| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Filippo Consonni, Solange Moreno, Blanca Vinuales Colell, Marie-Claude Stolzenberg, Alicia Fernandes, Mélanie Parisot, Cécile Masson, Nathalie Neveux, Jérémie Rosain, Sarah Bamberger, Marie-Gabrielle Vigue, Marion Malphettes, Pierre Quartier, Capucine Picard, Frédéric Rieux-Laucat, Aude Mageru. Study of the potential role of CASPASE-10 mutations in the development of autoimmune lymphoproliferative syndrome. Cell death & disease. vol 15. issue 5. 2024-05-04. PMID:38704374. |
the genetic landscape of alps includes mutations in fas, faslg, and fadd, all associated with apoptosis deficiency, while the role of casp10 defect in the disease remains debated. |
2024-05-04 |
2024-05-07 |
human |
| Sophie I Worsfold, Kristyn Carter, Moeed Akbar, Lisa Hackett, Neal L Millar, George A C Murrel. Rotator Cuff Tendinopathy: Pathways of Apoptosis. Sports medicine and arthroscopy review. vol 32. issue 1. 2024-05-02. PMID:38695498. |
a prospective cohort study was conducted with 28 patients-14 rotator cuff tear patients, 5 instability patients, and 9 anterior cruciate ligament reconstruction patients to determine whether there was any increase in several genes implicated in apoptosis, including fas receptor (fasr), fas ligand, aifm-1, bcl-2, fadd, bax, and caspase-3. |
2024-05-02 |
2024-05-04 |
Not clear |
| Bin Shen, Wenwen Han, Xiangrong Tan, Kyle J Gu, Danial F Naseem, Guibin Zheng, Guojun Li, Jianlin Lou, Chao Che. Expression of RIPK1 and FADD are associated with chemosensitivity and survival in head and heck squamous cell carcinoma via tanshinone IIA-mediated modulation of the RIPK1-FADD-Caspase 8 complex. Molecular carcinogenesis. 2024-05-02. PMID:38695620. |
moreover, tan iia reduced the expression of ripk1 and fadd in hnscc chemoresistant cell lines, which could increase the chemosensitivity of cisplatin and promote apoptosis. |
2024-05-02 |
2024-05-04 |
Not clear |
| Kishu Ranjan, Chandramani Patha. Cellular Dynamics of Fas-Associated Death Domain in the Regulation of Cancer and Inflammation. International journal of molecular sciences. vol 25. issue 6. 2024-03-28. PMID:38542202. |
fas-associated death domain (fadd) is an adaptor protein that predominantly transduces the apoptosis signal from the death receptor (dr) to activate caspases, leading to the initiation of apoptotic signaling and the coordinated removal of damaged, infected, or unwanted cells. |
2024-03-28 |
2024-03-30 |
Not clear |
| Xin Zhang, Yujie Huang, Lei Yang, Shuhuang Chen, Youlian Liu, Ni Tang, Zhiqiong Li, Xiaoli Zhang, Liangyu Li, Defang Che. Dietary exposure to 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) induces oxidative damage promoting cell apoptosis primarily via mitochondrial pathway in the hepatopancreas of carp, Cyprinus carpio. Ecotoxicology and environmental safety. vol 274. 2024-03-10. PMID:38461574. |
the results of apoptosis pathway genes showed that the mitochondrial pathway genes bax, casp3, and casp9 were significantly upregulated and bcl2 was significantly downregulated, while the transcription levels of fadd and perk were significantly enhanced. |
2024-03-10 |
2024-03-14 |
cat |
| Zhi-Jie Lu, Wen-Jun Shi, Dong-Dong Ma, Jin-Ge Zhang, Xiao-Bing Long, Si-Ying Li, Fang-Zhou Gao, Qian-Qian Zhang, Guang-Guo Yin. The azole biocide climbazole induces oxidative stress, inflammation, and apoptosis in fish gut. The Science of the total environment. 2024-03-07. PMID:38453063. |
climbazole increased pro-apoptosis-related genes (fadd, bad1, and caspase3), and decreased anti-apoptosis-associated genes (bcl2, and bcl-xl), suggesting a direct reaction to apoptosis. |
2024-03-07 |
2024-03-10 |
cat |
| Kittisak Taoma, Marasri Ruengjitchatchawalya, Monrudee Liangruksa, Teeraphan Laomettachi. Boolean modeling of breast cancer signaling pathways uncovers mechanisms of drug synergy. PloS one. vol 19. issue 2. 2024-02-23. PMID:38394152. |
clustering analysis allowed us to identify distinct patterns in the protein activities that correspond to five different modes of synergy: 1) synergistic activation of fadd and bid (extrinsic apoptosis pathway), 2) synergistic inhibition of bcl2 (intrinsic apoptosis pathway), 3) synergistic inhibition of mtorc1, 4) synergistic inhibition of esr1, and 5) synergistic inhibition of cyclin d. our approach offers a mechanistic understanding of the efficacy of drug combinations and provides direction for selecting potential drug pairs worthy of further laboratory investigation. |
