| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anirban Banerjee, Krishnamurthy Thyagarajan, Shilpak Chatterjee, Paramita Chakraborty, Pravin Kesarwani, Myroslawa Soloshchenko, Mazen Al-Hommrani, Kristina Andrijauskaite, Kelly Moxley, Harinarayanan Janakiraman, Matthew J Scheffel, Kristi Helke, Kent Armenson, Viswanathan Palanisamy, Mark P Rubinstein, Elizabeth-Garrett Mayer, David J Cole, Chrystal M Paulos, Christina-Voelkel-Johnson, Michael I Nishimura, Shikhar Mehrotr. Lack of p53 Augments Antitumor Functions in Cytolytic T Cells. Cancer research. vol 76. issue 18. 2017-07-21. PMID:27466285. |
because tumor suppressor protein p53 is also a redox active transcription factor that regulates cellular ros generation that triggers downstream factor-mediating apoptosis, we determined if p53 levels could influence persistence and function of tumor-reactive t cells. |
2017-07-21 |
2023-08-13 |
mouse |
| Mohammad Althubiti, Miran Rada, Jesvin Samuel, Josep M Escorsa, Hishyar Najeeb, Koon-Guan Lee, Kong-Peng Lam, George D D Jones, Nickolai A Barlev, Salvador Maci. BTK Modulates p53 Activity to Enhance Apoptotic and Senescent Responses. Cancer research. vol 76. issue 18. 2017-07-21. PMID:27630139. |
p53 is a tumor suppressor that prevents the emergence of transformed cells by inducing apoptosis or senescence, among other responses. |
2017-07-21 |
2023-08-13 |
Not clear |
| Xiao-Hui Wang, Shu-Feng Zhang, Jun-Tao Bao, Fu-Yun Li. Oridonin synergizes with Nutlin-3 in osteosarcoma cells by modulating the levels of multiple Bcl-2 family proteins. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 6. 2017-07-18. PMID:28618955. |
flow cytometry assay showed that oridonin significantly enhanced nutlin-3-mediated apoptosis in wild-type p53 osteosarcoma cells. |
2017-07-18 |
2023-08-13 |
Not clear |
| Weiying Li, Baitang Lai, Xuehui Yang, Chunyan Zhang, Hui Wan. A truncated p53 in human lung cancer cells as a critical determinant of proliferation and invasiveness. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 6. 2017-07-18. PMID:28631571. |
the truncated p53 induced cell apoptosis. |
2017-07-18 |
2023-08-13 |
human |
| Weiying Li, Baitang Lai, Xuehui Yang, Chunyan Zhang, Hui Wan. A truncated p53 in human lung cancer cells as a critical determinant of proliferation and invasiveness. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 6. 2017-07-18. PMID:28631571. |
the expression levels of bax and p53 upregulated modulator of apoptosis were increased in h1299-p53(del) and 801d-p53(del) cells. |
2017-07-18 |
2023-08-13 |
human |
| Li Yang, Ling-Zhi Xu, Zhi-Qiang Liu, Gui Yang, Xiao-Rui Geng, Li-Hua Mo, Zhi-Gang Liu, Peng-Yuan Zheng, Ping-Chang Yan. Interleukin-13 interferes with activation-induced t-cell apoptosis by repressing p53 expression. Cellular & molecular immunology. vol 13. issue 5. 2017-07-18. PMID:26189367. |
interleukin-13 interferes with activation-induced t-cell apoptosis by repressing p53 expression. |
2017-07-18 |
2023-08-13 |
mouse |
| Li Yang, Ling-Zhi Xu, Zhi-Qiang Liu, Gui Yang, Xiao-Rui Geng, Li-Hua Mo, Zhi-Gang Liu, Peng-Yuan Zheng, Ping-Chang Yan. Interleukin-13 interferes with activation-induced t-cell apoptosis by repressing p53 expression. Cellular & molecular immunology. vol 13. issue 5. 2017-07-18. PMID:26189367. |
il-13 suppressed both the activation-induced apoptosis of cd4(+) t cells and the expression of p53 and fasl. |
2017-07-18 |
2023-08-13 |
mouse |
| Li Yang, Ling-Zhi Xu, Zhi-Qiang Liu, Gui Yang, Xiao-Rui Geng, Li-Hua Mo, Zhi-Gang Liu, Peng-Yuan Zheng, Ping-Chang Yan. Interleukin-13 interferes with activation-induced t-cell apoptosis by repressing p53 expression. Cellular & molecular immunology. vol 13. issue 5. 2017-07-18. PMID:26189367. |
