| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carlos Anerillas, Krystyna Mazan-Mamczarz, Allison B Herman, Rachel Munk, Kwan-Wood Gabriel Lam, Miguel Calvo-Rubio, Amanda Garrido, Dimitrios Tsitsipatis, Jennifer L Martindale, Gisela Alt\\xc3\\xa9s, Martina Rossi, Yulan Piao, Jinshui Fan, Chang-Yi Cui, Supriyo De, Kotb Abdelmohsen, Rafael de Cabo, Myriam Gorosp. The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress. Nature aging. 2023-09-04. PMID:37667102. |
reducing mtor function in senescent cells diminished endoplasmic reticulum (er) biogenesis, triggering er stress and apoptosis due to high demands on er function by the sasp. |
2023-09-04 |
2023-09-07 |
mouse |
| Brian C Searle, Allis Chien, Antonius Koller, David Hawke, Anthony W Herren, Jenny Kim, Kimberly A Lee, Ryan D Leib, Alissa J Nelson, Purvi Patel, Jian Min Ren, Paul M Stemmer, Yiying Zhu, Benjamin A Neely, Bhavin Pate. A multipathway phosphopeptide standard for rapid phosphoproteomics assay development. Molecular & cellular proteomics : MCP. 2023-09-01. PMID:37657519. |
this mixture contains 131 mass spectrometry vetted phosphopeptides specifically chosen to cover as many known biologically interesting phosphosites as possible from seven different signaling networks: ampk signaling, death and apoptosis signaling, erbb signaling, insulin/igf-1 signaling, mtor signaling, pi3k/akt signaling, and stress (p38/sapk/jnk) signaling. |
2023-09-01 |
2023-09-07 |
Not clear |
| Wangjian Li, Dongzhang Li, Quan Ma, Yongliang Chen, Zujian Hu, Yongheng Bai, Liping Xi. Targeted inhibition of mTOR by BML-275 induces mitochondrial-mediated apoptosis and autophagy in prostate cancer. European journal of pharmacology. 2023-09-01. PMID:37657741. |
targeted inhibition of mtor by bml-275 induces mitochondrial-mediated apoptosis and autophagy in prostate cancer. |
2023-09-01 |
2023-09-07 |
mouse |
| Wangjian Li, Dongzhang Li, Quan Ma, Yongliang Chen, Zujian Hu, Yongheng Bai, Liping Xi. Targeted inhibition of mTOR by BML-275 induces mitochondrial-mediated apoptosis and autophagy in prostate cancer. European journal of pharmacology. 2023-09-01. PMID:37657741. |
importantly, mtor, a common downstream negative protein of pi3k/akt and ampk signaling, was induced to inactivate, which may be associated with the induction of apoptosis and autophagy. |
2023-09-01 |
2023-09-07 |
mouse |
| Wangjian Li, Dongzhang Li, Quan Ma, Yongliang Chen, Zujian Hu, Yongheng Bai, Liping Xi. Targeted inhibition of mTOR by BML-275 induces mitochondrial-mediated apoptosis and autophagy in prostate cancer. European journal of pharmacology. 2023-09-01. PMID:37657741. |
the pharmacological activation of mtor by mhy1485 abolished the induction of apoptosis and autophagy of bml-275. |
2023-09-01 |
2023-09-07 |
mouse |
| Wangjian Li, Dongzhang Li, Quan Ma, Yongliang Chen, Zujian Hu, Yongheng Bai, Liping Xi. Targeted inhibition of mTOR by BML-275 induces mitochondrial-mediated apoptosis and autophagy in prostate cancer. European journal of pharmacology. 2023-09-01. PMID:37657741. |
thus, these findings indicated that bml-275 induces mitochondrial-mediated apoptosis and autophagy in pca by targeting mtor inhibition. |
2023-09-01 |
2023-09-07 |
mouse |
| Suk Wai Lam, Tulio M Silva, Jolanda Traast-Kooistra, Inge Briaire-de Bruijn, Brendy van den Akker, Pauline A C Bakker, Jules Lansu, Rick L M Haas, Judith V M G Bov\\xc3\\xa9. Histological response to radiotherapy is an early event in myxoid liposarcoma. Virchows Archiv : an international journal of pathology. 2023-08-12. PMID:37572156. |
furthermore, immunohistochemistry was performed for apoptosis (cleaved caspase-3), anti-apoptosis (bcl-2), activity of mtor signaling (phospho-s6), hypoxia (caix), proliferation (ki67), inflammation (cd45 and cd68), and microvessel density (cd34 chalkley count). |
2023-08-12 |
2023-08-16 |
Not clear |
