| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jinfeng Dong, Xiaoqiang Zhen. SENP1 knockdown potentiates the apoptosis, cell cycle arrest, and reduces cisplatin resistance of diffuse large B cell lymphoma cells via inducing ferroptosis. Biochemistry and cell biology = Biochimie et biologie cellulaire. 2024-05-06. PMID:38708853. |
senp1 depletion drove the ferroptosis of both parental and cisplatin-resistant dlbcl cells and ferroptosis inhibitor fer-1 reversed the influences of senp1 inhibition on cell viability, apoptosis, cell cycle, and cisplatin resistance in dlbcl. |
2024-05-06 |
2024-05-08 |
human |
| Zhezhe Qu, Xiaochen Pang, Zhongting Mei, Ying Li, Yaozhi Zhang, Chuanhao Huang, Kuiwu Liu, Shuting Yu, Changhao Wang, Zhiyong Sun, Yingqi Liu, Xin Li, Yingqiong Jia, Yuechao Dong, Meixi Lu, Tiantian Ju, Fan Wu, Min Huang, Na Li, Shunkang Dou, Jianhao Jiang, Xianhui Dong, Yi Zhang, Wanhong Li, Baofeng Yang, Weijie D. The positive feedback loop of the NAT10/Mybbp1a/p53 axis promotes cardiomyocyte ferroptosis to exacerbate cardiac I/R injury. Redox biology. vol 72. 2024-04-07. PMID:38583415. |
the inhibition of cardiomyocyte ferroptosis by fer-1 exerted superior cardioprotective effects against the nat10-induced exacerbation of post-i/r cardiac damage than the inhibition of apoptosis by emricasan. |
2024-04-07 |
2024-04-10 |
mouse |
| Bingchun Sun, Ligang Zhang, Binhua Wu, Xiping Lu. A morpholine derivative N-(4-morpholinomethylene)ethanesulfonamide induces ferroptosis in tumor cells by targeting NRF2. Biological & pharmaceutical bulletin. 2024-02-13. PMID:38296488. |
the results showed that mesa could induce ferroptosis to cause the proliferation inhibition and apoptosis effects of tumor cells according to the identification of ferroptosis inhibitor fer-1 and other cell death inhibitors. |
2024-02-13 |
2024-02-15 |
Not clear |
| Yongjia Ji, Huili Liu, Fang Niu, Bo Kang, Xiu Luo, Hua Yang, Zhen Tian, Juan Yan. Endoplasmic Reticulum Stress Promotes Neuronal Damage in Neonatal Hypoxic-Ischemic Brain Damage by Inducing Ferroptosis. Molecular biotechnology. 2024-02-08. PMID:38329706. |
in the ogd-induced h19-7 neurons, fer-1 treatment counteracted the suppressive effects of tg on viability, the exacerbation of apoptosis, the promotion of ferroptosis and the activation of the grp78-perk-chop pathway. |
2024-02-08 |
2024-02-10 |
rat |
| Jiao Junzhe, Li Meng, Huang Weifan, Xu Min, Lin Jiacheng, Qian Yihan, Zhen Ke, Wang Fang, Xu Dongwei, Wu Hailong, Kong Xiaon. Potential effects of different cell death inhibitors in protecting against ischemia-reperfusion injury in steatotic liver. International immunopharmacology. vol 128. 2024-01-20. PMID:38244517. |
all four types of cell death inhibitors showed protective effects, but ferroptosis inhibitor fer-1 and pyroptosis inhibitor vx765 exerted better protective effects compared the apoptosis inhibitor z-vad and necroptosis inhibitor nec-1. |
2024-01-20 |
2024-01-23 |
mouse |
| Binjie Yan, Darrell Belke, Yu Gui, Yong-Xiang Chen, Zhi-Sheng Jiang, Xi-Long Zhen. Pharmacological inhibition of MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) induces ferroptosis in vascular smooth muscle cells. Cell death discovery. vol 9. issue 1. 2023-12-14. PMID:38097554. |
mi-2 treatment led to concentration- and time-dependent cell death of cultured aortic smcs, which was rescued by the iron chelator deferoxamine (dfo) or ferrostatin-1 (fer-1), a specific inhibitor of ferroptosis, but not by inhibitors of apoptosis (z-vad-fmk), pyroptosis (z-yvad-fmk), or necrosis (necrostatin-1, nec-1). |
2023-12-14 |
2023-12-17 |
mouse |
| Zilin Liu, Xuezhong Wang, Jianping Li, Xiaoming Yang, Jun Huang, Chuang Ji, Xuyang Li, Lan Li, Jianlin Zhou, Yong H. Gambogenic acid induces cell death in human osteosarcoma through altering iron metabolism, disturbing the redox balance, and activating the P53 signaling pathway. Chemico-biological interactions. 2023-06-11. PMID:37302459. |
