| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rashmi J Rao, Jimin Yang, Siyi Jiang, Wadih El-Khoury, Neha Hafeez, Satoshi Okawa, Yi Yin Tai, Ying Tang, Yassmin Al Aaraj, John Sembrat, Stephen Y Cha. Post-transcriptional regulation of IFI16 promotes inflammatory endothelial pathophenotypes observed in pulmonary arterial hypertension. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345560. |
inflammatory stimulus of paecs with il-1β up-regulates ifi16 expression, inducing proinflammatory cytokine up-regulation and cellular apoptosis. |
2024-09-30 |
2024-10-02 |
human |
| Hua-Fang Bao, Chun-Hui She, Cheng-Cheng Hou, Da-Nian Ji, Dan Hu, Jun Zou, Yan Shen, Lei-Lei Jian, Jian-Fei Cai, Jing-Fen Ye, Dan Luo, Hai-Fen Ma, Jian-Long Gua. PLK1-activating IFI16-STING-TBK1 pathway induces apoptosis of intestinal epithelial cells in patients with intestinal Behçet's syndrome. The FEBS journal. 2024-04-27. PMID:38676954. |
using ifi16 knockdown, pbmc-ncm460 co-culture, tnf-α neutralizing monoclonal antibody (mab), stimulator of interferon genes (sting) agonist 2'3'-cgamp, and the plk1 inhibitor sbe 13 hcl, we found that plk1 promotes the secretion of tnf-α from pbmcs of intestinal bs patients, which causes overexpression of ifi16 and induces apoptosis of iecs via the sting-tbk1 pathway. |
2024-04-27 |
2024-04-30 |
human |
| Julie Frion, Anna Meller, Gwendoline Marbach, Dominique Lévesque, Xavier Roucou, François-Michel Boisver. CRISPR/Cas9-mediated knockout of the ubiquitin variant UbKEKS reveals a role in regulating nucleolar structures and composition. Biology open. 2023-09-06. PMID:37670689. |
lack of ubkeks favours nucleolar sequestration of known apoptotic regulators such as ifi16 or p14arf, resulting in an increase of apoptosis observed by flow cytometry and real-time monitoring. |
2023-09-06 |
2023-10-07 |
Not clear |
| Shalabh Mishra, Athira S Raj, Akhilesh Kumar, Ashwathi Rajeevan, Puja Kumari, Himanshu Kuma. Innate immune sensing of influenza A viral RNA through IFI16 promotes pyroptotic cell death. iScience. vol 25. issue 1. 2022-01-24. PMID:35072006. |
the activation of ifi16 triggers the production of type i, iii interferons, and also pro-inflammatory cytokines via the sting-tbk1 and pro-caspase-1 signaling axis, thereby promoting cell death (apoptosis and pyroptosis in iav infected cells). |
2022-01-24 |
2023-08-13 |
Not clear |
| Natthakan Thongon, Feiyang Ma, Andrea Santoni, Matteo Marchesini, Elena Fiorini, Ashley Rose, Vera Adema, Irene Ganan-Gomez, Emma M Groarke, Fernanda Gutierrez-Rodrigues, Shuaitong Chen, Pamela Lockyer, Sarah Schneider, Carlos Bueso-Ramos, Guillermo Montalban-Bravo, Caleb A Class, Kelly A Soltysiak, Matteo Pellegrini, Ergun Sahin, Alison A Bertuch, Courtney D DiNardo, Guillermo Garcia-Manero, Neal S Young, Karen Dwyer, Simona Coll. Hematopoiesis under telomere attrition at the single-cell resolution. Nature communications. vol 12. issue 1. 2021-12-12. PMID:34824242. |
this study challenges the historical hypothesis that telomere attrition limits the proliferative potential of hematopoietic stem cells by inducing apoptosis, autophagy, or senescence, and suggests that targeting ifi16 signaling axis might prevent hematopoietic stem cell functional decline in conditions affecting telomere maintenance. |
2021-12-12 |
2023-08-13 |
mouse |
| Dapei Li, Lifen Xie, Zigang Qiao, Sanyue Mai, Jingfei Zhu, Fan Zhang, Shengchuan Chen, Liang Li, Fangrong Shen, Yanghua Qin, Haiping Yao, Sudan He, Feng M. STING-mediated degradation of IFI16 negatively regulates apoptosis by inhibiting p53 phosphorylation at serine 392. The Journal of biological chemistry. vol 297. issue 2. 2021-11-03. PMID:34216619. |
sting-mediated degradation of ifi16 negatively regulates apoptosis by inhibiting p53 phosphorylation at serine 392. |
2021-11-03 |
2023-08-13 |
Not clear |
| Dapei Li, Lifen Xie, Zigang Qiao, Sanyue Mai, Jingfei Zhu, Fan Zhang, Shengchuan Chen, Liang Li, Fangrong Shen, Yanghua Qin, Haiping Yao, Sudan He, Feng M. STING-mediated degradation of IFI16 negatively regulates apoptosis by inhibiting p53 phosphorylation at serine 392. The Journal of biological chemistry. vol 297. issue 2. 2021-11-03. PMID:34216619. |
