen, Junzhi Lin, Wentong Zeng, Juan Zhao, Yindan Liang, Qinrui Tan, Chao Yang, Hui L. Synergy between von Hippel-Lindau and P53 contributes to chemosensitivity of clear cell renal cell carcinoma. Molecular medicine reports. vol 14. issue 3. 2017-04-06. PMID:27485825. |
overall, vhl and p53 have important roles in the regulation of cell proliferation and apoptosis in ccrcc. |
2017-04-06 |
2023-08-13 |
Not clear |
| Man Zhao, Shuliang Yu, Man Zhan. Differential expression of multidrug resistance‑related proteins in adriamycin‑resistant (pumc‑91/ADM) and parental (pumc‑91) human bladder cancer cell lines. Molecular medicine reports. vol 14. issue 5. 2017-04-06. PMID:27748815. |
several mechanisms have been implicated in the development of mdr, including extrusion of the drug by cell membrane pumps, associated with p‑glycoprotein (p‑gp) and multidrug resistance‑associated protein (mrp); increased dna damage repair, associated with topoisomerase ii (topo ii); suppression of drug‑induced apoptosis, associated with p53; and regulation of cancer cell growth, associated with vascular endothelial growth factor (vegf). |
2017-04-06 |
2023-08-13 |
human |
| Huimin Shi, Aiqing Zhang, Yanfang He, Min Yang, Weihua Ga. Effects of p53 on aldosterone-induced mesangial cell apoptosis in vivo and in vitro. Molecular medicine reports. vol 13. issue 6. 2017-04-06. PMID:27109859. |
effects of p53 on aldosterone-induced mesangial cell apoptosis in vivo and in vitro. |
2017-04-06 |
2023-08-13 |
rat |
| Huimin Shi, Aiqing Zhang, Yanfang He, Min Yang, Weihua Ga. Effects of p53 on aldosterone-induced mesangial cell apoptosis in vivo and in vitro. Molecular medicine reports. vol 13. issue 6. 2017-04-06. PMID:27109859. |
the aim of the present study was to investigate the effects of p53 on ald‑induced mc apoptosis and elucidate the underlying molecular mechanism. |
2017-04-06 |
2023-08-13 |
rat |
| Huimin Shi, Aiqing Zhang, Yanfang He, Min Yang, Weihua Ga. Effects of p53 on aldosterone-induced mesangial cell apoptosis in vivo and in vitro. Molecular medicine reports. vol 13. issue 6. 2017-04-06. PMID:27109859. |
the cell apoptosis ratio was assessed by flow cytometry, and the expression level of p53 was assessed by reverse transcription quantitative polymerase chain reaction and western blotting. |
2017-04-06 |
2023-08-13 |
rat |
| Huimin Shi, Aiqing Zhang, Yanfang He, Min Yang, Weihua Ga. Effects of p53 on aldosterone-induced mesangial cell apoptosis in vivo and in vitro. Molecular medicine reports. vol 13. issue 6. 2017-04-06. PMID:27109859. |
in order to confirm the role of p53 in ald‑regulated cell apoptosis, a rescue experiment was performed using targeted small interfering (si)rna to downregulate the expression of p53. |
2017-04-06 |
2023-08-13 |
rat |