| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christina Pfeiffer, Alexander M Grandits, Hélène Asnagli, Anja Schneller, Julia Huber, Niklas Zojer, Martin Schreder, Andrew E Parker, Arnold Bolomsky, Philip A Beer, Heinz Ludwi. CTPS1 is a novel therapeutic target in multiple myeloma which synergizes with inhibition of CHEK1, ATR or WEE1. Leukemia. 2023-10-29. PMID:37898670. |
combination of stp-b with pharmacological inhibitors of key components of the ddr pathway (atr, chek1 or wee1) resulted in synergistic growth inhibition and early apoptosis. |
2023-10-29 |
2023-11-08 |
Not clear |
| Nuo Li, Baoming Wan. Suppressive effects of umbilical cord mesenchymal stem cell-derived exosomal miR-15a-5p on the progression of cholangiocarcinoma by inhibiting CHEK1 expression. Cell death discovery. vol 8. issue 1. 2022-04-16. PMID:35428780. |
overexpression of mir-15a-5p promoted apoptosis but suppressed malignancy and tumorigenicity of cca cells as well as emt through downregulating chek1. |
2022-04-16 |
2023-08-13 |
Not clear |
| Xiaobin Bai, Jia Wang, Longwei Huo, Yuchen Xie, Wanfu Xie, Gaofeng Xu, Maode Wan. Serine/Threonine Kinase CHEK1-Dependent Transcriptional Regulation of RAD54L Promotes Proliferation and Radio Resistance in Glioblastoma. Translational oncology. vol 11. issue 1. 2021-01-09. PMID:29287241. |
mechanically, chek1 induced radio resistance in gbm cells, and chek1 knockdown increased cell apoptosis when combined with radiotherapy via regulation of the dna repair/recombination protein 54l (rad54l) expression. |
2021-01-09 |
2023-08-13 |
Not clear |
| G F Mukhammadiyeva, D O Karimov, T G Kutlina, Ya V Valova, N Yu Khusnutdinova, E F Repina, A B Bakiro. [Expression of Cell Cycle, Oxidative Stress, and Apoptosis Related Genes Chek1, Hmox1, Casp7 in Rat Liver Exposed to Carbon Tetrachloride]. Molekuliarnaia biologiia. vol 53. issue 1. 2019-08-15. PMID:30895955. |
[expression of cell cycle, oxidative stress, and apoptosis related genes chek1, hmox1, casp7 in rat liver exposed to carbon tetrachloride]. |
2019-08-15 |
2023-08-13 |
rat |
| Cinzia Giagulli, Pasqualina D'Ursi, Wangxiao He, Simone Zorzan, Francesca Caccuri, Kristen Varney, Alessandro Orro, Stefania Marsico, Benoît Otjacques, Carlo Laudanna, Luciano Milanesi, Riccardo Dolcetti, Simona Fiorentini, Wuyuan Lu, Arnaldo Carus. A single amino acid substitution confers B-cell clonogenic activity to the HIV-1 matrix protein p17. Scientific reports. vol 7. issue 1. 2019-02-04. PMID:28747658. |
here, we show that a single arginine (r) to glycine (g) mutation at position 76 in the refp17 backbone (p17r76g), as in the s75x variant, is per se sufficient to confer a b-cell clonogenic potential to the viral protein and modulate, through activation of the pten/pi3k/akt signaling pathway, different molecules involved in apoptosis inhibition (casp-9, casp-7, dff-45, npm, ywhaz, src, pax2, mapk8), cell cycle promotion and cancer progression (cdk1, cdk2, cdk8, chek1, chek2, gsk-3 beta, npm, pak1, pp2c-alpha). |
2019-02-04 |
2023-08-13 |
Not clear |
| Marianne K Kim, Jana James, Christina M Annunziat. Topotecan synergizes with CHEK1 (CHK1) inhibitor to induce apoptosis in ovarian cancer cells. BMC cancer. vol 15. 2016-02-01. PMID:25884494. |
topotecan synergizes with chek1 (chk1) inhibitor to induce apoptosis in ovarian cancer cells. |
2016-02-01 |
2023-08-13 |
Not clear |
| Eckhard U Alt, Christiane Senst, Subramanyam N Murthy, Douglas P Slakey, Charles L Dupin, Abigail E Chaffin, Philip J Kadowitz, Reza Izadpana. Aging alters tissue resident mesenchymal stem cell properties. Stem cell research. vol 8. issue 2. 2012-05-09. PMID:22265741. |
the expression of genes related to senescence such as chek1 and cyclin-dependent kinase inhibitor p16(ink4a) was increased with age, however genes of apoptosis were downregulated. |
2012-05-09 |
2023-08-12 |
