| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yunsik Choi, Yuri Lee, Jin Seo Kim, Peijing Zhang, Jongchan Ki. USP39-Mediated Non-Proteolytic Control of ETS2 Suppresses Nuclear Localization and Activity. Biomolecules. vol 13. issue 10. 2023-10-30. PMID:37892157. |
ets2 is a member of the ets family of transcription factors and has been implicated in the regulation of cell proliferation, differentiation, apoptosis, and tumorigenesis. |
2023-10-30 |
2023-11-08 |
human |
| Rong Tang, Wei Lin, Chanjuan Shen, Xueling Hu, Leilin Yu, Ting Meng, Linlin Zhang, Peter J Eggenhuizen, Joshua D Ooi, Peng Jin, Xiang Ding, Xiangcheng Xiao, Yong Zhon. Single-cell transcriptomics uncover hub genes and cell-cell crosstalk in patients with hypertensive nephropathy. International immunopharmacology. vol 125. issue Pt A. 2023-10-28. PMID:37897949. |
the htn endothelium upregulated cellular adhesion genes (icam2 and ceacam1), inflammatory genes (ets2 and ifi6) and apoptosis related genes (cnn3). |
2023-10-28 |
2023-11-08 |
human |
| Shuxiang Chen, Xiaotong Zhu, Wenhuan Ou, Le Kang, Jian Situ, Zhipeng Liao, Li Huang, Weizhong Qi, Songjia N. ETS2 overexpression ameliorates cartilage injury in osteoarthritis by the ETS2/miR-155/STAT1/DNMT1 feedback loop pathway. Biochimica et biophysica acta. Gene regulatory mechanisms. 2023-07-31. PMID:37524226. |
functional experiments in vitro demonstrated that the overexpressed ets2 strikingly enhanced proliferation, outstandingly suppressed apoptosis, and dramatically reduced inflammation and ecm degradation in il-1β-induced oa chondrocytes, whereas the knockdown of ets2 led to the opposite effects. |
2023-07-31 |
2023-08-14 |
mouse |
| Li Tan, Di Xiong, Hui Zhang, Sirou Xiao, Ruilan Yi, Jian W. ETS2 promotes cardiomyocyte apoptosis and autophagy in heart failure by regulating lncRNA TUG1/miR-129-5p/ATG7 axis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 6. 2023-05-12. PMID:37171262. |
ets2 promotes cardiomyocyte apoptosis and autophagy in heart failure by regulating lncrna tug1/mir-129-5p/atg7 axis. |
2023-05-12 |
2023-08-14 |
Not clear |
| Krishna Kumar Haridhasapavalan, Pradeep Kumar Sundaravadivelu, Rajkumar P Thumme. Codon Optimization, Cloning, Expression, Purification, and Secondary Structure Determination of Human ETS2 Transcription Factor. Molecular biotechnology. vol 62. issue 10. 2021-06-08. PMID:32808171. |
transcription factor ets2 regulates genes involved in development, differentiation, angiogenesis, proliferation, and apoptosis. |
2021-06-08 |
2023-08-13 |
human |
| Jing Li, Hongling Su, Yan Zhu, Yunshan Cao, Xuming M. ETS2 and microRNA-155 regulate the pathogenesis of heart failure through targeting and regulating GPR18 expression. Experimental and therapeutic medicine. vol 19. issue 6. 2020-09-28. PMID:32346408. |
in conclusion, the present study suggested that gpr18 may be a target of ets2 and mir-155, and mir-155 may regulate cell viability and apoptosis in h9c2 (2-1) cells through targeting and regulating gpr18. |
2020-09-28 |
2023-08-13 |
Not clear |
| Xuejun Liu, Chuqin Zhang, Zhonghua Zhang, Zuping Zhang, Wei Ji, Shengda Cao, Xiaolan Cai, Dapeng Lei, Xinliang Pa. E26 Transformation-Specific Transcription Factor ETS2 as an Oncogene Promotes the Progression of Hypopharyngeal Cancer. Cancer biotherapy & radiopharmaceuticals. vol 32. issue 9. 2018-07-05. PMID:29111780. |
in addition, knockdown of ets2 by sirna in pharyngeal cancer cell line, fadu, significantly decreased cell's vitality and colony-forming ability by inducing caspase-3-dependent apoptosis and cell cycle arrest. |
2018-07-05 |
2023-08-13 |
Not clear |
| Qinghua Li, Lu Yang, Kang Han, Liqiang Zhu, Yanting Zhang, Shanshan Ma, Kun Zhang, Bo Yang, Fangxia Gua. Ets2 knockdown inhibits tumorigenesis in esophageal squamous cell carcinoma in vivo and in vitro. Oncotarget. vol 7. issue 38. 2018-01-30. PMID:27556183. |
here, the rise of ets2 was confirmed in escc cells and ets2 depletion by rna interference promotes cell apoptosis, inhibits cell proliferation, attenuates cell invasion and induces cell cycle g0/g1 arrest in vitro. |
2018-01-30 |
2023-08-13 |
mouse |
| Serena Bonin, Francesca Filon Larese, Giusto Trevisan, Andrea Avian, Francesca Rui, Giorgio Stanta, Massimo Bovenz. Gene expression changes in peripheral blood mononuclear cells in occupational exposure to nickel. Experimental dermatology. vol 20. issue 2. 2011-06-21. PMID:21054559. |
the mrna expression level of six genes involved in cell growth (pim1 and ets2), metabolism/synthesis (hsd11b1 and prdx4), apoptosis (casp8) and signal transduction (cish) was investigated by means of quantitative real-time rt-pcr in a cohort of 110 subjects, including healthy controls (n=51), nickel-exposed workers (n=23) and patients allergic to nickel (n=36). |
