| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Heng Xiao, Rongliang Tong, Beng Yang, Zhen Lv, Chengli Du, Chuanhui Peng, Chaofeng Ding, Shaobing Cheng, Lin Zhou, Haiyang Xie, Jian Wu, Shusen Zhen. TAZ regulates cell proliferation and sensitivity to vitamin D3 in intrahepatic cholangiocarcinoma. Cancer letters. vol 381. issue 2. 2017-07-28. PMID:27554639. |
taz knockdown results in an increase in cell apoptosis, a promotion of cell-cycle arrest and a decrease in tumor size and weight in vivo through an increased expression of p53. |
2017-07-28 |
2023-08-13 |
Not clear |
| Andrew J Crowther, Jennifer K Ocasio, Fang Fang, Jessica Meidinger, Jaclyn Wu, Allison M Deal, Sha X Chang, Hong Yuan, Ralf Schmid, Ian Davis, Timothy R Gersho. Radiation Sensitivity in a Preclinical Mouse Model of Medulloblastoma Relies on the Function of the Intrinsic Apoptotic Pathway. Cancer research. vol 76. issue 11. 2017-07-28. PMID:27197166. |
deletion of bax, which blocked apoptosis downstream of p53, was sufficient to render tumors radiation resistant. |
2017-07-28 |
2023-08-13 |
mouse |
| Erica Silberstein, Laura Ulitzky, Livia Alves Lima, Nicoleta Cehan, Andréa Teixeira-Carvalho, Philippe Roingeard, Deborah R Taylo. HCV-Mediated Apoptosis of Hepatocytes in Culture and Viral Pathogenesis. PloS one. vol 11. issue 6. 2017-07-27. PMID:27280444. |
screening of a human pcr array demonstrated a gene expression profile that contained upregulated markers of apoptosis, including tumor necrosis factor, caspases and caspase activators, fas, bcl2-interacting killer (bik) and tumor suppressor protein, p53, as a result of hcv genotype 1b infection. |
2017-07-27 |
2023-08-13 |
human |
| S-M Ju, M-S Kim, Y-S Jo, Y-M Jeon, J-S Bae, H-O Pae, B-H Jeo. Licorice and its active compound glycyrrhizic acid ameliorates cisplatin-induced nephrotoxicity through inactivation of p53 by scavenging ROS and overexpression of p21 in human renal proximal tubular epithelial cells. European review for medical and pharmacological sciences. vol 21. issue 4. 2017-07-27. PMID:28272690. |
cisplatin-induced apoptosis in renal cells is associated with reactive oxygen species (ros)-mediated p53 activation. |
2017-07-27 |
2023-08-13 |
human |
| Won Sub Kang, Jin Kyung Park, Young Jong Kim, Ah Rang Cho, Hae Jeong Park, Su Kang Kim, Jong-Woo Paik, Kang Joon Lee, Hae Ri Na, Young Youl Kim, Hyun Kook Lim, Hyun-Ghang Jeong, Jong Woo Ki. Association of tripartite motif family-like 2 (TRIML2) polymorphisms with late-onset Alzheimer's disease risk in a Korean population. Neuroscience letters. vol 630. 2017-07-26. PMID:27471163. |
apoptosis is a prominent feature in the progression of alzheimer's disease (ad), regulated in part by the activity of p53. |
2017-07-26 |
2023-08-13 |
Not clear |
| Jaruwan Chatwichien, Subhasree Basu, Anna Budina-Kolomets, Maureen E Murphy, Jeffrey D Winkle. PUMA-dependent apoptosis in NSCLC cancer cells by a dimeric β-carboline. Bioorganic & medicinal chemistry letters. vol 26. issue 20. 2017-07-26. PMID:27650927. |
dimeric β-carboline 1, which is more potent than the corresponding monomer in nsclc cell lines, is a lysosomotropic agent that inhibits autophagy and mediates cell death by apoptosis, upregulating the pro-apoptotic bh3-only protein puma (p53 upregulated modulator of apoptosis) in a dose dependent manner. |
2017-07-26 |
2023-08-13 |
Not clear |
