| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haixia Zhao, Jing Liu, Laixin Song, Zhencai Liu, Guifang Han, Ding Yuan, Ting Wang, Yaoyan Dun, Zhiyong Zhou, Zhaoqi Liu, Yongjun Wang, Changcheng Zhan. Oleanolic acid rejuvenates testicular function through attenuating germ cell DNA damage and apoptosis via deactivation of NF-κB, p53 and p38 signalling pathways. The Journal of pharmacy and pharmacology. vol 69. issue 3. 2017-06-08. PMID:27935635. |
oleanolic acid rejuvenates testicular function through attenuating germ cell dna damage and apoptosis via deactivation of nf-κb, p53 and p38 signalling pathways. |
2017-06-08 |
2023-08-13 |
rat |
| Loana Musso, Raffaella Cincinelli, Valentina Zuco, Michelandrea De Cesare, Franco Zunino, Anna Lucia Fallacara, Maurizio Botta, Sabrina Dallavall. 3-Arylidene-N-hydroxyoxindoles: A New Class of Compounds Endowed with Antitumor Activity. ChemMedChem. vol 11. issue 16. 2017-06-06. PMID:27311681. |
the differential response of ovarian carcinoma cells depending on p53 status was also reflected in the varied susceptibility to apoptosis of the treated cell lines. |
2017-06-06 |
2023-08-13 |
mouse |
| Kensuke Kojima, Jo Ishizawa, Michael Andreef. Pharmacological activation of wild-type p53 in the therapy of leukemia. Experimental hematology. vol 44. issue 9. 2017-06-06. PMID:27327543. |
the clinical trial results of the first clinically used mdm2 inhibitor, rg7112, illustrated promising p53 activation and apoptosis induction in leukemia cells as proof of concept. |
2017-06-06 |
2023-08-13 |
human |
| Sophie Denamur, Lidvine Boland, Maxime Beyaert, Sandrine L Verstraeten, Marianne Fillet, Paul M Tulkens, Françoise Bontemps, Marie-Paule Mingeot-Leclerc. Subcellular mechanisms involved in apoptosis induced by aminoglycoside antibiotics: Insights on p53, proteasome and endoplasmic reticulum. Toxicology and applied pharmacology. vol 309. 2017-06-06. PMID:27568863. |
subcellular mechanisms involved in apoptosis induced by aminoglycoside antibiotics: insights on p53, proteasome and endoplasmic reticulum. |
2017-06-06 |
2023-08-13 |
Not clear |
| Sophie Denamur, Lidvine Boland, Maxime Beyaert, Sandrine L Verstraeten, Marianne Fillet, Paul M Tulkens, Françoise Bontemps, Marie-Paule Mingeot-Leclerc. Subcellular mechanisms involved in apoptosis induced by aminoglycoside antibiotics: Insights on p53, proteasome and endoplasmic reticulum. Toxicology and applied pharmacology. vol 309. 2017-06-06. PMID:27568863. |
in order to better understand the multiple interconnected pathways of gentamicin-induced apoptosis and ensuing renal cell toxicity, we investigated the effect of gentamicin on p53 and p21 levels. |
2017-06-06 |
2023-08-13 |
Not clear |
| Jielu Hao, Qiang Lou, Qingqing Wei, Shuqin Mei, Lin Li, Guangyu Wu, Qing-Sheng Mi, Changlin Mei, Zheng Don. MicroRNA-375 Is Induced in Cisplatin Nephrotoxicity to Repress Hepatocyte Nuclear Factor 1-β. The Journal of biological chemistry. vol 292. issue 11. 2017-06-06. PMID:28119452. |
together, these results suggest that upon cisplatin exposure, p53 and nf-κb collaboratively induce mir-375 expression, which, in turn, represses hnf-1β activity, resulting in renal tubular cell apoptosis and nephrotoxicity. |
2017-06-06 |
2023-08-13 |
mouse |
| Hiroshi Tazawa, Shunsuke Kagawa, Toshiyoshi Fujiwar. p53 Replacement Therapy for Cancer. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer. vol 209. 2017-06-05. PMID:28101684. |
the most potent therapeutic tsg for tumor suppression is the multifunctional transcription factor p53 gene that regulates diverse cellular phenomena such as cell cycle arrest, senescence, apoptosis, and autophagy. |
2017-06-05 |
2023-08-13 |
human |
