| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fuqiang Yuan, Xiaopan Chen, Jie Liu, Wenke Feng, Xiaoyang Wu, Shao-Yu Che. Up-regulation of Siah1 by ethanol triggers apoptosis in neural crest cells through p38 MAPK-mediated activation of p53 signaling pathway. Archives of toxicology. vol 91. issue 2. 2017-07-13. PMID:27270636. |
these results demonstrate that siah1 plays a crucial role in ethanol-induced apoptosis in nccs, and that the up-regulation of siah1 by ethanol can trigger apoptosis through p38 mapk-mediated activation of the p53 signaling pathway. |
2017-07-13 |
2023-08-13 |
Not clear |
| Yuki Taniguchi, Manabu Kawata, Song Ho Chang, Daisuke Mori, Keita Okada, Hiroshi Kobayashi, Shurei Sugita, Yoko Hosaka, Hiroshi Inui, Shuji Taketomi, Fumiko Yano, Toshiyuki Ikeda, Haruhiko Akiyama, Alea A Mills, Ung-Il Chung, Sakae Tanaka, Hiroshi Kawaguchi, Taku Sait. Regulation of Chondrocyte Survival in Mouse Articular Cartilage by p63. Arthritis & rheumatology (Hoboken, N.J.). vol 69. issue 3. 2017-07-12. PMID:27792866. |
transcription factor p63, of the p53 family, regulates cell proliferation, survival, and apoptosis in various cells and tissues. |
2017-07-12 |
2023-08-13 |
mouse |
| Bin Sun, Susan M Ross, Sean Rowley, Yeyejide Adeleye, Rebecca A Clewel. Contribution of ATM and ATR kinase pathways to p53-mediated response in etoposide and methyl methanesulfonate induced DNA damage. Environmental and molecular mutagenesis. vol 58. issue 2. 2017-07-12. PMID:28195382. |
p53 is a key integrator of cellular response to dna damage, supporting post-translational repair and driving transcription-mediated responses including cell cycle arrest, apoptosis, and repair. |
2017-07-12 |
2023-08-13 |
Not clear |
| Bin Sun, Susan M Ross, Sean Rowley, Yeyejide Adeleye, Rebecca A Clewel. Contribution of ATM and ATR kinase pathways to p53-mediated response in etoposide and methyl methanesulfonate induced DNA damage. Environmental and molecular mutagenesis. vol 58. issue 2. 2017-07-12. PMID:28195382. |
however, inhibition of the atm pathway showed a greater effect on p53 activtation, apoptosis, and accumulation of dna damage than atr-chk 1 or the map kinases regardless of the chemical used. |
2017-07-12 |
2023-08-13 |
Not clear |
| Shwetha K Shetty, Nivedita Tiwari, Amarnath S Marudamuthu, Bijesh Puthusseri, Yashodhar P Bhandary, Jian Fu, Jeffrey Levin, Steven Idell, Sreerama Shett. p53 and miR-34a Feedback Promotes Lung Epithelial Injury and Pulmonary Fibrosis. The American journal of pathology. vol 187. issue 5. 2017-07-11. PMID:28273432. |
we found induction of tumor suppressor protein, p53, and apoptosis with suppression of urokinase-type plasminogen activator (upa) and the upa receptor in aecs from the lungs of ipf patients, and in mice with bleomycin, cigarette smoke, silica, or sepsis-induced lung injury. |
2017-07-11 |
2023-08-13 |
mouse |
| Shwetha K Shetty, Nivedita Tiwari, Amarnath S Marudamuthu, Bijesh Puthusseri, Yashodhar P Bhandary, Jian Fu, Jeffrey Levin, Steven Idell, Sreerama Shett. p53 and miR-34a Feedback Promotes Lung Epithelial Injury and Pulmonary Fibrosis. The American journal of pathology. vol 187. issue 5. 2017-07-11. PMID:28273432. |
csp-mediated inhibition of mir-34a restored sirt1, suppressed p53 acetylation and apoptosis in injured aecs, and prevented pulmonary fibrosis (pf). |
2017-07-11 |
2023-08-13 |
mouse |
