| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Qiu, Zhaoming Huan. Downregulation of IGFBP7 Alleviates LPS-induced Inflammation and Apoptosis in WI-38 Cells via Enhancing Mitophagy. Cell biochemistry and biophysics. 2024-09-30. PMID:39347911. |
downregulation of igfbp7 alleviates lps-induced inflammation and apoptosis in wi-38 cells via enhancing mitophagy. |
2024-09-30 |
2024-10-02 |
human |
| Li Qiu, Zhaoming Huan. Downregulation of IGFBP7 Alleviates LPS-induced Inflammation and Apoptosis in WI-38 Cells via Enhancing Mitophagy. Cell biochemistry and biophysics. 2024-09-30. PMID:39347911. |
next, igfbp7 interference plasmid was constructed, and cell viability and apoptosis were detected by cck8, flow cytometry and western blot. |
2024-09-30 |
2024-10-02 |
human |
| Li Qiu, Zhaoming Huan. Downregulation of IGFBP7 Alleviates LPS-induced Inflammation and Apoptosis in WI-38 Cells via Enhancing Mitophagy. Cell biochemistry and biophysics. 2024-09-30. PMID:39347911. |
to further investigate the regulatory mechanism of igfbp7, we administered cyclosporin a, a mitophagy inhibitor, and then detected apoptosis and inflammation. |
2024-09-30 |
2024-10-02 |
human |
| Li Qiu, Zhaoming Huan. Downregulation of IGFBP7 Alleviates LPS-induced Inflammation and Apoptosis in WI-38 Cells via Enhancing Mitophagy. Cell biochemistry and biophysics. 2024-09-30. PMID:39347911. |
interference with igfbp7 expression in lps-induced cells significantly increased cell activity, decreased apoptosis and cellular inflammation levels. |
2024-09-30 |
2024-10-02 |
human |
| Li Qiu, Zhaoming Huan. Downregulation of IGFBP7 Alleviates LPS-induced Inflammation and Apoptosis in WI-38 Cells via Enhancing Mitophagy. Cell biochemistry and biophysics. 2024-09-30. PMID:39347911. |
to be concluded, inhibition of igfbp7 alleviates lps-induced inflammation and apoptosis in wi-38 cells via enhancing mitophagy. |
2024-09-30 |
2024-10-02 |
human |
| Li Chen, Linhu Hui, Jun L. The multifaceted role of insulin-like growth factor binding protein 7. Frontiers in cell and developmental biology. vol 12. 2024-07-31. PMID:39081862. |
furthermore, the review thoroughly examines the multifaceted functions of igfbp7, encompassing its regulatory effects on cell proliferation, apoptosis, and migration, elucidating the underlying mechanistic pathways. |
2024-07-31 |
2024-08-02 |
Not clear |
| Xiaonan Tang, Jing Mu, Li Ma, Qifan Tan, Jinghui Wang, Jinjing Tan, Shucai Zhan. IGFBP7 overexpression promotes acquired resistance to AZD9291 in non-small cell lung cancer. Biochemical and biophysical research communications. vol 571. 2021-11-17. PMID:34303194. |
reduced igfbp7 in hcc827/azdr cells by si-rna interference recovered the sensitivity to azd9291 partially and increased azd9291-induced cell apoptosis. |
2021-11-17 |
2023-08-13 |
Not clear |
| Peng An, Jianxiao Xing, Aihong Peng, Xincheng Zhao, Wenjuan Chang, Nannan Liang, Yue Cao, Juan Li, Junqin Li, Ruixia Hou, Xinhua Li, Kaiming Zhan. The regulation of dermal mesenchymal stem cells on keratinocytes apoptosis. Cell and tissue banking. vol 22. issue 1. 2021-11-15. PMID:32990869. |
