| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alessandro Annibaldi, Mathieu Heulot, Jean-Claude Martinou, Christian Widman. TAT-RasGAP317-326-mediated tumor cell death sensitization can occur independently of Bax and Bak. Apoptosis : an international journal on programmed cell death. vol 19. issue 4. 2015-02-26. PMID:24362790. |
surprisingly, in the hct116 colon carcinoma cell line, the absence of bax and bak did not prevent cisplatin-induced apoptosis and the ability of tat-rasgap317-326 to augment this response. |
2015-02-26 |
2023-08-12 |
mouse |
| Subhadip Mukhopadhyay, Prashanta Kumar Panda, Niharika Sinha, Durgesh Nandini Das, Sujit Kumar Bhuti. Autophagy and apoptosis: where do they meet? Apoptosis : an international journal on programmed cell death. vol 19. issue 4. 2015-02-26. PMID:24415198. |
cellular stress causes the displacement of bcl-2 from beclin-1 and bax, thereby triggering autophagy and apoptosis, respectively. |
2015-02-26 |
2023-08-12 |
human |
| Subhadip Mukhopadhyay, Prashanta Kumar Panda, Niharika Sinha, Durgesh Nandini Das, Sujit Kumar Bhuti. Autophagy and apoptosis: where do they meet? Apoptosis : an international journal on programmed cell death. vol 19. issue 4. 2015-02-26. PMID:24415198. |
the mechanisms linking autophagy and apoptosis are not fully defined; however, recent discoveries have revealed that several apoptotic proteins (e.g., puma, noxa, nix, bax, xiap, and bim) modulate autophagy. |
2015-02-26 |
2023-08-12 |
human |
| Hamed Karimian, Syam Mohan, Soheil Zorofchian Moghadamtousi, Mehran Fadaeinasab, Mahboubeh Razavi, Aditya Arya, Behnam Kamalidehghan, Hapipah Mohd Ali, Mohamad Ibrahim Noordi. Tanacetum polycephalum (L.) Schultz-Bip. induces mitochondrial-mediated apoptosis and inhibits migration and invasion in MCF7 cells. Molecules (Basel, Switzerland). vol 19. issue 7. 2015-02-26. PMID:24995928. |
treatment of mcf7 cells with tphe encouraged apoptosis through reduction of mmp by down-regulation of bcl-2 and up-regulation of bax, triggering the cytochrome c leakage from mitochondria to the cytosol. |
2015-02-26 |
2023-08-13 |
Not clear |
| Stephanie Bleicken, Gunnar Jeschke, Carolin Stegmueller, Raquel Salvador-Gallego, Ana J García-Sáez, Enrica Bordigno. Structural model of active Bax at the membrane. Molecular cell. vol 56. issue 4. 2015-02-26. PMID:25458844. |
bax plays a central role in the mitochondrial pathway of apoptosis. |
2015-02-26 |
2023-08-13 |
Not clear |
| Young Rae Ji, Hei Jung Kim, Dong Hun Yu, Ki Beom Bae, Seo Jin Park, Si Jun Park, Woo Young Jang, Min-Cheol Kang, Jain Jeong, Yong Hun Sung, Minjee Choi, Taejun Park, Taesun Park, Jong Won Yun, Hyun-Shik Lee, Sanggyu Lee, Myoung Ok Kim, Zae Young Ryo. Over-expression of Roquin aggravates T cell mediated hepatitis in transgenic mice using T cell specific promoter. Biochemical and biophysical research communications. vol 452. issue 3. 2015-02-25. PMID:25201726. |
furthermore, roquin regulates the immune response and apoptosis in con a induced hepatitis via stats, bax and bcl2. |
2015-02-25 |
2023-08-13 |
mouse |
| Weiwei Sun, Lulu Chen, Wei Zhang, Rong Wang, David Goltzman, Dengshun Mia. Active vitamin D deficiency mediated by extracellular calcium and phosphorus results in male infertility in young mice. American journal of physiology. Endocrinology and metabolism. vol 308. issue 1. 2015-02-25. PMID:25370849. |
the proliferation of spermatogenic cells was decreased with downregulation of cyclin e and cdk2 and upregulation of p53 and p21 expression, whereas apoptosis of spermatogenic cells was increased with upregulation of bax and p-caspase 3 expression and downregulation of bcl-xl expression. |
2015-02-25 |
2023-08-13 |
mouse |
