| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weiguo Zhang, Vivian R Ruvolo, Chen Gao, Liran Zhou, William Bornmann, Twee Tsao, Wendy D Schober, Paul Smith, Sylvie Guichard, Marina Konopleva, Michael Andreef. Evaluation of apoptosis induction by concomitant inhibition of MEK, mTOR, and Bcl-2 in human acute myelogenous leukemia cells. Molecular cancer therapeutics. vol 13. issue 7. 2015-04-20. PMID:24739393. |
furthermore, the modulation of survivin, bax, puma, and x-chromosome-linked inhibitor of apoptosis protein (xiap) expression suggested a role for mitochondria-mediated apoptosis in the cytotoxicity of the drug combination. |
2015-04-20 |
2023-08-13 |
human |
| Sandra-Annika Quast, Anja Berger, Michael Plötz, Jürgen Eberl. Sensitization of melanoma cells for TRAIL-induced apoptosis by activation of mitochondrial pathways via Bax. European journal of cell biology. vol 93. issue 1-2. 2015-04-19. PMID:24361324. |
sensitization of melanoma cells for trail-induced apoptosis by activation of mitochondrial pathways via bax. |
2015-04-19 |
2023-08-12 |
Not clear |
| Sandra-Annika Quast, Anja Berger, Michael Plötz, Jürgen Eberl. Sensitization of melanoma cells for TRAIL-induced apoptosis by activation of mitochondrial pathways via Bax. European journal of cell biology. vol 93. issue 1-2. 2015-04-19. PMID:24361324. |
thus, trail resistance in melanoma is explained by three major steps, namely high levels of antiapoptotic bcl-2 proteins, high levels of inhibitor of apoptosis proteins (ciaps) and suppressed bax activity. |
2015-04-19 |
2023-08-12 |
Not clear |
| Yi Luo, Sheng-xiang Wang, Ze-quan Zhou, Zheng Wang, Yan-gao Zhang, Yu Zhang, Peng Zha. Apoptotic effect of genistein on human colon cancer cells via inhibiting the nuclear factor-kappa B (NF-κB) pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 11. 2015-04-17. PMID:25128065. |
in the present study, we demonstrated that genistein could induce apoptosis in human colon cancer lovo and ht-29 cells through inhibiting nf-κb pathway, as well as downregulation of bcl-2 and upregulation of bax, thus providing basis for clinical application of genistein in colon cancer cases. |
2015-04-17 |
2023-08-13 |
human |
| Matthew Brentnall, David B Weir, Anthony Rongvaux, Adam I Marcus, Lawrence H Bois. Procaspase-3 regulates fibronectin secretion and influences adhesion, migration and survival independently of catalytic function. Journal of cell science. vol 127. issue Pt 10. 2015-04-16. PMID:24610949. |
however, previous work has demonstrated that caspase-3-deficient mouse embryonic fibroblasts (mefs) are resistant to mitochondrially mediated cell death and display a delay in the mitochondrial events of apoptosis, including bax activation, momp and release of cytochrome c. here, we show that caspase-3 regulates fibronectin secretion and impacts on cell morphology, adhesion and migration. |
2015-04-16 |
2023-08-12 |
mouse |
| Peipei An, Yu Ding, Aibing Wang, Wentao Tan, Fei Gao, Anran Fan, Bo Tang, Xueming Zhang, Ziyi L. Effects of WT1 gene downregulation on apoptosis in porcine fetal fibroblasts. In vitro cellular & developmental biology. Animal. vol 50. issue 6. 2015-04-16. PMID:24652047. |
our results indicated that wt1 was expressed in pffs, the plv3-wt1 shrna dramatically reduced the expression of wt1, and downregulation of wt1 directly led to early cell apoptosis by downregulating the expression of antiapoptotic gene bcl-2 and upregulating the expression of proapoptotic gene bax in pffs. |
2015-04-16 |
2023-08-12 |
Not clear |
| Achinto Saha, Jorge Blando, Eric Silver, Linda Beltran, Jonathan Sessler, John DiGiovann. 6-Shogaol from dried ginger inhibits growth of prostate cancer cells both in vitro and in vivo through inhibition of STAT3 and NF-κB signaling. Cancer prevention research (Philadelphia, Pa.). vol 7. issue 6. 2015-04-16. PMID:24691500. |
