| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manoela Mota, Bubu A Banini, Sophie C Cazanave, Arun J Sanya. Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease. Metabolism: clinical and experimental. vol 65. issue 8. 2017-05-18. PMID:26997538. |
through upregulation of proteins involved in various pathways including pkr-like er kinase (perk), ccaat/enhancer-binding homologous protein (chop), c-jun nh2-terminal kinase-1 (jnk), bcl-2 interacting mediator (bim), p53 upregulated modulator of apoptosis (puma), and eventually caspases, hepatocytes in lipotoxic states ultimately undergo apoptosis. |
2017-05-18 |
2023-08-13 |
Not clear |
| Yin-Tao Lei, Jun-Fu Li, Juan Jiang, Xiao-Guang Li, Dai-Yun Che. [Expression and clinical significance of PUMA gene in salivary adenoid cystic carcinoma]. Shanghai kou qiang yi xue = Shanghai journal of stomatology. vol 25. issue 3. 2017-05-17. PMID:27609385. |
to explore the expression of p53 up-regulated modulator of apoptosis (puma) gene in salivary adenoid cystic carcinoma (sacc) and its clinical significance. |
2017-05-17 |
2023-08-13 |
Not clear |
| Kerstin Holzer, Elisabeth Drucker, Stephanie Roessler, Daniel Dauch, Florian Heinzmann, Nina Waldburger, Eva-Maria Eiteneuer, Esther Herpel, Kai Breuhahn, Lars Zender, Peter Schirmacher, Alessandro Ori, Stephan Singe. Proteomic Analysis Reveals GMP Synthetase as p53 Repression Target in Liver Cancer. The American journal of pathology. vol 187. issue 2. 2017-05-16. PMID:27939741. |
in response to different types of stress, p53 mediates several antiproliferative cellular outcomes, such as cell cycle arrest, apoptosis, and senescence, by activation or repression of its target genes. |
2017-05-16 |
2023-08-13 |
human |
| Ning Yang, Yuying Zhao, Zhipeng Wang, Yu Liu, Yanqiao Zhan. Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway. Molecular medicine reports. vol 15. issue 2. 2017-05-16. PMID:28035355. |
scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway. |
2017-05-16 |
2023-08-13 |
human |
| Ning Yang, Yuying Zhao, Zhipeng Wang, Yu Liu, Yanqiao Zhan. Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway. Molecular medicine reports. vol 15. issue 2. 2017-05-16. PMID:28035355. |
collectively, scutellarin reduced the viability and induced apoptosis of human colon carcinoma cells, potentially by regulating p53 and bcl‑2/bax expression. |
2017-05-16 |
2023-08-13 |
human |
| Mariana F da Mota, Alane P Cortez, Polyana L Benfica, Bruna Dos S Rodrigues, Thalyta F Castro, Larissa M Macedo, Carlos H Castro, Luciano M Lião, Flávio S de Carvalho, Luiz A S Romeiro, Ricardo Menegatti, Hugo Verli, Bianca Villavicencio, Marize C Valadare. Induction of apoptosis in Ehrlich ascites tumour cells via p53 activation by a novel small-molecule MDM2 inhibitor - LQFM030. The Journal of pharmacy and pharmacology. vol 68. issue 9. 2017-05-15. PMID:27350017. |
induction of apoptosis in ehrlich ascites tumour cells via p53 activation by a novel small-molecule mdm2 inhibitor - lqfm030. |
2017-05-15 |
2023-08-13 |
Not clear |
| Vijay Mohan, Rajesh Agarwal, Rana P Sing. A novel alkaloid, evodiamine causes nuclear localization of cytochrome-c and induces apoptosis independent of p53 in human lung cancer cells. Biochemical and biophysical research communications. vol 477. issue 4. 2017-05-15. PMID:27402273. |
a novel alkaloid, evodiamine causes nuclear localization of cytochrome-c and induces apoptosis independent of p53 in human lung cancer cells. |
2017-05-15 |
2023-08-13 |
human |
