| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rong Tang, Wei Lin, Chanjuan Shen, Xueling Hu, Leilin Yu, Ting Meng, Linlin Zhang, Peter J Eggenhuizen, Joshua D Ooi, Peng Jin, Xiang Ding, Xiangcheng Xiao, Yong Zhon. Single-cell transcriptomics uncover hub genes and cell-cell crosstalk in patients with hypertensive nephropathy. International immunopharmacology. vol 125. issue Pt A. 2023-10-28. PMID:37897949. |
the htn endothelium upregulated cellular adhesion genes (icam2 and ceacam1), inflammatory genes (ets2 and ifi6) and apoptosis related genes (cnn3). |
2023-10-28 |
2023-11-08 |
human |
| Y Gao, J Dai, X P Xu, P F Liu, R H Sh. Role of interferon alpha-inducible protein 6 in modulating the proliferation, apoptosis and senescence of oesophageal squamous cell carcinoma cells. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 74. issue 3. 2023-09-03. PMID:37661181. |
ifi6 overexpression inhibited cell senescence and apoptosis but did not influence cell cycle progression, while ifi6 downregulation increased cell senescence and apoptosis. |
2023-09-03 |
2023-09-07 |
mouse |
| Y Gao, J Dai, X P Xu, P F Liu, R H Sh. Role of interferon alpha-inducible protein 6 in modulating the proliferation, apoptosis and senescence of oesophageal squamous cell carcinoma cells. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 74. issue 3. 2023-09-03. PMID:37661181. |
cck-8-based analyses and edu staining, colony formation, \xce\xb2-galactosidase staining and annexin v/pi double-staining assays were used to determine the influence of ifi6 on cell growth, senescence and apoptosis. |
2023-09-03 |
2023-09-07 |
mouse |
| Jeong-Woong Park, Marc Ndimukaga, Jaerung So, Sujung Kim, Anh Duc Truong, Ha Thi Thanh Tran, Hoang Vu Dang, Ki-Duk Son. Molecular analysis of chicken Journal of animal science and technology. vol 65. issue 1. 2023-04-24. PMID:37093904. |
molecular analysis of chicken interferon-alpha inducible protein 6 (ifi6) is an interferon-stimulated gene (isg), belonging to the fam14 family of proteins and is localized in the mitochondrial membrane, where it plays a role in apoptosis. |
2023-04-24 |
2023-08-14 |
chicken |
| Chen Huang, Tao Zhou, Lihua Ma, Shipeng Zha. IFI6 Downregulation Reverses Oxaliplatin Resistance of Colorectal Cancer Cells by Activating the ROS-Induced p38MAPK Signaling Pathway. Biological & pharmaceutical bulletin. vol 46. issue 1. 2023-01-03. PMID:36596524. |
the influence of ifi6 on oxa sensitivity, cell proliferation and apoptosis were evaluated by overexpression or knockdown ifi6 in cells. |
2023-01-03 |
2023-08-14 |
Not clear |
| Chen Huang, Tao Zhou, Lihua Ma, Shipeng Zha. IFI6 Downregulation Reverses Oxaliplatin Resistance of Colorectal Cancer Cells by Activating the ROS-Induced p38MAPK Signaling Pathway. Biological & pharmaceutical bulletin. vol 46. issue 1. 2023-01-03. PMID:36596524. |
and upregulated ifi6 promoted the proliferation and repressed apoptosis in hct116 cells, while suppressed ifi6 markedly reduced proliferation and increased apoptosis in hct116/oxa cells. |
2023-01-03 |
2023-08-14 |
Not clear |
| Chen Huang, Tao Zhou, Lihua Ma, Shipeng Zha. IFI6 Downregulation Reverses Oxaliplatin Resistance of Colorectal Cancer Cells by Activating the ROS-Induced p38MAPK Signaling Pathway. Biological & pharmaceutical bulletin. vol 46. issue 1. 2023-01-03. PMID:36596524. |