2011-06-21 |
2023-08-12 |
human |
| Guo Wei, Ruchika Srinivasan, Carmen Z Cantemir-Stone, Sudarshana M Sharma, Ramasamy Santhanam, Michael Weinstein, Natarajan Muthusamy, Albert K Man, Robert G Oshima, Gustavo Leone, Michael C Ostrowsk. Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis. Blood. vol 114. issue 5. 2009-09-21. PMID:19411629. |
consistent with these observations, endothelial cell apoptosis was significantly increased both in vivo and in vitro when both ets1 and ets2 were mutated. |
2009-09-21 |
2023-08-12 |
Not clear |
| Dakang Xu, Julie Dwyer, He Li, Wei Duan, Jun-Ping Li. Ets2 maintains hTERT gene expression and breast cancer cell proliferation by interacting with c-Myc. The Journal of biological chemistry. vol 283. issue 35. 2008-10-03. PMID:18586674. |
reconstitution with recombinant htert rescues the apoptosis induced by ets2 depression. |
2008-10-03 |
2023-08-12 |
human |
| Giuseppina M Carbone, Sara Napoli, Alessandra Valentini, Franco Cavalli, Dennis K Watson, Carlo V Catapan. Triplex DNA-mediated downregulation of Ets2 expression results in growth inhibition and apoptosis in human prostate cancer cells. Nucleic acids research. vol 32. issue 14. 2004-08-19. PMID:15314206. |
triplex dna-mediated downregulation of ets2 expression results in growth inhibition and apoptosis in human prostate cancer cells. |
2004-08-19 |
2023-08-12 |
human |
| E J Wolvetang, O M Bradfield, T Hatzistavrou, P J Crack, J Busciglio, I Kola, P J Hertzo. Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis. Neurobiology of disease. vol 14. issue 3. 2004-03-05. PMID:14678752. |
here we show that the chromosome 21 transcription factor ets2, a gene that is overexpressed in down syndrome, is expressed in neurons, and that moderate overexpression of ets2 leads to increased apoptosis of primary neuronal cultures from ets2 tg mice that involves activation of caspase-3. |
2004-03-05 |
2023-08-12 |
mouse |
| E J Wolvetang, O M Bradfield, T Hatzistavrou, P J Crack, J Busciglio, I Kola, P J Hertzo. Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis. Neurobiology of disease. vol 14. issue 3. 2004-03-05. PMID:14678752. |
overexpression of the chromosome 21 transcription factor ets2 induces neuronal apoptosis. |
2004-03-05 |
2023-08-12 |
mouse |
| E J Wolvetang, O M Bradfield, T Hatzistavrou, P J Crack, J Busciglio, I Kola, P J Hertzo. Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis. Neurobiology of disease. vol 14. issue 3. 2004-03-05. PMID:14678752. |
our data therefore suggest that overexpression of ets2 may contribute to the increased rate of apoptosis of neurons in down syndrome. |
2004-03-05 |
2023-08-12 |
mouse |
| E J Wolvetang, T J Wilson, E Sanij, J Busciglio, T Hatzistavrou, A Seth, P J Hertzog, I Kol. ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway. Human molecular genetics. vol 12. issue 3. 2003-09-24. PMID:12554679. |
in the human hela cancer cell line, transfection with functional p53 enables ets2 overexpression to induce apoptosis. |
2003-09-24 |
2023-08-12 |
mouse |
| E J Wolvetang, T J Wilson, E Sanij, J Busciglio, T Hatzistavrou, A Seth, P J Hertzog, I Kol. ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway. Human molecular genetics. vol 12. issue 3. 2003-09-24. PMID:12554679. |
therefore, we conclude that overexpression of human chromosome 21-encoded ets2 induces apoptosis that is dependent on p53. |
2003-09-24 |
2023-08-12 |
mouse |
| E J Wolvetang, T J Wilson, E Sanij, J Busciglio, T Hatzistavrou, A Seth, P J Hertzog, I Kol. ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway. Human molecular genetics. vol 12. issue 3. 2003-09-24. PMID:12554679. |
this study demonstrates that overexpression of ets2 results in apoptosis. |
2003-09-24 |
2023-08-12 |
mouse |
| E J Wolvetang, T J Wilson, E Sanij, J Busciglio, T Hatzistavrou, A Seth, P J Hertzog, I Kol. ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway. Human molecular genetics. vol 12. issue 3. 2003-09-24. PMID:12554679. |
ets2 overexpression in transgenic models and in down syndrome predisposes to apoptosis via the p53 pathway. |
2003-09-24 |
2023-08-12 |
mouse |
| E J Wolvetang, T J Wilson, E Sanij, J Busciglio, T Hatzistavrou, A Seth, P J Hertzog, I Kol. ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway. Human molecular genetics. vol 12. issue 3. 2003-09-24. PMID:12554679. |
furthermore, crossing the ets2 transgenic mice with p53(-/-) mice genetically rescued the thymic apoptosis phenotype. |
2003-09-24 |
2023-08-12 |
mouse |