administration of an anti-il-13 antibody enhanced the effect of specific immunotherapy on allergic inflammation in the mouse intestine, enforced the expression of p53 in intestinal cd4(+) t cells, and enhanced the frequency of cd4(+) t-cell apoptosis upon challenge with specific antigens. |
2017-07-18 |
2023-08-13 |
mouse |
| Alaa El-Din Hamid Sayed, Tomomi Watanabe-Asaka, Shoji Oda, Hiroshi Mitan. Apoptotic cell death in erythrocytes of p53-deficient medaka (Oryzias latipes) after γ-irradiation. International journal of radiation biology. vol 92. issue 10. 2017-07-17. PMID:27584718. |
previous studies have examined the effects of γ-irradiation (γ-ir) on wild-type and p53 mutant medaka (oryzias latipes) 24 hours after irradiation and in the present work, apoptosis and alterations in erythrocytes of 4, 8 and 24 h and 14 days after gamma-ray irradiation were reported as genotoxic biomarkers of γ-irradiation. |
2017-07-17 |
2023-08-13 |
Not clear |
| Maya Maor-Nof, Erez Romi, Hadas Sar Shalom, Valeria Ulisse, Calanit Raanan, Aviv Nof, Dena Leshkowitz, Roland Lang, Avraham Yaro. Axonal Degeneration Is Regulated by a Transcriptional Program that Coordinates Expression of Pro- and Anti-degenerative Factors. Neuron. vol 92. issue 5. 2017-07-17. PMID:27889097. |
mechanistically, dusp16 negatively regulates the transcription factor p53 and antagonizes the expression of the pro-degenerative factor, puma (p53 upregulated modulator of apoptosis). |
2017-07-17 |
2023-08-13 |
Not clear |
| Shaoguang Wang, Xiaomei Meng, Yaozhong Don. Ursolic acid nanoparticles inhibit cervical cancer growth in vitro and in vivo via apoptosis induction. International journal of oncology. vol 50. issue 4. 2017-07-17. PMID:28259944. |
data indicated that ursolic acid nanoparticles, indeed, significantly suppress cervial cancer cell proliferation, invasion and migration compared to the control group, and apoptosis was induced by ursolic acid nanoparticles in cervical cancer cells through activating caspases, p53 and suppressing anti-apoptosis-related signals. |
2017-07-17 |
2023-08-13 |
Not clear |
| Cheng-Yuan Wang, Zhi-Bin Xu, Jiang-Ping Wang, Yong Jiao, Bo Zhan. Rb deficiency accelerates progression of carcinoma of the urinary bladder in vivo and in vitro through inhibiting autophagy and apoptosis. International journal of oncology. vol 50. issue 4. 2017-07-17. PMID:28259945. |
interestingly, rb knockout and knockdown result in autophagy and apoptosis inhibition via suppressing p53 and caspase-3 signaling pathways, enhancing bladder cancer development in vitro and in vivo. |
2017-07-17 |
2023-08-13 |
mouse |
| Dan Liu, Lei Cui, Yuan Wang, Guifang Yang, Jing He, Ruidong Hao, Chengpeng Fan, Mengmeng Qu, Zhepeng Liu, Min Wang, Lang Chen, Hui Li, Deyin Gu. Hepatitis B e antigen and its precursors promote the progress of hepatocellular carcinoma by interacting with NUMB and decreasing p53 activity. Hepatology (Baltimore, Md.). vol 64. issue 2. 2017-07-17. PMID:27106262. |
hbeag and its precursors could disrupt p53-numb and hdm2-numb interactions and tricomplex p53-hdm2-numb formation, inhibit the acetylation and translocation of p53 from cytosol to the nucleus, promote hdm2-mediated ubiquitination and degradation of p53, and suppress p53-dependent apoptosis. |
2017-07-17 |
2023-08-13 |
mouse |
| Gloria López Valverde, Elena Garcia Martin, José M Larrosa Povés, Vicente Polo Llorens, Javier Fernández Mateos, Luis E Pablo Júlvez, Rogelio González Sarmient. Study of Association between Pre-Senile Cataracts and the Polymorphisms rs2228000 in XPC and rs1042522 in p53 in Spanish Population. PloS one. vol 11. issue 6. 2017-07-17. PMID:27248495. |
