| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lisa M Lindqvist, David L Vau. BCL2 and related prosurvival proteins require BAK1 and BAX to affect autophagy. Autophagy. vol 10. issue 8. 2015-03-30. PMID:24991825. |
in cells able to undergo mitochondria-mediated apoptosis, inhibiting the endogenous prosurvival bcl2 family members induces both autophagy and cell death, but when bax and bak1 are deleted, neither inhibiting nor overexpressing bcl2, bcl2l1, or mcl1 causes any detectable effect on lc3b lipidation, lc3b turnover, or autolysosome formation. |
2015-03-30 |
2023-08-13 |
Not clear |
| Mohamed Hassan, Hidemichi Watari, Ali AbuAlmaaty, Yusuke Ohba, Noriaki Sakurag. Apoptosis and molecular targeting therapy in cancer. BioMed research international. vol 2014. 2015-03-30. PMID:25013758. |
the tumor cells may use some of several molecular mechanisms to suppress apoptosis and acquire resistance to apoptotic agents, for example, by the expression of antiapoptotic proteins such as bcl-2 or by the downregulation or mutation of proapoptotic proteins such as bax. |
2015-03-30 |
2023-08-13 |
Not clear |
| Pengfei Zhang, Caifeng Bi, Sara M Schmitt, Xin Li, Yuhua Fan, Nan Zhang, Q Ping Do. Metal-based 2,3-indolinedione derivatives as proteasome inhibitors and inducers of apoptosis in human cancer cells. International journal of molecular medicine. vol 34. issue 3. 2015-03-30. PMID:25017797. |
the results revealed that the complexes, c1, c3 and c5, but not their counterparts, c2, c4 and c6, inhibited the chymotrypsin-like activity of the human cancer cellular 26s proteasome; in addition, these complexes promoted the accumulation of the proteasome target protein, bax, inhibited cell growth and induced apoptosis in a concentration- and time-dependent manner due to their unique structures. |
2015-03-30 |
2023-08-13 |
human |
| Nao Nishida, Misa Noguchi, Kouichi Kuroda, Mitsuyoshi Ued. A design for the control of apoptosis in genetically modified Saccharomyces cerevisiae. Bioscience, biotechnology, and biochemistry. vol 78. issue 2. 2015-03-30. PMID:25036693. |
human apoptotic factor bax (no homolog in yeast), under the control of the fbp1 (gluconeogenesis enzyme) promoter, was conditionally expressed to induce yeast cell apoptosis after glucose depletion. |
2015-03-30 |
2023-08-13 |
human |
| Alexander V Sirotkin, Gabriela Kisová, Pauline Brenaut, Dmitriy Ovcharenko, Roland Grossmann, Milos Mlynce. Involvement of microRNA Mir15a in control of human ovarian granulosa cell proliferation, apoptosis, steroidogenesis, and response to FSH. MicroRNA (Shariqah, United Arab Emirates). vol 3. issue 1. 2015-03-30. PMID:25069510. |
accumulation of markers of proliferation (mapk/erk1,2 and pcna) and apoptosis (caspase 3 and bax), and release of steroid hormones (progesterone, testosterone, and estradiol) were evaluated by immunocytochemical analysis and by enzyme immunoassay. |
2015-03-30 |
2023-08-13 |
human |
| Yong Huang, Feng Dong, Qian Du, Hongling Zhang, Xiaomao Luo, Xiangjun Song, Xiaomin Zhao, Wenlong Zhang, Dewen Ton. Swainsonine induces apoptosis through mitochondrial pathway and caspase activation in goat trophoblasts. International journal of biological sciences. vol 10. issue 7. 2015-03-30. PMID:25076855. |
sw treatment increased bax protein levels, reduced bcl-2 protein levels, induced bax translocation to mitochondria, and triggered the release of cytochrome c from mitochondria into cytosol, which in turn activated caspase-9 and caspase-3, and cleaved parp, resulting in gtcs apoptosis. |
2015-03-30 |
2023-08-13 |
Not clear |
| Jie Xu, Li Wang, Xu-Guang Song, Qing-Yun Wu, Kai Zhao, Ling-Yu Zeng, Zheng-Xiang Han, Chong Chen, Kai-Lin X. [Effect of BRD4 inhibitor GSK525762A on proliferation and apoptosis of KU812 leukemic cells and its mechanism]. Zhongguo shi yan xue ye xue za zhi. vol 22. issue 5. 2015-03-30. PMID:25338565. |