moreover, 33 genes with the function of induced cell apoptosis were highly expressed in dmscs, including insulin-like growth factor-binding protein 4 (2828.13), igfbp7 (1805.69), cathepsin d (1694.34), cathepsin b (ctsb, 1641.40) and dickkopf wnt signaling pathway inhibitor 1 (dkk1, 384.79). |
2021-11-15 |
2023-08-13 |
Not clear |
| Katarzyna Hetmańczyk-Sawicka, Roksana Iwanicka-Nowicka, Anna Fogtman, Jarosław Cieśla, Paweł Włodarski, Barbara Żyżyńska-Granica, Mirella Filocamo, Andrea Dardis, Paolo Peruzzo, Małgorzata Bednarska-Makaruk, Marta Koblowska, Agnieszka Ługowsk. Changes in global gene expression indicate disordered autophagy, apoptosis and inflammatory processes and downregulation of cytoskeletal signalling and neuronal development in patients with Niemann-Pick C disease. Neurogenetics. vol 21. issue 2. 2021-05-27. PMID:31927669. |
downregulated genes were associated with cytoskeletal signalling (actg2, cnn1); inflammation and oxidative stress (cnn1); inhibition of cell proliferation, migration and differentiation; erk-mapk pathway (col4a1, col4a2, cpa4); cell adhesion (igfbp7); autophagy and apoptosis (cdh2, igfbp7, col4a2); neuronal function and development (csrp1); and extracellular matrix stability (plod2). |
2021-05-27 |
2023-08-13 |
Not clear |
| Xiaojun Cai, Lei Wang, Xuling Wang, Fengyan Ho. Silence of IGFBP7 suppresses apoptosis and epithelial mesenchymal transformation of high glucose induced-podocytes. Experimental and therapeutic medicine. vol 16. issue 2. 2020-09-30. PMID:30112052. |
silence of igfbp7 suppresses apoptosis and epithelial mesenchymal transformation of high glucose induced-podocytes. |
2020-09-30 |
2023-08-13 |
Not clear |
| Xiaojun Cai, Lei Wang, Xuling Wang, Fengyan Ho. Silence of IGFBP7 suppresses apoptosis and epithelial mesenchymal transformation of high glucose induced-podocytes. Experimental and therapeutic medicine. vol 16. issue 2. 2020-09-30. PMID:30112052. |
it was demonstrated that silencing igfbp7 inhibited apoptosis and epithelial mesenchymal transformation (emt) of podocytes mediated by high glucose (hg). |
2020-09-30 |
2023-08-13 |
Not clear |
| Xiaolin Wang, Teng Ma, Xiaojian Wan, Yan Meng, Zhenzhen Zhao, Jinjun Bian, Rui Bao, Xiaoming Deng, Tao Yan. IGFBP7 regulates sepsis-induced acute kidney injury through ERK1/2 signaling. Journal of cellular biochemistry. 2019-11-20. PMID:30450602. |
hk-2 cells with lps induction showed cell cycle arrest at g1-g0 phases and cell apoptosis and activated erk1/2 parallel with the changes in the proteins belonging to the erk1/2 pathway, including cyclin d1, p21, bax, and bcl-2, which were inhibited by the igfbp7 knockdown. |
2019-11-20 |
2023-08-13 |
mouse |
| Xiaolin Wang, Teng Ma, Xiaojian Wan, Yan Meng, Zhenzhen Zhao, Jinjun Bian, Rui Bao, Xiaoming Deng, Tao Yan. IGFBP7 regulates sepsis-induced acute kidney injury through ERK1/2 signaling. Journal of cellular biochemistry. 2019-11-20. PMID:30450602. |
moreover, igfbp7 overexpression significantly induced cell cycle arrest at g1-g0 phases and cell apoptosis of hk-2 cells, which were inhibited by pd98509, an erk1/2 signaling inhibitor. |
2019-11-20 |
2023-08-13 |
mouse |
| Xiaolin Wang, Teng Ma, Xiaojian Wan, Yan Meng, Zhenzhen Zhao, Jinjun Bian, Rui Bao, Xiaoming Deng, Tao Yan. IGFBP7 regulates sepsis-induced acute kidney injury through ERK1/2 signaling. Journal of cellular biochemistry. 2019-11-20. PMID:30450602. |
