| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karina Elisa Machado, Kely Navakoski de Oliveira, Haíra Maria Slobodianuk Andreossi, Lorena Dos Santos Bubniak, Ana Carolina Rabello de Moraes, Pâmela Cristina Gaspar, Evilásio da Silva Andrade, Ricardo José Nunes, Maria Cláudia Santos-Silv. Apoptotic events induced by maleimides on human acute leukemia cell lines. Chemical research in toxicology. vol 26. issue 12. 2015-01-12. PMID:24304350. |
the results demonstrate the involvement of the intrinsic pathway of apoptosis, evidenced by the reduction in mitochondrial potential, an increase in the level of aif protein expression, a decreased level of expression of anti-apoptotic bcl-2 protein, and an increased level of expression of pro-apoptotic protein bax in both k562 and jurkat cells treated with cyclic imides (8, 10, and 12). |
2015-01-12 |
2023-08-12 |
human |
| Jean Carlos Barbosa Ferreira, Marília Oliveira Morais, Marcela Ramos Abrahão Elias, Aline Carvalho Batista, Claudio Rodriguês Leles, Elismauro Francisco Mendonç. Pleomorphic adenoma of oral minor salivary glands: An investigation of its neoplastic potential based on apoptosis, mucosecretory activity and cellular proliferation. Archives of oral biology. vol 59. issue 6. 2015-01-12. PMID:24681706. |
the aim of this study was to investigate the neoplastic potential of the pa of minor oral salivary glands measured by apoptosis (bcl-2, bax and p53), mucosecretory activity (muc1), and cellular proliferation (ki-67). |
2015-01-12 |
2023-08-12 |
Not clear |
| Lai Jin, Chuanhua Li, Rong Li, Zongxing Sun, Xianjun Fang, Shengnan L. Corticotropin-releasing hormone receptors mediate apoptosis via cytosolic calcium-dependent phospholipase A₂ and migration in prostate cancer cell RM-1. Journal of molecular endocrinology. vol 52. issue 3. 2015-01-10. PMID:24776847. |
previously, we discovered the mechanism of crhr-mediated apoptosis of mouse prostate cancer cell line (rm-1) to be a change of bcl-2:bax ratio, and crh was found to inhibit transforming growth factor β migration of breast cancer cells via crhrs. |
2015-01-10 |
2023-08-13 |
mouse |
| Lai Jin, Chuanhua Li, Rong Li, Zongxing Sun, Xianjun Fang, Shengnan L. Corticotropin-releasing hormone receptors mediate apoptosis via cytosolic calcium-dependent phospholipase A₂ and migration in prostate cancer cell RM-1. Journal of molecular endocrinology. vol 52. issue 3. 2015-01-10. PMID:24776847. |
silencing of cpla2 attenuated a crhr1 agonist, crh-induced apoptosis, and the decrease of the bcl-2:bax ratio, whereas silencing of cpla2 aggravated crhr2 agonist, urocortin 2 (ucn2)-inhibited apoptosis, and the increase of the bcl-2:bax ratio. |
2015-01-10 |
2023-08-13 |
mouse |
| Hyun Il Jung, Mi Jeong Jo, Hyung-Rak Kim, Yung Hyun Choi, Gun-Do Ki. Extract of Saccharina japonica induces apoptosis companied by cell cycle arrest and endoplasmic reticulum stress in SK-Hep1 human hepatocellular carcinoma cells. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 7. 2015-01-10. PMID:24815436. |
the caspase-dependent cell death pathway is mediated by cell surface death receptors and activated caspase-8 amplified the apoptotic signal either through direct activation of downstream caspase-3 or pro-apoptotic proteins (bad, bax and bak) subsequently leading to the release of cytochrome c. on the other hand, caspase-independent apoptosis appeared mediated by disruption of mitochondrial membrane potential and translocation of aif to the nucleus where they induced chromatin condensation and/or large-scale dna fragmentation. |
2015-01-10 |
2023-08-13 |
human |
| Li-Wei Zhao, Xiu-Hong Zhong, Shu-Yan Yang, Yi-Zhong Zhang, Ning-Jiang Yan. Inotodiol inhabits proliferation and induces apoptosis through modulating expression of cyclinE, p27, bcl-2, and bax in human cervical cancer HeLa cells. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 7. 2015-01-10. PMID:24815470. |
