| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paul Krimpenfort, Anton Bern. Rejuvenation by Therapeutic Elimination of Senescent Cells. Cell. vol 169. issue 1. 2017-06-23. PMID:28340347. |
show how foxo4 protects senescent cell viability by keeping p53 sequestered in nuclear bodies, preventing it from inducing apoptosis. |
2017-06-23 |
2023-08-13 |
Not clear |
| Raheela Awais, David G Spiller, Michael R H White, Luminita Paraoa. p63 is required beside p53 for PERP-mediated apoptosis in uveal melanoma. British journal of cancer. vol 115. issue 8. 2017-06-21. PMID:27584665. |
p63 is required beside p53 for perp-mediated apoptosis in uveal melanoma. |
2017-06-21 |
2023-08-13 |
Not clear |
| Raheela Awais, David G Spiller, Michael R H White, Luminita Paraoa. p63 is required beside p53 for PERP-mediated apoptosis in uveal melanoma. British journal of cancer. vol 115. issue 8. 2017-06-21. PMID:27584665. |
perp (p53 apoptosis effector related to pmp-22), a transcriptional target of p53, is downregulated and contributes to the impairment of apoptosis in uveal melanoma (um). |
2017-06-21 |
2023-08-13 |
Not clear |
| Han Shan, Yaqi Bian, Zhaoma Shu, Linxia Zhang, Jialei Zhu, Jianhua Ding, Ming Lu, Ming Xiao, Gang H. Fluoxetine protects against IL-1β-induced neuronal apoptosis via downregulation of p53. Neuropharmacology. vol 107. 2017-06-21. PMID:26976669. |
fluoxetine protects against il-1β-induced neuronal apoptosis via downregulation of p53. |
2017-06-21 |
2023-08-13 |
mouse |
| Han Shan, Yaqi Bian, Zhaoma Shu, Linxia Zhang, Jialei Zhu, Jianhua Ding, Ming Lu, Ming Xiao, Gang H. Fluoxetine protects against IL-1β-induced neuronal apoptosis via downregulation of p53. Neuropharmacology. vol 107. 2017-06-21. PMID:26976669. |
with twice injections at 1 h and 12 h after transient middle cerebral artery occlusion (tmcao) respectively alleviated neurological deficits and neuronal apoptosis in a mouse ischemic stroke model, accompanied by inhibiting interleukin-1β (il-1β), bax and p53 expression and upregulating anti-apoptotic protein bcl-2 level. |
2017-06-21 |
2023-08-13 |
mouse |
| Han Shan, Yaqi Bian, Zhaoma Shu, Linxia Zhang, Jialei Zhu, Jianhua Ding, Ming Lu, Ming Xiao, Gang H. Fluoxetine protects against IL-1β-induced neuronal apoptosis via downregulation of p53. Neuropharmacology. vol 107. 2017-06-21. PMID:26976669. |
we next mimicked neuroinflammation in ischemic stroke with il-1β in primary cultured cortical neurons and found that pretreatment with fluoxetine (1 μm) prevented il-1β-induced neuronal apoptosis and upregulation of p53 expression. |
2017-06-21 |
2023-08-13 |
mouse |
| Han Shan, Yaqi Bian, Zhaoma Shu, Linxia Zhang, Jialei Zhu, Jianhua Ding, Ming Lu, Ming Xiao, Gang H. Fluoxetine protects against IL-1β-induced neuronal apoptosis via downregulation of p53. Neuropharmacology. vol 107. 2017-06-21. PMID:26976669. |
furthermore, we demonstrated that p53 overexpression in n2a cell line abolished the anti-apoptotic effect of fluoxetine, indicating that p53 downregulation is required for the protective role of fluoxetine in il-1β-induced neuronal apoptosis. |
2017-06-21 |
2023-08-13 |
mouse |
| Ryo Maeda, Hiroyuki Tamashiro, Kazunori Takano, Hiro Takahashi, Hidefumi Suzuki, Shinta Saito, Waka Kojima, Noritaka Adachi, Kiyoe Ura, Takeshi Endo, Taka-Aki Tamur. TBP-like Protein (TLP) Disrupts the p53-MDM2 Interaction and Induces Long-lasting p53 Activation. The Journal of biological chemistry. vol 292. issue 8. 2017-06-19. PMID:28082682. |