| Li Mai, Faping Yi, Xiaoyan Gou, Ji Zhang, Changdong Wang, Geli Liu, Youquan Bu, Chengfu Yuan, Linman Deng, Fangzhou Son. The overexpression of MCPH1 inhibits cell growth through regulating cell cycle-related proteins and activating cytochrome c-caspase 3 signaling in cervical cancer. Molecular and cellular biochemistry. vol 392. issue 1-2. 2015-02-24. PMID:24633962. |
moreover, the overexpression of mcph1 activated mitochondrial apoptosis through regulating several apoptosis-related proteins such as p53, bcl-2, bax, cytochrome c, caspase-3, and parp-1. |
2015-02-24 |
2023-08-12 |
Not clear |
| Sara H Hazem, Mohamed E Shaker, Sylvia A Ashamallah, Tarek M Ibrahi. The novel Janus kinase inhibitor ruxolitinib confers protection against carbon tetrachloride-induced hepatotoxicity via multiple mechanisms. Chemico-biological interactions. vol 220. 2015-02-24. PMID:24973641. |
these comprise (i) reducing infiltration of neutrophils and macrophages, as demonstrated by reducing myeloperoxidase activity and f4/80 positive macrophages; (ii) abating apoptosis of hepatocytes, as denoted by decreasing hepatocytes positive for bax protein; (iii) inhibiting elevation of tnf-α, il-1β and il-10; (iv) inhibiting nf-κb activation and translocation to the nucleus, as visualized immunohistochemically; (v) attenuating activation of the il-23/il-17 pathway via targeting il-17, but not il-23; (vi) antagonizing hepatic oxidative stress by increasing the antioxidant levels (reduced glutathione, glutathione-s-transferase and superoxide dismutase) and decreasing products of lipid peroxidation (malondialdehyde and 4-hydroxynonenal) and total nitrate/nitrite; and (vii) more interestingly, modulating hepatocyte regeneration according to the extent of damage, as quantified by pcna-immunohistochemistry. |
2015-02-24 |
2023-08-13 |
mouse |
| Qiang Fang, Wei-hua Fu, Jing Yang, Xing Li, Zhan-song Zhou, Zhi-weng Chen, Jin-hong Pa. Knockdown of ZFX suppresses renal carcinoma cell growth and induces apoptosis. Cancer genetics. vol 207. issue 10-12. 2015-02-24. PMID:25441684. |
functional analysis indicated that zfx silencing significantly inhibited renal cell carcinoma cell proliferation and cell cycle progression, probably because of suppression of cdk4 and cyclin d1, and induced apoptosis via activation of bax, caspase 3, and puma in a p53-dependent manner. |
2015-02-24 |
2023-08-13 |
human |
| Jinying Wang, Peng Wang, Shuhong Li, Shilei Wang, Yu Li, Nan Liang, Min Wan. Mdivi-1 prevents apoptosis induced by ischemia-reperfusion injury in primary hippocampal cells via inhibition of reactive oxygen species-activated mitochondrial pathway. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. vol 23. issue 6. 2015-02-23. PMID:24774441. |
the redox state, cell apoptosis, and expression of drp1, bcl-2, bax, and cytochrome c proteins were measured. |
2015-02-23 |
2023-08-13 |
rat |
| Jinying Wang, Peng Wang, Shuhong Li, Shilei Wang, Yu Li, Nan Liang, Min Wan. Mdivi-1 prevents apoptosis induced by ischemia-reperfusion injury in primary hippocampal cells via inhibition of reactive oxygen species-activated mitochondrial pathway. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. vol 23. issue 6. 2015-02-23. PMID:24774441. |
the data showed that administration of mdivi-1 at the doses of 50 μm significantly reduced oxidative stress, attenuated cell apoptosis, upregulated bcl-2 expression, and downregulated drp1, bax, and cytochrome c expression. |
2015-02-23 |
2023-08-13 |
rat |
| Jin-Hua He, Xiao-Li Liao, Wei Wang, Dan-Dan Li, Wen-Dan Chen, Rong Deng, Dajun Yang, Ze-Ping Han, Jian-Wei Jiang, Xiao-Feng Zh. Apogossypolone, a small-molecule inhibitor of Bcl-2, induces radiosensitization of nasopharyngeal carcinoma cells by stimulating autophagy. International journal of oncology. vol 45. issue 3. 2015-02-23. PMID:24919770. |
previously, we showed that apogossypolone (apog2) induced apoptosis by blocking the binding of bcl-2 to bax, arresting the cell cycle in the s phase, in turn inhibiting proliferation of npc cells both in vitro and in vivo. |