igfbp7 knockdown effectively alleviated the severity of the renal injury, evidenced by decreases in the urinary levels of creatinine, blood urea nitrogen, and albumin, cell apoptosis, and activation of erk1/2 signaling in clp mice. |
2019-11-20 |
2023-08-13 |
mouse |
| S Mohr, A Neuville, M C Bottin, J C Micillino, G Keith, B H Rih. Immune Signature of Malignant Pleural Mesothelioma as Assessed by Transcriptome Analysis. Cancer genomics & proteomics. vol 2. issue 3. 2019-08-09. PMID:31394644. |
the main genes conferring immunoresistance are cd74, hladoa, hladmb, ptgs1, igfbp7 and tgfb3, by favoring immune tolerance, and cflar, dffa, tnfrsf6, bnip3l by impairing apoptosis. |
2019-08-09 |
2023-08-13 |
human |
| Chunyan Yue, Manyi Yang, Qinggang Tian, Fongming Mo, Jian Peng, Yan Ma, Yanning Huang, Dongcui Wang, Yuehua Wang, Zhiyuan H. IGFBP7 is associated to prognosis and could suppress cell survival in cholangiocarcinoma. Artificial cells, nanomedicine, and biotechnology. vol 46. issue sup2. 2019-06-05. PMID:29991293. |
and the biological functions triggered by level changes of igfbp7 were assessed, including proliferation, cell cycle distribution, apoptosis and invasion evaluation. |
2019-06-05 |
2023-08-13 |
Not clear |
| Jin Kim, Woo Ho Kim, Sun-Ju Byeon, Byung Lan Lee, Min A Ki. Epigenetic Downregulation and Growth Inhibition of IGFBP7 in Gastric Cancer Asian Pacific journal of cancer prevention : APJCP. vol 19. issue 3. 2018-09-19. PMID:29580038. |
the effects of igfbp7 on gastric cancer cellswere investigated by various experimental conditions, such as proliferation, colony formation, apoptosis, invasion,and migration assay. |
2018-09-19 |
2023-08-13 |
human |
| Jin Kim, Woo Ho Kim, Sun-Ju Byeon, Byung Lan Lee, Min A Ki. Epigenetic Downregulation and Growth Inhibition of IGFBP7 in Gastric Cancer Asian Pacific journal of cancer prevention : APJCP. vol 19. issue 3. 2018-09-19. PMID:29580038. |
igfbp7 knockdown increased gastric cancer cell growth, invasion, and migration, whereas igfbp7overexpression in gastric cancer cells induced cell growth inhibition and apoptosis. |
2018-09-19 |
2023-08-13 |
human |
| Maaged Akiel, Chunqing Guo, Xia Li, Devaraja Rajasekaran, Rachel G Mendoza, Chadia L Robertson, Nidhi Jariwala, Fang Yuan, Mark A Subler, Jolene Windle, Dawn K Garcia, Zhao Lai, Hung-I Harry Chen, Yidong Chen, Shah Giashuddin, Paul B Fisher, Xiang-Yang Wang, Devanand Sarka. IGFBP7 Deletion Promotes Hepatocellular Carcinoma. Cancer research. vol 77. issue 15. 2017-09-26. PMID:28619711. |
igfbp7 abrogates tumors by inhibiting angiogenesis and inducing cancer-specific senescence and apoptosis. |
2017-09-26 |
2023-08-13 |
mouse |
| Yuan-Bin Chen, Xiao-Yu Liao, Jiang-Bo Zhang, Fang Wang, Hai-De Qin, Lanjun Zhang, Yin Yao Shugart, Yi-Xin Zeng, Wei-Hua Ji. ADAR2 functions as a tumor suppressor via editing IGFBP7 in esophageal squamous cell carcinoma. International journal of oncology. vol 50. issue 2. 2017-05-02. PMID:28035363. |
mechanistically, rna editing may stabilize igfbp7 protein by changing the protease recognition site of matriptase and this is essential for igfbp7 to induce apoptosis. |
2017-05-02 |
2023-08-13 |
Not clear |