| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Linhe Lu, Yalan Shao, Nisha Wang, Xiang Xiong, Mengen Zhai, Jiayou Tang, Yang Liu, Jian Yang, Lifang Yan. Follistatin-like protein 1 attenuates doxorubicin-induced cardiomyopathy by inhibiting MsrB2-mediated mitophagy. Molecular and cellular biochemistry. 2024-05-02. PMID:38696001. |
fstl1 treatment attenuated dox-induced cardiac dysfunction, cardiac fibrosis, and cellular apoptosis by inhibiting excess mitochondrial matrix protein methionine sulfoxide reductase b2 (msrb2)-mediated mitophagy. |
2024-05-02 |
2024-05-04 |
Not clear |
| Haijun Xu, Hong Guo, Zhigang Tang, Ruijun Hao, Shaowei Wang, Ping Ji. Follistatin-like 1 protects against doxorubicin-induced cardiotoxicity by preventing mitochondrial dysfunction through the SIRT6/Nrf2 signaling pathway. Cell biology international. 2024-03-04. PMID:38436106. |
furthermore, fstl1 can alleviate doxorubicin-induced mitochondrial dysfunction by inhibiting autophagy and apoptosis. |
2024-03-04 |
2024-03-06 |
Not clear |
| Haijun Xu, Hong Guo, Zhigang Tang, Ruijun Hao, Shaowei Wang, Ping Ji. Follistatin-like 1 protects against doxorubicin-induced cardiotoxicity by preventing mitochondrial dysfunction through the SIRT6/Nrf2 signaling pathway. Cell biology international. 2024-03-04. PMID:38436106. |
these results suggested that the protective mechanism of fstl1 on doxorubicin-induced cardiotoxicity may be related with the inhibition of autophagy and apoptosis, partly through the activation of sirt6/nrf2. |
2024-03-04 |
2024-03-06 |
Not clear |
| Ruijuan Du, Kai Li, Kelei Guo, Zhiguo Chen, Li Han, Hua Bia. FSTL1: a double-edged sword in cancer development. Gene. 2024-02-12. PMID:38346455. |
furthermore, we discuss the functional role of fstl1 in various processes that involve tumor cell proliferation, metastasis, immune responses, stemness, cell apoptosis, and resistance to chemotherapy. |
2024-02-12 |
2024-02-15 |
Not clear |
| Zhen Liu, Hong Zhang, Xiaoxia H. Analysis of the expression and mechanism of follistatin‑like protein 1 in cervical cancer. Oncology reports. vol 50. issue 6. 2023-10-27. PMID:37888756. |
the effects of abnormal expression of fstl1 on cervical cancer cells were assessed using colony formation, mtt, wound‑healing, transwell, apoptosis, and nude mouse tumorigenicity assays. |
2023-10-27 |
2023-11-08 |
mouse |
| Zhen Liu, Hong Zhang, Xiaoxia H. Analysis of the expression and mechanism of follistatin‑like protein 1 in cervical cancer. Oncology reports. vol 50. issue 6. 2023-10-27. PMID:37888756. |
moreover, fstl1 inhibited the proliferation, migration, and invasion of cervical cancer cells as well as xenograft tumor growth and promoted cell apoptosis. |
2023-10-27 |
2023-11-08 |
mouse |
| Zhen Liu, Hong Zhang, Xiaoxia H. Analysis of the expression and mechanism of follistatin‑like protein 1 in cervical cancer. Oncology reports. vol 50. issue 6. 2023-10-27. PMID:37888756. |
fstl1 inhibited the proliferation, migration, and invasion of cervical cancer cells and promoted their apoptosis. |
2023-10-27 |
2023-11-08 |
mouse |
| Yi Luo, Youzhi He, Yongfu Wang, Yuxia Xu, Li Yan. LncRNA HCG18 promotes inflammation and apoptosis in intervertebral disc degeneration via the miR-495-3p/FSTL1 axis. Molecular and cellular biochemistry. 2023-05-03. PMID:37138144. |
silencing of hcg18 or fstl1, as well as mir-495-3p overexpression in np cells alleviated il-1β-induced apoptosis and inflammation of np cells. |
2023-05-03 |
2023-08-14 |
Not clear |
| Yi Luo, Youzhi He, Yongfu Wang, Yuxia Xu, Li Yan. LncRNA HCG18 promotes inflammation and apoptosis in intervertebral disc degeneration via the miR-495-3p/FSTL1 axis. Molecular and cellular biochemistry. 2023-05-03. PMID:37138144. |
overexpression of fstl1 abolished the effects of hcg18 silencing on il-1β-induced apoptosis and inflammation. |
2023-05-03 |
2023-08-14 |
Not clear |
| Ekta Kumari, Aoxi Xu, Runwen Chen, Yuxin Yan, Zhuo Yang, Tao Zhan. FSTL1-knockdown improves neural oscillation via decreasing neuronal-inflammation regulating apoptosis in Aβ Experimental neurology. 2022-09-26. PMID:36162512. |
fstl1-knockdown improves neural oscillation via decreasing neuronal-inflammation regulating apoptosis in aβ follistatin like protein 1 (fstl1) is a famous growth regulatory protein. |
2022-09-26 |
2023-08-14 |
mouse |
| Zhong Yu, Ling Ouyan. Odd-skipped related 1 plays a tumor suppressor role in ovarian cancer via promoting follistatin-like protein 1 transcription. Human cell. 2022-08-14. PMID:35964260. |
moreover, fstl1 knockdown reversed the action of osr1 overexpression in oc progression, including cell viability, migration, invasion, and apoptosis. |