human |
| Hala Gali-Muhtasib, Doerthe Kuester, Christian Mawrin, Khuloud Bajbouj, Antje Diestel, Matthias Ocker, Caroline Habold, Charlotte Foltzer-Jourdainne, Peter Schoenfeld, Brigitte Peters, Mona Diab-Assaf, Ulf Pommrich, Wafica Itani, Hans Lippert, Albert Roessner, Regine Schneider-Stoc. Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells. Cancer research. vol 68. issue 14. 2008-08-06. PMID:18632613. |
p53-/- cells transplanted to nude mice treated with thymoquinone up-regulated chek1 expression and did not undergo apoptosis unlike p53+/+ cells. |
2008-08-06 |
2023-08-12 |
mouse |
| Hala Gali-Muhtasib, Doerthe Kuester, Christian Mawrin, Khuloud Bajbouj, Antje Diestel, Matthias Ocker, Caroline Habold, Charlotte Foltzer-Jourdainne, Peter Schoenfeld, Brigitte Peters, Mona Diab-Assaf, Ulf Pommrich, Wafica Itani, Hans Lippert, Albert Roessner, Regine Schneider-Stoc. Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells. Cancer research. vol 68. issue 14. 2008-08-06. PMID:18632613. |
we confirmed the in vivo existence of this chek1/p53 link in human colorectal cancer, showing that tumors lacking p53 had higher levels of chek1, which was accompanied by poorer apoptosis. |
2008-08-06 |
2023-08-12 |
mouse |
| Hala Gali-Muhtasib, Doerthe Kuester, Christian Mawrin, Khuloud Bajbouj, Antje Diestel, Matthias Ocker, Caroline Habold, Charlotte Foltzer-Jourdainne, Peter Schoenfeld, Brigitte Peters, Mona Diab-Assaf, Ulf Pommrich, Wafica Itani, Hans Lippert, Albert Roessner, Regine Schneider-Stoc. Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells. Cancer research. vol 68. issue 14. 2008-08-06. PMID:18632613. |
thymoquinone triggers inactivation of the stress response pathway sensor chek1 and contributes to apoptosis in colorectal cancer cells. |
2008-08-06 |
2023-08-12 |
mouse |
| Hala Gali-Muhtasib, Doerthe Kuester, Christian Mawrin, Khuloud Bajbouj, Antje Diestel, Matthias Ocker, Caroline Habold, Charlotte Foltzer-Jourdainne, Peter Schoenfeld, Brigitte Peters, Mona Diab-Assaf, Ulf Pommrich, Wafica Itani, Hans Lippert, Albert Roessner, Regine Schneider-Stoc. Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells. Cancer research. vol 68. issue 14. 2008-08-06. PMID:18632613. |
immunofluorescence analysis revealed that the apoptosis resistance in p53-/- cells after thymoquinone treatment might be conveyed by shuttling of chek1 into the nucleus. |
2008-08-06 |
2023-08-12 |
mouse |
| Hala Gali-Muhtasib, Doerthe Kuester, Christian Mawrin, Khuloud Bajbouj, Antje Diestel, Matthias Ocker, Caroline Habold, Charlotte Foltzer-Jourdainne, Peter Schoenfeld, Brigitte Peters, Mona Diab-Assaf, Ulf Pommrich, Wafica Itani, Hans Lippert, Albert Roessner, Regine Schneider-Stoc. Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells. Cancer research. vol 68. issue 14. 2008-08-06. PMID:18632613. |
in p53-/- cells, transfection with p53-wt vector and chek1 small interfering rna treatment decreased chek1 mrna and protein levels and restored apoptosis to the levels of the p53+/+ cells. |
2008-08-06 |
2023-08-12 |
mouse |
| Preetha Rajaraman, Sophia S Wang, Nathaniel Rothman, Merideth M Brown, Peter M Black, Howard A Fine, Jay S Loeffler, Robert G Selker, William R Shapiro, Stephen J Chanock, Peter D Inski. Polymorphisms in apoptosis and cell cycle control genes and risk of brain tumors in adults. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. vol 16. issue 8. 2007-10-11. PMID:17684142. |
using data from a hospital-based case-control study conducted by the national cancer institute between 1994 and 1998, we evaluated risk of glioma (n = 388), meningioma (n = 162), and acoustic neuroma (n = 73) with respect to 12 single nucleotide polymorphisms from 10 genes involved in apoptosis and cell cycle control: casp8, ccnd1, ccnh, cdkn1a, cdkn2a, chek1, chek2, mdm2, pten, and tp53. |
2007-10-11 |
2023-08-12 |
Not clear |