in addition, ferroptosis inhibitors (fer-1) and apoptosis inhibitors (nac) can partially reversed gna' s effects on os cells. |
2023-06-11 |
2023-08-14 |
mouse |
| Peng-Wei Ma, Wei-Long Wang, Jia-Wei Chen, Hao Yuan, Pei-Heng Lu, Wei Gao, Xue-Rui Ding, Yu-Qiang Lun, Rui Liang, Zu-Hong He, Qian Yang, Lian-Jun L. Treatment with the Ferroptosis Inhibitor Ferrostatin-1 Attenuates Noise-Induced Hearing Loss by Suppressing Ferroptosis and Apoptosis. Oxidative medicine and cellular longevity. vol 2022. 2022-12-19. PMID:36531206. |
our findings suggest that fer-1 is a promising drug for treating nihl because of its ability to inhibit noise-induced hair cell apoptosis and ferroptosis, opening new avenues for the treatment of nihl. |
2022-12-19 |
2023-08-14 |
mouse |
| Peng-Wei Ma, Wei-Long Wang, Jia-Wei Chen, Hao Yuan, Pei-Heng Lu, Wei Gao, Xue-Rui Ding, Yu-Qiang Lun, Rui Liang, Zu-Hong He, Qian Yang, Lian-Jun L. Treatment with the Ferroptosis Inhibitor Ferrostatin-1 Attenuates Noise-Induced Hearing Loss by Suppressing Ferroptosis and Apoptosis. Oxidative medicine and cellular longevity. vol 2022. 2022-12-19. PMID:36531206. |
these results suggest that fer-1 exerted its protective effects by scavenging of ros and inhibition of tfr1-mediated ferroptosis and p53-aifm2 signaling pathway-mediated apoptosis. |
2022-12-19 |
2023-08-14 |
mouse |
| Miao Guo, Yanfang Zhu, Ying Shi, Xiangda Meng, Xue Dong, Haokun Zhang, Xiaohong Wang, Mei Du, Hua Ya. Inhibition of ferroptosis promotes retina ganglion cell survival in experimental optic neuropathies. Redox biology. vol 58. 2022-11-22. PMID:36413918. |
in addition, compared to the apoptosis inhibitor z-vad-fmk, fer-1 showed better effect in rescuing rgcs death in onc retinas. |
2022-11-22 |
2023-08-14 |
mouse |
| Junying Liu, Yan Zhou, Chenchen Xie, Ci Li, Li Ma, Yamei Zhan. Anti-Ferroptotic Effects of bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicles Loaded with Ferrostatin-1 in Cerebral ischemia-reperfusion Injury Associate with the GPX4/COX-2 Axis. Neurochemical research. 2022-11-02. PMID:36322371. |
after fer-1 was confirmed to be successfully delivered by mscs-evs to neurons, we found that mscs-evs loaded with fer-1 (mscs-evs/fer-1) reduced neuron apoptosis and enhanced viability, along with curtailed inflammation and ferroptosis. |
2022-11-02 |
2023-08-14 |
mouse |
| Meng Gao, Jun Hu, Yuejie Zhu, Xianqing Wang, Shumin Zeng, Yijiang Hong, Guang Zha. Ferroptosis and Apoptosis Are Involved in the Formation of L-Selenomethionine-Induced Ocular Defects in Zebrafish Embryos. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563172. |
two antioxidants-reduced glutathione (gsh) and n-acetylcysteine (nac)-and the ferroptosis inhibitor ferrostatin (fer-1) were unable to rescue selenium-induced eye defects, but the ferroptosis and apoptosis activator cisplatin (cddp) was able to improve microphthalmia and the expression of retina-specific genes in selenium-stressed embryos. |
2022-05-14 |
2023-08-13 |
zebrafish |
| Ying Luo, Nattayaporn Apaijai, Suchan Liao, Chayodom Maneechote, Titikorn Chunchai, Busarin Arunsak, Juthipong Benjanuwattra, Panat Yanpiset, Siriporn C Chattipakorn, Nipon Chattipakor. Therapeutic potentials of cell death inhibitors in rats with cardiac ischaemia/reperfusion injury. Journal of cellular and molecular medicine. 2022-03-22. PMID:35315192. |
infarct size, lv dysfunction, mitochondrial dysfunction, apoptosis and ferroptosis were all reduced to a similar extent in rats treated with z-vad (low and medium doses) or fer-1 (medium and high doses). |
2022-03-22 |
2023-08-13 |
rat |
