| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohamed K Hassan, Hidemichi Watari, Alaa-Eldin Salah-Eldin, Ahmed S Sultan, Zainab Mohamed, Yoichiro Fujioka, Yusuke Ohba, Noriaki Sakurag. Histone deacetylase inhibitors sensitize lung cancer cells to hyperthermia: involvement of Ku70/SirT-1 in thermo-protection. PloS one. vol 9. issue 4. 2014-12-31. PMID:24728004. |
ku70 regulates apoptosis by sequestering pro-apoptotic bax. |
2014-12-31 |
2023-08-13 |
Not clear |
| Francesca Forini, Claudia Kusmic, Giuseppina Nicolini, Laura Mariani, Riccardo Zucchi, Marco Matteucci, Giorgio Iervasi, Letizia Pitt. Triiodothyronine prevents cardiac ischemia/reperfusion mitochondrial impairment and cell loss by regulating miR30a/p53 axis. Endocrinology. vol 155. issue 11. 2014-12-31. PMID:25137026. |
the concomitant decrease in p53 protein content reduces bax expression and limits mitochondrial membrane depolarization resulting in preserved mitochondrial function and decreased apoptosis and necrosis extent in the aar. |
2014-12-31 |
2023-08-13 |
rat |
| Xiang Chen, Bo Wei, Xiaoyan Han, Zongheng Zheng, Jianglong Huang, Jianpei Liu, Yong Huang, Hongbo We. LGR5 is required for the maintenance of spheroid-derived colon cancer stem cells. International journal of molecular medicine. vol 34. issue 1. 2014-12-30. PMID:24789370. |
in addition, silencing of lgr5 inhibited cell proliferation, secondary tumor sphere formation and induced cell apoptosis, and g0/g1 phase arrest in vitro by modulating bcl-2, bcl-xl and bax. |
2014-12-30 |
2023-08-13 |
Not clear |
| Xiaoyan Wang, Haoyu Meng, Pengsheng Chen, Naiquan Yang, Xin Lu, Ze-Mu Wang, Wei Gao, Ningtian Zhou, Min Zhang, Zhihui Xu, Bo Chen, Zhengxian Tao, Liangsheng Wang, Zhijian Yang, Tiebin Zh. Beneficial effects of muscone on cardiac remodeling in a mouse model of myocardial infarction. International journal of molecular medicine. vol 34. issue 1. 2014-12-30. PMID:24807380. |
treatment with muscone also reduced myocardial apoptosis by enhancing bcl-2 and suppressing bax expression. |
2014-12-30 |
2023-08-13 |
mouse |
| Tae-Wook Chung, Hee-Jung Choi, Seok-Jo Kim, Choong-Hwan Kwak, Kwon-Ho Song, Un-Ho Jin, Young-Chae Chang, Hyeun Wook Chang, Young-Choon Lee, Ki-Tae Ha, Cheorl-Ho Ki. The ganglioside GM3 is associated with cisplatin-induced apoptosis in human colon cancer cells. PloS one. vol 9. issue 5. 2014-12-30. PMID:24829158. |
cddp induced apoptosis within cells through the generation of reactive oxygen species (ros), regulated the ros-mediated expression of bax, bcl-2, and p53, and induced the degradation of the poly (adp-ribosyl) polymerase (parp). |
2014-12-30 |
2023-08-13 |
human |
| Hui Fu, Qiao-Sheng Wang, Qiong Luo, Si Tan, Hua Su, Shi-Lin Tang, Zheng-Liang Zhao, Li-Ping Huan. Simvastatin inhibits apoptosis of endothelial cells induced by sepsis through upregulating the expression of Bcl-2 and downregulating Bax. World journal of emergency medicine. vol 5. issue 4. 2014-12-30. PMID:25548604. |
simvastatin inhibits apoptosis of endothelial cells induced by sepsis through upregulating the expression of bcl-2 and downregulating bax. |
2014-12-30 |
2023-08-13 |
Not clear |
| Li Wang, Li Qia. miR-24 regulates intrinsic apoptosis pathway in mouse cardiomyocytes. PloS one. vol 9. issue 1. 2014-12-29. PMID:24454859. |
in mitochondria-involved intrinsic pathway, mir-24 inhibits the initiation of apoptosis through suppression of cytochrome c release and bax translocation from cytosol to mitochondria. |
2014-12-29 |
2023-08-12 |
mouse |