2024-02-23 |
2024-02-26 |
Not clear |
| Elizabeth Cooper, Caitlin R M Oyagawa, Rebecca Johnson, Peter J Choi, Jena Macapagal Foliaki, Jason Correia, Patrick Schweder, Peter Heppner, Edward Mee, Clinton Turner, Richard Faull, William A Denny, Mike Dragunow, Jiney Jose, Thomas I-H Par. Involvement of the tumour necrosis factor receptor system in glioblastoma cell death induced by palbociclib-heptamethine cyanine dye conjugate. Cell communication and signaling : CCS. vol 22. issue 1. 2024-01-11. PMID:38212807. |
this shift of palbociclib from cytostatic to cytotoxic when conjugated to mhi-148 was due to increased dna damage, as indicated by an increase in γh2ax foci, followed by an increased expression of key extrinsic apoptosis genes, including tp53, tnfr1, trail, fadd and caspase 8. |
2024-01-11 |
2024-01-14 |
Not clear |
| Lingxia Wang, Xixi Zhang, Haiwei Zhang, Kaili Lu, Ming Li, Xiaoming Li, Yangjing Ou, Xiaoming Zhao, Xiaoxia Wu, Xuanhui Wu, Jianling Liu, Mingyan Xing, Han Liu, Yue Zhang, Yongchang Tan, Fang Li, Xiaoxue Deng, Jiangshan Deng, Xiaojie Zhang, Jinbao Li, Yuwu Zhao, Qiurong Ding, Haikun Wang, Xiuzhe Wang, Yan Luo, Ben Zhou, Haibing Zhan. Excessive apoptosis of Rip1-deficient T cells leads to premature aging. EMBO reports. 2023-11-15. PMID:37965894. |
consistent with this, blocking apoptosis by co-deletion of fadd in rip1-deficient t cells significantly rescues lymphopenia, the imbalance between naïve and memory t cells, and aging-like phenotypes, and prolongs life span in t-cell-specific rip1 ko mice. |
2023-11-15 |
2023-11-20 |
mouse |
| Hong-Bin Wang, Tao Li, Dong-Zhou Ma, Yan-Xin Ji, Hua Zh. Retraction notice to "Overexpression of FADD and Caspase-8 inhibits proliferation and promotes apoptosis of human glioblastoma cells" [Biomed. Pharmacother. 93 (2017) 1-7]. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023-10-06. PMID:37802723. |
retraction notice to "overexpression of fadd and caspase-8 inhibits proliferation and promotes apoptosis of human glioblastoma cells" [biomed. |
2023-10-06 |
2023-10-15 |
human |
| Zilong Lin, Jiana Zhang, Runa Wu, Guanmei Chen, Jieying Peng, Renai Li, Shengqiang Che. Pathogenic mechanisms and potential therapeutic targets for Parkinson disease revealed by bioinformatic analysis of necroptosis and immune cell infiltration. Medicine. vol 102. issue 39. 2023-09-29. PMID:37773866. |
thirteen nrdegs were identified in the gse26927 and gse49036 datasets, including receptor interacting serine/threonine kinase 1, casp8 and fadd like apoptosis regulator, tnfrsf1a associated via death domain, and interleukin 1 beta, of which 6 were validated in the gse54536 dataset. |
2023-09-29 |
2023-10-07 |
Not clear |
| Farhad Zamani, Solmaz Khalighfard, Mohammad Reza Kalhori, Amirhoushang Poorkhani, Taghi Amiriani, Payam Hosseinzadeh, Ebrahim Esmati, Mahdi Alemrajabi, Alireza Nikoofar, Fahimeh Safarnezhad Tameshkel, Ali Mohammad Alizade. Expanding CYLD protein in NF-κβ/TNF-α signaling pathway in response to Lactobacillus acidophilus in non-metastatic rectal cancer patients. Medical oncology (Northwood, London, England). vol 40. issue 10. 2023-09-19. PMID:37725175. |
moreover, tnf-α induces apoptosis by binding caspase-3 to fadd. |
2023-09-19 |
2023-10-07 |
Not clear |
| Fortunato Morabito, Carlo Adornetto, Paola Monti, Adriana Amaro, Francesco Reggiani, Monica Colombo, Yissel Rodriguez-Aldana, Giovanni Tripepi, Graziella D'Arrigo, Claudia Vener, Federica Torricelli, Teresa Rossi, Antonino Neri, Manlio Ferrarini, Giovanna Cutrona, Massimo Gentile, Gianluigi Grec. Genes selection using deep learning and explainable artificial intelligence for chronic lymphocytic leukemia predicting the need and time to therapy. Frontiers in oncology. vol 13. 2023-09-18. PMID:37719021. |
among them, fadd, fibp, fibp, gne, igf1r, mkl1, pigp, and slc39a6 were identified in the reactome pathway database as involved in signal transduction, transcription, protein metabolism, immune system, cell cycle, and apoptosis. |
2023-09-18 |
2023-10-07 |
Not clear |
