| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christina Pfeiffer, Alexander M Grandits, H\\xc3\\xa9l\\xc3\\xa8ne Asnagli, Anja Schneller, Julia Huber, Niklas Zojer, Martin Schreder, Andrew E Parker, Arnold Bolomsky, Philip A Beer, Heinz Ludwi. CTPS1 is a novel therapeutic target in multiple myeloma which synergizes with inhibition of CHEK1, ATR or WEE1. Leukemia. 2023-10-29. PMID:37898670. |
in cellular experiments, ctps1 knockout induced apoptosis of mm cell lines. |
2023-10-29 |
2023-11-08 |
Not clear |
| Christina Pfeiffer, Alexander M Grandits, H\\xc3\\xa9l\\xc3\\xa8ne Asnagli, Anja Schneller, Julia Huber, Niklas Zojer, Martin Schreder, Andrew E Parker, Arnold Bolomsky, Philip A Beer, Heinz Ludwi. CTPS1 is a novel therapeutic target in multiple myeloma which synergizes with inhibition of CHEK1, ATR or WEE1. Leukemia. 2023-10-29. PMID:37898670. |
exposure of mm cells to stp-b, a novel and highly selective pharmacological inhibitor of ctps1, inhibited proliferation, induced s phase arrest and led to cell death by apoptosis. |
2023-10-29 |
2023-11-08 |
Not clear |
| H\\xc3\\xa9l\\xc3\\xa8ne Asnagli, Norbert Minet, Christina Pfeiffer, Eef Hoeben, Rebecca Lane, David Laughton, Louise Birch, Geraint Jones, Andrew Novak, Andrew E Parker, Heinz Ludwig, Alain Fischer, Sylvain Latour, Philip A Bee. CTP Synthase 1 Is a Novel Therapeutic Target in Lymphoma. HemaSphere. vol 7. issue 4. 2023-04-03. PMID:37008165. |
importantly, pharmacological ctps1 inhibition induced cell death by apoptosis in the majority of lymphoid cell lines tested, thus demonstrating a cytotoxic mechanism of action. |
2023-04-03 |
2023-08-14 |
human |