to determine if the presence of certain polymorphisms in the dna repair gene xpc and the apoptosis inductor gene p53 is associated with pre-senile cataract development. |
2017-07-17 |
2023-08-13 |
Not clear |
| Yang Zeng, Meng Fu, Gang-Wei Wu, An-Zu Zhang, Jin-Ping Chen, Hong-Yue Lin, Yong-An Fu, Jing Jia, Zong-Da Cai, Xiao-Jian Wu, Ping La. Upregulation of microRNA-370 promotes cell apoptosis and inhibits proliferation by targeting PTEN in human gastric cancer. International journal of oncology. vol 49. issue 4. 2017-07-13. PMID:27499479. |
in addition, the combination of mir‑370 and pten inactivated akt, mdm2 and mtor while stimulated caspase-3, p53 and gsk3β expression, promoting apoptosis and suppressing proliferation of gastric cancer cells. |
2017-07-13 |
2023-08-13 |
human |
| Jin Wang, Jianxiang Song, Zhengya Gao, Xudong Huo, Yajun Zhang, Wencai Wang, Jianwei Qi, Shiying Zhen. Analysis of gene expression profiles of non-small cell lung cancer at different stages reveals significantly altered biological functions and candidate genes. Oncology reports. vol 37. issue 3. 2017-07-13. PMID:28098899. |
the degs in early‑stage tumors were closely related with the negative regulation of signal transduction, the apoptosis pathway and the p53 signaling pathway. |
2017-07-13 |
2023-08-13 |
Not clear |
| Shuxia Wu, Lijun Wang, Xingye Ren, Yulu Pan, Yan Peng, Xiaoyan Zou, Cuige Shi, Youzhong Zhan. Involvement of retinoblastoma-associated protein 48 during photodynamic therapy of cervical cancer cells. Molecular medicine reports. vol 15. issue 3. 2017-07-13. PMID:28138695. |
reduction of rbap48 led to the reduced suppression of proliferation and apoptosis induced by ala‑pdt in cervical cancer cells, which was associated with a reduction in tumor suppressor protein 53 (p53), retinoblastoma (rb), apoptosis‑related enzyme caspase‑3, and increased levels of the oncogenic genes, human papillomavirus e6 and e7. |
2017-07-13 |
2023-08-13 |
mouse |
| Fuqiang Yuan, Xiaopan Chen, Jie Liu, Wenke Feng, Xiaoyang Wu, Shao-Yu Che. Up-regulation of Siah1 by ethanol triggers apoptosis in neural crest cells through p38 MAPK-mediated activation of p53 signaling pathway. Archives of toxicology. vol 91. issue 2. 2017-07-13. PMID:27270636. |
up-regulation of siah1 by ethanol triggers apoptosis in neural crest cells through p38 mapk-mediated activation of p53 signaling pathway. |
2017-07-13 |
2023-08-13 |
Not clear |
| Fuqiang Yuan, Xiaopan Chen, Jie Liu, Wenke Feng, Xiaoyang Wu, Shao-Yu Che. Up-regulation of Siah1 by ethanol triggers apoptosis in neural crest cells through p38 MAPK-mediated activation of p53 signaling pathway. Archives of toxicology. vol 91. issue 2. 2017-07-13. PMID:27270636. |
this study was designed to test the hypothesis that siah1 mediates ethanol-induced apoptosis in nccs through p38 mapk-mediated activation of the p53 signaling pathway. |
2017-07-13 |
2023-08-13 |
Not clear |
| Fuqiang Yuan, Xiaopan Chen, Jie Liu, Wenke Feng, Xiaoyang Wu, Shao-Yu Che. Up-regulation of Siah1 by ethanol triggers apoptosis in neural crest cells through p38 MAPK-mediated activation of p53 signaling pathway. Archives of toxicology. vol 91. issue 2. 2017-07-13. PMID:27270636. |
in addition, ethanol exposure resulted in a significant increase in the expression of p53 downstream targets and apoptosis in nccs, which can be significantly diminished by down-regulation of siah1 with sirna. |
2017-07-13 |
2023-08-13 |
Not clear |