| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yonghua Zhuang, Heather M Berens-Norman, J Smith Leser, Penny Clarke, Kenneth L Tyle. Mitochondrial p53 Contributes to Reovirus-Induced Neuronal Apoptosis and Central Nervous System Injury in a Mouse Model of Viral Encephalitis. Journal of virology. vol 90. issue 17. 2017-05-09. PMID:27307572. |
previous reports demonstrated that the binding of p53 to bak at mitochondria causes bak activation and results in apoptosis. |
2017-05-09 |
2023-08-13 |
mouse |
| Yonghua Zhuang, Heather M Berens-Norman, J Smith Leser, Penny Clarke, Kenneth L Tyle. Mitochondrial p53 Contributes to Reovirus-Induced Neuronal Apoptosis and Central Nervous System Injury in a Mouse Model of Viral Encephalitis. Journal of virology. vol 90. issue 17. 2017-05-09. PMID:27307572. |
inhibition of the mitochondrial translocation of p53 with pifithrin μ prevents the formation of p53/bak complexes following reovirus infection of ex vivo brain slice cultures and results in decreased apoptosis and tissue injury. |
2017-05-09 |
2023-08-13 |
mouse |
| Deepika Ahuja, Ashish Goyal, Partho Sarothi Ra. Interplay between RNA-binding protein HuR and microRNA-125b regulates p53 mRNA translation in response to genotoxic stress. RNA biology. vol 13. issue 11. 2017-05-09. PMID:27592685. |
on the other hand, the microrna mir-125b is reported to repress p53 expression and stress-induced apoptosis. |
2017-05-09 |
2023-08-13 |
Not clear |
| Mohamed S Abdelfattah, Naoki Ishikawa, Utpal K Karmakar, Kazuki Yamaku, Masami Ishibash. New phenazine analogues from Streptomyces sp. IFM 11694 with TRAIL resistance-overcoming activities. The Journal of antibiotics. vol 69. issue 6. 2017-05-09. PMID:26669750. |
aotaphenazine (1) enhanced the levels of apoptosis inducing proteins dr4, dr5, p53 and also decreased the levels of cell survival protein bcl-2 in trail-resistant human gastric adenocarcinoma (ags) cells in a dose-dependent manner. |
2017-05-09 |
2023-08-13 |
human |
| Norlaily Mohd Ali, M Nadeem Akhtar, Huynh Ky, Kian Lam Lim, Nadiah Abu, Seema Zareen, Wan Yong Ho, Han Kiat Alan-Ong, Sheau Wei Tan, Noorjahan Banu Alitheen, Jamil Bin Ismail, Swee Keong Yeap, Tunku Kamaru. Flavokawain derivative FLS induced G2/M arrest and apoptosis on breast cancer MCF-7 cell line. Drug design, development and therapy. vol 10. 2017-05-08. PMID:27358555. |
the roles of plk-1, wee-1, and phosphorylation of cdc-2 in g2/m arrest and proapoptotic factors (bax, caspase 9, and p53) in promotion of apoptosis of fls against mcf-7 cells were discovered using fluorometric, quantitative real-time polymerase chain reaction, and western blot analysis. |
2017-05-08 |
2023-08-13 |
human |
| Samira Hajiaghalou, Bita Ebrahimi, Abdolhossein Shahverdi, Mina Sharbatoghli, Nasim Beigi Boroujen. Comparison of apoptosis pathway following the use of two protocols for vitrification of immature mouse testicular tissue. Theriogenology. vol 86. issue 8. 2017-05-08. PMID:27492762. |
morphology, cell viability, apoptosis incidence, and apoptosis gene expression (bax, bcl2, caspase 3, fas, fas ligand, p53) were evaluated at 0, 3, and 20 hours of culture by light microscopy, flow cytometry, and real-time polymerase chain reaction, respectively. |
2017-05-08 |
2023-08-13 |
mouse |