| Shwetha K Shetty, Nivedita Tiwari, Amarnath S Marudamuthu, Bijesh Puthusseri, Yashodhar P Bhandary, Jian Fu, Jeffrey Levin, Steven Idell, Sreerama Shett. p53 and miR-34a Feedback Promotes Lung Epithelial Injury and Pulmonary Fibrosis. The American journal of pathology. vol 187. issue 5. 2017-07-11. PMID:28273432. |
aec-specific suppression of mir-34a inhibited bleomycin-induced p53, pai-1, and apoptosis and prevented pf, whereas overexpression of precursor-mir-34a increased p53, pai-1, and apoptosis in aecs of mice unexposed to bleomycin. |
2017-07-11 |
2023-08-13 |
mouse |
| Zulfin Shaikh, K C Niranja. Cell cycle aberration in ameloblastoma and adenomatoid odontogenic tumor: As evidenced by the expression of p53 and survivin. Indian journal of dental research : official publication of Indian Society for Dental Research. vol 26. issue 6. 2017-07-11. PMID:26888232. |
p53 and survivin are involved in cell cycle progression and inhibition of apoptosis, respectively. |
2017-07-11 |
2023-08-13 |
Not clear |
| Sisi Wu, Guonian Zhu, Yinyun Ni, Tingkai Zhang, Wei Jian. [Cucurbitacin I (JSI-124)-induced apoptosis of HepG2 cells via p53 signaling pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 33. issue 1. 2017-07-10. PMID:28031111. |
[cucurbitacin i (jsi-124)-induced apoptosis of hepg2 cells via p53 signaling pathway]. |
2017-07-10 |
2023-08-13 |
human |
| Sisi Wu, Guonian Zhu, Yinyun Ni, Tingkai Zhang, Wei Jian. [Cucurbitacin I (JSI-124)-induced apoptosis of HepG2 cells via p53 signaling pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 33. issue 1. 2017-07-10. PMID:28031111. |
conclusion jsi-124 induces the apoptosis of hepg2 cells through the activation of p53 and its downstream pro-apoptotic factors. |
2017-07-10 |
2023-08-13 |
human |
| Y Li, T Zhang, Q Huang, Y Sun, X Chang, H Zhang, Y Zhu, X Ha. Inhibition of tumor suppressor p53 preserves glycation-serum induced pancreatic beta-cell demise. Endocrine. vol 54. issue 2. 2017-07-07. PMID:27160820. |
further, p53 activation could induce cellular apoptosis in primary rat islets. |
2017-07-07 |
2023-08-13 |
rat |
| Ankush Borlepawar, Ashraf Yusuf Rangrez, Alexander Bernt, Lynn Christen, Samuel Sossalla, Derk Frank, Norbert Fre. TRIM24 protein promotes and TRIM32 protein inhibits cardiomyocyte hypertrophy via regulation of dysbindin protein levels. The Journal of biological chemistry. vol 292. issue 24. 2017-07-06. PMID:28465353. |
this study also implies that trim32 is a key regulator of cell viability and apoptosis in cardiomyocytes via simultaneous activation of p53 and caspase-3/-7 and inhibition of x-linked inhibitor of apoptosis. |
2017-07-06 |
2023-08-13 |
rat |
| Dong Yan, GuangYu An, Macus Tien Ku. C-Jun N-terminal kinase signalling pathway in response to cisplatin. Journal of cellular and molecular medicine. vol 20. issue 11. 2017-06-30. PMID:27374471. |
c-jun n-terminal kinase regulates several important cellular functions including cell proliferation, differentiation, survival and apoptosis while activating and inhibiting substrates for phosphorylation transcription factors (c-jun, atf2: activating transcription factor 2, p53 and so on), which subsequently induce pro-apoptosis and pro-survival factors expression. |
2017-06-30 |
2023-08-13 |
human |
| Ye Cheng, Gang Zhao, Siwen Zhang, Fares Nigim, Guangtong Zhou, Zhiyun Yu, Yang Song, Yong Chen, Yunqian L. AS1411-Induced Growth Inhibition of Glioma Cells by Up-Regulation of p53 and Down-Regulation of Bcl-2 and Akt1 via Nucleolin. PloS one. vol 11. issue 12. 2017-06-29. PMID:27907160. |