interferon-γ-inducible factor 16 (ifi16) triggers stimulator of interferon (ifn) genes (sting)-dependent type i ifn production during host antiviral immunity and facilitates p53-dependent apoptosis during suppressing tumorigenesis. |
2021-11-03 |
2023-08-13 |
Not clear |
| Dapei Li, Lifen Xie, Zigang Qiao, Sanyue Mai, Jingfei Zhu, Fan Zhang, Shengchuan Chen, Liang Li, Fangrong Shen, Yanghua Qin, Haiping Yao, Sudan He, Feng M. STING-mediated degradation of IFI16 negatively regulates apoptosis by inhibiting p53 phosphorylation at serine 392. The Journal of biological chemistry. vol 297. issue 2. 2021-11-03. PMID:34216619. |
however, it is unknown whether sting also suppresses ifi16/p53-dependent apoptosis via degradation of ifi16. |
2021-11-03 |
2023-08-13 |
Not clear |
| Dapei Li, Lifen Xie, Zigang Qiao, Sanyue Mai, Jingfei Zhu, Fan Zhang, Shengchuan Chen, Liang Li, Fangrong Shen, Yanghua Qin, Haiping Yao, Sudan He, Feng M. STING-mediated degradation of IFI16 negatively regulates apoptosis by inhibiting p53 phosphorylation at serine 392. The Journal of biological chemistry. vol 297. issue 2. 2021-11-03. PMID:34216619. |
here, our results from flow cytometry apoptosis detection and immunoblot assays show that ifi16 and nutlin-3, a p53 pathway activator, synergistically induce apoptosis in u2os and a549 cells. |
2021-11-03 |
2023-08-13 |
Not clear |
| Dapei Li, Lifen Xie, Zigang Qiao, Sanyue Mai, Jingfei Zhu, Fan Zhang, Shengchuan Chen, Liang Li, Fangrong Shen, Yanghua Qin, Haiping Yao, Sudan He, Feng M. STING-mediated degradation of IFI16 negatively regulates apoptosis by inhibiting p53 phosphorylation at serine 392. The Journal of biological chemistry. vol 297. issue 2. 2021-11-03. PMID:34216619. |
in summary, our current study demonstrates that sting-mediated ifi16 degradation negatively regulates ifi16-mediated p53-dependent apoptosis in osteosarcoma and non-small cell lung cancer cells, which suggests a protumorigenic role for sting in certain cancer types because of its potent ability to degrade upstream ifi16. |
2021-11-03 |
2023-08-13 |
Not clear |
| Pier Paolo Piccaluga, Claudio Agostinelli, Simona Righi, Maria Ciccone, Maria Carla Re, Giuseppina Musumeci, Erica Diani, Caterina Signoretto, Isabella Bon, Ottavio Piccin, Antonio Cuneo, Claudio Tripodo, Cristina Ponti, Donato Zipeto, Santo Landolfo, Davide Gibellin. IFI16 reduced expression is correlated with unfavorable outcome in chronic lymphocytic leukemia. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 125. issue 6. 2017-07-10. PMID:28517553. |
in this paper, we show for the first time that the expression of the interferon-inducible dna sensor ifi16, a member of the pyhin protein family involved in proliferation inhibition and apoptosis regulation, is associated with the clinical outcome in cll. |
2017-07-10 |
2023-08-13 |
Not clear |
| Benjamin A Diner, Tuo Li, Todd M Greco, Marni S Crow, John A Fuesler, Jennifer Wang, Ileana M Criste. The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA. Molecular systems biology. vol 11. issue 1. 2016-09-30. PMID:25665578. |
the human pyhin proteins, aim2, ifi16, ifix, and mnda, are critical regulators of immune response, transcription, apoptosis, and cell cycle. |
2016-09-30 |
2023-08-13 |
human |
| Ning Li, Yan Fu, Wei Chen, Gui-Qiu Hu, Min Zhou, Shui-Xing Yu, Xiao-Jing Zhang, Chong-Tao Du, Yong-Jun Yan. IFI16 mediates soluble Flt-1 and endoglin production by trophoblast cells. Journal of hypertension. vol 33. issue 8. 2016-04-08. PMID:26002845. |
the interferon-inducible protein 16 (ifi16) - a member of the hin-200 family - is an innate immune receptor for intracellular dna, which is implicated in the control of cell growth, apoptosis, angiogenesis, and immunomodulation; however, its role in preeclampsia remains unresolved. |
2016-04-08 |
2023-08-13 |
Not clear |
| Mandar Bawadekar, Marco De Andrea, Marisa Gariglio, Santo Landolf. Mislocalization of the interferon inducible protein IFI16 by environmental insults: implications in autoimmunity. Cytokine & growth factor reviews. vol 26. issue 2. 2016-01-19. PMID:25466628. |
