| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenjun Zhou, Biao Li, Zhijuan Wang, Shuang Liu, Weiyong Wang, Sihui He, Ye Chen, Xiaodan Zhang, Meijia Zhan. Premeiotic deletion of Eif2s2 causes oocyte arrest at the early diplotene stage and apoptosis in mice. Cell proliferation. 2024-07-24. PMID:39044637. |
our findings demonstrate that the depletion of eif2s2 in premeiotic germ cells causes oocyte arrest at the pachytene and early diplotene stages at 1 day postpartum (dpp) and 5 dpp, respectively, and eventually leads to oocyte apoptosis and failure of primordial follicle formation. |
2024-07-24 |
2024-07-26 |
mouse |
| Tomas Navarro, Antonella Iannini, Marta Neto, Alejandro Campoy-Lopez, Javier Muñoz-García, Paulo S Pereira, Saúl Ares, Fernando Casare. Feedback control of organ size precision is mediated by BMP2-regulated apoptosis in the Drosophila eye. PLoS biology. vol 22. issue 1. 2024-01-30. PMID:38289899. |
in turn, apoptosis of progenitor cells is hampered by dpp, a bmp2/4 signaling molecule transiently produced by early differentiating retinal cells. |
2024-01-30 |
2024-02-02 |
drosophila_melanogaster |
| Tomas Navarro, Antonella Iannini, Marta Neto, Alejandro Campoy-Lopez, Javier Muñoz-García, Paulo S Pereira, Saúl Ares, Fernando Casare. Feedback control of organ size precision is mediated by BMP2-regulated apoptosis in the Drosophila eye. PLoS biology. vol 22. issue 1. 2024-01-30. PMID:38289899. |
our genetic and computational experiments show how the status of retinal differentiation is communicated to progenitors through the differentiation-dependent production of dpp, which, by adjusting the rate of apoptosis, exerts a feedback control over the net growth of progenitors to reduce final eye size variability. |
2024-01-30 |
2024-02-02 |
drosophila_melanogaster |
| Cairu Liu, Haiqin Feng, Lihong Song, Shuirui Li, Yiping Wu, Liping Yan. Synergistic effects of thalidomide and cisplatin are mediated via the PI3K/AKT and JAK1/STAT3 signaling pathways in cervical cancer. Oncology reports. vol 48. issue 4. 2022-08-03. PMID:35920185. |
subsequently, combined treatment with thd and ddp suppressed relative cell viability, whereas it promoted cell apoptosis compared with thd or dpp monotherapy; it also inhibited the pi3k/akt and jak1/stat3 signaling pathways compared with dpp or thd monotherapy in both hela and siha cells. |
2022-08-03 |
2023-08-14 |
Not clear |
| Fangyuan Chen, Jingyue Deng, Lishi Luo, Ying Zhu, Yuying Dong, Yuanting Yang, Rijia Zhang, Jian Chen, Qing Zho. Crosslinked Decellularized Porcine Pericardium as a Substrate for Conjunctival Reconstruction. Stem cells international. vol 2022. 2022-03-28. PMID:35342430. |
in vitro dpp showed lower apoptosis, highly desirable, well preservation of extracellular matrix components, and favorable macro-microstructure, which was confirmed by histology, immunofluorescence, electron microscopy, collagen and dna quantification, and cytotoxicity assay, compared to the native porcine pericardium (npp). |
2022-03-28 |
2023-08-13 |
human |
| Yu Zhang, Juan Cheng, Jing Li, Junxian He, Xiaomao Li, Fen X. The GLP-1R Agonist Exendin-4 Attenuates Hyperglycemia-Induced Chemoresistance in Human Endometrial Cancer Cells Through ROS-Mediated Mitochondrial Pathway. Frontiers in oncology. vol 11. 2022-01-06. PMID:34988025. |
dpp treatment significantly induced apoptosis and cell cycle arrest in the s phase under ng, and hg reduced these effects. |
2022-01-06 |
2023-08-13 |
human |
| Sergio B Velarde, Alvaro Quevedo, Carlos Estella, Antonio Baonz. Dpp and Hedgehog promote the glial response to neuronal apoptosis in the developing Drosophila visual system. PLoS biology. vol 19. issue 8. 2021-11-18. PMID:34379617. |