here we report that as1411 induces cell apoptosis and cycle arrest, and inhibits cell viability by up-regulation of p53 and down-regulation of bcl-2 and akt1 in human glioma cells. |
2017-06-29 |
2023-08-13 |
mouse |
| Ye Cheng, Gang Zhao, Siwen Zhang, Fares Nigim, Guangtong Zhou, Zhiyun Yu, Yang Song, Yong Chen, Yunqian L. AS1411-Induced Growth Inhibition of Glioma Cells by Up-Regulation of p53 and Down-Regulation of Bcl-2 and Akt1 via Nucleolin. PloS one. vol 11. issue 12. 2017-06-29. PMID:27907160. |
further, as1411 induced cell apoptosis, which was prevented by silencing of p53 and overexpression of bcl-2. |
2017-06-29 |
2023-08-13 |
mouse |
| Chang-Hong Cheng, Chao-Xia Ye, Zhi-Xun Guo, An-Li Wan. Immune and physiological responses of pufferfish (Takifugu obscurus) under cold stress. Fish & shellfish immunology. vol 64. 2017-06-29. PMID:28263881. |
furthermore, the gene expression of apoptotic related genes including p53, caspase-9 and caspase-3 were up-regulated, suggesting that caspase-dependent pathway could play important roles in low temperature-induced apoptosis in fish. |
2017-06-29 |
2023-08-13 |
cat |
| Jia-Zhi Wang, Bi-Sheng Huang, Yan Cao, Ke-Li Chen, Juan L. Anti-hepatoma activities of ethyl acetate extract from Ampelopsis sinica root. Oncology reports. vol 37. issue 4. 2017-06-29. PMID:28350090. |
this study was designed to investigate cytotoxicity by mtt assay, induction of apoptosis via hoechst 33258 staining, scanning electron microscopy and bivariate flow cytometric analysis (annexin v-fitc/pi), inflammation and apoptosis related genes expression by rt-pcr and p53 protein expression by immunofluorescence assay in hepg2 cells. |
2017-06-29 |
2023-08-13 |
mouse |
| Nasi Li, Darleny Y Lizardo, G Ekin Atilla-Gokcume. Specific Triacylglycerols Accumulate via Increased Lipogenesis During 5-FU-Induced Apoptosis. ACS chemical biology. vol 11. issue 9. 2017-06-26. PMID:27428610. |
based on our data, we propose that regulation of triacylglycerols at the molecular level happens downstream of p53 activation and potentially is a mechanism to prevent lipid oxidation during apoptosis. |
2017-06-26 |
2023-08-13 |
Not clear |
| Cheng Fan, Wendy Wang, Ji Jin, Zhuo Yu, Xiping Xi. RASSF10 is Epigenetically Inactivated and Suppresses Cell Proliferation and Induces Cell Apoptosis by Activating the p53 Signalling Pathway in Papillary Thyroid Carcinoma Cancer. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 41. issue 3. 2017-06-26. PMID:28268222. |
rassf10 is epigenetically inactivated and suppresses cell proliferation and induces cell apoptosis by activating the p53 signalling pathway in papillary thyroid carcinoma cancer. |
2017-06-26 |
2023-08-13 |
Not clear |
| Cheng Fan, Wendy Wang, Ji Jin, Zhuo Yu, Xiping Xi. RASSF10 is Epigenetically Inactivated and Suppresses Cell Proliferation and Induces Cell Apoptosis by Activating the p53 Signalling Pathway in Papillary Thyroid Carcinoma Cancer. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 41. issue 3. 2017-06-26. PMID:28268222. |
we aimed to confirm whether rassf10 activated the p53 signalling pathway, thereby modulating cell proliferation, migration, invasion, and apoptosis in papillary thyroid carcinoma (ptc) cells. |
2017-06-26 |
2023-08-13 |
Not clear |