| Eswar Shankar, Ailin Zhang, Daniel Franco, Sanjay Gupt. Betulinic Acid-Mediated Apoptosis in Human Prostate Cancer Cells Involves p53 and Nuclear Factor-Kappa B (NF-κB) Pathways. Molecules (Basel, Switzerland). vol 22. issue 2. 2017-06-05. PMID:28208611. |
betulinic acid-mediated apoptosis in human prostate cancer cells involves p53 and nuclear factor-kappa b (nf-κb) pathways. |
2017-06-05 |
2023-08-13 |
human |
| Eswar Shankar, Ailin Zhang, Daniel Franco, Sanjay Gupt. Betulinic Acid-Mediated Apoptosis in Human Prostate Cancer Cells Involves p53 and Nuclear Factor-Kappa B (NF-κB) Pathways. Molecules (Basel, Switzerland). vol 22. issue 2. 2017-06-05. PMID:28208611. |
we demonstrate that ba may induce apoptosis by stabilizing p53 and downregulating nf-κb pathway in human prostate cancer cells, irrespective of the androgen association, and therefore can potentially be developed as a molecule of interest in cancer chemoprevention. |
2017-06-05 |
2023-08-13 |
human |
| Sinéad Kearns, Rudi Lurz, Elena V Orlova, Andrei L Okoroko. Two p53 tetramers bind one consensus DNA response element. Nucleic acids research. vol 44. issue 13. 2017-06-05. PMID:27034469. |
in response to genotoxic stress p53 activates dna repair, cell cycle arrest, apoptosis or senescence, which are initiated via p53 binding to its specific dna response elements (re). |
2017-06-05 |
2023-08-13 |
human |
| Keiko Omori, Eiji Kobayashi, Hirotake Komatsu, Jeffrey Rawson, Garima Agrawal, Mounika Parimi, Alina R Oancea, Luis Valiente, Kevin Ferreri, Ismail H Al-Abdullah, Fouad Kandeel, Masafumi Takahashi, Yoko Mulle. Involvement of a proapoptotic gene (BBC3) in islet injury mediated by cold preservation and rewarming. American journal of physiology. Endocrinology and metabolism. vol 310. issue 11. 2017-06-05. PMID:27117005. |
in this study, we examined mechanisms of pancreatic cold preservation and rewarming-induced injury by interrogating the proapoptotic gene bbc3/bbc3, also known as puma (p53 upregulated modulator of apoptosis), using three experimental models: 1) bioluminescence imaging of isolated luciferase-transgenic ("firefly") lewis rat islets, 2) cold preservation of en bloc-harvested pancreata from bbc3-knockout (ko) mice, and 3) cold preservation and rewarming of human pancreata and isolated islets. |
2017-06-05 |
2023-08-13 |
mouse |
| Georges Kalouche, Céline Boucher, Annick Coste, Laurent Debussche, Cécile Orsini, Christophe Baudouin, Thomas Debeir, Xavier Vigé, William Rostèn. Prostaglandin EP2 receptor signaling protects human trabecular meshwork cells from apoptosis induced by ER stress through down-regulation of p53. Biochimica et biophysica acta. vol 1863. issue 9. 2017-06-01. PMID:27321910. |
prostaglandin ep2 receptor signaling protects human trabecular meshwork cells from apoptosis induced by er stress through down-regulation of p53. |
2017-06-01 |
2023-08-13 |
human |
| Georges Kalouche, Céline Boucher, Annick Coste, Laurent Debussche, Cécile Orsini, Christophe Baudouin, Thomas Debeir, Xavier Vigé, William Rostèn. Prostaglandin EP2 receptor signaling protects human trabecular meshwork cells from apoptosis induced by ER stress through down-regulation of p53. Biochimica et biophysica acta. vol 1863. issue 9. 2017-06-01. PMID:27321910. |
the er stress-induced intrinsic apoptosis inhibited by the ep2 receptor agonist was correlated with a decreased accumulation of the cellular stress sensor p53. |
2017-06-01 |
2023-08-13 |
human |
| Georges Kalouche, Céline Boucher, Annick Coste, Laurent Debussche, Cécile Orsini, Christophe Baudouin, Thomas Debeir, Xavier Vigé, William Rostèn. Prostaglandin EP2 receptor signaling protects human trabecular meshwork cells from apoptosis induced by ER stress through down-regulation of p53. Biochimica et biophysica acta. vol 1863. issue 9. 2017-06-01. PMID:27321910. |