dpp and hedgehog promote the glial response to neuronal apoptosis in the developing drosophila visual system. |
2021-11-18 |
2023-08-13 |
drosophila_melanogaster |
| Shi-Wei He, Yuan Zhang, Lei Chen, Wei-Jie Luo, Xiao-Min Li, Yang Chen, Sheng-Yan Huang, Qing-Mei He, Xiao-Jing Yang, Ying-Qin Li, Na Liu, Yin Zhao, Jun M. Gemcitabine synergizes with cisplatin to inhibit nasopharyngeal carcinoma cell proliferation and tumor growth. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 10. 2021-10-12. PMID:34478585. |
in vitro studies reveal that gem or dpp treated alone induces cell cycle arrest, promotes cell apoptosis, forces dna damage response, and gem synergism with ddp significantly increases the above effects in npc cells. |
2021-10-12 |
2023-08-13 |
mouse |
| Shi-Wei He, Yuan Zhang, Lei Chen, Wei-Jie Luo, Xiao-Min Li, Yang Chen, Sheng-Yan Huang, Qing-Mei He, Xiao-Jing Yang, Ying-Qin Li, Na Liu, Yin Zhao, Jun M. Gemcitabine synergizes with cisplatin to inhibit nasopharyngeal carcinoma cell proliferation and tumor growth. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 10. 2021-10-12. PMID:34478585. |
gem synergizes with dpp to inhibit npc cell proliferation and tumor growth by inducing cell cycle arrest, cell apoptosis, and dna damage response, which reveals the mechanisms of combined gem and ddp induction chemotherapy in improving locoregionally advanced npc. |
2021-10-12 |
2023-08-13 |
mouse |
| Xiang Li, Yu Xie, An Kang, Yue Wan. New bitongling (NBTL) ameliorates rheumatoid arthritis in rats through inhibiting JAK2/STAT3 signaling pathway. European journal of histochemistry : EJH. vol 65. issue 1. 2021-08-05. PMID:33634679. |
furthermore, nbtl inhibited inflammation of fls, induced cell apoptosis and hindered cell proliferation, which was reversed by dipeptidyl peptidase (dpp), a jak2/stat3 pathway activator. |
2021-08-05 |
2023-08-13 |
rat |
| Jialin Qian, Hao Bai, Zhiqiang Gao, Y U Dong, Jun Pei, Meili Ma, Baohui Ha. Downregulation of HIF-1α inhibits the proliferation and invasion of non-small cell lung cancer NCI-H157 cells. Oncology letters. vol 11. issue 3. 2020-10-01. PMID:26998070. |
similar to dpp treatment, hif-1α sirna treatment may reduce cell proliferation and the invasiveness of tumor cells while promoting apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Cheng-Bi Xu, Xue-Shi-Bo-Jie Liu, Jin-Qiu Li, Xue Zhao, Ding Xin, Dan Y. microRNA-539 functions as a tumor suppressor in papillary thyroid carcinoma via the transforming growth factor β1/Smads signaling pathway by targeting secretory leukocyte protease inhibitor. Journal of cellular biochemistry. vol 120. issue 6. 2020-07-20. PMID:30706537. |
the obtained results indicated that cgthw-3 cells treated with silenced slpi or overexpressed mir-539 suppressed the cell proliferation, migration, invasion abilities, and resistance to apoptosis of ptc cells, corresponding to increased expression of bcl-2-associated x protein, tgf-β1, sekelsky mothers against dpp 4, and epithelial cadherin, and decreased b cell lymphoma 2, vimentin, and n-cadherin. |
2020-07-20 |
2023-08-13 |
Not clear |
| Sindhuja Heggavadipura Natarajamurthy, Srinivas Sistla, Shylaja M Dharmes. Disruption of galectin-3 and galectin-3 binding protein (G3BP) interaction by dietary pectic polysaccharides (DPP) - Arrest of metastasis, inhibition of proliferation and induction of apoptosis. International journal of biological macromolecules. vol 139. 2020-04-13. PMID:31356934. |
disruption of galectin-3 and galectin-3 binding protein (g3bp) interaction by dietary pectic polysaccharides (dpp) - arrest of metastasis, inhibition of proliferation and induction of apoptosis. |
