| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Wang, H Wang, Y Tao, S Zhang, J Wang, X Fen. Necroptosis inhibitor necrostatin-1 promotes cell protection and physiological function in traumatic spinal cord injury. Neuroscience. vol 266. 2015-02-13. PMID:24561219. |
further study indicated that nec-1 could inhibit necroptosis by inhibiting rip1/3-mlkl recruitment and inhibit apoptosis by inhibiting caspase 3 and bax while activating bcl-2. |
2015-02-13 |
2023-08-12 |
rat |
| Xiaoling Wu, Guangcun Deng, Xiujing Hao, Yong Li, Jin Zeng, Chunyan Ma, Yulong He, Xiaoming Liu, Yujiong Wan. A caspase-dependent pathway is involved in Wnt/β-catenin signaling promoted apoptosis in Bacillus Calmette-Guerin infected RAW264.7 macrophages. International journal of molecular sciences. vol 15. issue 3. 2015-02-13. PMID:24663056. |
immunoblotting analysis further demonstrated that wnt/β-catenin signaling-induced cell apoptosis partly through a caspase-dependent apoptosis mechanism by down-regulation of anti-apoptotic protein mcl-1, and up-regulation of pro-apoptotic proteins bax and cleaved-caspase-3, as well as enhancement of caspase-3 activity in bcg-infected raw264.7 cells. |
2015-02-13 |
2023-08-12 |
Not clear |
| Venkateshwar Madka, Altaf Mohammed, Qian Li, Yuting Zhang, Jagan M R Patlolla, Laura Biddick, Stan Lightfoot, Xue-Ru Wu, Vernon Steele, Levy Kopelovich, Chinthalapally V Ra. Chemoprevention of urothelial cell carcinoma growth and invasion by the dual COX-LOX inhibitor licofelone in UPII-SV40T transgenic mice. Cancer prevention research (Philadelphia, Pa.). vol 7. issue 7. 2015-02-13. PMID:24795386. |
urothelial tumors of the licofelone-fed mice showed an increase in apoptosis (p53, p21, bax, and caspase3) with a decrease in proliferation, inflammation, and angiogenesis markers (proliferating cell nuclear antigen, cox-2, 5-lox, prostaglandin e synthase 1, flap, and vegf). |
2015-02-13 |
2023-08-13 |
mouse |
| Tao Huang, Dakuan Gao, Xiaofan Jiang, Shijie Hu, Lei Zhang, Zhou Fe. Resveratrol inhibits oxygen-glucose deprivation-induced MMP-3 expression and cell apoptosis in primary cortical cells via the NF-κB pathway. Molecular medicine reports. vol 10. issue 2. 2015-02-12. PMID:24840287. |
in addition, ogd was shown to induce cell apoptosis, the expression of bax and the activation of caspase-3, and inhibit the expression of bcl-2, and these effects were also reversed by res treatment. |
2015-02-12 |
2023-08-13 |
Not clear |
| V Mignard, L Lalier, F Paris, F M Vallett. Bioactive lipids and the control of Bax pro-apoptotic activity. Cell death & disease. vol 5. 2015-02-12. PMID:24874738. |
we describe how, during apoptosis, lipids can act simultaneously or in parallel as receptors or ligands for bax to stimulate or inhibit its pro-death activity. |
2015-02-12 |
2023-08-13 |
Not clear |
| Bo Liu, Yue-Qiu Gao, Xiao-Min Wang, Yu-Chun Wang, Li-Qi F. Germacrone inhibits the proliferation of glioma cells by promoting apoptosis and inducing cell cycle arrest. Molecular medicine reports. vol 10. issue 2. 2015-02-12. PMID:24889088. |
flow cytometric analysis and dna fragmentation revealed that germacrone promoted apoptosis of glioma cells, associated with an increased expression of p53 and bax and decreased expression of bcl‑2. |
2015-02-12 |
2023-08-13 |
human |
| Juthika Kundu, Bu Young Choi, Chul-Ho Jeong, Joydeb Kumar Kundu, Kyung-Soo Chu. Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Src‑mediated phosphorylation of EGF receptor tyrosine kinase. Oncology reports. vol 32. issue 2. 2015-02-12. PMID:24890449. |