in addition, p53 down-regulation was associated with inhibition of its transcriptional activity, which led to decreased expression of the pro-apoptotic p53-upregulated modulator of apoptosis (puma). |
2017-06-01 |
2023-08-13 |
human |
| Georges Kalouche, Céline Boucher, Annick Coste, Laurent Debussche, Cécile Orsini, Christophe Baudouin, Thomas Debeir, Xavier Vigé, William Rostèn. Prostaglandin EP2 receptor signaling protects human trabecular meshwork cells from apoptosis induced by ER stress through down-regulation of p53. Biochimica et biophysica acta. vol 1863. issue 9. 2017-06-01. PMID:27321910. |
in conclusion, we showed that ep2 receptor activation protects against er stress-dependent mitochondrial apoptosis through down-regulation of p53. |
2017-06-01 |
2023-08-13 |
human |
| Jia-Min Zhang, Fei-Er Feng, Qian-Ming Wang, Xiao-Lu Zhu, Hai-Xia Fu, Lan-Ping Xu, Kai-Yan Liu, Xiao-Jun Huang, Xiao-Hui Zhan. Platelet-Derived Growth Factor-BB Protects Mesenchymal Stem Cells (MSCs) Derived From Immune Thrombocytopenia Patients Against Apoptosis and Senescence and Maintains MSC-Mediated Immunosuppression. Stem cells translational medicine. vol 5. issue 12. 2017-06-01. PMID:27471307. |
p53 and p21 expression were upregulated in msc-itp, but inhibition of p53 with pifithrin-α markedly inhibited apoptosis and senescence. |
2017-06-01 |
2023-08-13 |
Not clear |
| Michihiro Shirasugi, Keisuke Nishioka, Toshiro Yamamoto, Takaaki Nakaya, Narisato Kanamur. Normal human gingival fibroblasts undergo cytostasis and apoptosis after long-term exposure to butyric acid. Biochemical and biophysical research communications. vol 482. issue 4. 2017-06-01. PMID:27914813. |
butyric acid induced apoptosis in hgfs via the intrinsic pathway, followed by activation of caspase 9; there was no dna damage or p53 activation. |
2017-06-01 |
2023-08-13 |
mouse |
| Hong Li, Xiumei Jiang, Xuemei Ni. Long Non-Coding RNA Reprogramming (ROR) Promotes Cell Proliferation in Colorectal Cancer via Affecting P53. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2017-06-01. PMID:28216611. |
conclusions our study demonstrates that lncrna-ror participates in controlling crc proliferation, viability, and apoptosis, partially by modulating p53, which provides potential and prospective therapeutic targets for crc. |
2017-06-01 |
2023-08-13 |
mouse |
| C Pan, Y Wang, M K Qiu, S Q Wang, Y B Liu, Z W Quan, J M O. Knockdown of HMGB1 inhibits cell proliferation and induces apoptosis in hemangioma via downregulation of AKT pathway. Journal of biological regulators and homeostatic agents. vol 31. issue 1. 2017-06-01. PMID:28337869. |
moreover, knockdown of hmgb1 gene in vitro suppressed eoma cell proliferation and colony formation and induced cell apoptosis and cycle arrest at g0/g1 phase by downregulation of pcna, cyclind1, p-akt and upregulation of p53 and cleaved parp. |
2017-06-01 |
2023-08-13 |
human |
| Laetitia Mazelin, Baptiste Panthu, Anne-Sophie Nicot, Edwige Belotti, Lionel Tintignac, Geoffrey Teixeira, Qing Zhang, Valérie Risson, Dominique Baas, Emilie Delaune, Geneviève Derumeaux, Daniel Taillandier, Théophile Ohlmann, Michel Ovize, Yann-Gaël Gangloff, Laurent Schaeffe. mTOR inactivation in myocardium from infant mice rapidly leads to dilated cardiomyopathy due to translation defects and p53/JNK-mediated apoptosis. Journal of molecular and cellular cardiology. vol 97. 2017-05-31. PMID:27133769. |
in addition, infant mtorcmko hearts displayed markedly increased apoptosis linked to stretch-induced ankrd1 (ankyrin repeat-domain containing protein 1) up-regulation, jnk kinase activation and p53 accumulation. |
2017-05-31 |
2023-08-13 |
mouse |