| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Beatrice D'Orsi, Seán M Kilbride, Gang Chen, Sergio Perez Alvarez, Helena P Bonner, Shona Pfeiffer, Nikolaus Plesnila, Tobias Engel, David C Henshall, Heiko Düssmann, Jochen H M Preh. Bax regulates neuronal Ca2+ homeostasis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 4. 2015-04-07. PMID:25632145. |
reintroduction of bax or a bax mutant incapable of proapoptotic oligomerization equally restored neuronal ca(2+) dynamics during nmda excitation, suggesting that bax controlled ca(2+) signaling independently of its role in apoptosis execution. |
2015-04-07 |
2023-08-13 |
mouse |
| Sanhu Zhao, Yanyong Yang, Wen Liu, Zhiqiang Xuan, Shouming Wu, Shunfei Yu, Ke Mei, Yijuan Huang, Pei Zhang, Jianming Cai, Jin Ni, Yaoxian Zha. Protective effect of hydrogen-rich saline against radiation-induced immune dysfunction. Journal of cellular and molecular medicine. vol 18. issue 5. 2015-04-06. PMID:24618260. |
cell apoptosis was evaluated by an annexin v-fitc and propidium iodide staining method as well as the apoptotic proteins such as bcl-2, bax, caspase-3 and c-caspase-3. |
2015-04-06 |
2023-08-12 |
mouse |
| Claudia Alva-Sanchez, Adair Rodriguez, Ivan Villanueva, Brenda Anguiano, Carmen Aceves, Jorge Pacheco-Rosad. The NMDA receptor antagonist MK-801 abolishes the increase in both p53 and Bax/Bcl2 index induced by adult-onset hypothyroidism in rat. Acta neurobiologiae experimentalis. vol 74. issue 1. 2015-04-06. PMID:24718050. |
in this work we measured the expression of specific proteins that control cell proliferation (cycline-d1), cell arrest (p21), damage (p53) or apoptosis (bax and bcl2) in the hippocampus of hypothyroid rats treated with the nmda receptor (nmdar) blocker mk-801 during the induction of hypothyroidism. |
2015-04-06 |
2023-08-13 |
rat |
| Bin-bin Yu, Shu-ying Dong, Mei-ling Yu, Guo-Jun Jiang, Jie Ji, Xu-hui Ton. Total flavonoids of litsea coreana enhance the cytotoxicity of oxaliplatin by increasing gap junction intercellular communication. Biological & pharmaceutical bulletin. vol 37. issue 8. 2015-04-06. PMID:24871203. |
furthermore, apoptosis-related protein (bax, bcl-2, caspase-3/9) results showed that the bax/bcl-2 ratio and activated caspase-3/9 increased when tflc was used compared with treatment with oxaliplatin alone, which suggests that the mechanism of increased oxaliplatin-induced apoptosis was through the mitochondrial pathway. |
2015-04-06 |
2023-08-13 |
mouse |
| Ligang Jie, Hongyan Du, Qingchun Huang, Song Wei, Runyue Huang, Weifeng Su. Tanshinone IIA induces apoptosis in fibroblast-like synoviocytes in rheumatoid arthritis via blockade of the cell cycle in the G2/M phase and a mitochondrial pathway. Biological & pharmaceutical bulletin. vol 37. issue 8. 2015-04-06. PMID:24920239. |
our data demonstrate that tan iia induced apoptosis of ra-fls, blocked the cell cycle in the g2/m phase, and regulated the protein expression of bcl-2, bax, and apaf-1, the release of mitochondrial cyt-c, and the activation of caspase-9 and caspase-3. |
2015-04-06 |
2023-08-13 |
Not clear |
| Pranjal Sarma, M Janaki Ramaiah, Ahmed Kamal, Utpal Bhadra, Manika Pal Bhadr. A novel bisindole-PBD conjugate causes DNA damage induced apoptosis via inhibition of DNA repair pathway. Cancer biology & therapy. vol 15. issue 10. 2015-04-06. PMID:25010292. |
further downregulation of bcl-xl and activation of bax showed dna damage induced apoptosis in mcf-7 and mdamb-231 cells. |
2015-04-06 |
2023-08-13 |
Not clear |
