| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Belinda Halling Sørensen, Dorthe Nielsen, Unnur Arna Thorsteinsdottir, Else Kay Hoffmann, Ian Henry Lamber. Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against Cisplatin-induced expression of p53, MDM2, p21Waf1/Cip1, and Caspase-9/-3 activation. American journal of physiology. Cell physiology. vol 310. issue 11. 2017-05-30. PMID:26984736. |
in contrast, cisplatin-resistant cells do not enter apoptosis, i.e., their p53 and downstream signaling are reduced and caspase activity unaltered following cisplatin exposure. |
2017-05-30 |
2023-08-13 |
human |
| Fabiana Ourique, Maicon R Kviecinski, Guilherme Zirbel, Luiza S E P W Castro, Allisson Jhonatan Gomes Castro, Fátima Regina Mena Barreto Silva, Jaime A Valderrama, David Rios, Julio Benites, Pedro Buc Calderon, Rozangela Curi Pedros. In vivo inhibition of tumor progression by 5 hydroxy-1,4-naphthoquinone (juglone) and 2-(4-hydroxyanilino)-1,4-naphthoquinone (Q7) in combination with ascorbate. Biochemical and biophysical research communications. vol 477. issue 4. 2017-05-29. PMID:27346131. |
hypoxia inducible factor hif-1α, glut1, proteins driving cell cycle (p53, p16 and cyclin a) and apoptosis (poly-adp-polymerase parp, bax and bcl-xl) were assessed by western blot. |
2017-05-29 |
2023-08-13 |
mouse |
| Xiaopeng Cui, Xiaohang Shan, Ji Qian, Qianqian Ji, Liang Wang, Xiaotong Wang, Manhua Li, Haifang Ding, Qingqing Liu, Lingling Chen, Dongmei Zhang, Runzhou N. The suppressor of cytokine signaling SOCS1 promotes apoptosis of intestinal epithelial cells via p53 signaling in Crohn's disease. Experimental and molecular pathology. vol 101. issue 1. 2017-05-29. PMID:27236107. |
the suppressor of cytokine signaling socs1 promotes apoptosis of intestinal epithelial cells via p53 signaling in crohn's disease. |
2017-05-29 |
2023-08-13 |
mouse |
| Xiaopeng Cui, Xiaohang Shan, Ji Qian, Qianqian Ji, Liang Wang, Xiaotong Wang, Manhua Li, Haifang Ding, Qingqing Liu, Lingling Chen, Dongmei Zhang, Runzhou N. The suppressor of cytokine signaling SOCS1 promotes apoptosis of intestinal epithelial cells via p53 signaling in Crohn's disease. Experimental and molecular pathology. vol 101. issue 1. 2017-05-29. PMID:27236107. |
using ifn-γ treated ht-29 cells as an apoptotic model of intestinal epithelial cells in vitro, we confirmed that socs1 promoted apoptosis of intestinal epithelial cells by activating p53. |
2017-05-29 |
2023-08-13 |
mouse |
| Xiaopeng Cui, Xiaohang Shan, Ji Qian, Qianqian Ji, Liang Wang, Xiaotong Wang, Manhua Li, Haifang Ding, Qingqing Liu, Lingling Chen, Dongmei Zhang, Runzhou N. The suppressor of cytokine signaling SOCS1 promotes apoptosis of intestinal epithelial cells via p53 signaling in Crohn's disease. Experimental and molecular pathology. vol 101. issue 1. 2017-05-29. PMID:27236107. |
when knocking socs1 down by using socs1 sirna, phosphorylation of p53 and apoptosis of intestinal epithelial cells which was induced by ifn-γ were significantly inhibited. |
2017-05-29 |
2023-08-13 |
mouse |
| Xiaopeng Cui, Xiaohang Shan, Ji Qian, Qianqian Ji, Liang Wang, Xiaotong Wang, Manhua Li, Haifang Ding, Qingqing Liu, Lingling Chen, Dongmei Zhang, Runzhou N. The suppressor of cytokine signaling SOCS1 promotes apoptosis of intestinal epithelial cells via p53 signaling in Crohn's disease. Experimental and molecular pathology. vol 101. issue 1. 2017-05-29. PMID:27236107. |
in summary, our findings suggest that socs1 may promote apoptosis of intestinal epithelial cells at least partly through mediating p53 signaling. |
2017-05-29 |
2023-08-13 |
mouse |
| Jan L Lyche, Irena M Grześ, Camilla Karlsson, Rasoul Nourizadeh-Lillabadi, Peter Aleström, Erik Ropsta. Parental exposure to natural mixtures of persistent organic pollutants (POP) induced changes in transcription of apoptosis-related genes in offspring zebrafish embryos. Journal of toxicology and environmental health. Part A. vol 79. issue 13-15. 2017-05-26. PMID:27484141. |