| Ying Luo, Nattayaporn Apaijai, Suchan Liao, Chayodom Maneechote, Titikorn Chunchai, Busarin Arunsak, Juthipong Benjanuwattra, Panat Yanpiset, Siriporn C Chattipakorn, Nipon Chattipakor. Therapeutic potentials of cell death inhibitors in rats with cardiac ischaemia/reperfusion injury. Journal of cellular and molecular medicine. 2022-03-22. PMID:35315192. |
i/r-operated rats were divided into 4 groups: vehicle, apoptosis (z-vad), ferroptosis (fer-1) and necroptosis (nec-1) inhibition. |
2022-03-22 |
2023-08-13 |
rat |
| Linya Wang, Shuguang Liu, Chao Gao, Hui Chen, Jing Li, Jiran Lu, Yuan Yuan, Xueling Zheng, Hongbo He, Xixi Zhang, Ruidong Zhang, Yuanyuan Zhang, Ying Wu, Wei Lin, Huyong Zhen. Arsenic trioxide-induced cardiotoxicity triggers ferroptosis in cardiomyoblast cells. Human & experimental toxicology. vol 41. 2022-02-23. PMID:35195477. |
the results indicated that ato exposure induced h9c2 cell death and apoptosis, and the ferroptosis inhibitor fer-1, administered for 24 h before ato exposure, suppressed ato-induced cell death, and apoptosis, as determined by annexin v-apc/7-aad apoptosis assay. |
2022-02-23 |
2023-08-13 |
rat |
| Suchan Liao, Nattayaporn Apaijai, Ying Luo, Jun Wu, Titikorn Chunchai, Kodchanan Singhanat, Busarin Arunsak, Juthipong Benjanuwattra, Nipon Chattipakorn, Siriporn C Chattipakor. Cell death inhibitors protect against brain damage caused by cardiac ischemia/reperfusion injury. Cell death discovery. vol 7. issue 1. 2021-11-05. PMID:34689160. |
z-vad, necrostatin-1 (nec-1), and ferrostatin-1 (fer-1) were used as apoptosis, necroptosis, and ferroptosis inhibitor, respectively. |
2021-11-05 |
2023-08-13 |
rat |
| Shumei Ma, Xinxin Fu, Lin Liu, Yi Liu, Hao Feng, Heya Jiang, Xiaomei Liu, Rui Liu, Zhenzhen Liang, Mengke Li, Zhujun Tian, Boqi Hu, Yongheng Bai, Bing Liang, Xiaodong Li. Iron-Dependent Autophagic Cell Death Induced by Radiation in MDA-MB-231 Breast Cancer Cells. Frontiers in cell and developmental biology. vol 9. 2021-11-02. PMID:34722507. |
iron chelator deferoxamine (dfo), the autophagy inhibitor 3ma, silencing of the autophagy-related genes atg5, and beclin 1 could decrease radiation induced cell death in mda-mb-231 cells, while inhibitors of apoptosis such as z-vad-fmk, ferroptosis inhibitor ferrostatin-1 (fer-1), and necroptosis inhibitor necrostatin-1 showed no change. |
2021-11-02 |
2023-08-13 |
Not clear |
| Yuchen Li, Yao Liu, Pei Wu, Yang Tian, Binbing Liu, Jinju Wang, Ji Bihl, Huaizhang Sh. Inhibition of Ferroptosis Alleviates Early Brain Injury After Subarachnoid Hemorrhage In Vitro and In Vivo via Reduction of Lipid Peroxidation. Cellular and molecular neurobiology. vol 41. issue 2. 2021-09-03. PMID:32314126. |
however, fer-1 had no effect on the apoptosis. |
2021-09-03 |
2023-08-13 |
rat |
| Haiyan Zhang, Zheng Wang, Zhengxia Liu, Kang Du, Xiang L. Protective Effects of Dexazoxane on Rat Ferroptosis in Doxorubicin-Induced Cardiomyopathy Through Regulating HMGB1. Frontiers in cardiovascular medicine. vol 8. 2021-08-03. PMID:34336950. |
finally, the viability, level of malondialdehyde (mda), and expressions of ferroptosis-related markers (ptgs2, gpx4, and fth1) of rat cardiomyocyte h9c2 exposed to dox combined with fer-1, zvad (an apoptosis inhibitor), dxz, or not were detected by performing molecular experiments. |
2021-08-03 |
2023-08-13 |
rat |
| Jing Du, Yi Zhou, Yanchun Li, Jun Xia, Yongjian Chen, Sufeng Chen, Xin Wang, Weidong Sun, Tongtong Wang, Xueying Ren, Xu Wang, Yihan An, Kang Lu, Wanye Hu, Siyuan Huang, Jianghui Li, Xiangmin Tong, Ying Wan. Identification of Frataxin as a regulator of ferroptosis. Redox biology. vol 32. 2021-06-18. PMID:32169822. |
in addition, this type of cell death was confirmed to be ferroptosis, since it could be pharmacologically restored by ferroptotic inhibitor fer-1 or gsh, but not by inhibitors of apoptosis, necrosis. |
2021-06-18 |
2023-08-13 |
Not clear |