| Xiaohui Li, Xin Zhao, Hongmin Wang, Junqing Han, Li Li. A polysaccharide from the fruiting bodies of Agaricus blazei Murill induces caspase-dependent apoptosis in human leukemia HL-60 cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 9. 2014-12-29. PMID:24903379. |
the increase in abp-induced apoptosis was accompanied by loss of mitochondria membrane potential (∆Ψm), cytochrome c release from the mitochondria, activation of caspase-3, degradation of poly(adp-ribose) polymerase (parp), and the elevated ratio of bcl-2-associated x (bax)/b-cell lymphoma 2 (bcl-2). |
2014-12-29 |
2023-08-13 |
human |
| Hui-Hsuan Lin, Ming-Der Shi, Hsien-Chun Tseng, Jing-Hsien Che. Andrographolide sensitizes the cytotoxicity of human colorectal carcinoma cells toward cisplatin via enhancing apoptosis pathways in vitro and in vivo. Toxicological sciences : an official journal of the Society of Toxicology. vol 139. issue 1. 2014-12-28. PMID:24563380. |
the addition of andro to cddp induced synergistic apoptosis, which could be corroborated to the changes in protein and mrna levels of bax and bcl-2, and the increased fas/fasl association in these cells, resulting in increased release of cytochrome c, and activation of caspases. |
2014-12-28 |
2023-08-12 |
human |
| Hui-Hsuan Lin, Ming-Der Shi, Hsien-Chun Tseng, Jing-Hsien Che. Andrographolide sensitizes the cytotoxicity of human colorectal carcinoma cells toward cisplatin via enhancing apoptosis pathways in vitro and in vivo. Toxicological sciences : an official journal of the Society of Toxicology. vol 139. issue 1. 2014-12-28. PMID:24563380. |
pretreatment of nok-1 monoclonal antibody, a fas signaling inhibitor, or bax inhibitor peptide v5 repressed the andro-induced cleavage of procaspase and the sensitization to cddp-induced apoptosis. |
2014-12-28 |
2023-08-12 |
human |
| Yubin Luo, Zhifeng Wei, Guixin Chou, Zhengtao Wang, Yufeng Xia, Yue Da. Norisoboldine induces apoptosis of fibroblast-like synoviocytes from adjuvant-induced arthritis rats. International immunopharmacology. vol 20. issue 1. 2014-12-28. PMID:24613208. |
these findings indicated that nor-induced apoptosis in aia fls is achieved via a mitochondrial-dependent pathway, which may be mediated by promoting the release of cytochrome c and by regulating the expression of bax and bcl-2 proteins, and p53 might also be required for nor-induced apoptosis in aia fls. |
2014-12-28 |
2023-08-12 |
rat |
| Caiyu Lin, Li Wang, Hong Wang, Shengtao Fang, Quanbo Zhang, Liuqi Yang, Huijie Guo, Ping Lin, Jie Zhang, Xiujie Wan. Lithocarpus polystachyus REHD leaf aqueous extract inhibits human breast cancer growth in vitro and in vivo. Nutrition and cancer. vol 66. issue 4. 2014-12-22. PMID:24660968. |
the findings in this experimental study suggested that lpae has potential cytotoxic and apoptotic effects on human breast cancer cells in vitro and inhibits the cancer growth in vivo, and its mechanism of activity might be associated with apoptosis induction of cancer cells through upregulation of the mrna and protein expressions of pparγ, bax, and capase-3 genes and downregulation of the expressions of cyclin d1 and bcl-2 genes. |
2014-12-22 |
2023-08-12 |
human |
| Zi-Hui Liu, Ming-Hui Wang, Hong-Jiu Ren, Wei Qu, Li-Mei Sun, Qing-Fu Zhang, Xue-Shan Qiu, En-Hua Wan. Interleukin 7 signaling prevents apoptosis by regulating bcl-2 and bax via the p53 pathway in human non-small cell lung cancer cells. International journal of clinical and experimental pathology. vol 7. issue 3. 2014-12-19. PMID:24695377. |
interleukin 7 signaling prevents apoptosis by regulating bcl-2 and bax via the p53 pathway in human non-small cell lung cancer cells. |