| Miao He, Yingying He, Jian Xu, Youcai Zhang, Xiaoyu Cao, Li Wang, Feng Lu. Upregulated FADD is associated with poor prognosis, immune exhaustion, tumor malignancy, and immunotherapy resistance in patients with lung adenocarcinoma. Frontiers in oncology. vol 13. 2023-09-06. PMID:37671047. |
fas-associated death structural domain (fadd) proteins are important proteins that regulate apoptosis and are also involved in many nonapoptotic pathways in tumors. |
2023-09-06 |
2023-10-07 |
Not clear |
| Shengtao Guo, Mengsha Zeng, Lei Chen, Hanxi Chen, Wenxue Gao, Zhongyi Wang, Qiong Shi, Zhaobin Son. Characterization and expression profiling of fadd gene in response to exogenous Aeromonas hydrophila or Edwardsiella tarda challenge in the hybrid yellow catfish (Pelteobagrus fulvidraco ♀ × P. vachelli ♂). Fish & shellfish immunology. 2023-08-26. PMID:37633342. |
in mammals, fas-associated protein with death domain (fadd) is involved in the process of cell apoptosis and plays a key role in innate immune signaling. |
2023-08-26 |
2023-09-07 |
Not clear |
| Xinyu Wang, Tingting Zhang, Jianlong Zhai, Zhongli Wang, Yan Wang, Lili He, Sai Ma, Hanying Xing, Yifang Gu. MiR-21 attenuates FAS-mediated cardiomyocyte apoptosis by regulating HIPK3 expression. Bioscience reports. 2023-08-15. PMID:37581369. |
our results showed that: (i) mir-21 overexpression or hipk3 downregulation significantly attenuated h9c2 cells apoptosis after h/r; (ii) suppression of mir-21 expression promoted apoptosis; (iii) mir-21 overexpression inhibited hipk3 expression; (iv) hipk3 was the direct and main target of mir-21; (v) mir-21/hipk3 formed part of a reciprocal, negative feedback loop; and (vi) hipk3 downregulation decreased fas-mediated apoptosis by inhibiting the phosphorylation of fadd, which subsequently inhibited the expression of bax and cleaved caspase-3 and increased the expression of bcl2. |
2023-08-15 |
2023-09-07 |
rat |
| Elham F Ahanin, Rebecca A Sager, Sarah J Backe, Diana M Dunn, Natela Dushukyan, Adam R Blanden, Nilamber A Mate, Tamie Suzuki, Tyler Anderson, Merin Roy, Jasmeen Oberoi, Chrisostomos Prodromou, Imad Nsouli, Michael Daneshvar, Gennady Bratslavsky, Mark R Woodford, Dimitra Bourboulia, John D Chisholm, Mehdi Mollapou. Catalytic inhibitor of Protein Phosphatase 5 activates the extrinsic apoptotic pathway by disrupting complex II in kidney cancer. Cell chemical biology. 2023-08-01. PMID:37527661. |
specifically, pp5 dephosphorylates and inactivates the death effector protein fadd, preserving complex ii integrity and regulating extrinsic apoptosis. |
2023-08-01 |
2023-08-14 |
Not clear |
| Ashish Verma, Nilesh Rai, Priyamvada Gupta, Swati Singh, Harshita Tiwari, Shashi Bhushan Chauhan, Vikas Kailashiya, Vibhav Gauta. Exploration of in vitro cytotoxic and in ovo antiangiogenic activity of ethyl acetate extract of Penicillium oxalicum. Environmental toxicology. 2023-07-18. PMID:37461856. |
furthermore, the treatment of ea extract of p. oxalicum mediates apoptosis by increasing the expression of bax, p21, fadd, and caspase-8 genes, with increased caspase-3 activity. |
2023-07-18 |
2023-08-14 |
human |
| Taketo Inoue, Michiko Aoyama-Ishikawa, Mikiko Uemura, Keisuke Kohama, Noritomo Fujisaki, Hiromoto Murakami, Taihei Yamada, Junichi Hirat. The role of death receptor signaling pathways in mouse Sertoli cell avoidance of apoptosis during LPS- and IL-18-induced inflammatory conditions. Journal of reproductive immunology. vol 158. 2023-06-01. PMID:37263030. |
we stimulated tm4 cells, a mouse sertoli cell line, with lps (200 or 1000 ng/ml) or ril-18 (0.1-100 ng/ml) at levels that induced leydig cell apoptosis in our previous study and assessed caspase 3 cleavage and the mrna expression of inflammatory cytokines and markers of apoptotic pathways (tnfr1, fasl, fas, fadd) after stimulation. |
2023-06-01 |
2023-08-14 |
mouse |
| Taketo Inoue, Michiko Aoyama-Ishikawa, Mikiko Uemura, Keisuke Kohama, Noritomo Fujisaki, Hiromoto Murakami, Taihei Yamada, Junichi Hirat. The role of death receptor signaling pathways in mouse Sertoli cell avoidance of apoptosis during LPS- and IL-18-induced inflammatory conditions. Journal of reproductive immunology. vol 158. 2023-06-01. PMID:37263030. |
lps had little influence on tnfr1 or fadd mrna expression and did not induce apoptosis. |
2023-06-01 |
2023-08-14 |
mouse |