interferon-alpha inducible protein 6 (ifi6) has been proved to promote proliferation and suppress apoptosis in several tumor cells, while the impacts of ifi6 on oxa resistance in crc still need exploration. |
2023-01-03 |
2023-08-14 |
Not clear |
| Roshan Dutta, Praveen Guruvaiah, Kiran Kumar Reddi, Suresh Bugide, Dhana Sekhar Reddy Bandi, Yvonne J K Edwards, Kamaljeet Singh, Romi Gupt. UBE2T promotes breast cancer tumor growth by suppressing DNA replication stress. NAR cancer. vol 4. issue 4. 2022-11-07. PMID:36338541. |
consistently, ube2t inhibition downregulated ifi6 expression, promoting dna replication stress, cell cycle arrest, and apoptosis and suppressing breast cancer cell growth. |
2022-11-07 |
2023-08-14 |
mouse |
| Elizabeth Y Li, Jason Xu, Nya D Nelson, David T Teachey, Kai Tan, Neil Romberg, Ed Behrens, Vinodh Pilla. Kikuchi-Fujimoto disease is mediated by an aberrant type I interferon response. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2021-12-25. PMID:34952944. |
apoptosis regulator ifi6 was identified as a key seed gene. |
2021-12-25 |
2023-08-13 |
Not clear |
| Hongyu Zhao, Zhefeng Li, Yan Gao, Jie Li, Xiaoting Zhao, Wentao Yu. Single-Cell RNA-Sequencing Portraying Functional Diversity and Clinical Implications of IFI6 in Ovarian Cancer. Frontiers in cell and developmental biology. vol 9. 2021-09-14. PMID:34513825. |
functional enrichment analysis demonstrates that its functions involve g2m and cisplatin resistance, and downregulation of ifi6 suppresses proliferation capabilities and significantly potentiates cisplatin-induced apoptosis of oc cells |
2021-09-14 |
2023-08-13 |
Not clear |
| Xin Yin, Jingyan Yang, Jintian Chen, Ruiqi Ni, Yanhao Zhou, Hao Song, Liang Jin, Tingting Tang, Yi Pa. LncRNA CTD-3252C9.4 modulates pancreatic cancer cell survival and apoptosis through regulating IFI6 transcription. Cancer cell international. vol 21. issue 1. 2021-08-20. PMID:34399768. |
lncrna ctd-3252c9.4 modulates pancreatic cancer cell survival and apoptosis through regulating ifi6 transcription. |
2021-08-20 |
2023-08-13 |
Not clear |
| Jiao Li, Kaimeng Huang, Gongcheng Hu, Isaac A Babarinde, Yaoyi Li, Xiaotao Dong, Yu-Sheng Chen, Liping Shang, Wenjing Guo, Junwei Wang, Zhaoming Chen, Andrew P Hutchins, Yun-Gui Yang, Hongjie Ya. An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis. Nature communications. vol 10. issue 1. 2019-05-01. PMID:30948729. |
taken together, this study reveals a non-canonical function for ctcf-s that antagonizes the genomic binding of canonical ctcf and cohesin, and that modulates chromatin looping and causes apoptosis by stimulating ifi6 expression. |
2019-05-01 |
2023-08-13 |
human |
| Jiao Li, Kaimeng Huang, Gongcheng Hu, Isaac A Babarinde, Yaoyi Li, Xiaotao Dong, Yu-Sheng Chen, Liping Shang, Wenjing Guo, Junwei Wang, Zhaoming Chen, Andrew P Hutchins, Yun-Gui Yang, Hongjie Ya. An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis. Nature communications. vol 10. issue 1. 2019-05-01. PMID:30948729. |
ctcf-s binding disrupts ctcf/cohesin binding, alters ctcf-mediated chromatin looping and promotes the activation of ifi6 that leads to apoptosis. |
2019-05-01 |
2023-08-13 |
human |
| Yiming Qi, Ying Li, Yingke Zhang, Lin Zhang, Zilian Wang, Xuzhi Zhang, Lian Gui, Junqi Huan. IFI6 Inhibits Apoptosis via Mitochondrial-Dependent Pathway in Dengue Virus 2 Infected Vascular Endothelial Cells. PloS one. vol 10. issue 8. 2016-05-13. PMID:26244642. |