in both exposure groups the main executors of apoptosis p53, casp 2, casp 6, cassp 8, and bax displayed upregulation compared to controls, suggesting that these pop induce apoptosis via a p53-dependent mechanism. |
2017-05-26 |
2023-08-13 |
zebrafish |
| Minghong Wu, Chenyuan Pan, Zhong Chen, Lihui Jiang, Penghui Lei, Ming Yan. Bioconcentration pattern and induced apoptosis of bisphenol A in zebrafish embryos at environmentally relevant concentrations. Environmental science and pollution research international. vol 24. issue 7. 2017-05-26. PMID:28083739. |
in addition, the expression patterns of four genes related to apoptosis including caspase-3, bax, p53, and c-jun were significantly up-regulated (p < 0.05) in fish embryos/larvae upon bpa exposure at 72 and 168 hpf. |
2017-05-26 |
2023-08-13 |
zebrafish |
| Gabriel Silva, Mozart Marins, Ana Lúcia Fachin, Seong-Ho Lee, Seung Joon Bae. Anti-cancer activity of trans-chalcone in osteosarcoma: Involvement of Sp1 and p53. Molecular carcinogenesis. vol 55. issue 10. 2017-05-26. PMID:26294168. |
building on this knowledge, we evaluated the ability of trans-chalcone to reduce viability, to induce apoptosis, and to alter gene expression of p53 and sp1 in human osteosarcoma cell lines. |
2017-05-26 |
2023-08-13 |
human |
| Hongmei Liu, Xiaoling Li, Guozhu Ning, Shu Zhu, Xiaolu Ma, Xiuli Liu, Chunying Liu, Min Huang, Ina Schmitt, Ullrich Wüllner, Yamei Niu, Caixia Guo, Qiang Wang, Tie-Shan Tan. The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53. PLoS biology. vol 14. issue 11. 2017-05-24. PMID:27851749. |
atx-3 deletion destabilizes p53, resulting in deficiency of p53 activity and functions, whereas ectopic expression of atx-3 induces selective transcription/expression of p53 target genes and promotes p53-dependent apoptosis in both mammalian cells and the central nervous system of zebrafish. |
2017-05-24 |
2023-08-13 |
mouse |
| Tomoya Takeda, Masanobu Tsubaki, Kotaro Sakamoto, Eri Ichimura, Aya Enomoto, Yuri Suzuki, Tatsuki Itoh, Motohiro Imano, Genzoh Tanabe, Osamu Muraoka, Hideaki Matsuda, Takao Satou, Shozo Nishid. Mangiferin, a novel nuclear factor kappa B-inducing kinase inhibitor, suppresses metastasis and tumor growth in a mouse metastatic melanoma model. Toxicology and applied pharmacology. vol 306. 2017-05-23. PMID:27417526. |
mangiferin treatment also increased the expression of cleaved caspase-3, cleaved poly adp ribose polymerase-1 (parp-1), p53 upregulated modulator of apoptosis (puma), p53, and phosphorylated p53 proteins, and decreased the expression of survivin and bcl-associated x (bcl-xl) proteins in vivo. |
2017-05-23 |
2023-08-13 |
mouse |
| Jiaxuan Zhang, Beibei Su, Chen Gong, Qingsongg Xi, Tengfei Cha. miR-214 promotes apoptosis and sensitizes breast cancer cells to doxorubicin by targeting the RFWD2-p53 cascade. Biochemical and biophysical research communications. vol 478. issue 1. 2017-05-23. PMID:27422604. |
remarkably, restoration of mir-214 expression induces apoptosis and sensitizes the mcf7 cells sustaining wild-type p53, but not the p53 null mda-mb-157 cells, to doxorubicin. |
2017-05-23 |
2023-08-13 |
Not clear |
| Marco Napoli, Elsa R Flore. The p53 family orchestrates the regulation of metabolism: physiological regulation and implications for cancer therapy. British journal of cancer. vol 116. issue 2. 2017-05-23. PMID:27884017. |
although previously this was exclusively associated with the ability of the p53 family to induce cell cycle arrest and apoptosis, an increasing number of reports have now indisputably demonstrated that the tumour suppressive functions of the p53 family members also rely on their ability to control and regulate cellular metabolism and maintain cellular oxidative homeostasis. |