| Vijay Mohan, Rajesh Agarwal, Rana P Sing. A novel alkaloid, evodiamine causes nuclear localization of cytochrome-c and induces apoptosis independent of p53 in human lung cancer cells. Biochemical and biophysical research communications. vol 477. issue 4. 2017-05-15. PMID:27402273. |
pifithrin-α, a p53 inhibitor, slightly inhibited growth of a549 cells and under p53 inhibitory condition evodiamine-induced apoptosis could not be reversed. |
2017-05-15 |
2023-08-13 |
human |
| Vijay Mohan, Rajesh Agarwal, Rana P Sing. A novel alkaloid, evodiamine causes nuclear localization of cytochrome-c and induces apoptosis independent of p53 in human lung cancer cells. Biochemical and biophysical research communications. vol 477. issue 4. 2017-05-15. PMID:27402273. |
together these findings suggest that evodiamine is a strong inducer of apoptosis in lung epithelial cancer cells independent of their p53 status and that could involve both intrinsic as well as extrinsic pathway of apoptosis. |
2017-05-15 |
2023-08-13 |
human |
| YoungHyun Shin, Hoyong Lim, Byeong-Sun Choi, Kyung-Chang Kim, Chun Kang, Yong-Soo Bae, Cheol-Hee Yoo. Highly activated p53 contributes to selectively increased apoptosis of latently HIV-1 infected cells upon treatment of anticancer drugs. Virology journal. vol 13. issue 1. 2017-05-15. PMID:27527606. |
highly activated p53 contributes to selectively increased apoptosis of latently hiv-1 infected cells upon treatment of anticancer drugs. |
2017-05-15 |
2023-08-13 |
human |
| Julio E Molineros, Wanling Yang, Xu-Jie Zhou, Celi Sun, Yukinori Okada, Huoru Zhang, Kek Heng Chua, Yu-Lung Lau, Yuta Kochi, Akari Suzuki, Kazuhiko Yamamoto, Jianyang Ma, So-Young Bang, Hye-Soon Lee, Kwangwoo Kim, Sang-Cheol Bae, Hong Zhang, Nan Shen, Loren L Looger, Swapan K Nat. Confirmation of five novel susceptibility loci for systemic lupus erythematosus (SLE) and integrated network analysis of 82 SLE susceptibility loci. Human molecular genetics. vol 26. issue 6. 2017-05-15. PMID:28108556. |
transcription factor binding sites for p53, mef2a and e2f1 were significantly (p < 0.05) over-represented in sle loci, consistent with apoptosis playing a critical role in sle. |
2017-05-15 |
2023-08-13 |
Not clear |
| Xian-Xiang Xu, Xiao-Hong Zhang, Yong Diao, Yu-Xiang Huan. Achyranthes bidentate saponins protect rat articular chondrocytes against interleukin-1β-induced inflammation and apoptosis in vitro. The Kaohsiung journal of medical sciences. vol 33. issue 2. 2017-05-15. PMID:28137413. |
abs suppressed il-1β-induced apoptosis by suppressing the activation of caspase-3, inhibiting levels of proapoptotic proteins bax and bad, decreasing p53 protein phosphorylation, and promoting the expression of antiapoptotic protein bcl-x |
2017-05-15 |
2023-08-13 |
rat |
| Xue Zhou, Dongfeng Xian, Jiehua Xia, Ying Tang, Wenda Li, Xiaohui Chen, Zhibin Zhou, Dihan Lu, Xia Fen. MicroRNA-34c is regulated by p53 and is involved in sevoflurane-induced apoptosis in the developing rat brain potentially via the mitochondrial pathway. Molecular medicine reports. vol 15. issue 4. 2017-05-15. PMID:28259954. |
microrna-34c is regulated by p53 and is involved in sevoflurane-induced apoptosis in the developing rat brain potentially via the mitochondrial pathway. |
2017-05-15 |
2023-08-13 |
rat |
| Xue Zhou, Dongfeng Xian, Jiehua Xia, Ying Tang, Wenda Li, Xiaohui Chen, Zhibin Zhou, Dihan Lu, Xia Fen. MicroRNA-34c is regulated by p53 and is involved in sevoflurane-induced apoptosis in the developing rat brain potentially via the mitochondrial pathway. Molecular medicine reports. vol 15. issue 4. 2017-05-15. PMID:28259954. |