we found that tlp acts to stabilize p53 protein to ensure long-lasting p53 activation, leading to potentiation of p53-induced apoptosis and senescence after genotoxic stress. |
2017-06-19 |
2023-08-13 |
Not clear |
| Aikaterini Fragou, Georgios Tzimagiorgis, Christos Karageorgopoulos, Nikolaos Barbetakis, Axilleas Lazopoulos, Maria Papaioannou, Costas Haitoglou, Sofia Kouido. Increased Δ133p53 mRNA in lung carcinoma corresponds with reduction of p21 expression. Molecular medicine reports. vol 15. issue 4. 2017-06-19. PMID:28260096. |
modification of p53 expression levels and its principle apoptosis and cell cycle regulatory partners, mouse double minute 2 homolog (mdm‑2) and p21, has been previously reported in various types of cancer. |
2017-06-19 |
2023-08-13 |
mouse |
| Bo-Xiang Chen, Shao-Kui Yi, Wei-Feng Wang, Yan He, Yan Huang, Ze-Xia Gao, Hong Liu, Wei-Min Wang, Huan-Ling Wan. Transcriptome comparison reveals insights into muscle response to hypoxia in blunt snout bream (Megalobrama amblycephala). Gene. vol 624. 2017-06-19. PMID:28431977. |
a similar hypoxia-induced transcription patterns suggested a common hypoxia response involved in cell cycle, p53 signaling pathway, apoptosis, heart contraction and blood circulation. |
2017-06-19 |
2023-08-13 |
Not clear |
| Liang Zhou, Shuang Chen, Yu Zhang, Maciej Kmieciak, Yun Leng, Lihong Li, Hui Lin, Kathryn A Rizzo, Catherine I Dumur, Andrea Ferreira-Gonzalez, Mohamed Rahmani, Lawrence Povirk, Sri Chalasani, Allison J Berger, Yun Dai, Steven Gran. The NAE inhibitor pevonedistat interacts with the HDAC inhibitor belinostat to target AML cells by disrupting the DDR. Blood. vol 127. issue 18. 2017-06-19. PMID:26851293. |
mln4924/belinostat coadministration synergistically induced aml cell apoptosis with or without p53 deficiency or flt3-internal tandem duplication (itd), whereas p53 short hairpin rna (shrna) knockdown or enforced flt3-itd expression significantly sensitized cells to the regimen. |
2017-06-19 |
2023-08-13 |
Not clear |
| Ahmed Malki, Rasha Y Elbayaa, Omnia Ali, Ahmed Sultan, Amal M Yousse. Novel quinuclidinone derivatives induced apoptosis in human breast cancer via targeting p53. Bioorganic chemistry. vol 72. 2017-06-16. PMID:28366825. |
novel quinuclidinone derivatives induced apoptosis in human breast cancer via targeting p53. |
2017-06-16 |
2023-08-13 |
human |
| Ahmed Malki, Rasha Y Elbayaa, Omnia Ali, Ahmed Sultan, Amal M Yousse. Novel quinuclidinone derivatives induced apoptosis in human breast cancer via targeting p53. Bioorganic chemistry. vol 72. 2017-06-16. PMID:28366825. |
the above findings demonstrate that derivative 2e induces apoptosis in mcf-7 cells via targeting p53 which merits further development. |
2017-06-16 |
2023-08-13 |
human |
| Goutam Karan, Huaiyu Wang, Amit Chakrabarti, Sukanya Karan, Zhigang Liu, Zhiqiang Xia, Mahesh Gundluru, Stephen Moreton, Yogen Saunthararajah, Mark W Jackson, Mukesh K Agarwal, David N Wal. Identification of a Small Molecule That Overcomes HdmX-Mediated Suppression of p53. Molecular cancer therapeutics. vol 15. issue 4. 2017-06-15. PMID:26883273. |
as p53 plays a key role in regulating proliferation or apoptosis in response to dna-damaging chemotherapies, strategies aimed at reactivating p53 are increasingly being sought. |
2017-06-15 |
2023-08-13 |
mouse |
