| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhijun Dong, Xiangyi Tao, Xiaoxiao Fu, Haibin Wang, Donghua Wang, Tiemin Zhan. Protective effects of Purendan superfine powder on retinal neuron apoptosis in a rat model of type 2 diabetes mellitus. Neural regeneration research. vol 7. issue 3. 2015-03-13. PMID:25767500. |
this study sought to investigate the effects of purendan superfine powder comprised of momordica charantia, radix ginseng, and radix salviae miltiorrhiae on neuronal apoptosis and expression of bcl-2, bax, and caspase-3, which are retinal apoptosis-associated factors in rats with diabetes mellitus induced by continuous intraperitoneal injection of streptozotocin. |
2015-03-13 |
2023-08-13 |
rat |
| Guo-Fu Huang, Jing Zou, Jing Shi, Dong-You Zhang, Hong-Fen Peng, Qi Zhang, Yu Gao, Bo-Yi Wang, Tang-Fa Zhan. Electroacupuncture stimulates remodeling of extracellular matrix by inhibiting apoptosis in a rabbit model of disc degeneration. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-03-12. PMID:25763091. |
apoptosis involvement was determined with tunel staining and western blot for the protein expression of bax and bcl-2. |
2015-03-12 |
2023-08-13 |
rabbit |
| Franziska Todt, Zeynep Cakir, Frank Reichenbach, Frederic Emschermann, Joachim Lauterwasser, Andrea Kaiser, Gabriel Ichim, Stephen W G Tait, Stephan Frank, Harald F Langer, Frank Edlic. Differential retrotranslocation of mitochondrial Bax and Bak. The EMBO journal. vol 34. issue 1. 2015-03-11. PMID:25378477. |
the bcl-2 proteins bax and bak can permeabilize the outer mitochondrial membrane and commit cells to apoptosis. |
2015-03-11 |
2023-08-13 |
human |
| Franziska Todt, Zeynep Cakir, Frank Reichenbach, Frederic Emschermann, Joachim Lauterwasser, Andrea Kaiser, Gabriel Ichim, Stephen W G Tait, Stephan Frank, Harald F Langer, Frank Edlic. Differential retrotranslocation of mitochondrial Bax and Bak. The EMBO journal. vol 34. issue 1. 2015-03-11. PMID:25378477. |
strikingly, the reduction of bax shuttling to the level of bak retrotranslocation results in full bax toxicity even in absence of apoptosis induction. |
2015-03-11 |
2023-08-13 |
human |
| Jong-Rung Tsai, Inn-Wen Chong, Yung-Hsiang Chen, Jhi-Jhu Hwang, Wei-Hsian Yin, Hsiu-Lin Chen, Shah-Hwa Chou, Chien-Chih Chiu, Po-Len Li. Magnolol induces apoptosis via caspase-independent pathways in non-small cell lung cancer cells. Archives of pharmacal research. vol 37. issue 4. 2015-03-10. PMID:23943503. |
magnolol triggered the release of pro-apoptotic proteins: bid, bax and cytochrome c from mitochondria, but did not activate the caspase-3, -8, and -9, suggesting that magnolol induces apoptosis of nsclc cell lines via a caspase-independent pathway. |
2015-03-10 |
2023-08-12 |
human |
| I-Te Wang, Shou-Chu Chou, Ying-Chin Li. Zoledronic acid induces apoptosis and autophagy in cervical cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 12. 2015-03-10. PMID:25142231. |
induction of apoptosis was determined by quantitation of expression level of b cell lymphoma 2 (bcl-2) and bax messenger rna (mrna) and identification of the proteolytic cleavage of poly (adp)-ribose polymerase (parp) and caspase-3. |
2015-03-10 |
2023-08-13 |
human |
| I-Te Wang, Shou-Chu Chou, Ying-Chin Li. Zoledronic acid induces apoptosis and autophagy in cervical cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 12. 2015-03-10. PMID:25142231. |
za-induced cell death displayed features characteristic to both apoptosis and autophagy and was associated with different changes in the levels of bcl-2 and bax in the various cervical cancer lines. |