2022-08-14 |
2023-08-14 |
Not clear |
| Yamato Ogiwara, Makoto Nakagawa, Fumihiko Nakatani, Yasushi Uemura, Rong Zhang, Chie Kudo-Sait. Blocking FSTL1 boosts NK immunity in treatment of osteosarcoma. Cancer letters. 2022-04-19. PMID:35439537. |
indeed, fstl1 stimulation suppressed nk activity partly via apoptosis induction, but blocking fstl1 or cd6, a receptor for alcam, significantly restored nk activity. |
2022-04-19 |
2023-08-13 |
mouse |
| Marijn C Peters, Sofia Di Martino, Thomas Boelens, Jiabin Qin, Alain van Mil, Pieter A Doevendans, Steven A J Chamuleau, Joost P G Sluijter, Klaus Nee. Follistatin-like 1 promotes proliferation of matured human hypoxic iPSC-cardiomyocytes and is secreted by cardiac fibroblasts. Molecular therapy. Methods & clinical development. vol 25. 2022-03-23. PMID:35317048. |
depending on its glycosylation state, follistatin-like 1 (fstl1) has been shown to increase cardiomyocyte (cm) proliferation, decrease cm apoptosis, and prevent cardiac rupture in animal models of ischemic heart disease. |
2022-03-23 |
2023-08-13 |
human |
| Jie Shi, Shaoyi Wang, Qiting He, Kaiwen Liu, Wei Zhao, Qing Xie, Lei Chen. TNF-α induces up-regulation of MicroRNA-27a via the P38 signalling pathway, which inhibits intervertebral disc degeneration by targeting FSTL1. Journal of cellular and molecular medicine. vol 25. issue 15. 2021-10-15. PMID:34190406. |
ectopic mir27a expression inhibited apoptosis, suppressed the inflammatory response and attenuated the catabolism of the extracellular matrix by targeting fstl1. |
2021-10-15 |
2023-08-13 |
human |
| Jie Shi, Shaoyi Wang, Qiting He, Kaiwen Liu, Wei Zhao, Qing Xie, Lei Chen. TNF-α induces up-regulation of MicroRNA-27a via the P38 signalling pathway, which inhibits intervertebral disc degeneration by targeting FSTL1. Journal of cellular and molecular medicine. vol 25. issue 15. 2021-10-15. PMID:34190406. |
at the same time, mir27a is up-regulated by tnf-α via the p38 signalling pathway, which ameliorates inflammation, apoptosis and matrix degradation by targeting fstl1. |
2021-10-15 |
2023-08-13 |
human |
| Yintao Zhao, Jingjing Sun, Wei Zhang, Meng Peng, Jun Chen, Lu Zheng, Xiangqin Zhang, Haibo Yang, Yuan Li. Follistatin-Like 1 Protects against Doxorubicin-Induced Cardiomyopathy through Upregulation of Nrf2. Oxidative medicine and cellular longevity. vol 2020. 2021-06-08. PMID:32831995. |
fstl1 prevented dox-related cardiac injury and inhibited cardiac oxidative stress and apoptosis, thereby improving cardiac function in mice. |
2021-06-08 |
2023-08-13 |
mouse |
| Mengjie Wu, Yongfeng Ding, Nan Wu, Junjie Jiang, Yingying Huang, Fanyu Zhang, Haiyong Wang, Quan Zhou, Yan Yang, Wei Zhuo, Lisong Ten. FSTL1 promotes growth and metastasis in gastric cancer by activating AKT related pathway and predicts poor survival. American journal of cancer research. vol 11. issue 3. 2021-04-02. PMID:33791149. |
down or up-regulation of fstl1 inhibited or increased, respectively, the proliferation by reducing apoptosis, clonogenicity, migration and invasion of gc cells |
2021-04-02 |
2023-08-13 |
Not clear |
| Shitong Xiang, Yuying Zhang, Tianyue Jiang, Ziying Ke, Yingchun Shang, Wen Ning, Zhuo Yang, Tao Zhan. Knockdown of Follistatin-like 1 disrupts synaptic transmission in hippocampus and leads to cognitive impairments. Experimental neurology. vol 333. 2021-03-05. PMID:32721453. |
it proves that fstl1 suppresses synaptic transmission by activating na/k-atpase in drg neurons and inhibits neuronal apoptosis by phosphorylation akt signaling. |
2021-03-05 |
2023-08-13 |
mouse |
| Zhigang Hu, Pengxin Zhao, Kaili Zhang, Leilei Zang, Haiying Liao, Weiyuan M. Hsa_circ_0011290 regulates proliferation, apoptosis and glycolytic phenotype in papillary thyroid cancer via miR-1252/ FSTL1 signal pathway. Archives of biochemistry and biophysics. vol 685. 2020-07-13. PMID:32234499. |
hsa_circ_0011290 regulates proliferation, apoptosis and glycolytic phenotype in papillary thyroid cancer via mir-1252/ fstl1 signal pathway. |
2020-07-13 |
2023-08-13 |
Not clear |
| Kun-Sheng Li, Wei-Peng Jiang, Qiu-Chang Li, Hao-Wen Zhang, Yang Bai, Xia Zhang, Hai-Ying L. MiR-29a in mesenchymal stem cells inhibits FSTL1 secretion and promotes cardiac myocyte apoptosis in hypoxia-reoxygenation injury. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. vol 46. 2020-06-22. PMID:31945680. |
mir-29a in mesenchymal stem cells inhibits fstl1 secretion and promotes cardiac myocyte apoptosis in hypoxia-reoxygenation injury. |
2020-06-22 |
2023-08-13 |
Not clear |