treatment of cells with tq induced apoptosis, which was associated with the upregulation of bax and inhibition of bcl-2 and bcl-xl expression. |
2015-02-12 |
2023-08-13 |
human |
| A Shamas-Din, D Satsoura, O Khan, W Zhu, B Leber, C Fradin, D W Andrew. Multiple partners can kiss-and-run: Bax transfers between multiple membranes and permeabilizes those primed by tBid. Cell death & disease. vol 5. 2015-02-12. PMID:24901048. |
during apoptosis bid and bax are sufficient for mitochondrial outer membrane permeabilization, releasing pro-apoptotic proteins such as cytochrome c and smac/diablo into the cytoplasm. |
2015-02-12 |
2023-08-13 |
Not clear |
| A Shamas-Din, D Satsoura, O Khan, W Zhu, B Leber, C Fradin, D W Andrew. Multiple partners can kiss-and-run: Bax transfers between multiple membranes and permeabilizes those primed by tBid. Cell death & disease. vol 5. 2015-02-12. PMID:24901048. |
therefore, regulation of apoptosis is closely linked with the interactions of tbid and bax with mitochondria. |
2015-02-12 |
2023-08-13 |
Not clear |
| Shun-Quan Wu, Zhen-Zhen Xu, Wen-Yan Niu, Hao-Bo Huang, Rong Zha. ShRNA-mediated Bmi-1 silencing sensitizes multiple myeloma cells to bortezomib. International journal of molecular medicine. vol 34. issue 2. 2015-02-12. PMID:24913180. |
cell cycle progression and apoptosis were analyzed by flow cytometry (fcm), and the mrna and protein expression of associated genes (bmi-1, p14, p21, bcl-2 and bax) was quantified by rt-qpcr and western blot analysis, respectively. |
2015-02-12 |
2023-08-13 |
human |
| Shun-Quan Wu, Zhen-Zhen Xu, Wen-Yan Niu, Hao-Bo Huang, Rong Zha. ShRNA-mediated Bmi-1 silencing sensitizes multiple myeloma cells to bortezomib. International journal of molecular medicine. vol 34. issue 2. 2015-02-12. PMID:24913180. |
the expression of p21 and bax (apoptosis inducer) was upregulated, whereas that of the anti-apoptotic protein, bcl-2, was downregulated in the bmi-1‑silenced cells (p<0.05). |
2015-02-12 |
2023-08-13 |
human |
| Xue-Qin Hou, Dian-Wei Wu, Chun-Xia Zhang, Rong Yan, Cong Yang, Cui-Ping Rong, Lei Zhang, Xiang Chang, Ru-Yu Su, Shi-Jie Zhang, Wen-Qing He, Zhao Qu, Shi Li, Zi-Ren Su, Yun-Bo Chen, Qi Wang, Shu-Huan Fan. Bushen‑Yizhi formula ameliorates cognition deficits and attenuates oxidative stress‑related neuronal apoptosis in scopolamine‑induced senescence in mice. International journal of molecular medicine. vol 34. issue 2. 2015-02-12. PMID:24919922. |
moreover, the neural apoptosis in the hippocampus of scop‑treated mice was reversed by bsyz by regulating the expression of bcl‑2, bax and caspase‑3. |
2015-02-12 |
2023-08-13 |
mouse |
| C P Li, J H Li, S Y He, P Li, X L Zhon. Roles of Fas/Fasl, Bcl-2/Bax, and Caspase-8 in rat nonalcoholic fatty liver disease pathogenesis. Genetics and molecular research : GMR. vol 13. issue 2. 2015-02-12. PMID:24938610. |
the apoptosis percentage was measured by flow cytometry, the immunohistochemical assay was performed for the determination of fas, fasl, bcl-2, and bax expressions, and a real-time polymerase chain reaction (pcr) assay was performed to detect caspase-8 mrna expression. |
2015-02-12 |
2023-08-13 |
rat |
| C P Li, J H Li, S Y He, P Li, X L Zhon. Roles of Fas/Fasl, Bcl-2/Bax, and Caspase-8 in rat nonalcoholic fatty liver disease pathogenesis. Genetics and molecular research : GMR. vol 13. issue 2. 2015-02-12. PMID:24938610. |
