| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weifeng Mao, Xin Yi, Jianbing Qin, Meiling Tian, Guohua Ji. CXCL12 inhibits cortical neuron apoptosis by increasing the ratio of Bcl-2/Bax after traumatic brain injury. The International journal of neuroscience. vol 124. issue 4. 2015-01-19. PMID:23984821. |
our results indicated that after tbi in rats cxcl12 combing cxcr4 receptors could inhibit the caspase-3 pathway by upregulating bcl-2:bax ratio, which protect neurons from apoptosis. |
2015-01-19 |
2023-08-12 |
rat |
| Kuei-Chuan Chan, Hsieh-Hsun Ho, Ming-Cheng Lin, Cheng-Hsun Wu, Chien-Ning Huang, Wen-Chun Chang, Chau-Jong Wan. Mulberry water extracts inhibit rabbit atherosclerosis through stimulation of vascular smooth muscle cell apoptosis via activating p53 and regulating both intrinsic and extrinsic pathways. Journal of agricultural and food chemistry. vol 62. issue 22. 2015-01-19. PMID:24833292. |
we also found that mwes initially activate jnk/p38 and p53, which in turn activate both fas-ligand and mitochondria pathways, thereby causing mitochondria translocation of bax and the reduction of bcl-2 that trigger the cleavage of procaspases, finally resulting in apoptosis of vsmcs. |
2015-01-19 |
2023-08-13 |
rabbit |
| Yun-feng Lou, Zheng-zhi Zou, Pin-jia Chen, Guo-bin Huang, Bin Li, De-qing Zheng, Xiu-rong Yu, Xiao-yong Lu. Combination of gefitinib and DNA methylation inhibitor decitabine exerts synergistic anti-cancer activity in colon cancer cells. PloS one. vol 9. issue 5. 2015-01-19. PMID:24874286. |
concomitantly, cell apoptosis resulting from the co-treatment of gefitinib and decitabine was accompanied by induction of bax, cleaved caspase 3 and cleaved parp, along with reduction of bcl-2 compared to treatment with either drug alone. |
2015-01-19 |
2023-08-13 |
human |
| Howard Donninger, Jennifer A Clark, Megan K Monaghan, M Lee Schmidt, Michele Vos, Geoffrey J Clar. Cell cycle restriction is more important than apoptosis induction for RASSF1A protein tumor suppression. The Journal of biological chemistry. vol 289. issue 45. 2015-01-17. PMID:25225292. |
rassf1a modulates apoptosis via the hippo and bax pathways but also modulates the cell cycle. |
2015-01-17 |
2023-08-13 |
human |
| Dong Yu, Zi-Wei Zhang, Hai-Dong Yao, Shu Li, Shi-Wen X. Antioxidative role of selenoprotein W in oxidant-induced chicken splenic lymphocyte death. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 27. issue 2. 2015-01-16. PMID:24515840. |
the lymphocytes were examined for cell viability, cell apoptosis and mrna expression levels of selw and apoptosis-related genes (bcl-2, bax, bak-1, caspase-3 and p53). |
2015-01-16 |
2023-08-12 |
chicken |
| William Beau Mitchell, Mariana P Pinheiro, Nayla Boulad, David Kaplan, Michele N Edison, Bethan Psaila, Marissa Karpoff, Michael J White, Emma C Josefsson, Benjamin T Kile, James B Busse. Effect of thrombopoietin receptor agonists on the apoptotic profile of platelets in patients with chronic immune thrombocytopenia. American journal of hematology. vol 89. issue 12. 2015-01-16. PMID:25132654. |
platelet survival depends upon mediators of apoptosis e.g., bcl-xl, bax, and bak, which are regulated by thrombopoietin (tpo)-mediated akt signaling. |
2015-01-16 |
2023-08-13 |
Not clear |
| D Westphal, R M Kluck, G Dewso. Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis. Cell death and differentiation. vol 21. issue 2. 2015-01-15. PMID:24162660. |
building blocks of the apoptotic pore: how bax and bak are activated and oligomerize during apoptosis. |
2015-01-15 |
2023-08-12 |
Not clear |