in conclusion, the results of the present study suggest that mirna‑34c may be regulated by p53 and is involved in sevoflurane‑induced neural apoptosis in the hippocampus of developing rat brains, potentially via the mitochondrial pathway. |
2017-05-15 |
2023-08-13 |
rat |
| Zhenyou Zou, Mengjie Ni, Jing Zhang, Yongfeng Chen, Hongyu Ma, Shihan Qian, Longhua Tang, Jiamei Tang, Hailun Yao, Chengbin Zhao, Xiongwen Lu, Hongyang Sun, Jue Qian, Xiaoting Mao, Xulin Lu, Qun Liu, Juping Zen, Hanbing Wu, Zhaosheng Bao, Shudan Lin, Hongyu Sheng, Yunlong Li, Yong Liang, Zhiqiang Chen, Dan Zon. miR-30a can inhibit DNA replication by targeting RPA1 thus slowing cancer cell proliferation. The Biochemical journal. vol 473. issue 14. 2017-05-15. PMID:27208176. |
furthermore, ataxia telangiectasia mutated (atm) and checkpoint kinase 2 (chk2) were phosphorylated after dna damage, which induced p53 expression, thus triggering the s-phase checkpoint, arresting cell cycle progression and ultimately initiating cancer cell apoptosis. |
2017-05-15 |
2023-08-13 |
Not clear |
| Debanjan Bhattacharya, Manoj Kumar Singh, Suhnrita Chaudhuri, Ankur Datta, Swapna Chaudhur. T11TS Treatment Augments Apoptosis of Glioma Associated Brain Endothelial Cells, Hint Toward Anti-Angiogenic Action in Glioma. Journal of cellular physiology. vol 232. issue 3. 2017-05-15. PMID:27255231. |
the study demonstrates that t11ts induces apoptosis in glioma-associated brain endothelial cells via p53 accumulation and activation of intrinsic as well as fas-dependent extrinsic pathway. |
2017-05-15 |
2023-08-13 |
rat |
| Aradhan Sarkar, Hiroaki Iwasa, Shakhawoat Hossain, Xiaoyin Xu, Takeru Sawada, Takanobu Shimizu, Junichi Maruyama, Kyoko Arimoto-Matsuzaki, Yutaka Hat. Domain analysis of Ras-association domain family member 6 upon interaction with MDM2. FEBS letters. vol 591. issue 2. 2017-05-12. PMID:28054709. |
rassf6 antagonizes mdm2, stabilizes p53, and induces apoptosis and cell cycle arrest. |
2017-05-12 |
2023-08-13 |
Not clear |
| Hongbing Gui, Zanming She. Concentrate diet modulation of ruminal genes involved in cell proliferation and apoptosis is related to combined effects of short-chain fatty acid and pH in rumen of goats. Journal of dairy science. vol 99. issue 8. 2017-05-12. PMID:27236768. |
the gene expression of apoptosis genes (caspase 3, caspase 8, caspase 9, p53, and bax) was significantly higher, and the ratio of bcl-2 to bax (bcl-2/bax) expression was lower in the mc group than in the lc group. |
2017-05-12 |
2023-08-13 |
Not clear |
| Yu Fan, Qian Zhan, Hongying Xu, Lili Li, Chen Li, Qian Xiao, Shili Xiang, Tianli Hui, Tingxiu Xiang, Guosheng Re. Epigenetic identification of ZNF545 as a functional tumor suppressor in multiple myeloma via activation of p53 signaling pathway. Biochemical and biophysical research communications. vol 474. issue 4. 2017-05-10. PMID:27150632. |
znf545 transcriptionally activated the p53 signaling pathway but had no effect on akt in mm, whereas ectopic expression of znf545 in silenced cells suppressed their proliferation and induced apoptosis. |
2017-05-10 |
2023-08-13 |
Not clear |
| Yonghua Zhuang, Heather M Berens-Norman, J Smith Leser, Penny Clarke, Kenneth L Tyle. Mitochondrial p53 Contributes to Reovirus-Induced Neuronal Apoptosis and Central Nervous System Injury in a Mouse Model of Viral Encephalitis. Journal of virology. vol 90. issue 17. 2017-05-09. PMID:27307572. |
mitochondrial p53 contributes to reovirus-induced neuronal apoptosis and central nervous system injury in a mouse model of viral encephalitis. |
2017-05-09 |
2023-08-13 |
mouse |