2015-02-23 |
2023-08-13 |
mouse |
| J-M Ou, W-S Lian, M-K Qiu, Y-X Dai, Q Dong, J Shen, P Dong, X-F Wang, Y-B Liu, Z-W Quan, Z-W Fe. Knockdown of IGF2R suppresses proliferation and induces apoptosis in hemangioma cells in vitro and in vivo. International journal of oncology. vol 45. issue 3. 2015-02-23. PMID:24968760. |
furthermore, knockdown of igf2r in vitro significantly diminished the proliferative activity and induced apoptosis and cycle arrest with decreased expression of pcna, ki-67, bcl-2, cyclin d1 and e and increased the expression of bax in the proliferative phase has (hdec and crl-2586 eoma cells). |
2015-02-23 |
2023-08-13 |
mouse |
| Ki Mo Kim, Deok Rim Heo, Jun Lee, Jong-Shik Park, Myung-Gi Baek, Jin-Mu Yi, Haejin Kim, Ok-Sun Ban. 5,3'-Dihydroxy-6,7,4'-trimethoxyflavanone exerts its anticancer and antiangiogenesis effects through regulation of the Akt/mTOR signaling pathway in human lung cancer cells. Chemico-biological interactions. vol 225. 2015-02-23. PMID:25446852. |
dhtmf significantly suppressed growth and induced apoptosis in lung carcinoma cells in a dose-dependent manner, as indicated by a decrease in bcl-2 levels and increases in bax and cleaved caspase-3 levels. |
2015-02-23 |
2023-08-13 |
mouse |
| Chi-Rei Wu, Chia-Wen Tsai, Shu-Wei Chang, Chia-Yuan Lin, Li-Chun Huang, Chia-Wen Tsa. Carnosic acid protects against 6-hydroxydopamine-induced neurotoxicity in in vivo and in vitro model of Parkinson's disease: involvement of antioxidative enzymes induction. Chemico-biological interactions. vol 225. 2015-02-23. PMID:25446857. |
however, bam7, an activator of bax, attenuated the effect of ca on apoptosis in sh-sy5y cells. |
2015-02-23 |
2023-08-13 |
rat |
| Yuzhe Tang, Ruibao Chen, Yan Huang, Guodong Li, Yiling Huang, Jiepeng Chen, Lili Duan, Bao-Ting Zhu, J Brantley Thrasher, Xu Zhang, Benyi L. Natural compound Alternol induces oxidative stress-dependent apoptotic cell death preferentially in prostate cancer cells. Molecular cancer therapeutics. vol 13. issue 6. 2015-02-19. PMID:24688053. |
we also demonstrated that the proapoptotic bax protein was activated after alternol treatment and was critical for alternol-induced apoptosis. |
2015-02-19 |
2023-08-12 |
mouse |
| Catherine Gratas, Quentin Séry, Marion Rabé, Lisa Oliver, François M Vallett. Bak and Mcl-1 are essential for Temozolomide induced cell death in human glioma. Oncotarget. vol 5. issue 9. 2015-02-19. PMID:24811082. |
using rna interference, we showed that tmz induced apoptosis is dependent on the pro-apoptotic protein bak but independent of the pro-apoptotic protein bax. |
2015-02-19 |
2023-08-13 |
human |
| Ning Ge, Qing Xia, Zhong-Hua Yang, Qun-Fang Ding, Zhi Zen. Vascular endothelial injury and apoptosis in rats with severe acute pancreatitis. Gastroenterology research and practice. vol 2015. 2015-02-17. PMID:25688263. |
after 12 hours, the aortic endothelial apoptosis index and bax mrna expression in aortic endothelial cells had increased in the experimental group, but bcl-2 mrna levels had decreased. |
2015-02-17 |
2023-08-13 |
rat |
| X Chen, X-S Duan, L-J Xu, J-J Zhao, Z-F She, W-W Chen, Z-J Zheng, G-D Jian. Interleukin-10 mediates the neuroprotection of hyperbaric oxygen therapy against traumatic brain injury in mice. Neuroscience. vol 266. 2015-02-13. PMID:24291771. |
hbo therapy after tbi reduced lesion volume, attenuated cerebral edema, improved neurological status including motor and cognitive function, inhibited apoptosis evidenced by decreased ratio of cleaved caspase-3 (c3) to pro-c3 and bax expression and increased bcl-2 expression, and attenuated inflammation marked by reduced expression of il-1β, il-6, macrophage inflammatory protein-2 (mip-2), and monocyte chemoattractant protein-1 (mcp-1) and activity of matrix metalloproteinase-9 (mmp9). |
2015-02-13 |
2023-08-12 |
mouse |