inotodiol inhabits proliferation and induces apoptosis through modulating expression of cycline, p27, bcl-2, and bax in human cervical cancer hela cells. |
2015-01-10 |
2023-08-13 |
human |
| Li-Wei Zhao, Xiu-Hong Zhong, Shu-Yan Yang, Yi-Zhong Zhang, Ning-Jiang Yan. Inotodiol inhabits proliferation and induces apoptosis through modulating expression of cyclinE, p27, bcl-2, and bax in human cervical cancer HeLa cells. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 7. 2015-01-10. PMID:24815470. |
the mtt assay was used to evaluate cell proliferating ability, flow cytometry (fcm) was employed for cell cycle analysis and cell apoptosis, while expression of cycline, p27, bcl-2 and bax was detected by immunocytochemistry. |
2015-01-10 |
2023-08-13 |
human |
| Li-Wei Zhao, Xiu-Hong Zhong, Shu-Yan Yang, Yi-Zhong Zhang, Ning-Jiang Yan. Inotodiol inhabits proliferation and induces apoptosis through modulating expression of cyclinE, p27, bcl-2, and bax in human cervical cancer HeLa cells. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 7. 2015-01-10. PMID:24815470. |
the mechanisms may be related to promoting apoptosis through increasing the expression of bax and cutting bcl-2 and affecting the cell cycle by down-regulation the expression of cyclin e and up-regulation of p27. |
2015-01-10 |
2023-08-13 |
human |
| Xiao-Jia Liu, Yun-Qian Li, Qiu-Yue Chen, Sheng-Jun Xiao, Si-En Zen. Up-regulating of RASD1 and apoptosis of DU-145 human prostate cancer cells induced by formononetin in vitro. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 6. 2015-01-07. PMID:24761910. |
du-145 cells were treated with different concentrations of formononetin and cell proliferation was assessed by mtt assay, cell apoptosis by hoechst 33258 and flow cytometry, and protein levels of rasd1, bcl-2 and bax by western blotting. |
2015-01-07 |
2023-08-13 |
human |
| John L Shannonhouse, Henryk F Urbanski, Shih-Lung Woo, Li An Fong, Scott D Goddard, William F Lucas, Edward R Jones, Chaodong Wu, Caurnel Morga. Aquaporin-11 control of testicular fertility markers in Syrian hamsters. Molecular and cellular endocrinology. vol 391. issue 1-2. 2015-01-06. PMID:24791736. |
correlations were also strongest for aqp11 with expression levels of reference cdnas that control spermatogenesis (hspa2 and tnp2), steroidogenesis (cox2, 3βhsd, and srebp2), sperm motility (catsper1, pgk2, and tnp2), inflammation (cox2), and apoptosis (bax and bcl2). |
2015-01-06 |
2023-08-13 |
Not clear |
| Wei Zhang, Hang Xiao, Kirk L Parki. Apoptosis in MCF-7 breast cancer cells induced by S-alkenylmercaptocysteine (CySSR) species derived from Allium tissues in combination with sodium selenite. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 68. 2015-01-05. PMID:24614136. |
corresponding increases in phospho-p53, bax and bad levels were observed, indicating apoptosis occurred via the mitochondrial pathway. |
2015-01-05 |
2023-08-12 |
Not clear |
| Dakuan Gao, Tao Huang, Xiaofan Jiang, Shijie Hu, Lei Zhang, Zhou Fe. Resveratrol protects primary cortical neuron cultures from transient oxygen-glucose deprivation by inhibiting MMP-9. Molecular medicine reports. vol 9. issue 6. 2015-01-05. PMID:24682241. |
ogd induced cell apoptosis, the expression of bax and the activation of caspase-3 and erk, inhibited the expression of bcl-2 and increased the expression of mmp-9, while these effects were reversed by treatment with resveratrol. |
2015-01-05 |
2023-08-12 |
mouse |
| Dakuan Gao, Tao Huang, Xiaofan Jiang, Shijie Hu, Lei Zhang, Zhou Fe. Resveratrol protects primary cortical neuron cultures from transient oxygen-glucose deprivation by inhibiting MMP-9. Molecular medicine reports. vol 9. issue 6. 2015-01-05. PMID:24682241. |
treatment with u0126 inhibited mmp-9 and bax expression and caspase-3 activation, while it further promoted the expression of the anti-apoptotic molecule bcl-2, suggesting that resveratrol inhibits mmp-9 expression and cell apoptosis by attenuating the activation of erk1/2. |
