| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zeyu Yang, Hongdan Chen, Supeng Yin, Hongbiao Mo, Fan Chai, Peng Luo, Yao Li, Le Ma, Ziying Yi, Yizeng Sun, Yan Chen, Jie Wu, Weihua Wang, Tingjie Yin, Junping Zhu, Chunmeng Shi, Fan Zhan. PGR-KITLG signaling drives a tumor-mast cell regulatory feedback to modulate apoptosis of breast cancer cells. Cancer letters. 2024-03-31. PMID:38556106. |
grn attenuates tnfα-induced apoptosis in bc cells by competitively binding to tnfr1. |
2024-03-31 |
2024-04-03 |
Not clear |
| Rebecca Yun, Eunji Hong, Junil Kim, Bora Park, Staci Jakyong Kim, Bona Lee, Yong Sang Song, Seong-Jin Kim, Sujin Park, Jin Muk Kan. N-linked glycosylation is essential for anti-tumor activities of KIAA1324 in gastric cancer. Cell death & disease. vol 14. issue 8. 2023-08-23. PMID:37612293. |
rna sequencing (rnaseq) analysis revealed that genes most relevant to the apoptosis and cell cycle arrest pathways were modulated by kiaa1324 with the n-linked glycosylation, and gene regulatory network (grn) analysis suggested novel targets of kiaa1324 for anti-tumor effects in the transcription level. |
2023-08-23 |
2023-09-07 |
Not clear |
| Jiaxing Chen, ChinWang Cheong, Liang Lan, Xin Zhou, Jiming Liu, Aiping Lyu, William K Cheung, Lu Zhan. DeepDRIM: a deep neural network to reconstruct cell-type-specific gene regulatory network using single-cell RNA-seq data. Briefings in bioinformatics. vol 22. issue 6. 2021-11-15. PMID:34424948. |
we focused on the cell-type-specific grn alteration and observed targets of tfs that were differentially expressed between the two statuses to be enriched in lysosome, apoptosis, response to decreased oxygen level and microtubule, which had been proved to be associated with coronavirus infection. |
2021-11-15 |
2023-08-13 |
Not clear |
| Bin Deng, Zhe Zheng, Jialing Zheng, Wanlin Yang, Yu Huang, Yuqi Luo, Dana Jin, Lu Shen, Kunlin Jin, Qing Wan. FTD-PSP is an Unusual Clinical Phenotype in A Frontotemporal Dementia Patient with A Novel Progranulin Mutation. Aging and disease. vol 12. issue 7. 2021-10-12. PMID:34631218. |
cellular apoptosis and survival test were performed to identify the function of grn. |
2021-10-12 |
2023-08-13 |
Not clear |
| Songkiad Upontain, Piya Sereerak, Thewarach Laha, Banchob Sripa, Prasarn Tangkawatana, Paul J Brindley, Sirikachorn Tangkawatan. Granulin Expression in Hamsters during Opisthorchis viverrini Infection-Induced Cholangiocarcinogenesis Asian Pacific journal of cancer prevention : APJCP. vol 19. issue 9. 2019-01-03. PMID:30255697. |
grn stimulatescell growth and development while inhibiting apoptosis. |
2019-01-03 |
2023-08-13 |
Not clear |
| Ezra Y Rosen, Eric M Wexler, Revital Versano, Giovanni Coppola, Fuying Gao, Kellen D Winden, Michael C Oldham, Lauren Herl Martens, Ping Zhou, Robert V Farese, Daniel H Geschwin. Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling. Neuron. vol 71. issue 6. 2011-11-14. PMID:21943601. |
furthermore, we observed that the wnt receptor fzd2 was one of only a few genes upregulated at 6 weeks in a grn knockout mouse, and that fzd2 reduction caused increased apoptosis, while its upregulation promoted neuronal survival in vitro. |
2011-11-14 |
2023-08-12 |
mouse |
| Ezra Y Rosen, Eric M Wexler, Revital Versano, Giovanni Coppola, Fuying Gao, Kellen D Winden, Michael C Oldham, Lauren Herl Martens, Ping Zhou, Robert V Farese, Daniel H Geschwin. Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling. Neuron. vol 71. issue 6. 2011-11-14. PMID:21943601. |
this highlighted key pathways such as apoptosis and ubiquitination in grn deficient human neurons, while revealing an unexpected major role for the wnt signaling pathway, which was confirmed by analysis of gene expression data from postmortem ftd brain. |
2011-11-14 |
2023-08-12 |
mouse |
| Gernot Kleinberger, Hans Wils, Peter Ponsaerts, Geert Joris, Jean-Pierre Timmermans, Christine Van Broeckhoven, Samir Kumar-Sing. Increased caspase activation and decreased TDP-43 solubility in progranulin knockout cortical cultures. Journal of neurochemistry. vol 115. issue 3. 2010-12-02. PMID:20731760. |
in primary cortical neurons derived from grn knockout (grn(-/-) ) mice, we found that grn-deficiency causes significantly reduced neuronal survival and increased caspase-mediated apoptosis, which was not observed in primary mouse embryonic fibroblasts derived from grn(-/-) mice. |
2010-12-02 |
2023-08-12 |
mouse |
| P J Beresford, Z Xia, A H Greenberg, J Lieberma. Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation. Immunity. vol 10. issue 5. 1999-06-17. PMID:10367904. |
cytotoxic lymphocytes trigger apoptosis by releasing perforin and granzymes (grn). |
1999-06-17 |
2023-08-12 |
Not clear |