2014-12-19 |
2023-08-13 |
human |
| Zi-Hui Liu, Ming-Hui Wang, Hong-Jiu Ren, Wei Qu, Li-Mei Sun, Qing-Fu Zhang, Xue-Shan Qiu, En-Hua Wan. Interleukin 7 signaling prevents apoptosis by regulating bcl-2 and bax via the p53 pathway in human non-small cell lung cancer cells. International journal of clinical and experimental pathology. vol 7. issue 3. 2014-12-19. PMID:24695377. |
these results strongly suggest that il-7/il-7r prevents apoptosis by upregulating the expression of bcl-2 and by downregulating the expression of bax, potentially via the p53 pathway in a549 and hbe cells. |
2014-12-19 |
2023-08-13 |
human |
| Nurul Husna Shafie, Norhaizan Mohd Esa, Hairuszah Ithnin, Norazalina Saad, Ashok Kumar Panduranga. Pro-apoptotic effect of rice bran inositol hexaphosphate (IP6) on HT-29 colorectal cancer cells. International journal of molecular sciences. vol 14. issue 12. 2014-12-18. PMID:24317430. |
in particular, our data provided strong evidence for the induction of apoptotic cell death, which may be attributable to the up-regulation of bax and down-regulation of bcl-xl in favor of apoptosis. |
2014-12-18 |
2023-08-12 |
human |
| Nurul Husna Shafie, Norhaizan Mohd Esa, Hairuszah Ithnin, Norazalina Saad, Ashok Kumar Panduranga. Pro-apoptotic effect of rice bran inositol hexaphosphate (IP6) on HT-29 colorectal cancer cells. International journal of molecular sciences. vol 14. issue 12. 2014-12-18. PMID:24317430. |
collectively, this present study has shown that rice bran ip6 induces apoptosis, by regulating the pro- and anti-apoptotic markers; bax and bcl-xl and via the activation of caspase molecules (caspase-3 and -8). |
2014-12-18 |
2023-08-12 |
human |
| Lian-Hong Chen, Jia-Le Song, Yu Qian, Xin Zhao, Hua-Yi Suo, Jian L. Increased preventive effect on colon carcinogenesis by use of resistant starch (RS3) as the carrier for polysaccharide of Larimichthys crocea swimming bladder. International journal of molecular sciences. vol 15. issue 1. 2014-12-18. PMID:24413751. |
plcsb significantly induced apoptosis in tissues of mice (p < 0.05) by up-regulating bax, caspase-3, and caspase-9, and down-regulating bcl-2. |
2014-12-18 |
2023-08-12 |
mouse |
| S-H Park, H-S Cho, I-J Y. Effect of bovine follicular fluid on reactive oxygen species and glutathione in oocytes, apoptosis and apoptosis-related gene expression of in vitro-produced blastocysts. Reproduction in domestic animals = Zuchthygiene. vol 49. issue 3. 2014-12-18. PMID:24592966. |
embryonic development and apoptosis, as well as the relative abundance of infτ, bax, bcl2 and hsp70 transcripts in blastocysts, were also monitored. |
2014-12-18 |
2023-08-12 |
cattle |
| Guofang Zeng, Jie Liu, Hege Chen, Bin Liu, Qingyu Zhang, Mingyi Li, Runzhi Zh. Dihydromyricetin induces cell cycle arrest and apoptosis in melanoma SK-MEL-28 cells. Oncology reports. vol 31. issue 6. 2014-12-17. PMID:24789439. |
tunel assay was used to evaluate dhm-mediated apoptosis, and western blotting was applied to examine expression levels of p53, p21, cdc25a, cdc2, p-cdc2, bax, ikk-α, nf-κb p65, p38 and p-p38 proteins. |
2014-12-17 |
2023-08-13 |
human |
| Guofang Zeng, Jie Liu, Hege Chen, Bin Liu, Qingyu Zhang, Mingyi Li, Runzhi Zh. Dihydromyricetin induces cell cycle arrest and apoptosis in melanoma SK-MEL-28 cells. Oncology reports. vol 31. issue 6. 2014-12-17. PMID:24789439. |
additionally, dhm significantly induced the apoptosis of sk-mel-28 cells, and enhanced the expression levels of bax proteins and decreased the protein levels of ikk-α, nf-κb (p65) and p-p38. |
2014-12-17 |
2023-08-13 |
human |