| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meiwen Lv, Xuelian Li, Chang Zheng, Wen Tian, He Yang, Zhihua Yin, Baosen Zho. Exosomal miR-130b-3p suppresses metastasis of non-small cell lung cancer cells by targeting DEPDC1 via TGF-β signaling pathway. International journal of biological macromolecules. 2024-07-03. PMID:38960258. |
depdc1 level affected the proliferation, migration, and apoptosis of nsclc cells via tgf-β signaling pathway. |
2024-07-03 |
2024-07-10 |
Not clear |
| Meiwen Lv, Xuelian Li, Chang Zheng, Wen Tian, He Yang, Zhihua Yin, Baosen Zho. Exosomal miR-130b-3p suppresses metastasis of non-small cell lung cancer cells by targeting DEPDC1 via TGF-β signaling pathway. International journal of biological macromolecules. 2024-07-03. PMID:38960258. |
finally, exosomal mir-130b-3p suppressed nsclc cell growth and migration, promoted their apoptosis via tgf-β signaling pathway by decreasing depdc1 expression, and suppressed epithelial-mesenchymal transition (emt) in nsclc cells. |
2024-07-03 |
2024-07-10 |
Not clear |
| Meiwen Lv, Xuelian Li, Zhihua Yin, He Yang, Baosen Zho. Comprehensive analysis and validation reveal DEPDC1 as a potential diagnostic biomarker associated with tumor immunity in non-small-cell lung cancer. PloS one. vol 19. issue 4. 2024-04-02. PMID:38564630. |
according to the in vitro mts and apoptotic assays, downregulated depdc1 expression targeting p53 signaling pathway inhibited the proliferation of nsclc cells while promoting apoptosis of nsclc cells. |
2024-04-02 |
2024-04-05 |
Not clear |
| Tingting Lou, Luqing Zhang, Zongshan Jin, Chundi Miao, Jinqiu Wang, Kongliang K. miR-455-5p enhances 5-fluorouracil sensitivity in colorectal cancer cells by targeting PIK3R1 and DEPDC1. Open medicine (Warsaw, Poland). vol 17. issue 1. 2022-05-18. PMID:35582195. |
overexpression of pik3r1 and depdc1 could attenuate the effects of mir-455-5p mimic on the viability and apoptosis of 5-fu-treated cells. |
2022-05-18 |
2023-08-13 |
Not clear |
| Anna Tosi, Silvia Dalla Santa, Elisa Cappuzzello, Carolina Marotta, Dawid Walerych, Giannino Del Sal, Paola Zanovello, Roberta Sommaggio, Antonio Rosat. Identification of a HLA-A*0201-restricted immunogenic epitope from the universal tumor antigen DEPDC1. Oncoimmunology. vol 6. issue 8. 2021-01-12. PMID:28919988. |
recent studies support the involvement of depdc1 in many aspects of cancer traits, such as cell proliferation, resistance to induction of apoptosis and cell invasion, suggesting that it may play key roles in the oncogenic process. |
2021-01-12 |
2023-08-13 |
human |
| Qingqing Wang, Aili Li, Junfei Jin, Guojin Huan. Targeted interfering DEP domain containing 1 protein induces apoptosis in A549 lung adenocarcinoma cells through the NF-κB signaling pathway. OncoTargets and therapy. vol 10. 2020-09-30. PMID:28979136. |
in conclusion, depdc1 might be a novel therapeutic target for lung cancer, and the 11r-dep:611-628 peptide is a potent apoptosis inducer in a549 cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Qingqing Wang, Aili Li, Junfei Jin, Guojin Huan. Targeted interfering DEP domain containing 1 protein induces apoptosis in A549 lung adenocarcinoma cells through the NF-κB signaling pathway. OncoTargets and therapy. vol 10. 2020-09-30. PMID:28979136. |
depdc1 inhibitor mir-130a was overexpressed in a549 cells, and the proliferation and apoptosis of these cells were analyzed with cell counting and flow cytometry assay. |