in addition, 6-sho decreased the level of several stat3 and nf-κb-regulated target genes at the protein level, including cyclin d1, survivin, and cmyc and modulated mrna levels of chemokine, cytokine, cell cycle, and apoptosis regulatory genes (il-7, ccl5, bax, bcl2, p21, and p27). |
2015-04-16 |
2023-08-13 |
mouse |
| Yun Li, Hongwei Shen, Jingming Shi, Luosheng Tan. The effects of alpha lipoic acid in preventing oxidative stress-induced retinal pigment epithelial cell injury. Canadian journal of physiology and pharmacology. vol 92. issue 9. 2015-04-14. PMID:25179747. |
h2o2 (12.5 μmol/l) induced early stage apoptosis, significantly decreased akt phosphorylation, and increased bax protein level 4 h after stimulation. |
2015-04-14 |
2023-08-13 |
human |
| Daiying Zuo, Dandan Guo, Xuewei Jiang, Qi Guan, Huan Qi, Jingwen Xu, Zengqiang Li, Fushan Yang, Weige Zhang, Yingliang W. 3-(3-Hydroxy-4-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-1,2,5-selenadiazole (G-1103), a novel combretastatin A-4 analog, induces G2/M arrest and apoptosis by disrupting tubulin polymerization in human cervical HeLa cells and fibrosarcoma HT-1080 cells. Chemico-biological interactions. vol 227. 2015-04-14. PMID:25529822. |
however, g-1103 induced ht-1080 cell apoptosis by up-regulating cleaved caspase-3, fas, cleaved caspase-8, bax and cleaved caspase-9 expression and down-regulating anti-apoptotic protein bcl-2 expression, which indicated that g-1103 induced ht-1080 cell apoptosis was associated with both mitochondrial and death receptor pathway. |
2015-04-14 |
2023-08-13 |
human |
| J Zhang, X Cui, L Wang, F Liu, T Jiang, C Li, D Li, M Huang, S Liao, J Wang, J Chen, H Jia, J He, Z Tang, Z Yin, M Li. The mitochondrial thioredoxin is required for liver development in zebrafish. Current molecular medicine. vol 14. issue 6. 2015-04-13. PMID:24894169. |
the dysregulation of bax, puma and bcl-xl promoted the reduction of mitochondrial trans-membrane potential and the mitochondria membrane permeabilization (mmp), which initiated the mitochondrial apoptosis pathway. |
2015-04-13 |
2023-08-13 |
mouse |
| Dinesh Thummuri, Manish Kumar Jeengar, Shweta Shrivastava, Aparna Areti, Veera Ganesh Yerra, Samyuktha Yamjala, Prashanth Komirishetty, V G M Naidu, Ashutosh Kumar, Ramakrishna Sistl. Boswellia ovalifoliolata abrogates ROS mediated NF-κB activation, causes apoptosis and chemosensitization in Triple Negative Breast Cancer cells. Environmental toxicology and pharmacology. vol 38. issue 1. 2015-04-13. PMID:24908637. |
apoptotic studies showed that bl ethoh was able to induce apoptosis and western blot studies demonstrated that bl ethoh significantly decreased the phospho-nf-κb (ser536), pcna, anti-apoptotic protein bcl-2 expression and increased the expression of pro-apoptotic protein bax, in mda-mb-231 and mda-mb-453 cell lines when compared with untreated cells. |
2015-04-13 |
2023-08-13 |
Not clear |
| S Srigopalram, I A Jayraaj, B Kaleeswaran, K Balamurugan, M Ranjithkumar, T Senthil Kumar, J I Park, I S No. Ellagic acid normalizes mitochondrial outer membrane permeabilization and attenuates inflammation-mediated cell proliferation in experimental liver cancer. Applied biochemistry and biotechnology. vol 173. issue 8. 2015-04-13. PMID:24972653. |
this is the first report that implies a possible role of ea in controlling liver cancer through activation of mitochondrial outer membrane permeability via activating proteins such as bax, bcl-2, cyt-c, and caspase-9, which play important roles in apoptosis. |
2015-04-13 |
2023-08-13 |
rat |