2017-05-23 |
2023-08-13 |
Not clear |
| Do-Hee Kim, Ki-Woong Park, In Gyeong Chae, Juthika Kundu, Eun-Hee Kim, Joydeb Kumar Kundu, Kyung-Soo Chu. Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells. Molecular carcinogenesis. vol 55. issue 6. 2017-05-23. PMID:26152521. |
treatment with ca induced apoptosis, which was associated with the induction of p53 and bax, inhibition of mdm2, bcl-2, and bcl-xl expression, activation of caspase-9, and -3, and the cleavage of parp in hct116 cells. |
2017-05-23 |
2023-08-13 |
human |
| Do-Hee Kim, Ki-Woong Park, In Gyeong Chae, Juthika Kundu, Eun-Hee Kim, Joydeb Kumar Kundu, Kyung-Soo Chu. Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells. Molecular carcinogenesis. vol 55. issue 6. 2017-05-23. PMID:26152521. |
pretreatment of cells with ros scavenger n-acetyl cysteine abrogated the inhibitory effect of ca on the jak2-stat3/src-stat3 signaling and rescued cells from ca-induced apoptosis by blocking the induction of p53 and the cleavage of caspase-3 and parp in hct116 cells. |
2017-05-23 |
2023-08-13 |
human |
| Do-Hee Kim, Ki-Woong Park, In Gyeong Chae, Juthika Kundu, Eun-Hee Kim, Joydeb Kumar Kundu, Kyung-Soo Chu. Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells. Molecular carcinogenesis. vol 55. issue 6. 2017-05-23. PMID:26152521. |
in conclusion, our study provides the first report that ca induced apoptosis in hct116 cells via generation of ros, induction of p53, activation of caspases, and inhibition of stat3 signaling pathway. |
2017-05-23 |
2023-08-13 |
human |
| Sarah Wong, Eleonora Napoli, Paula Krakowiak, Flora Tassone, Irva Hertz-Picciotto, Cecilia Giuliv. Role of p53, Mitochondrial DNA Deletions, and Paternal Age in Autism: A Case-Control Study. Pediatrics. vol 137. issue 4. 2017-05-23. PMID:27033107. |
the tumor suppressor p53 responds to a variety of environmental stressors by regulating cell cycle arrest, apoptosis, senescence, dna repair, bioenergetics and mitochondrial dna (mtdna) copy number maintenance. |
2017-05-23 |
2023-08-13 |
mouse |
| Che-Pei Kung, Maureen E Murph. The role of the p53 tumor suppressor in metabolism and diabetes. The Journal of endocrinology. vol 231. issue 2. 2017-05-22. PMID:27613337. |
functioning primarily as a transcription factor, p53 helps fend off the initiation and progression of tumors by inducing cell cycle arrest, senescence or programmed cell death (apoptosis) in cells at the earliest stages of precancerous development. |
2017-05-22 |
2023-08-13 |
human |
| Xing Liu, Xu Wang, Jian Ton. Radon-induced alterations in p53-mediated energy metabolism of malignantly transformed human bronchial epithelial cells. Journal of toxicology and environmental health. Part A. vol 79. issue 9-10. 2017-05-19. PMID:27267826. |
between passages 30 and 35, p53 target gene synthesis of cytochrome c oxidase 2 (sco2), tp53-induced glycolysis, and apoptosis regulator (tigar) expression were significantly decreased. |
2017-05-19 |
2023-08-13 |
human |
| Yeter Topcu-Tarladacalisir, Melike Sapmaz-Metin, Turan Karac. Curcumin counteracts cisplatin-induced nephrotoxicity by preventing renal tubular cell apoptosis. Renal failure. vol 38. issue 10. 2017-05-18. PMID:27758164. |
in this study, the major finding is that curcumin treatment ameliorates the following conditions associated with cisplatin-induced nephrotoxicity: (1) the development of kidney injury (histopathology), (2) inflammatory responses [myeloperoxidase (mpo) and tumor necrosis factor-alpha (tnf-α), interleukin-1 beta (il-1β), il-6, il-10 levels], (3) the degree of lipid peroxidation [malondialdehyde (mda) level], (4) renal tubular cell apoptosis (active caspase-3) and expression of related proteins [p53, fas, and fas ligand (fas-l)] by immunohistochemistry, (5) renal dysfunction (serum urea and creatinine). |
2017-05-18 |
2023-08-13 |
rat |