| Suk Wai Lam, Tulio M Silva, Jolanda Traast-Kooistra, Inge Briaire-de Bruijn, Brendy van den Akker, Pauline A C Bakker, Jules Lansu, Rick L M Haas, Judith V M G Bov\\xc3\\xa9. Histological response to radiotherapy is an early event in myxoid liposarcoma. Virchows Archiv : an international journal of pathology. 2023-08-12. PMID:37572156. |
immunohistochemical markers for apoptosis, anti-apoptosis, activity of mtor signaling, proliferation, and hypoxia did not show any marked changes within the remaining tumor cells during and after radiotherapy. |
2023-08-12 |
2023-08-16 |
Not clear |
| Antonios N Gargalionis, Kostas A Papavassiliou, Athanasios G Papavassilio. Implication of mTOR Signaling in NSCLC: Mechanisms and Therapeutic Perspectives. Cells. vol 12. issue 15. 2023-08-11. PMID:37566093. |
non-small cell lung cancer (nsclc) is a frequent type of solid tumor in both genders, where aberrant regulation of the mtor pathway contributes to the development of oncogenesis, apoptosis resistance, angiogenesis, cancer progression, and metastasis. |
2023-08-11 |
2023-08-16 |
Not clear |
| Yu Chen, Junren Chen, Ziwei Xing, Cheng Peng, Dan L. Autophagy in Neuroinflammation: A Focus on Epigenetic Regulation. Aging and disease. 2023-08-07. PMID:37548945. |
inhibition of mtor and activation of ampk and foxo1 enhance autophagy and thereby suppress nlrp3 inflammasome activity and apoptosis, leading to the relief of neuroinflammatory response. |
2023-08-07 |
2023-08-14 |
Not clear |
| Suhail Ahmad Mir, Ashraf Dar, Saad Ali Alshehri, Shadma Wahab, Laraibah Hamid, Mohammad Ali Abdullah Almoyad, Tabasum Ali, Ghulam Nabi Bade. Exploring the mTOR Signalling Pathway and Its Inhibitory Scope in Cancer. Pharmaceuticals (Basel, Switzerland). vol 16. issue 7. 2023-07-29. PMID:37513916. |
additionally, mtor is involved in interplay of signalling pathways that regulate apoptosis and autophagy. |
2023-07-29 |
2023-08-14 |
Not clear |
| Zhongwei Xu, Jun Bao, Xiaohan Jin, Heng Li, Kaiyuan Fan, Zhidong Wu, Min Yao, Yan Zhang, Gang Liu, Dan Wang, Xiaoping Yu, Jia Guo, Ruicheng Xu, Qian Gong, Fengmei Wang, Jin Wan. The Effects of Cinobufagin on Hepatocellular Carcinoma Cells Enhanced by MRT68921, an Autophagy Inhibitor. The American journal of Chinese medicine. 2023-07-25. PMID:37489112. |
as determined using transcriptome analysis, cinobufagin-triggered protective autophagy suppressed cell apoptosis in liver cancer hepg2 and huh-7 cells by inhibiting the phosphoinositide-3-kinase (pi3k)-akt serine/threonine kinase (akt)-mammalian target of rapamycin (mtor) pathway. |
2023-07-25 |
2023-08-14 |
Not clear |
| Yao Chen, Xudan Liu, Qianhui Zhang, Huanhuan Wang, Ruo Zhang, Yanhong Ge, Huning Liang, Wanying Li, Juanjun Fan, Huimin Liu, Zhengyang Lv, Wenting Dou, Yi Wang, Xin L. Arsenic induced autophagy-dependent apoptosis in hippocampal neurons via AMPK/mTOR signaling pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-07-22. PMID:37481228. |
intervention by autophagy activator rapamycin or inhibitor 3-ma, both targeting at mtor, accordingly induced activation or inhibition of apoptosis. |
2023-07-22 |
2023-08-14 |
Not clear |
| Nicole C Beller, Yijia Wang, Amanda B Hummo. Evaluating the Pharmacokinetics and Pharmacodynamics of Chemotherapeutics within a Spatial SILAC-Labeled Spheroid Model System. Analytical chemistry. 2023-07-18. PMID:37462741. |
regorafenib treatment of outer spheroids inhibits proteins involved in critical pathways such as mtor signaling, extracellular signal-regulated kinase (erk)/mitogen-activated protein kinase (mapk) signaling, and colorectal cancer metastasis signaling, resulting in decreased proliferation and cellular apoptosis. |
2023-07-18 |
2023-08-14 |
Not clear |
| Raghad Sabaawi Ibrahim, Shahad Sabaawi Ibrahim, Ahmed El-Naas, Lenka Koklesov\\xc3\\xa1, Peter Kubatka, Dietrich B\\xc3\\xbcsselber. Could Metformin and Resveratrol Support Glioblastoma Treatment? A Mechanistic View at the Cellular Level. Cancers. vol 15. issue 13. 2023-07-14. PMID:37444478. |