| Sun-A Ock, Yeon-Mi Lee, Ji-Sung Park, Sharath Belame Shivakumar, Seon-Woung Moon, Nak-Ju Sung, Won-Jae Lee, Si-Jung Jang, Ju-Mi Park, Seung-Chan Lee, Sung-Lim Lee, Gyu-Jin Rh. Evaluation of phenotypic, functional and molecular characteristics of porcine mesenchymal stromal/stem cells depending on donor age, gender and tissue source. The Journal of veterinary medical science. vol 78. issue 6. 2017-06-15. PMID:26922917. |
mscs were analyzed for alkaline phosphatase (ap) activity, cd90 and oct3/4 expression, in vitro differentiation ability, senescence-associated β-galactosidase (sa-β-gal) activity, telomeric properties, cell cycle status and expression of senescence (il6, c-myc, tgfβ, p53 and p21)- and apoptosis (bak and bcl2)-related proteins. |
2017-06-15 |
2023-08-13 |
Not clear |
| Xin Qi, Brandon Davis, Yung-Hsiao Chiang, Emily Filichia, Austin Barnett, Nigel H Greig, Barry Hoffer, Yu Lu. Dopaminergic neuron-specific deletion of p53 gene is neuroprotective in an experimental Parkinson's disease model. Journal of neurochemistry. vol 138. issue 5. 2017-06-14. PMID:27317935. |
however, in da-p53ko mice treated with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), we found that the induction of bax and p53 up-regulated modulator of apoptosis (puma) mrna and protein levels by mptp were diminished in both striatum and substantia nigra of these mice. |
2017-06-14 |
2023-08-13 |
mouse |
| Ahmed A Moustafa, Mohammed Ziada, Abubaker Elshaikh, Amrita Datta, Hogyoung Kim, Krzysztof Moroz, Sudesh Srivastav, Raju Thomas, Jonathan L Silberstein, Krishnarao Moparty, Fatma Elzahraa H Salem, Ola H El-Habit, Asim B Abdel-Magee. Identification of microRNA signature and potential pathway targets in prostate cancer. Experimental biology and medicine (Maywood, N.J.). vol 242. issue 5. 2017-06-14. PMID:27903835. |
integrated in silico and computational prediction analyses demonstrated that the dysregulated mirna signature map to key regulatory factors involved in tumorigenesis, including cell cycle, apoptosis, and p53 pathways. |
2017-06-14 |
2023-08-13 |
human |
| Rulan Jiang, Bo Lönnerda. Bovine lactoferrin and lactoferricin exert antitumor activities on human colorectal cancer cells (HT-29) by activating various signaling pathways. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 95. issue 1. 2017-06-14. PMID:28169560. |
transcriptome analysis indicated that blf, cyclic lfcinb, and linear lfcinb exerted antitumor activities by differentially activating diverse signaling pathways, including p53, apoptosis, and angiopoietin signaling. |
2017-06-14 |
2023-08-13 |
human |
| Keum-Young So, Seon-Hee O. Heme oxygenase-1-mediated apoptosis under cadmium-induced oxidative stress is regulated by autophagy, which is sensitized by tumor suppressor p53. Biochemical and biophysical research communications. vol 479. issue 1. 2017-06-13. PMID:27620489. |
heme oxygenase-1-mediated apoptosis under cadmium-induced oxidative stress is regulated by autophagy, which is sensitized by tumor suppressor p53. |
2017-06-13 |
2023-08-13 |
human |
| Keum-Young So, Seon-Hee O. Heme oxygenase-1-mediated apoptosis under cadmium-induced oxidative stress is regulated by autophagy, which is sensitized by tumor suppressor p53. Biochemical and biophysical research communications. vol 479. issue 1. 2017-06-13. PMID:27620489. |
collectively, the role of ho-1 in apoptosis could be modulated by autophagy, which is sensitized by p53 expression in human cancer cell lines. |
2017-06-13 |
2023-08-13 |
human |