in addition, the pro-apoptotic protein x-linked inhibitor of apoptosis (xiap)-associated factor 1(xaf1) expression had been reported to be up-regulated and led to the induction of apoptosis in denv2-infected vecs,but the relationship between xaf1 and ifi6 dengue virus-induced apoptosis in vecs warrants further study. |
2016-05-13 |
2023-08-13 |
human |
| Yiming Qi, Ying Li, Yingke Zhang, Lin Zhang, Zilian Wang, Xuzhi Zhang, Lian Gui, Junqi Huan. IFI6 Inhibits Apoptosis via Mitochondrial-Dependent Pathway in Dengue Virus 2 Infected Vascular Endothelial Cells. PloS one. vol 10. issue 8. 2016-05-13. PMID:26244642. |
ifi6 inhibits apoptosis via mitochondrial-dependent pathway in dengue virus 2 infected vascular endothelial cells. |
2016-05-13 |
2023-08-13 |
human |
| Yiming Qi, Ying Li, Yingke Zhang, Lin Zhang, Zilian Wang, Xuzhi Zhang, Lian Gui, Junqi Huan. Correction: IFI6 Inhibits Apoptosis via Mitochondrial-Dependent Pathway in Dengue Virus 2 Infected Vascular Endothelial Cells. PloS one. vol 10. issue 9. 2015-12-15. PMID:26393359. |
correction: ifi6 inhibits apoptosis via mitochondrial-dependent pathway in dengue virus 2 infected vascular endothelial cells. |
2015-12-15 |
2023-08-13 |
Not clear |
| Junqi Huang, Ying Li, Yiming Qi, Yingke Zhang, Lin Zhang, Zilian Wang, Xuzhi Zhang, Lian Gu. Coordinated regulation of autophagy and apoptosis determines endothelial cell fate during Dengue virus type 2 infection. Molecular and cellular biochemistry. vol 397. issue 1-2. 2015-06-29. PMID:25138703. |
our data suggest that xaf1 and ifi6 are involved in regulating the balance between autophagy and apoptosis in denv2-infected endothelial cells. |
2015-06-29 |
2023-08-13 |
human |
| Junqi Huang, Ying Li, Yiming Qi, Yingke Zhang, Lin Zhang, Zilian Wang, Xuzhi Zhang, Lian Gu. Coordinated regulation of autophagy and apoptosis determines endothelial cell fate during Dengue virus type 2 infection. Molecular and cellular biochemistry. vol 397. issue 1-2. 2015-06-29. PMID:25138703. |
interferon-alpha-inducible protein 6 (ifi6), a putative apoptosis regulator, inhibited denv2-induced autophagy in ea.hy926 cells, while xaf1, an inhibitor of anti-apoptotic xiap, facilitated autophagy. |
2015-06-29 |
2023-08-13 |
human |
| Geun-Hee Park, Kyoung-Yeon Kim, Sung Won Cho, Jae Youn Cheong, Gyeong Im Yu, Dong Hoon Shin, Kyu Bum Kwac. Association between Interferon-Inducible Protein 6 (IFI6) Polymorphisms and Hepatitis B Virus Clearance. Genomics & informatics. vol 11. issue 1. 2013-05-08. PMID:23613678. |
interferon-inducible protein 6 (ifi6) delays type i interferon-induced apoptosis in cells. |
2013-05-08 |
2023-08-12 |
Not clear |
| Elena Domingo-Gil, Jos\\xc3\\xa9 Manuel Gonz\\xc3\\xa1lez, Mariano Esteba. Identification of cellular genes induced in human cells after activation of the OAS/RNaseL pathway by vaccinia virus recombinants expressing these antiviral enzymes. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 30. issue 3. 2010-08-17. PMID:20038200. |
we found that activation of the 2-5a system from vacv recombinants produces a remarkable stimulation of transcription for genes that regulate many cellular processes, like those that promote cell growth arrest, gadd45b and kctd11, apoptosis as cul2, pdcd6, and tnfaip8l2, ifn-stimulated genes as ifi6, and related to tumor suppression as pla2g2a. |
2010-08-17 |
2023-08-12 |
human |