| Samira Hajiaghalou, Bita Ebrahimi, Abdolhossein Shahverdi, Mina Sharbatoghli, Nasim Beigi Boroujen. Comparison of apoptosis pathway following the use of two protocols for vitrification of immature mouse testicular tissue. Theriogenology. vol 86. issue 8. 2017-05-08. PMID:27492762. |
the apoptosis incidence after vitrification may have occurred independent of p53. |
2017-05-08 |
2023-08-13 |
mouse |
| Atul Ranjan, Tomoo Iwakum. Non-Canonical Cell Death Induced by p53. International journal of molecular sciences. vol 17. issue 12. 2017-05-08. PMID:27941671. |
p53 is a well characterized tumor suppressor that controls cell proliferation and apoptosis and has also been linked to non-apoptotic, non-canonical cell death mechanisms. |
2017-05-08 |
2023-08-13 |
Not clear |
| Atul Ranjan, Tomoo Iwakum. Non-Canonical Cell Death Induced by p53. International journal of molecular sciences. vol 17. issue 12. 2017-05-08. PMID:27941671. |
in this review article, we summarize and discuss the involvement of p53 in several non-canonical modes of cell death, including caspase-independent apoptosis (cia), ferroptosis, necroptosis, autophagic cell death, mitotic catastrophe, paraptosis, and pyroptosis, as well as its role in efferocytosis which is the process of clearing dead or dying cells. |
2017-05-08 |
2023-08-13 |
Not clear |
| Chang-Han Chen, Ming-Feng Chen, S Joseph Huang, Chun-Yen Huang, Hao-Kuang Wang, Wen-Chuan Hsieh, Chih-Hao Huang, Li-Feng Liu, Li-Yen Shi. Saikosaponin a Induces Apoptosis through Mitochondria-Dependent Pathway in Hepatic Stellate Cells. The American journal of Chinese medicine. vol 45. issue 2. 2017-05-08. PMID:28231747. |
moreover, ssa upregulated pro-apoptotic proteins [bak, bcl-2-associated death promoter (bad), and p53 upregulated modulator of apoptosis (puma)] and downregulated anti-apoptotic proteins (bcl-2). |
2017-05-08 |
2023-08-13 |
human |
| Ming-Ke Qiu, Shu-Qing Wang, Chang Pan, Yang Wang, Zhi-Wei Quan, Ying-Bin Liu, Jing-Min O. ROCK inhibition as a potential therapeutic target involved in apoptosis in hemangioma. Oncology reports. vol 37. issue 5. 2017-05-08. PMID:28339093. |
y-27632 induced p53 expression and downregulated vegf expression, significantly inhibited cell proliferation, and induced cell apoptosis in ha cells. |
2017-05-08 |
2023-08-13 |
mouse |
| Hao Jiang, Dong-Ping Liu, Dong Xie, Dong-Zhi We. [Up-regulation of ErbB3-binding protein 1 inhibits the growth of esophageal carcinoma cells]. Sheng li xue bao : [Acta physiologica Sinica]. vol 68. issue 6. 2017-05-05. PMID:28004068. |
besides, ebp1 overexpression induced apoptosis, increased rb and p53 expressions, and decreased cyclind1 expression in eca109 and kyse150 cells. |
2017-05-05 |
2023-08-13 |
mouse |
| S J Peng, J Li, Y Zhou, M Tuo, X X Qin, Q Yu, H Cheng, Y M L. In vitro effects and mechanisms of lycopene in MCF-7 human breast cancer cells. Genetics and molecular research : GMR. vol 16. issue 2. 2017-05-04. PMID:28407181. |
in conclusion, lycopene inhibits proliferation and facilitates apoptosis of mcf-7 cells in vitro, possibly by regulating the expression of p53 and bax. |
2017-05-04 |
2023-08-13 |
human |
| Dennis Bromley, Matthias R Bauer, Alan R Fersht, Valerie Dagget. An in silico algorithm for identifying stabilizing pockets in proteins: test case, the Y220C mutant of the p53 tumor suppressor protein. Protein engineering, design & selection : PEDS. vol 29. issue 9. 2017-05-03. PMID:27503952. |