2020-09-30 |
2023-08-13 |
Not clear |
| Qingqing Wang, Aili Li, Junfei Jin, Guojin Huan. Targeted interfering DEP domain containing 1 protein induces apoptosis in A549 lung adenocarcinoma cells through the NF-κB signaling pathway. OncoTargets and therapy. vol 10. 2020-09-30. PMID:28979136. |
these findings indicate that depdc1 inhibits apoptosis of a549 cell by suppressing a20 expression to regulate nf-κb activity, and that jnk plays a protective role upon 11r-dep:611-628 peptide treatment. |
2020-09-30 |
2023-08-13 |
Not clear |
| Aili Li, Qingqing Wang, Gaofeng He, Junfei Jin, Guojin Huan. DEP domain containing 1 suppresses apoptosis via inhibition of A20 expression, which activates the nuclear factor κB signaling pathway in HepG2 cells. Oncology letters. vol 16. issue 1. 2020-09-30. PMID:29963168. |
in conclusion, the data indicated that depdc1 suppresses apoptosis to promote cell proliferation through the nf-κb signaling pathway in hepg2 cells and that depdc1 is a potential target for the treatment of liver cancer. |
2020-09-30 |
2023-08-13 |
Not clear |
| Ryogo Kikuchi, Oltea Sampetrean, Hideyuki Saya, Kazunari Yoshida, Masahiro Tod. Functional analysis of the DEPDC1 oncoantigen in malignant glioma and brain tumor initiating cells. Journal of neuro-oncology. vol 133. issue 2. 2018-04-18. PMID:28555424. |
suppression of endogenous depdc1 expression by small interfering rna (sirna) inhibited glioma cell viability and induced apoptosis through nfκb signaling. |
2018-04-18 |
2023-08-13 |
mouse |
| Yihua Yang, Yan Jiang, Man Jiang, Jiamiao Zhang, Bing Yang, Yuanping She, Wanxue Wang, Yan Deng, Yuan Y. Protocadherin 10 inhibits cell proliferation and induces apoptosis via regulation of DEP domain containing 1 in endometrial endometrioid carcinoma. Experimental and molecular pathology. vol 100. issue 2. 2016-09-06. PMID:26970279. |
dishevelled, egl-10 and pleckstrin domain containing 1 (depdc1) was a potential downstream mediator of pcdh10 as revealed by rna-sequencing, and mechanistic studies suggested that depdc1 is a downstream mediator and promotes cell growth and induces apoptosis in eec cells. |
2016-09-06 |
2023-08-13 |
Not clear |
| Ataman Sendoel, Simona Maida, Xue Zheng, Youjin Teo, Lilli Stergiou, Carlo-Alberto Rossi, Deni Subasic, Sergio M Pinto, Jason M Kinchen, Moyin Shi, Steffen Boettcher, Joel N Meyer, Markus G Manz, Daniele Bano, Michael O Hengartne. DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis. Nature cell biology. vol 16. issue 8. 2014-12-19. PMID:25064737. |
collectively, these data uncover an evolutionarily conserved mediator of anti-tubulin drug-induced apoptosis and suggest that depdc1 levels could be an additional determinant for therapy response upstream of mcl1. |
2014-12-19 |
2023-08-13 |
human |
| Yosuke Harada, Mitsugu Kanehira, Yoshiko Fujisawa, Ryo Takata, Taro Shuin, Tsuneharu Miki, Tomoaki Fujioka, Yusuke Nakamura, Toyomasa Katagir. Cell-permeable peptide DEPDC1-ZNF224 interferes with transcriptional repression and oncogenicity in bladder cancer cells. Cancer research. vol 70. issue 14. 2010-08-24. PMID:20587513. |
inhibiting this interaction with a cell-permeable peptide corresponding to the znf224-interacting domain in depdc1 induced apoptosis of bladder cancer cells in vitro and in vivo. |
2010-08-24 |
2023-08-12 |
Not clear |