| Ahm Khurshid Alam, Asm Sakhawat Hossain, Muhammad Ali Khan, Syed Rashel Kabir, Md Abu Reza, Md Mahbubur Rahman, Mohammad Saiful Islam, Md Aziz Abdur Rahman, Mamunur Rashid, Md Golam Sadi. The Antioxidative Fraction of White Mulberry Induces Apoptosis through Regulation of p53 and NFκB in EAC Cells. PloS one. vol 11. issue 12. 2017-07-26. PMID:27936037. |
the antioxidative fraction of white mulberry induces apoptosis through regulation of p53 and nfκb in eac cells. |
2017-07-26 |
2023-08-13 |
mouse |
| Ahm Khurshid Alam, Asm Sakhawat Hossain, Muhammad Ali Khan, Syed Rashel Kabir, Md Abu Reza, Md Mahbubur Rahman, Mohammad Saiful Islam, Md Aziz Abdur Rahman, Mamunur Rashid, Md Golam Sadi. The Antioxidative Fraction of White Mulberry Induces Apoptosis through Regulation of p53 and NFκB in EAC Cells. PloS one. vol 11. issue 12. 2017-07-26. PMID:27936037. |
interestingly, apoptosis correlated with the upregulation of p53 and its target genes parp-1 and bax, and also with the down-regulation of nfκb and its target genes bcl-2 and bcl-xl. |
2017-07-26 |
2023-08-13 |
mouse |
| Ahm Khurshid Alam, Asm Sakhawat Hossain, Muhammad Ali Khan, Syed Rashel Kabir, Md Abu Reza, Md Mahbubur Rahman, Mohammad Saiful Islam, Md Aziz Abdur Rahman, Mamunur Rashid, Md Golam Sadi. The Antioxidative Fraction of White Mulberry Induces Apoptosis through Regulation of p53 and NFκB in EAC Cells. PloS one. vol 11. issue 12. 2017-07-26. PMID:27936037. |
our results suggest that the tumor- suppressive effect of the antioxidative fraction of white mulberry is likely due to apoptosis mediated by p53 and nfκb signaling. |
2017-07-26 |
2023-08-13 |
mouse |
| Zubaida Saifudee. Tissue-Specific Functions of p53 During Kidney Development. Results and problems in cell differentiation. vol 60. 2017-07-26. PMID:28409344. |
p53 is best identified as a tumor suppressor for its transcriptional control of genes involved in cell cycle progression and apoptosis. |
2017-07-26 |
2023-08-13 |
Not clear |
| Tianda Feng, Yunhui Liu, Chao Li, Zhen Li, Heng Ca. DEK proto-oncogene is highly expressed in astrocytic tumors and regulates glioblastoma cell proliferation and apoptosis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 7. 2017-07-26. PMID:28670979. |
dek depletion also induced cell apoptosis, with up-regulated expression of p53 and p21 and down-regulated expression of bcl-2 and c-myc. |
2017-07-26 |
2023-08-13 |
Not clear |
| Nurmaa Dashzeveg, Kiyotsugu Yoshid. Crosstalk between tumor suppressors p53 and PKCδ: Execution of the intrinsic apoptotic pathways. Cancer letters. vol 377. issue 2. 2017-07-26. PMID:27130668. |
p53 is a transcription factor that is frequently mutated in human cancers; it regulates apoptosis in transcription-dependent and -independent ways in response to genotoxic stresses. |
2017-07-26 |
2023-08-13 |
human |
| Nurmaa Dashzeveg, Kiyotsugu Yoshid. Crosstalk between tumor suppressors p53 and PKCδ: Execution of the intrinsic apoptotic pathways. Cancer letters. vol 377. issue 2. 2017-07-26. PMID:27130668. |
recent findings demonstrated that p53, in turn, binds onto the pkcδ promoter and induces its expression upon dna damage to facilitate apoptosis. |
2017-07-26 |
2023-08-13 |
human |
| Zhi Pan, Yingcai Niu, Yini Liang, Xiaojie Zhang, Miaoxian Don. β-Ecdysterone Protects SH-SY5Y Cells Against 6-Hydroxydopamine-Induced Apoptosis via Mitochondria-Dependent Mechanism: Involvement of p38(MAPK)-p53 Signaling Pathway. Neurotoxicity research. vol 30. issue 3. 2017-07-26. PMID:27229883. |