it is concluded that gsk525762a can inhibit the proliferation of ku812 cells and induce cell apoptosis possibly through depressing the transcription of c-myc, bcl-2, cdk6 and bcl-xl gene, and down-regulating bak and bax transcription. |
2015-03-30 |
2023-08-13 |
Not clear |
| Jia-Xin Fan, Ying-Jian Zeng, Jian-Wei Wu, Zhang-Qiu Li, Yuan-Ming Li, Rong Zheng, Guang-Yang Weng, Kun-Yuan Gu. [Synergistic killing effect of arsenic trioxide combined with curcumin on KG1a cells]. Zhongguo shi yan xue ye xue za zhi. vol 22. issue 5. 2015-03-30. PMID:25338570. |
the cell survival rate was mesured by mtt; colony formation capacity was examined by methylcellulose colony formation test; flow cytometry was used to analyse the cell surface molecules, cell apoptosis rate and cell cycle; the cell morphology was observed with wright-giemsa staining and the protein expression of bcl-2, bax, parp was detected by western blot. |
2015-03-30 |
2023-08-13 |
Not clear |
| Jia-Xin Fan, Ying-Jian Zeng, Jian-Wei Wu, Zhang-Qiu Li, Yuan-Ming Li, Rong Zheng, Guang-Yang Weng, Kun-Yuan Gu. [Synergistic killing effect of arsenic trioxide combined with curcumin on KG1a cells]. Zhongguo shi yan xue ye xue za zhi. vol 22. issue 5. 2015-03-30. PMID:25338570. |
arsenic trioxide combined with curcumin can effectively inhibit the kg1a cell proliferation and induce apoptosis, which may be associated with the downregulation of bcl-2 and parp protein expression and the upregulation of bax protein expression. |
2015-03-30 |
2023-08-13 |
Not clear |
| Kun Yao, Hai-Xia Zhu, Rong Zhang, Ai-Jun Liao, Wei Yang, Zhuo-Gang Li. [Effects of TIEG1 on K562 cell apoptosis and expression of BCL-2/BAX, PTEN]. Zhongguo shi yan xue ye xue za zhi. vol 22. issue 5. 2015-03-30. PMID:25338572. |
in process of k562 cell apoptosis, the expression level of bcl-2 gradually decreased (r = 0.48, p < 0.05), meanwhile the expression levels of bax (r = 0.69, p < 0.05) and pten (r = 0.57, p < 0.05) gradually increased. |
2015-03-30 |
2023-08-13 |
Not clear |
| Jyotsna Singh, Poonam Kakka. Oroxylin A, a constituent of Oroxylum indicum inhibits adipogenesis and induces apoptosis in 3T3-L1 cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 21. issue 12. 2015-03-30. PMID:25442284. |
annexin v/pi staining showed induction of apoptosis which was further confirmed by enhanced levels of pro-apoptotic proteins bax, cyt c, aif and chromatin condensation. |
2015-03-30 |
2023-08-13 |
Not clear |
| Lan Han, Zhaojie Ji, Weidong Chen, Dengke Yin, Fan Xu, Shanshan Li, Fangfang Chen, Guangyu Zhu, Daiyin Pen. Protective effects of tao-Hong-si-wu decoction on memory impairment and hippocampal damage in animal model of vascular dementia. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-03-30. PMID:25821478. |
moreover, the immunohistochemical staining and western blotting results also revealed that tsd decreased apoptosis via upregulated b-cell lymphoma-2 (bcl-2)/bcl-2 associated x protein (bax) ratio. |
2015-03-30 |
2023-08-13 |
rat |
| Hai-Dong Guo, Jin-Xin Tian, Jing Zhu, Li Li, Kui Sun, Shui-Jin Shao, Guo-Hong Cu. Electroacupuncture Suppressed Neuronal Apoptosis and Improved Cognitive Impairment in the AD Model Rats Possibly via Downregulation of Notch Signaling Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-03-26. PMID:25810743. |
ea obviously alleviated the cell apoptosis resulted by aβ infusion in hippocampus ca1 regions through upregulating the expression of bcl-2 and downregulating the expression of bax. |
2015-03-26 |
2023-08-13 |
rat |
| Prakash Tiwari, Satya Sahay, Manuraj Pandey, Syed S Y H Qadri, Krishna P Gupt. Combinatorial chemopreventive effect of butyric acid, nicotinamide and calcium glucarate against the 7,12-dimethylbenz(a)anthracene induced mouse skin tumorigenesis attained by enhancing the induction of intrinsic apoptotic events. Chemico-biological interactions. vol 226. 2015-03-24. PMID:25478867. |