the nuclear dna sensor ifi16, a member of pyhin family of proteins, was previously studied for its role in cell cycle regulation, tumor suppression, apoptosis and dna damage signaling. |
2016-01-19 |
2023-08-13 |
Not clear |
| Zhou Liu, Xiaoxiao Zheng, Yiwen Wang, Haiwei Son. Bacterial expression of the HINab domain of IFI16: purification, characterization of DNA binding activity, and co-crystallization with viral dsDNA. Protein expression and purification. vol 102. 2015-05-20. PMID:25050461. |
interferon-inducible protein 16 (ifi16) is a multifunctional p200-family protein that plays pivotal roles in p53-mediated apoptosis, tumor suppression and dna damage response. |
2015-05-20 |
2023-08-13 |
human |
| Moriyasu Yamauchi, Takafumi Nakano, Torahiko Nakashima, Ryuji Yasumatsu, Kazuki Hashimoto, Satoshi Toh, Hideki Shiratsuchi, Yoshinao Oda, Shizuo Komun. Interferon Inducible IFI16 Expression in p16 Positive Squamous Cell Carcinoma of the Oropharynx. ISRN otolaryngology. vol 2013. 2013-08-19. PMID:23956879. |
interferon inducible ifi16, which is implicated in the control of cell growth, apoptosis, angiogenesis, and immunomodulation in various types of cancers, is reported to be frequently expressed in the hpv-positive head and neck scc and to correlate with a better prognosis. |
2013-08-19 |
2023-08-12 |
Not clear |
| Yuudai Kondo, Kentaro Nagai, Shingo Nakahata, Yusuke Saito, Tomonaga Ichikawa, Akira Suekane, Tomohiko Taki, Reika Iwakawa, Masato Enari, Masafumi Taniwaki, Jun Yokota, Sumio Sakoda, Kazuhiro Morishit. Overexpression of the DNA sensor proteins, absent in melanoma 2 and interferon-inducible 16, contributes to tumorigenesis of oral squamous cell carcinoma with p53 inactivation. Cancer science. vol 103. issue 4. 2012-05-16. PMID:22320325. |
knockdown of aim2 or ifi16 in oscc cells results in the suppression of cell growth and apoptosis, accompanied by the downregulation of nuclear factor kappa-light-chain-enhancer of activated b cells activation. |
2012-05-16 |
2023-08-12 |
human |
| Francesca Gugliesi, Valentina Dell'oste, Marco De Andrea, Rossella Baggetta, Michele Mondini, Claudia Zannetti, Benedetta Bussolati, Gianni Camussi, Marisa Gariglio, Santo Landolf. Tumor-derived endothelial cells evade apoptotic activity of the interferon-inducible IFI16 gene. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 31. issue 8. 2011-11-28. PMID:21488755. |
forced ifi16 expression in normal human endothelial cells (ecs) inhibits cell growth and tube morphogenesis of ecs through the triggering of apoptosis by caspase-2 and caspase-3 via nuclear factor-κb (nf-κb) complex activation. |
2011-11-28 |
2023-08-12 |
human |
| Francesca Gugliesi, Marco De Andrea, Michele Mondini, Paola Cappello, Mirella Giovarelli, Yehuda Shoenfeld, PierLuigi Meroni, Marisa Gariglio, Santo Landolf. The proapoptotic activity of the Interferon-inducible gene IFI16 provides new insights into its etiopathogenetic role in autoimmunity. Journal of autoimmunity. vol 35. issue 2. 2011-03-15. PMID:20488664. |
in this study, we report for the first time that endothelial cells overexpressing ifi16 undergo apoptosis via the activation of caspase 2 and caspase 3, and that a positive feedback loop appears to link these two caspases. |
2011-03-15 |
2023-08-12 |
Not clear |
| Francesca Gugliesi, Marco De Andrea, Michele Mondini, Paola Cappello, Mirella Giovarelli, Yehuda Shoenfeld, PierLuigi Meroni, Marisa Gariglio, Santo Landolf. The proapoptotic activity of the Interferon-inducible gene IFI16 provides new insights into its etiopathogenetic role in autoimmunity. Journal of autoimmunity. vol 35. issue 2. 2011-03-15. PMID:20488664. |
the relevance of ifi16-mediated apoptosis is highlighted by the observation that ifi16 knock down by rna interference in endothelial cells inhibits the activation of both caspase 2 and caspase 3 by ifn-beta priming and synthetic double-stranded rna treatment. |
2011-03-15 |
2023-08-12 |
Not clear |