2020-04-13 |
2023-08-13 |
Not clear |
| Igojo Kang, Yourim Choi, Sueun Jung, Jae Yun Lim, Dooyoung Lee, Sumeet Gupta, Woongjoon Moon, Chanseok Shi. Identification of target genes regulated by the Drosophila histone methyltransferase Eggless reveals a role of Decapentaplegic in apoptotic signaling. Scientific reports. vol 8. issue 1. 2019-10-11. PMID:29740006. |
we propose a model in which egg regulates germ cell differentiation and apoptosis through canonical and noncanonical dpp pathways in drosophila oogenesis. |
2019-10-11 |
2023-08-13 |
drosophila_melanogaster |
| Junlian Gu, Yang Li, Jun Zeng, Bo Wang, Kun Ji, Yufeng Tang, Qing Su. Knockdown of HIF-1α by siRNA-expressing plasmid delivered by attenuated Salmonella enhances the antitumor effects of cisplatin on prostate cancer. Scientific reports. vol 7. issue 1. 2019-02-25. PMID:28790395. |
the in vitro and in vivo effects of hif-1α sirna treatment and/or dpp on pca cell proliferation, apoptosis, glycolysis, and production of reactive oxygen species (ros) were assessed by examining molecular markers specific to each process. |
2019-02-25 |
2023-08-13 |
mouse |
| Jianlin Long, Yuping Yang, Tianyi Kang, Wei Zhao, Hao Cheng, Yujiao Wu, Ting Du, Beibei Liu, Yang Li, Feng Luo, Maling Go. Ovarian Cancer Therapy by VSVMP Gene Mediated by a Paclitaxel-Enhanced Nanoparticle. ACS applied materials & interfaces. vol 9. issue 45. 2018-12-12. PMID:28944654. |
the encapsulation of paclitaxel in dpp nanoparticles increased the expression of vsvmp, enhancing vsvmp to induce antiproliferation and apoptosis in skov3 ovarian cancer cells. |
2018-12-12 |
2023-08-13 |
Not clear |
| Yu Zhao, Yu Zhang, Jia Li, Nana Zheng, Xiaoting Xu, Jing Yang, Guoliang Xia, Meijia Zhan. MAPK3/1 participates in the activation of primordial follicles through mTORC1-KITL signaling. Journal of cellular physiology. vol 233. issue 1. 2017-10-18. PMID:28218391. |
culture of 3 days post-parturition (dpp) ovaries with the mapk3/1 signaling inhibitor u0126 significantly reduced the number of activated follicles and was accompanied by dramatically reduced granulosa cell proliferation and increased oocyte apoptosis. |
2017-10-18 |
2023-08-13 |
Not clear |
| Sung Yeon Park, Brian G Stultz, Deborah A Hurs. Dual Role of Jun N-Terminal Kinase Activity in Bone Morphogenetic Protein-Mediated Drosophila Ventral Head Development. Genetics. vol 201. issue 4. 2016-09-13. PMID:26500262. |
here we document that disruption of this dpp expression causes apoptosis in peripodial cells and underlying disc proper cells. |
2016-09-13 |
2023-08-13 |
drosophila_melanogaster |
| Yi Zhang, Younan Chen, Jingqiu Cheng, Zhiguang Guo, Yanrong Lu, Bole Tia. DPP IV inhibitor suppresses STZ-induced islets injury dependent on activation of the IGFR/Akt/mTOR signaling pathways by GLP-1 in monkeys. Biochemical and biophysical research communications. vol 456. issue 1. 2015-03-10. PMID:25446112. |
to evaluate the protective effect of the dpp iv inhibitor in stz-induced islet injury and to identify the molecular events that protect islet against apoptosis. |
2015-03-10 |
2023-08-13 |
monkey |
| Jorge V Beira, Alexander Springhorn, Stefan Gunther, Lars Hufnagel, Giorgos Pyrowolakis, Jean-Paul Vincen. The Dpp/TGFβ-dependent corepressor Schnurri protects epithelial cells from JNK-induced apoptosis in drosophila embryos. Developmental cell. vol 31. issue 2. 2015-01-12. PMID:25307481. |
dpp signaling also protects cells from jnk-dependent apoptosis caused by epithelial disruption. |
2015-01-12 |
2023-08-13 |
drosophila_melanogaster |