| Guo-Hua Wang, Rui Lan, Xin-De Zhen, Wen Zhang, Jun Xiang, Ding-Fang Ca. An-Gong-Niu-Huang Wan protects against cerebral ischemia induced apoptosis in rats: up-regulation of Bcl-2 and down-regulation of Bax and caspase-3. Journal of ethnopharmacology. vol 154. issue 1. 2015-01-15. PMID:24690773. |
an-gong-niu-huang wan protects against cerebral ischemia induced apoptosis in rats: up-regulation of bcl-2 and down-regulation of bax and caspase-3. |
2015-01-15 |
2023-08-13 |
rat |
| Kyung Hee Jung, Hong Hua Yan, Zhenghuan Fang, Mi Kwon Son, Hyunseung Lee, Sungwoo Hong, Soon-Sun Hon. HS-104, a PI3K inhibitor, enhances the anticancer efficacy of gemcitabine in pancreatic cancer. International journal of oncology. vol 45. issue 1. 2015-01-15. PMID:24819705. |
compared to the treatment with either drug alone, the combination treatment resulted in apoptosis accompanied by increased levels of cleaved caspase-3 and bax. |
2015-01-15 |
2023-08-13 |
mouse |
| Xiao-Lin Liang, Meng Li, Jing Li, Xiu-Ling Wan. Equol induces apoptosis in human hepatocellular carcinoma SMMC-7721 cells through the intrinsic pathway and the endoplasmic reticulum stress pathway. Anti-cancer drugs. vol 25. issue 6. 2015-01-14. PMID:24487643. |
mitochondrion-mediated apoptosis was caused by upregulation of bax and downregulation of bcl-2, followed by activation of caspase-9, caspase-3, and cleaved poly (adp-ribose) polymerase, respectively. |
2015-01-14 |
2023-08-12 |
human |
| Li Sun, Lili Liu, Xiangqiang Liu, Yafang Wang, Mengbin Li, Liping Yao, Jianjun Yang, Genlin Ji, Changcun Guo, Yanglin Pan, Shuhui Liang, Biaoluo Wang, Jie Ding, Hongwei Zhang, Yongquan Sh. Gastric cancer cell adhesion to laminin enhances acquired chemotherapeutic drug resistance mediated by MGr1-Ag/37LRP. Oncology reports. vol 32. issue 1. 2015-01-14. PMID:24840404. |
in vivo and in vitro analyses revealed that binding of mgr1-ag/37lrp decreased intracellular drug accumulation by increasing p-glycoprotein and multidrug-associated protein expression, and inhibited drug-induced apoptosis by regulating bcl-2 and bax expression. |
2015-01-14 |
2023-08-13 |
Not clear |
| Yimin Lu, Yuanhua Liu, Jianzhong Jiang, Zhaoqing Xi, Ning Zhong, Shunbin Shi, Jinzhi Wang, Xiaodong We. Knocking down the expression of Aurora-A gene inhibits cell proliferation and induces G2/M phase arrest in human small cell lung cancer cells. Oncology reports. vol 32. issue 1. 2015-01-14. PMID:24841948. |
a potential mechanism for the increase of apoptosis is the downregulation of bcl-2 and upregulation of bax. |
2015-01-14 |
2023-08-13 |
human |
| Jin-Woo Jeong, Sejin Park, Cheol Park, Young-Chae Chang, Dong-Oh Moon, Sung Ok Kim, Gi-Young Kim, Hee-Jae Cha, Heui-Soo Kim, Young-Whan Choi, Wun-Jae Kim, Young Hyun Yoo, Yung Hyun Cho. N-benzyl-N-methyldecan-1-amine, a phenylamine derivative isolated from garlic cloves, induces G2/M phase arrest and apoptosis in U937 human leukemia cells. Oncology reports. vol 32. issue 1. 2015-01-14. PMID:24859825. |
nbnma-induced apoptosis was observed in parallel with an increased ratio of pro-apoptotic bax and bad/anti-apoptotic bcl-2 and bcl-xl, and inhibition of inhibitor of apoptosis protein (iap) family members xiap and ciap-1. |
2015-01-14 |
2023-08-13 |
human |
| Kaijie Wu, Zhongyun Ning, Jiancheng Zhou, Bin Wang, Jinhai Fan, Jianning Zhu, Yang Gao, Xinyang Wang, Jer-Tsong Hsieh, Dalin H. 2'-hydroxyflavanone inhibits prostate tumor growth through inactivation of AKT/STAT3 signaling and induction of cell apoptosis. Oncology reports. vol 32. issue 1. 2015-01-14. PMID:24859932. |