| Thibaud T Renault, Konstantinos V Floros, Rana Elkholi, Kelly-Ann Corrigan, Yulia Kushnareva, Shira Y Wieder, Claudia Lindtner, Madhavika N Serasinghe, James J Asciolla, Christoph Buettner, Donald D Newmeyer, Jerry E Chipu. Mitochondrial shape governs BAX-induced membrane permeabilization and apoptosis. Molecular cell. vol 57. issue 1. 2015-04-06. PMID:25482509. |
this work identifies a mechanistic contribution of mitochondrial size in dictating bax activation, momp, and apoptosis. |
2015-04-06 |
2023-08-13 |
Not clear |
| Xin Zhao, Liang Pang, Jing Li, Jia-Le Song, Li-Hua Qi. Apoptosis inducing effects of Kuding tea polyphenols in human buccal squamous cell carcinoma cell line BcaCD885. Nutrients. vol 6. issue 8. 2015-04-01. PMID:25100434. |
by rt-pcr and western blot assays, kuding tea polyphenol significantly induced apoptosis in bcacd885 cancer cells (p < 0.05) by upregulating caspase-3, caspase-8, caspase-9, fas/fasl, bax, p53, p21, e2f1, p73 and downregulating bcl-2, bcl-xl, hiap-1, and hiap-2 mrna and protein expressions. |
2015-04-01 |
2023-08-13 |
human |
| Patricia Grasa, Panayiota Ploutarchou, Suzannah A William. Oocytes lacking O-glycans alter follicle development and increase fertility by increasing follicle FSH sensitivity, decreasing apoptosis, and modifying GDF9:BMP15 expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 2. 2015-04-01. PMID:25416550. |
mutant follicles exhibited reduced levels of apoptosis, and both b-cell lymphoma 2 (bcl-2) and bcl-2-associated x protein (bax) were altered compared with controls. |
2015-04-01 |
2023-08-13 |
mouse |
| Xiang-An Zhang, Shuangxi Zhang, Qing Yin, Jing Zhan. Quercetin induces human colon cancer cells apoptosis by inhibiting the nuclear factor-kappa B Pathway. Pharmacognosy magazine. vol 11. issue 42. 2015-04-01. PMID:25829782. |
in this study, we demonstrate that quercetin induces apoptosis in human colon cancer caco-2 and sw-620 cells through inhibiting nf-κb pathway, as well as down-regulation of b-cell lymphoma 2 and up-regulation of bax, thus providing basis for clinical application of quercetin in colon cancer cases. |
2015-04-01 |
2023-08-13 |
human |
| Yingzhuan Zhan, Yinnan Chen, Rui Liu, Han Zhang, Yanmin Zhan. Potentiation of paclitaxel activity by curcumin in human breast cancer cell by modulating apoptosis and inhibiting EGFR signaling. Archives of pharmacal research. vol 37. issue 8. 2015-03-31. PMID:24318305. |
treatment of mcf-7 cell lines with paclitaxel and curcumin induced the apoptosis of regulatory protein bcl-2 but decreased bax expression. |
2015-03-31 |
2023-08-12 |
mouse |
| Francesca A Cupaioli, Fabio A Zucca, Diana Boraschi, Luigi Zecc. Engineered nanoparticles. How brain friendly is this new guest? Progress in neurobiology. vol 119-120. 2015-03-31. PMID:24820405. |
nps can also affect the respiratory chain of mitochondria and bax protein levels, thereby causing apoptosis. |
2015-03-31 |
2023-08-13 |
mouse |
| Yong Ling, Xinmei Zhao, Xianghua Li, Xuemin Wang, Yang Yang, Zhiqiang Wang, Xinyang Wang, Jie Zhang, Yihua Zhan. Novel FTS-diamine/cinnamic acid hybrids inhibit tumor cell proliferation and migration and promote apoptosis via blocking Ras-related signaling in vitro. Cancer chemotherapy and pharmacology. vol 75. issue 2. 2015-03-31. PMID:25542266. |
furthermore, the anti-proliferative effect of 7c in lovo cell lines followed a similar pattern, which included a dose-dependent induction of cell apoptosis via the up-regulation of bax as well as activated caspase-3 and down-regulation of bcl-2, and the inhibition of cancer cells migration and invasion in a concentration-dependent way. |
2015-03-31 |
2023-08-13 |
human |