2015-03-10 |
2023-08-13 |
human |
| Pei-Ching Hsiao, Wei-Jiunn Lee, Shun-Fa Yang, Peng Tan, Hui-Yu Chen, Liang-Ming Lee, Junn-Liang Chang, Gi-Ming Lai, Jyh-Ming Chow, Ming-Hsien Chie. Nobiletin suppresses the proliferation and induces apoptosis involving MAPKs and caspase-8/-9/-3 signals in human acute myeloid leukemia cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 12. 2015-03-10. PMID:25164609. |
furthermore, nobiletin effectively induced apoptosis of hl-60 cells through caspase-8, caspase-9, and caspases-3 activation concomitantly with a marked induction of p38 mitogen-activated protein kinase (mapk) activation, but without affecting expression levels of bcl-2, bax, or bid. |
2015-03-10 |
2023-08-13 |
human |
| Jiaoyuan Jia, Mei Yang, Yu Chen, Hongyan Yuan, Jinghe Li, Xueling Cui, Zhonghui Li. Inducing apoptosis effect of caffeic acid 3,4-dihydroxy-phenethyl ester on the breast cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 12. 2015-03-10. PMID:25190016. |
it can induce the cell apoptosis through downregulating bcl-2 expression, enhancing bax and caspase-3 expression levels, upregulating ros level and reducing the mitochondrial membrane potential of the breast cancer cells to trigger the mitochondrial signal pathway. |
2015-03-10 |
2023-08-13 |
Not clear |
| Jung Ok Lee, Ji Wook Moon, Soo Kyung Lee, So Mi Kim, Nami Kim, Seong-Gyu Ko, Hyeon Soo Kim, Sun Hwa Par. Rhus verniciflua extract modulates survival of MCF-7 breast cancer cells through the modulation of AMPK-pathway. Biological & pharmaceutical bulletin. vol 37. issue 5. 2015-03-06. PMID:24553147. |
the inhibition of ampk blocked rvs-induced p53 phosphorylation and bax expression, which suggests that ampk is involved in rvs-induced cancer apoptosis. |
2015-03-06 |
2023-08-12 |
human |
| Xukun Deng, Xiangpei Zhao, Zhou Lan, Jie Jiang, Wu Yin, Lvyi Che. Anti-tumor effects of flavonoids from the ethnic medicine Docynia delavayi (Franch.) Schneid. and its possible mechanism. Journal of medicinal food. vol 17. issue 7. 2015-03-06. PMID:24940817. |
these findings indicate that chrysin is the major flavonoid present in dds, and it induces hepg2 cell death via apoptosis, probably through the participation of caspase-3, bax, and bcl-2 proteins. |
2015-03-06 |
2023-08-13 |
human |
| Ninad Mehta, John Taylor, Douglas Quilty, Michele Barr. Ectromelia virus encodes an anti-apoptotic protein that regulates cell death. Virology. vol 475. 2015-03-06. PMID:25462348. |
collectively, our data indicates that evm025 inhibits apoptosis by sequestering bak and inhibiting the activity of bak and bax. |
2015-03-06 |
2023-08-13 |
Not clear |
| Krishna Kumar L Samaga, Gudapati Venkateshwara Rao, G Chandrashekara Reddy, Anil Kumar Kush, Latha Diwaka. Synthetic racemates of abyssinone I and II induces apoptosis through mitochondrial pathway in human cervix carcinoma cells. Bioorganic chemistry. vol 56. 2015-03-04. PMID:25019692. |
abyssinones promoted apoptosis by up regulation of p53 and bax, along with down regulation of bcl-2. |
2015-03-04 |
2023-08-13 |
human |
| Pierre-François Cartron, Elise Petit, Grégory Bellot, Lisa Oliver, François M Vallett. Metaxins 1 and 2, two proteins of the mitochondrial protein sorting and assembly machinery, are essential for Bak activation during TNF alpha triggered apoptosis. Cellular signalling. vol 26. issue 9. 2015-03-03. PMID:24794530. |