mechanistically, besides its known inhibitory effects on aldo‑keto reductase activity and de novo androgen synthesis, 2hf also markedly suppressed akt phosphorylation, signal transducer and activator of transcription-3 (stat3) phosphorylation and transactivation subsequently regulating the expression of members of the bcl-2 family (i.e., mcl-1, bcl-2 and bax) and modulating caspase-mediated cell apoptosis. |
2015-01-14 |
2023-08-13 |
Not clear |
| Cristhian Toruno, Seth Carbonneau, Rodney A Stewart, Cicely Jett. Interdependence of Bad and Puma during ionizing-radiation-induced apoptosis. PloS one. vol 9. issue 2. 2015-01-13. PMID:24516599. |
the bh3-only protein puma has previously been reported to activate mitochondrial apoptosis through direct interaction with the pro-apoptotic bcl-2 family proteins bax and bak, thus constituting the role of an "activator" bh3-only protein. |
2015-01-13 |
2023-08-12 |
mouse |
| Cristhian Toruno, Seth Carbonneau, Rodney A Stewart, Cicely Jett. Interdependence of Bad and Puma during ionizing-radiation-induced apoptosis. PloS one. vol 9. issue 2. 2015-01-13. PMID:24516599. |
this distinguishes it from bh3-only proteins like bad that are thought to indirectly promote apoptosis through binding to anti-apoptotic bcl-2 family members, thereby preventing the sequestration of activator bh3-only proteins and allowing them to directly interact with and activate bax and bak. |
2015-01-13 |
2023-08-12 |
mouse |
| Jun-Bo Tu, Quan-Yan Li, Fei Jiang, Xiao-Yi Hu, Rui-Zhao Ma, Qiang Dong, Hao Zhang, Parukjan Pattar, Shi-Xian L. Pingyangmycin stimulates apoptosis in human hemangioma-derived endothelial cells through activation of the p53 pathway. Molecular medicine reports. vol 10. issue 1. 2015-01-13. PMID:24789513. |
quantitative polymerase chain reaction confirmed that pingyangmycin significantly upregulated the expression of p53, p53‑induced protein with death domain, bax, p53 upregulated modulator of apoptosis and p53 inducible gene 3, and downregulated the expression of murine double minute 2. |
2015-01-13 |
2023-08-13 |
human |
| Jiayu Chen, Jiaqi Chen, Zhaoyun Li, Chibo Liu, Lihui Yi. The apoptotic effect of apigenin on human gastric carcinoma cells through mitochondrial signal pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 8. 2015-01-13. PMID:24805829. |
apigenin can inhibit cell lines hgc-27 and sgc-7901 proliferation in a time and dose-dependent manner, reduce anti-apoptotic protein bcl-2 levels, enhance apoptosis-promoting protein bax level, result in mitochondrial membrane potential decreasing and caspase-3 enzyme activating, then lead to cell apoptosis. |
2015-01-13 |
2023-08-13 |
human |
| Sumei Lu, Liang Yu, Yakui Mu, Juke Ma, Jiajun Tian, Wei Xu, Haibo Wan. Role and mechanism of Twist1 in modulating the chemosensitivity of FaDu cells. Molecular medicine reports. vol 10. issue 1. 2015-01-13. PMID:24805866. |
the anti-apoptotic capabilities of fadu/t cells were enhanced during mdr progression, with apoptosis-related proteins (bcl-2, bax, activated caspase-3 and caspase-9) changing to resist apoptosis. |
2015-01-13 |
2023-08-13 |
Not clear |
| Jayeeta Das, Sreemanti Das, Avijit Paul, Asmita Samadder, Anisur Rahman Khuda-Bukhs. Strong anticancer potential of nano-triterpenoid from Phytolacca decandra against A549 adenocarcinoma via a Ca(2+)-dependent mitochondrial apoptotic pathway. Journal of acupuncture and meridian studies. vol 7. issue 3. 2015-01-13. PMID:24929458. |
mitochondrial dysfunction-mediated apoptosis was determined by examining the changes in the intracellular calcium content, the reactive oxygen species accumulation, the cytochrome c release, the upregulation of bcl-2-associated-x protein (bax) and caspase 3, the downregulation of b cell lymphoma 2, and the mitochondrial membrane potential (ΔΨm) depolarization. |
2015-01-13 |
2023-08-13 |
Not clear |