| Ming Zhang, Tiansheng Zheng, Min Zong, Dechao Kong, Xiang Li, Cheng Xue, Peng Fu, Jiahu Fan. Sustained static stress-induced chondrocyte apoptosis in the rat cervical vertebral growth plate and its signal transduction mechanisms. European journal of orthopaedic surgery & traumatology : orthopedie traumatologie. vol 24 Suppl 1. 2015-03-30. PMID:23959036. |
in this paper, we have successfully established an experimental model induced by static stress and provided a useful method to study the mechanisms of chondrocyte apoptosis.a sustained static load of c0.2 mpa over at least 12 h was observed to induce chondrocyte apoptosis, up-regulation of bax and caspase-3 expression, and down-regulation of bcl-2 expression. |
2015-03-30 |
2023-08-12 |
rat |
| Saeed Samarghandian, Mohsen Azimi Nezhad, Gholamreza Mohammad. Role of caspases, Bax and Bcl-2 in chrysin-induced apoptosis in the A549 human lung adenocarcinoma epithelial cells. Anti-cancer agents in medicinal chemistry. vol 14. issue 6. 2015-03-30. PMID:24521149. |
role of caspases, bax and bcl-2 in chrysin-induced apoptosis in the a549 human lung adenocarcinoma epithelial cells. |
2015-03-30 |
2023-08-12 |
human |
| Xiaoling Zhu, Shasha Jiang, Nan Hu, Fuling Luo, Hailong Dong, Yu-Ming Kang, Kyla R Jones, Yunzeng Zou, Lize Xiong, Jun Re. Tumour necrosis factor-α inhibition with lenalidomide alleviates tissue oxidative injury and apoptosis in ob/ob obese mice. Clinical and experimental pharmacology & physiology. vol 41. issue 7. 2015-03-30. PMID:24739012. |
apoptosis was evaluated using caspase 3 activity, and levels of bax, bcl-2, bip, caspase 8, caspase 9 and tnf-α were assessed using western blot analysis. |
2015-03-30 |
2023-08-13 |
mouse |
| Marcel Benadiba, Iguatinã de M Costa, Rodrigo L S R Santos, Fernanda Oliveira Serachi, Denise de Oliveira Silva, Alison Colquhou. Growth inhibitory effects of the Diruthenium-Ibuprofen compound, [Ru2Cl(Ibp) 4], in human glioma cells in vitro and in the rat C6 orthotopic glioma in vivo. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 19. issue 6. 2015-03-30. PMID:24824561. |
ruibp increased the expression of cell cycle-related proteins such as p21 and p27 and the pro-apoptotic protein bax, as well as causing a reduction in mitochondrial membrane potential and a modest increase in apoptosis in vitro. |
2015-03-30 |
2023-08-13 |
human |
| K T Oseki, P T Monteforte, G J S Pereira, H Hirata, R P Ureshino, C Bincoletto, Y-T Hsu, S S Smail. Apoptosis induced by Aβ25-35 peptide is Ca(2+) -IP3 signaling-dependent in murine astrocytes. The European journal of neuroscience. vol 40. issue 3. 2015-03-30. PMID:24827147. |
this mechanism was related to aβ-mediated apoptosis by the intrinsic pathway because the expression of pro-apoptotic bax was accompanied by its translocation in cells transfected with gfp-bax. |
2015-03-30 |
2023-08-13 |
Not clear |
| B Li, R K Yadav, G S Jeong, H-R Kim, H-J Cha. The characteristics of Bax inhibitor-1 and its related diseases. Current molecular medicine. vol 14. issue 5. 2015-03-30. PMID:24894176. |
the expression of bi-1 in mammalian cells suppresses apoptosis induced by bax, a pro-apoptotic member of the bcl-2 family. |
2015-03-30 |
2023-08-13 |
Not clear |
| Lisa M Lindqvist, David L Vau. BCL2 and related prosurvival proteins require BAK1 and BAX to affect autophagy. Autophagy. vol 10. issue 8. 2015-03-30. PMID:24991825. |
to distinguish whether bcl2, bcl2l1/bcl-xl, or mcl1 influence autophagy directly, or indirectly, through their effects on apoptosis, we compared normal cells to those lacking bax and bak1. |
2015-03-30 |
2023-08-13 |
Not clear |