in the present study, pretreatment with β-ecd significantly reduced 6-ohda-induced apoptosis of sh-sy5y cells by a mitochondria-dependent pathway, as indicated by downregulation of bax and puma (p53 upregulated modulator of apoptosis) expression, suppressing ΔΨm loss, inhibiting cytochrome c release, and attenuating caspase-9 activation. |
2017-07-26 |
2023-08-13 |
Not clear |
| Zhi Pan, Yingcai Niu, Yini Liang, Xiaojie Zhang, Miaoxian Don. β-Ecdysterone Protects SH-SY5Y Cells Against 6-Hydroxydopamine-Induced Apoptosis via Mitochondria-Dependent Mechanism: Involvement of p38(MAPK)-p53 Signaling Pathway. Neurotoxicity research. vol 30. issue 3. 2017-07-26. PMID:27229883. |
furthermore, we showed that the inhibition of p38 mitogen-activated protein kinase (p38(mapk))-dependent p53 promoter activity contributed to the protection of sh-sy5y cells from apoptosis, which was validated by the use of sb203580 or p38β dominant negative (dn) mutants. |
2017-07-26 |
2023-08-13 |
Not clear |
| Zhi Pan, Yingcai Niu, Yini Liang, Xiaojie Zhang, Miaoxian Don. β-Ecdysterone Protects SH-SY5Y Cells Against 6-Hydroxydopamine-Induced Apoptosis via Mitochondria-Dependent Mechanism: Involvement of p38(MAPK)-p53 Signaling Pathway. Neurotoxicity research. vol 30. issue 3. 2017-07-26. PMID:27229883. |
these data provide the first evidence that β-ecd protects sh-sy5y cells against 6-ohda-induced apoptosis, possibly through mitochondria protection and p53 modulation via ros-dependent ask1-p38(mapk) pathways. |
2017-07-26 |
2023-08-13 |
Not clear |
| Vandana Sandhu, David C Wedge, Inger Marie Bowitz Lothe, Knut Jørgen Labori, Stefan C Dentro, Trond Buanes, Martina L Skrede, Astrid M Dalsgaard, Else Munthe, Ola Myklebost, Ole Christian Lingjærde, Anne-Lise Børresen-Dale, Tone Ikdahl, Peter Van Loo, Silje Nord, Elin H Kur. The Genomic Landscape of Pancreatic and Periampullary Adenocarcinoma. Cancer research. vol 76. issue 17. 2017-07-24. PMID:27488532. |
genes in the frequently codeleted region 17p13 and 18q21/22 were associated with cell cycle, apoptosis, and p53 and wnt signaling. |
2017-07-24 |
2023-08-13 |
Not clear |
| Masayuki Yamashita, Eriko Nitta, Toshio Sud. Regulation of hematopoietic stem cell integrity through p53 and its related factors. Annals of the New York Academy of Sciences. vol 1370. issue 1. 2017-07-24. PMID:26695737. |
aspp1, an apoptosis-stimulating protein of p53, is highly expressed in hscs and preserves hsc pool integrity via selective induction of apoptosis. |
2017-07-24 |
2023-08-13 |
Not clear |
| Masayuki Yamashita, Eriko Nitta, Toshio Sud. Regulation of hematopoietic stem cell integrity through p53 and its related factors. Annals of the New York Academy of Sciences. vol 1370. issue 1. 2017-07-24. PMID:26695737. |
in this paper, we discuss the role of p53 and mitochondrial apoptosis in hsc regulation and introduce the current understanding of how p53 activity is regulated to achieve a good balance between maintaining the hsc pool and preventing hematological malignancies. |
2017-07-24 |
2023-08-13 |
Not clear |
| Raita Fukaya, Shigeki Ohta, Tomonori Yaguchi, Yumi Matsuzaki, Eiji Sugihara, Hideyuki Okano, Hideyuki Saya, Yutaka Kawakami, Takeshi Kawase, Kazunari Yoshida, Masahiro Tod. MIF Maintains the Tumorigenic Capacity of Brain Tumor-Initiating Cells by Directly Inhibiting p53. Cancer research. vol 76. issue 9. 2017-07-24. PMID:26980763. |
in contrast, mif bound to mutant p53 in the cytoplasm and abrogated transcription-independent induction of apoptosis. |
2017-07-24 |
2023-08-13 |
mouse |