dmba treatment suppressed bax, bax/bcl-2 ratio, release of cyt c, apaf1, caspase-9, -3 mediated apoptosis. |
2015-03-24 |
2023-08-13 |
mouse |
| Prakash Tiwari, Satya Sahay, Manuraj Pandey, Syed S Y H Qadri, Krishna P Gupt. Combinatorial chemopreventive effect of butyric acid, nicotinamide and calcium glucarate against the 7,12-dimethylbenz(a)anthracene induced mouse skin tumorigenesis attained by enhancing the induction of intrinsic apoptotic events. Chemico-biological interactions. vol 226. 2015-03-24. PMID:25478867. |
simultaneous application of ba, na and cag induced a mitochondria-mediated apoptosis, characterized by a rise in the bax, bax/bcl-2 ratio, release of cyt c, upregulation of apaf1 with down-stream activation of caspase-9, -3. |
2015-03-24 |
2023-08-13 |
mouse |
| Hang-Jun Zhang, Yu-Huan Wu, Jing Zhao, Jian-Zhong Sha. [Toxic effect of nodularin on the apoptosis of grass carp (Ctenopharyngodon idellus) lymphocytes and related mechanisms]. Ying yong sheng tai xue bao = The journal of applied ecology. vol 24. issue 10. 2015-03-21. PMID:24483096. |
the nodularin-induced apoptosis was related to the increase of intracellular reactive oxygen species (ros), decline of mitochondrial transmembrane electric potential, up-regulation of intracellular ca2+, down-regulation of bcl-2, and up-regulation of bax. |
2015-03-21 |
2023-08-12 |
Not clear |
| Haiyan Dong, Xiang Yang, Jingjing Xie, Liping Xiang, Yuanfang Li, Minrui Ou, Ting Chi, Zhenhua Liu, Suhong Yu, Yu Gao, Jianzhong Chen, Jingwei Shao, Lee Ji. UP12, a novel ursolic acid derivative with potential for targeting multiple signaling pathways in hepatocellular carcinoma. Biochemical pharmacology. vol 93. issue 2. 2015-03-20. PMID:25522955. |
the combination selectively down-regulated the expression of bcl-2 and hkii proteins, up-regulated the expression of bax and p53, and collectively resulted in enhanced apoptosis related to caspase-3, -8, and -9 activities, in addition to inhibition on the cell mitochondrial membrane potential. |
2015-03-20 |
2023-08-13 |
Not clear |
| Jing Sun, Huijing Zhang, Lin Guan, Huan Zhou, Mingjun Su. Alpha-lipoic acid attenuates trinitrobenzene sulfonic acid-induced ulcerative colitis in mice. International journal of clinical and experimental medicine. vol 8. issue 1. 2015-03-18. PMID:25785006. |
furthermore, ala significantly inhibited tnbs-induced apoptosis, which partly due to up-regulation of bcl-2 expression, reduction of bax expression and caspase-3, caspase-9 activity. |
2015-03-18 |
2023-08-13 |
mouse |
| Sean C Patro, Sharmistha Pal, Yingtao Bi, Kenneth Lynn, Karam C Mounzer, Jay R Kostman, Ramana V Davuluri, Luis J Montane. Shift in monocyte apoptosis with increasing viral load and change in apoptosis-related ISG/Bcl2 family gene expression in chronically HIV-1-infected subjects. Journal of virology. vol 89. issue 1. 2015-03-16. PMID:25355877. |
multivariable analysis of clinical values and monocyte gene expression identified changes in ifi27, ifitm2, rb1, and bcl2 expression as determinants of constitutive apoptosis (p = 3.77 × 10(-5); adjusted r(2) = 0.5983), while changes in viral load, ifitm2, rb1, and bax expression were determinants of oxidative stress-induced apoptosis (p = 5.59 × 10(-5); adjusted r(2) = 0.5996). |
2015-03-16 |
2023-08-13 |
human |
| Mireille Happy, Jordan Dejoie, Cynthia K Zajac, Briseida Cortez, Karabi Chakraborty, Joseph Aderemi, Moira Sauan. Sigma 1 Receptor antagonist potentiates the anti-cancer effect of p53 by regulating ER stress, ROS production, Bax levels, and caspase-3 activation. Biochemical and biophysical research communications. vol 456. issue 2. 2015-03-13. PMID:25511708. |
furthermore, this combination treatment induced er stress, p38 mapk activation, ros production, and proteins involved in apoptosis (caspases-3, bax) in breast cancer cells. |
2015-03-13 |
2023-08-13 |
human |