| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huang Linhuan, Zhong Liangying, Lin Shaobin, Zhu Caixia, Cai Danlei, Huang Siqi, Hong Peiming, Kong Shu, Xie Yingjun, Luo Yanmi. Effect of MSX1 on the cellular function of cardiomyocytes. Gene. 2024-03-31. PMID:38556116. |
in this study, we used ac16 cell culture, real-time fluorescence quantitative pcr (qpcr), protein blotting (western blot), flow cytometry apoptosis assay and lactate dehydrogenase (ldh) elisa (enzyme-linked immunosorbnent assay) to investigate the effect of the msx1 gene on cardiomyocyte function. |
2024-03-31 |
2024-04-03 |
Not clear |
| James West, Anandharajan Rathinasabapathy, Xinping Chen, Sheila Shay, Shanti Gladson, Megha Talat. Overexpression of Msx1 in Mouse Lung Leads to Loss of Pulmonary Vessels Following Vascular Hypoxic Injury. Cells. vol 10. issue 9. 2021-11-17. PMID:34571956. |
under pathological conditions, msx1 overexpression can cause cell dedifferentiation or cell apoptosis. |
2021-11-17 |
2023-08-13 |
mouse |
| Myung Jin Son, Seung Bae Rho, Kwangbae Kim, Mijung Oh, Chaeyeon Son, Sang Yong Song, Kyoungsook Par. Homeoprotein Msx1-PIASy Interaction Inhibits Angiogenesis. Cells. vol 9. issue 8. 2021-03-23. PMID:32784646. |
previously, we demonstrated that the homeoprotein msx1 interaction with p53 inhibited tumor growth by inducing apoptosis. |
2021-03-23 |
2023-08-13 |
mouse |
| Yujuan Yue, Ying Yuan, Lili Li, Jiangxia Fan, Chen Li, Weiyan Peng, Guosheng Re. Homeobox protein MSX1 inhibits the growth and metastasis of breast cancer cells and is frequently silenced by promoter methylation. International journal of molecular medicine. vol 41. issue 5. 2018-08-27. PMID:29436596. |
the ectopic expression of msx1, induced by transfection with a lentiviral vector, significantly inhibited the clonogenicity, proliferation, migration and invasion of breast tumor cells by inducing g1/s cell cycle arrest and apoptosis. |
2018-08-27 |
2023-08-13 |
human |
| Yujuan Yue, Ying Yuan, Lili Li, Jiangxia Fan, Chen Li, Weiyan Peng, Guosheng Re. Homeobox protein MSX1 inhibits the growth and metastasis of breast cancer cells and is frequently silenced by promoter methylation. International journal of molecular medicine. vol 41. issue 5. 2018-08-27. PMID:29436596. |
in conclusion, msx1 exerts tumor-suppressive functions by inducing g1/s cell cycle arrest and apoptosis in breast tumorigenesis. |
2018-08-27 |
2023-08-13 |
human |
| Ali Nassif, Ibtisam Senussi, Fleur Meary, Sophia Loiodice, Dominique Hotton, Benoît Robert, Morad Bensidhoum, Ariane Berdal, Sylvie Babajk. Msx1 role in craniofacial bone morphogenesis. Bone. vol 66. 2015-03-30. PMID:24929242. |
msx1 appears to act as a modeling factor for membranous bone; it stimulates trabecular bone metabolism but limits cortical bone growth by promoting apoptosis, and concomitantly controls the collagen-based mineralization process. |
2015-03-30 |
2023-08-13 |
mouse |
| Ryo Aizawa, Atsushi Yamada, Dai Suzuki, Tadahiro Iimura, Hidetoshi Kassai, Takeshi Harada, Masayuki Tsukasaki, Gou Yamamoto, Tetsuhiko Tachikawa, Kazuki Nakao, Matsuo Yamamoto, Akira Yamaguchi, Atsu Aiba, Ryutaro Kamij. Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development. Mechanisms of development. vol 129. issue 1-4. 2014-09-08. PMID:22387309. |
whole mount in situ hybridization analysis of limb buds showed that the expression patterns of sox9 were ectopic, while those of bmp2, msx1, and msx2, known to promote apoptosis in the interdigital mesenchyme, were down-regulated. |
2014-09-08 |
2023-08-12 |
mouse |
| Nikhil Singh, Mudit Gupta, Chinmay M Trivedi, Manvendra K Singh, Li Li, Jonathan A Epstei. Murine craniofacial development requires Hdac3-mediated repression of Msx gene expression. Developmental biology. vol 377. issue 2. 2013-06-24. PMID:23506836. |
known regulators of cell cycle progression and apoptosis in neural crest, including msx1, msx2 and bmp4, are upregulated in hdac3-deficient cranial mesenchyme. |