the proteins bax and bak are central in the execution phase of apoptosis; however, little is known about the partners involved in the control of this complex process. |
2015-03-03 |
2023-08-13 |
Not clear |
| Yong Xia, Qian Lei, Yongxia Zhu, Tinghong Ye, Ningyu Wang, Guobo Li, Xuanhong Shi, Yantong Liu, Bin Shao, Tao Yin, Lifeng Zhao, Wenshuang Wu, Xuejiao Song, Ying Xiong, Yuquan Wei, Luoting Y. SKLB316, a novel small-molecule inhibitor of cell-cycle progression, induces G2/M phase arrest and apoptosis in vitro and inhibits tumor growth in vivo. Cancer letters. vol 355. issue 2. 2015-03-03. PMID:25301449. |
moreover, sklb316 could induce cancer cell apoptosis, which was associated with activation of caspase 9, downregulation of bcl-2 and upregulation of bax. |
2015-03-03 |
2023-08-13 |
mouse |
| Radha Munagala, Farrukh Aqil, Jeyaprakash Jeyabalan, Ramesh C Gupt. Tanshinone IIA inhibits viral oncogene expression leading to apoptosis and inhibition of cervical cancer. Cancer letters. vol 356. issue 2 Pt B. 2015-03-03. PMID:25304375. |
mechanistically in hpv positive caski cells, tan iia was found to (i) downregulate expression of hpv e6 and e7 genes and modulate associated proteins e6ap and e2f1, (ii) cause s phase cell cycle arrest, (iii) induce accumulation of p53 and alter expression of p53-dependent targets, (iv) modulate prb and related proteins, and (v) cause p53-mediated apoptosis by moderating bcl2, bax, caspase-3, and parp cleavage expressions. |
2015-03-03 |
2023-08-13 |
mouse |
| Shi Qiu, Yun Cai, Xing Gao, Shou-Zhi Gu, Ze-Jun Li. A small peptide derived from p53 linker region can resume the apoptotic activity of p53 by sequestering iASPP with p53. Cancer letters. vol 356. issue 2 Pt B. 2015-03-03. PMID:25444901. |
the results show that a34 can competitively combine with iaspp and therefore release p53 from iaspp; a34 can enhance the transcriptional activity of p53 on the promoters of bax and puma; a34 can increase cell apoptosis and slow tumor growth in vitro and vivo. |
2015-03-03 |
2023-08-13 |
Not clear |
| Yanhong Luo, Yaodong Wei, Taizhong Wang, Dongzhu Chen, Tiansheng Lu, Ruibo Wu, Keke S. Pine pollen inhibits cell apoptosis-related protein expression in the cerebral cortex of mice with arsenic poisoning. Neural regeneration research. vol 7. issue 12. 2015-02-27. PMID:25722672. |
results indicated that pine pollen suppressed cell apoptosis in the cerebral cortex of arsenic-poisoned mice by reducing bax, bcl-2 protein expression and increasing p53 protein expression. |
2015-02-27 |
2023-08-13 |
mouse |
| Boris K Pliyev, Anna V Ivanova, Valery G Savchenk. Extracellular NAD(+) inhibits human neutrophil apoptosis. Apoptosis : an international journal on programmed cell death. vol 19. issue 4. 2015-02-26. PMID:24292505. |
together, these results demonstrate that extracellular nad(+) inhibits neutrophil apoptosis via p2y11 receptor and camp/pka pathway by regulating mcl-1 level, bax targeting to the mitochondria and mitochondrial apoptotic pathway. |
2015-02-26 |
2023-08-12 |
human |
| Alessandro Annibaldi, Mathieu Heulot, Jean-Claude Martinou, Christian Widman. TAT-RasGAP317-326-mediated tumor cell death sensitization can occur independently of Bax and Bak. Apoptosis : an international journal on programmed cell death. vol 19. issue 4. 2015-02-26. PMID:24362790. |
the absence of bax and bak in mouse embryonic fibroblasts rendered them resistant to cisplatin-induced apoptosis and consequently to the sensitizing action of the rasgap-derived peptide. |
2015-02-26 |
2023-08-12 |
mouse |