2015-01-05 |
2023-08-12 |
mouse |
| Bu-Shan Xie, Xing-Xing He, Zheng-Lin Ai, Shu-Kun Ya. Involvement of β-catenin in matrine-induced autophagy and apoptosis in WB-F344 cells. Molecular medicine reports. vol 9. issue 6. 2015-01-05. PMID:24718323. |
a decrease in b-cell lymphoma (bcl-2) mrna expression, but an increase in bcl2-associated x protein (bax) mrna expression were observed in matrine-treated cells, which led to an upregulation of the bax/bcl-2 ratio, a molecular marker for determining the extent of apoptosis. |
2015-01-05 |
2023-08-13 |
rat |
| Wei-Xu Hu, Qin Xiang, Zhu Wen, Dan He, Xiao-Mu Wu, Guo-Zhu H. Neuroprotective effect of Atractylodes macrocephalaon polysaccharides in vitro on neuronal apoptosis induced by hypoxia. Molecular medicine reports. vol 9. issue 6. 2015-01-05. PMID:24718967. |
the observed improved neuronal growth and inhibition neuronal apoptosis by amps may be due to a decrease in the levels of bax and caspase-3 and an increase in the levels of bcl-2 and the ratio of bcl-2/bax in hypoxic neurons. |
2015-01-05 |
2023-08-13 |
rat |
| Xu-Zheng Chen, Jin-Nong Li, You-Quan Zhang, Zhi-Yun Cao, Zhi-Zhen Liu, Su-Qing Wang, Lian-Ming Liao, Jian D. Fuzheng Qingjie recipe induces apoptosis in HepG2 cells via P38 MAPK activation and the mitochondria-dependent apoptotic pathway. Molecular medicine reports. vol 9. issue 6. 2015-01-05. PMID:24737008. |
fzqj-induced apoptosis was accompanied by the loss of ∆ψ, downregulation of bcl-2 and upregulation of bax expression, and the activation of caspase-3, -9 and p38 mapk. |
2015-01-05 |
2023-08-13 |
mouse |
| Jingzhang Fan, Xin Yang, Zhenggang B. Acriflavine suppresses the growth of human osteosarcoma cells through apoptosis and autophagy. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 10. 2015-01-05. PMID:24961347. |
induction of apoptosis was examined by measuring the changes in expression of bcl-2 and bax in messenger rna (mrna) and protein levels. |
2015-01-05 |
2023-08-13 |
human |
| Zhenchang Sun, Kai Huang, Xiaorui Fu, Zhiyuan Zhou, Yingying Cui, Haopeng L. A chemically sulfated polysaccharide derived from Ganoderma lucidum induces mitochondrial-mediated apoptosis in human osteosarcoma MG63 cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 10. 2015-01-05. PMID:24997619. |
western blot analysis identified that scglp1-induced apoptosis was associated with an increased protein expression of proapoptotic bax and bad, decreased expression of antiapoptotic bcl-2 and bcl-xl, loss of mitochondrial membrane potential (Δψm), the release of mitochondrial cytochrome c to cytosol, and cleavage of caspase-9, caspase-3, and poly(adp-ribose) polymerase (parp). |
2015-01-05 |
2023-08-13 |
human |
| Xinghua Wei, Ping Zhou, Xuanting Lin, Yurong Lin, Sifeng Wu, Pengfei Diao, Haiqing Xie, Keji Xie, Ping Tan. MLN2238 synergizes BH3 mimetic ABT-263 in castration-resistant prostate cancer cells by induction of NOXA. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 10. 2015-01-05. PMID:25027405. |
the cell apoptosis induced by the combination drug treatment was evidenced by enhanced caspase-3 and poly (adp-ribose) polymerase (parp) cleavage, and annexin-v-positive staining was significantly depleted by bax knockdown. |
2015-01-05 |
2023-08-13 |
Not clear |
| Xinghua Wei, Ping Zhou, Xuanting Lin, Yurong Lin, Sifeng Wu, Pengfei Diao, Haiqing Xie, Keji Xie, Ping Tan. MLN2238 synergizes BH3 mimetic ABT-263 in castration-resistant prostate cancer cells by induction of NOXA. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 10. 2015-01-05. PMID:25027405. |
in conclusion, mln2238 and abt-263 synergistically triggered apoptosis in crpc cells by upregulating noxa and activating bax, indicating a promising therapeutic strategy for the treatment of crpc. |
2015-01-05 |
2023-08-13 |
Not clear |