2013-06-24 |
2023-08-12 |
mouse |
| Adolfo Allegra, Angelo Marino, Pedro Caballero Peregrin, Anna Lama, Aurea García-Segovia, Giusi Irma Forte, Rocío Núñez-Calonge, Cecilia Agueli, Sergio Mazzola, Aldo Volpe. Endometrial expression of selected genes in patients achieving pregnancy spontaneously or after ICSI and patients failing at least two ICSI cycles. Reproductive biomedicine online. vol 25. issue 5. 2013-06-14. PMID:22999554. |
the comparative analysis showed a significant different expression in 19 genes: five implicated in programmed cell death, known as apoptosis (casp8, fadd, casp10, apaf1, anxa4), three in immunity (lif, spp1, c4bpa), five in transcriptional activity (msx1, hoxa10, msx2, hoxa11, gata2), two in lipid metabolism (lepr, apod) and four in oxidative metabolism (aox1, aldh1a3, gpx3, nnmt). |
2013-06-14 |
2023-08-12 |
Not clear |
| Adolfo Allegra, Angelo Marino, Pedro Caballero Peregrin, Anna Lama, Aurea García-Segovia, Giusi Irma Forte, Rocío Núñez-Calonge, Cecilia Agueli, Sergio Mazzola, Aldo Volpe. Endometrial expression of selected genes in patients achieving pregnancy spontaneously or after ICSI and patients failing at least two ICSI cycles. Reproductive biomedicine online. vol 25. issue 5. 2013-06-14. PMID:22999554. |
the comparative analysis showed significantly different levels of expression in 19 genes, five implicated in apoptosis (casp8, fadd, casp10, apaf1, anxa4), three in immunity (lif, spp1, c4bpa), five in transcriptional activity (msx1, hoxa10, msx2, hoxa11, gata2), two in lipid metabolism (lepr, apod) and four in oxidative metabolism (aox1, aldh1a3, gpx3, nnmt). |
2013-06-14 |
2023-08-12 |
Not clear |
| Dai Suzuki, Atsushi Yamada, Takanori Amano, Rika Yasuhara, Ayako Kimura, Mizuho Sakahara, Noriyuki Tsumaki, Shu Takeda, Masaru Tamura, Masanori Nakamura, Naoyuki Wada, Tsutomu Nohno, Toshihiko Shiroishi, Atsu Aiba, Ryutaro Kamij. Essential mesenchymal role of small GTPase Rac1 in interdigital programmed cell death during limb development. Developmental biology. vol 335. issue 2. 2009-12-03. PMID:19766620. |
furthermore, the lack of interdigital programmed cell death and associated syndactyly was related to down-regulated gene expression of bmp2, bmp7, msx1, and msx2, which are known to promote apoptosis in the interdigital mesenchyme. |
2009-12-03 |
2023-08-12 |
mouse |
| Marcela Bonano, Celeste Tríbulo, Jaime De Calisto, Lorena Marchant, Sara S Sánchez, Roberto Mayor, Manuel J Ayba. A new role for the Endothelin-1/Endothelin-A receptor signaling during early neural crest specification. Developmental biology. vol 323. issue 1. 2008-11-24. PMID:18775422. |
we show that: (i) ednra is expressed in prospective neural crest; (ii) loss-of-function experiments with antisense morpholino or with specific chemical inhibitor suppress the expression of early neural crest markers; (iii) gain-of-function experiments expand the neural crest territory; (iv) epistatic experiments show that ednra/edn1 is downstream of the early neural crest gene msx1 and upstream of the late genes sox9 and sox10; and (v) edn1/ednra signaling inhibits apoptosis and controls cell specification of the neural crest. |
2008-11-24 |
2023-08-12 |
Not clear |
| Zhiliang Wu, Isao Nagano, Yuzo Takahash. Candidate genes responsible for common and different pathology of infected muscle tissues between Trichinella spiralis and T. pseudospiralis infection. Parasitology international. vol 57. issue 3. 2008-09-09. PMID:18501667. |
many of these differentially expressed genes were associated with satellite cell activation and proliferation (paired box gene 7, pax7; pax3; desmin; m-cadherin), myogenesis and muscle development (eyes absent 2 homolog, eya2; myocyte enhancer factor 2c, mef2c; pre b-cell leukemia transcription factor 1, pbx1; chordin-like 2, chrdl2), cell differentiation (galectin 1; insulin like growth factors, igfs; c-ski; msh-like 1, msx1; numb), cell proliferation and cycle regulation (retinoblastoma 1, rb1; granulin; p21, cdk4, cyclin a2), and apoptosis (tumor necrosis factor receptor 1, tnf-r1; programmed cell death protein 11, pdcd11; pdcd1; nuclear protein 1, nuprl; clusterin, clu). |