metformin and resveratrol inhibit cell proliferation by downregulating the pi3k/akt pathway, activating mtor, and increasing ampk phosphorylation, resulting in lower proliferation and higher apoptosis levels. |
2023-07-14 |
2023-08-14 |
Not clear |
| Haomiao Yu, Zishun Gong, Guodong Wang, Ruiqi Cao, Heyong Yin, Lifeng Ma, Ai Gu. DHA attenuates cartilage degeneration by mediating apoptosis and autophagy in human chondrocytes and rat models of osteoarthritis. In vitro cellular & developmental biology. Animal. 2023-07-14. PMID:37450265. |
therefore, dha promotes chondrocyte proliferation, reduces apoptosis, and increases autophagy in oa chondrocytes, a process that is accomplished by inhibiting the expression of mtor, c-jun n-terminal kinase (jnk), and p38 signaling pathways, providing new perspectives and bootstrap points for the prevention and treatment of oa. |
2023-07-14 |
2023-08-14 |
human |
| Li Li, Yan Liu, Yawei Zheng, Jian Zhu, Dan Wu, Xiaohui Yan, Changyin Li, Minghua Wu, Wenlei L. Exploring the mechanisms under Zuogui Pill's treatment of ischemic stroke through network pharmacology and Frontiers in pharmacology. vol 14. 2023-07-10. PMID:37426810. |
based on pathway enrichment studies, zuogui pill may exert neuroprotection through mapk signaling, pi3k-akt signaling and apoptosis, as well as enhance neurite outgrowth and axonal regeneration effect via mtor signaling, p53 signaling and wnt signaling pathways. |
2023-07-10 |
2023-08-14 |
Not clear |
| Muhammad Younis, Yongjian Wu, Qiongyan Fang, Hong Shan, Xi Huan. Synergistic therapeutic antitumor effect of PD-1 blockade cellular vesicles in combination with Iguratimod and Rhodium nanoparticles. Journal of colloid and interface science. vol 649. 2023-07-01. PMID:37392683. |
for the first time, this study revealed that igu exhibits an antitumor effect by inhibiting the phosphorylation of mammalian target of rapamycin (mtor) and rh-nps provided a photothermal effect by improving reactive oxygen species (ros)-dependent apoptosis in lung cancer cells. |
2023-07-01 |
2023-08-14 |
Not clear |
| Naser-Aldin Lashgari, Nazanin Momeni Roudsari, Hedieh Shamsnia, Maryam Shayan, Saeideh Momtaz, Amir Hossein Abdolghaffari, Maryam Matbou Riahi, Tannaz Jamialahmadi, Paul C Guest, \\xc5\\xbdeljko Reiner, Amirhossein Sahebka. Statins: Beneficial Effects in Treatment of COVID-19. Advances in experimental medicine and biology. vol 1412. 2023-06-28. PMID:37378783. |
various inflammatory pathways such as nuclear factor kappa b (nf-\xce\xbab), signal transducer of activators of transcription (stat), nod-like receptor family protein 3 (nlrp), toll-like receptors (tlrs), mitogen-activated protein kinase (mapk), and mammalian target of rapamycin (mtor) pathways and mediators, such as interleukin (il)-6, il-1\xce\xb2, tumor necrosis factor-\xce\xb1 (tnf-\xce\xb1), and interferon-\xce\xb3 (inf-\xce\xb3), cause cell apoptosis, reduce respiratory capacity and oxygen supply, eventually inducing respiratory system failure and death. |
2023-06-28 |
2023-08-14 |
Not clear |
| Wenting Yang, Lin Pan, Yiju Cheng, Xiao Wu, Songsong Huang, Juan Du, Honglan Zhu, Menglin Zhang, Yuquan Zhan. Amifostine attenuates bleomycin-induced pulmonary fibrosis in mice through inhibition of the PI3K/Akt/mTOR signaling pathway. Scientific reports. vol 13. issue 1. 2023-06-28. PMID:37380638. |
we then assessed histopathological changes, inflammatory factors, oxidative indicators, apoptosis, epithelial-mesenchymal transition, extracellular matrix changes, and levels of phosphatidylinositol 3-kinase (pi3k)/akt/mammalian target of rapamycin (mtor) signaling pathway-related proteins in the blm-treated mice to determine the effect of ami treatment on these factors. |
2023-06-28 |
2023-08-14 |
mouse |