the p53 tumor suppressor protein performs a critical role in stimulating apoptosis and cell cycle arrest in response to oncogenic stress. |
2017-05-03 |
2023-08-13 |
Not clear |
| Utpal K Karmakar, Naoki Ishikawa, Midori A Arai, Firoj Ahmed, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibash. Boesenberols, Pimarane Diterpenes with TRAIL-Resistance-Overcoming Activity from Boesenbergia pandurata. Journal of natural products. vol 79. issue 8. 2017-05-02. PMID:27508308. |
subtoxic doses of the major compound 9 sensitized ags cells to trail-induced apoptosis by up-regulating apoptosis-inducing proteins, such as dr4, dr5, p53, fas, chop, bak, and cleaved caspases-3, -8, and -9, and down-regulating the levels of cell survival proteins, such as bcl-2, c-flip, and gsk-3β, in trail-resistant ags cells. |
2017-05-02 |
2023-08-13 |
Not clear |
| Peng Song, Peng Chen, Dong Wang, Zhengrong Wu, Qiyu Gao, Aixia Wang, Ruilan Zhu, Yajun Wang, Xin Wang, Longhe Zhao, Ziyun Duan, Shuqian Zhu, Peng Cui, Yang Li, Hongyu L. Realgar transforming solution displays anticancer potential against human hepatocellular carcinoma HepG2 cells by inducing ROS. International journal of oncology. vol 50. issue 2. 2017-05-02. PMID:28035418. |
importantly, rts inhibited the cellular antioxidant defense system leading to abundant ros accumulation, and activated cell cycle arrest and mitochondrial pathway of apoptosis mediated by activating p53 due to cellular uncontrolled ros. |
2017-05-02 |
2023-08-13 |
human |
| Xiaowei Huo, Dongyu Liu, Li Gao, Liyong Li, Li Ca. Flavonoids Extracted from Licorice Prevents Colitis-Associated Carcinogenesis in AOM/DSS Mouse Model. International journal of molecular sciences. vol 17. issue 9. 2017-05-01. PMID:27563884. |
subsequently, the effects of lfs on expression of proteins associated with apoptosis and proliferation, levels of inflammatory cytokine, expression of phosphorylated-janus kinases 2 (p-jak2) and phosphorylated-signal transducer and activator of transcription 3 (p-stat3), and activation of nuclear factor-κb (nfκb) and p53 were assessed. |
2017-05-01 |
2023-08-13 |
mouse |
| Stephen R Armstrong, Hong Wu, Benfan Wang, Yasser Abuetabh, Consolato Sergi, Roger P Len. The Regulation of Tumor Suppressor p63 by the Ubiquitin-Proteasome System. International journal of molecular sciences. vol 17. issue 12. 2017-05-01. PMID:27929429. |
the protein p63 has been identified as a homolog of the tumor suppressor protein p53 and is capable of inducing apoptosis, cell cycle arrest, or senescence. |
2017-05-01 |
2023-08-13 |
Not clear |
| Prachi Sharma, David E Stallknecht, Elizabeth W Howert. Epizootic haemorrhagic disease virus induced apoptosis in bovine carotid artery endothelium is p53 independent. Veterinaria italiana. vol 52. issue 3-4. 2017-04-28. PMID:27723048. |
epizootic haemorrhagic disease virus induced apoptosis in bovine carotid artery endothelium is p53 independent. |
2017-04-28 |
2023-08-13 |
cattle |
| Prachi Sharma, David E Stallknecht, Elizabeth W Howert. Epizootic haemorrhagic disease virus induced apoptosis in bovine carotid artery endothelium is p53 independent. Veterinaria italiana. vol 52. issue 3-4. 2017-04-28. PMID:27723048. |
for some viruses, such as influenza, a p53 dependent mechanism has been demonstrated in viral induced apoptosis. |
2017-04-28 |
2023-08-13 |
cattle |