2008-09-09 |
2023-08-12 |
Not clear |
| Yi-Hui Chen, Mamoru Ishii, Jingjing Sun, Henry M Sucov, Robert E Maxso. Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract. Developmental biology. vol 308. issue 2. 2007-09-26. PMID:17601530. |
msx1 and msx2 play dual roles in outflow tract morphogenesis by both protecting secondary heart field (shf) precursors against apoptosis and inhibiting excessive proliferation of cardiac neural crest, endothelial and myocardial cells in the conotruncal cushions. |
2007-09-26 |
2023-08-12 |
Not clear |
| Olga Britanova, Michael J Depew, Manuela Schwark, Bethan L Thomas, Isabelle Miletich, Paul Sharpe, Victor Tarabyki. Satb2 haploinsufficiency phenocopies 2q32-q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw development. American journal of human genetics. vol 79. issue 4. 2006-10-31. PMID:16960803. |
full functional loss of satb2 results in amplification of these defects and leads both to increased apoptosis in the craniofacial mesenchyme where satb2 is usually expressed and to changes in the pattern of expression of three genes implicated in the regulation of craniofacial development in humans and mice: pax9, alx4, and msx1. |
2006-10-31 |
2023-08-12 |
mouse |
| Eric B Johnson, Robert E Hammer, Joachim Her. Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice. Human molecular genetics. vol 14. issue 22. 2006-02-03. PMID:16207730. |
ectopic expression and aberrant signaling of several molecules involved in limb patterning, including fgf8, shh, bmp2, bmp4 and wnt7a, as well as the wnt- and bmp-responsive transcription factors lmx1b and msx1, result in reduced apoptosis and symmetrical dorsal and ventral expansions of the aer. |
2006-02-03 |
2023-08-12 |
mouse |
| Kyoungsook Park, Kwangbae Kim, Seung Bae Rho, Kyusam Choi, Dojin Kim, Sun-Hee Oh, Jinhee Park, Seung-Hoon Lee, Je-Ho Le. Homeobox Msx1 interacts with p53 tumor suppressor and inhibits tumor growth by inducing apoptosis. Cancer research. vol 65. issue 3. 2005-03-14. PMID:15705871. |
homeobox msx1 interacts with p53 tumor suppressor and inhibits tumor growth by inducing apoptosis. |
2005-03-14 |
2023-08-12 |
mouse |
| Kyoungsook Park, Kwangbae Kim, Seung Bae Rho, Kyusam Choi, Dojin Kim, Sun-Hee Oh, Jinhee Park, Seung-Hoon Lee, Je-Ho Le. Homeobox Msx1 interacts with p53 tumor suppressor and inhibits tumor growth by inducing apoptosis. Cancer research. vol 65. issue 3. 2005-03-14. PMID:15705871. |
overexpression of homeobox msx1 induced apoptosis of cancer cells harboring nonfunctional wild-type p53 and suppressed growth of human tumor xenografts in nude mice. |
2005-03-14 |
2023-08-12 |
mouse |
| Celeste Tríbulo, Manuel J Aybar, Sara S Sánchez, Roberto Mayo. A balance between the anti-apoptotic activity of Slug and the apoptotic activity of msx1 is required for the proper development of the neural crest. Developmental biology. vol 275. issue 2. 2005-01-25. PMID:15501222. |
finally, we show that in the neural crest, the region of the neural folds where slug is expressed, cells undergo less apoptosis, than in the region where the msx1 gene is expressed, which correspond to cells adjacent to the neural crest. |
2005-01-25 |
2023-08-12 |
xenopus_laevis |
| Celeste Tríbulo, Manuel J Aybar, Sara S Sánchez, Roberto Mayo. A balance between the anti-apoptotic activity of Slug and the apoptotic activity of msx1 is required for the proper development of the neural crest. Developmental biology. vol 275. issue 2. 2005-01-25. PMID:15501222. |
the protective effect of expressing slug can be reversed by expressing the apoptotic factor bax, while the apoptosis promoted by msx1 can be abolished by expressing the xenopus homologue of bcl2 (xr11). |
2005-01-25 |
2023-08-12 |
xenopus_laevis |