the upregulation of bax and bcl-2 expression might be one important mechanism of the apoptosis in nafld. |
2015-02-12 |
2023-08-13 |
rat |
| Marc Kvansakul, Mark G Hind. The structural biology of BH3-only proteins. Methods in enzymology. vol 544. 2015-02-12. PMID:24974286. |
either by antagonizing prosurvival bcl-2 proteins or directly activating proapoptotic bcl-2 proteins (bax or bak) they initiate apoptosis. |
2015-02-12 |
2023-08-13 |
Not clear |
| Minzhao Huang, Su-Ni Tang, Ghanshyam Upadhyay, Justin L Marsh, Christopher P Jackman, Sharmila Shankar, Rakesh K Srivastav. Embelin suppresses growth of human pancreatic cancer xenografts, and pancreatic cancer cells isolated from KrasG12D mice by inhibiting Akt and Sonic hedgehog pathways. PloS one. vol 9. issue 4. 2015-02-10. PMID:24694877. |
embelin-treated mice showed significant inhibition in tumor growth which was associated with reduced expression of markers of cell proliferation (ki67, pcna and bcl-2) and cell cycle (cyclin d1, cdk2, and cdk6), and induction of apoptosis (activation of caspase-3 and cleavage of parp, and increased expression of bax). |
2015-02-10 |
2023-08-13 |
mouse |
| Ning Kang, Miao-Miao Wang, Ying-Hui Wang, Zhe-Nan Zhang, Hong-Rui Cao, Yuan-Hao Lv, Yang Yang, Peng-Hui Fan, Feng Qiu, Xiu-Mei Ga. Tetrahydrocurcumin induces G2/M cell cycle arrest and apoptosis involving p38 MAPK activation in human breast cancer cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 67. 2015-02-09. PMID:24593988. |
moreover, co-treatment of mcf-7 cells with thc and p38 mapk inhibitor, sb203580, effectively reversed the dissipation in mitochondrial membrane potential (Δψm), and blocked thc-mediated bax up-regulation, bcl-2 down-regulation, caspase-3 activation as well as p21 up-regulation, suggesting p38 mapk might mediate thc-induced apoptosis and g2/m arrest. |
2015-02-09 |
2023-08-12 |
human |
| Yanhong Li, Xueying Lu, Hongxue Qi, Xiaobo Li, Xiangwen Xiao, Jianfeng Ga. Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and suppression of ERK1/2 MAPK in HeLa cells. Journal of pharmacological sciences. vol 125. issue 2. 2015-02-09. PMID:24881958. |
here, we reported that ua induced apoptosis through the mitochondrial intrinsic pathway in hela cells, as shown by release of cytosol cytochrome c, activation of caspase-9 and -3, reduction of bcl-2 and bcl-xl, and increase of bax and bak. |
2015-02-09 |
2023-08-13 |
Not clear |
| Demei Xu, Lihua Hu, Chuanyang Su, Xiaomin Xia, Pu Zhang, Juanli Fu, Wenchao Wang, Duo Xu, Hong Du, Qiuling Hu, Erqun Song, Yang Son. Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: the prevention of curcumin. Toxicology and applied pharmacology. vol 280. issue 2. 2015-02-07. PMID:25123790. |
interestingly, tcbq has no effect on caspase family genes or b-cell lymphoma 2 (bcl-2)/bcl-2 associated x (bax) protein expressions, which implied that tcbq-induced hepatotoxicity is independent of apoptosis. |
2015-02-07 |
2023-08-13 |
mouse |
| Shaonian Xu, Jiachuan Liu, Yongming Zhang, Chunlin Wang, Jinbiao Wang, Yanyan Yang, Jian Huo, Wenjiang Su. Apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy. Neural regeneration research. vol 7. issue 17. 2015-02-06. PMID:25657662. |
expression of the apoptosis-regulating protein cytochrome c, the pro-apoptotic protein bax and the apoptosis marker caspase-3 in the tissues surrounding the area of injury was significantly reduced, while that of the anti-apoptotic protein bcl-2 was significantly increased. |
2015-02-06 |
2023-08-13 |
Not clear |