| Jia-Zhi Wang, Juan Li, Ping Zhao, Wen-Tao Ma, Xie-He Feng, Ke-Li Che. Antitumor Activities of Ethyl Acetate Extracts from Selaginella doederleinii Hieron In Vitro and In Vivo and Its Possible Mechanism. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-04-13. PMID:25866543. |
the mechanisms of tumorigenesis and cell apoptosis induced by sd extracts may be associated with decreasing the ratio of bcl-2 and bax mrna level, activating caspase-3, suppressing survivin, and decreasing the gene expression of cox-2, 5-lox, flap, and 12-lox mrna. |
2015-04-13 |
2023-08-13 |
mouse |
| Mee-Ran Shin, Hwa-Jeong Lee, Soo-Kyung Kang, Q-Schick Auh, Young-Man Lee, Youn-Chul Kim, Eun-Cheol Ki. Isocudraxanthone K induces growth inhibition and apoptosis in oral cancer cells via hypoxia inducible factor-1α. BioMed research international. vol 2014. 2015-04-10. PMID:25105148. |
cobalt chloride (cocl2), a hif-1α activator, attenuated the ik-induced growth-inhibiting and apoptosis-inducing effects, and blocked ik-induced expression of apoptosis regulatory proteins, such as bax, bcl-2, caspase-3, caspase-8, and caspase-9, and cytochrome c. collectively, these data provide the first evidence of antiproliferative and apoptosis-inducing effects of ik as a hif-1α inhibitor and suggest it may be a drug candidate for chemotherapy against oral cancer. |
2015-04-10 |
2023-08-13 |
Not clear |
| Li Li, Zhengtao Gu, Zhifeng Liu, Lei S. [The effect of reactive oxygen species regulation of expression of Bcl-2 and Bax in apoptosis of human umbilical vein endothelial cell induced by heat stress]. Zhonghua wei zhong bing ji jiu yi xue. vol 26. issue 7. 2015-04-08. PMID:25027422. |
[the effect of reactive oxygen species regulation of expression of bcl-2 and bax in apoptosis of human umbilical vein endothelial cell induced by heat stress]. |
2015-04-08 |
2023-08-13 |
human |
| Li Li, Zhengtao Gu, Zhifeng Liu, Lei S. [The effect of reactive oxygen species regulation of expression of Bcl-2 and Bax in apoptosis of human umbilical vein endothelial cell induced by heat stress]. Zhonghua wei zhong bing ji jiu yi xue. vol 26. issue 7. 2015-04-08. PMID:25027422. |
to observe the effect of heat stress-induced reactive oxygen species (ros) burst on the regulation of expression of bcl-2 and bax in human umbilical vein endothelial cell (huvec) apoptosis induced by heat stress, and explore the pathogenesis of vascular endothelial damage caused by severe heat stroke. |
2015-04-08 |
2023-08-13 |
human |
| Dongquan Chen, Todd A Stueckle, Sudjit Luanpitpong, Yon Rojanasakul, Yongju Lu, Liying Wan. Gene expression profile of human lung epithelial cells chronically exposed to single-walled carbon nanotubes. Nanoscale research letters. vol 10. 2015-04-08. PMID:25852310. |
based on differentially expressed genes, possible mechanisms of swcnt-associated apoptosis resistance and oncogenesis were identified, which included activation of pakt/p53/bcl-2 signaling axis, increased gene expression of ras family for cell cycle control, dsh-mediated notch 1, and downregulation of apoptotic genes bax and noxa. |
2015-04-08 |
2023-08-13 |
mouse |
| Carlos Hedman, Jaber Lyahyai, Hicham Filali, Belén Marín, Carmen Serrano, Eva Monleón, Bernardino Moreno, Pilar Zaragoza, Juan José Badiola, Inmaculada Martín-Burriel, Rosa Bole. Differential gene expression and apoptosis markers in presymptomatic scrapie affected sheep. Veterinary microbiology. vol 159. issue 1-2. 2015-04-07. PMID:22482719. |
the histopathology, immunolabelling of prp(sc), bax and activated caspase-3, and the analysis of the expression of 7 genes involved in the regulation of the mitochondrial pathway of apoptosis were investigated in the following 4 central nervous system areas: medulla oblongata, diencephalon, frontal cortex and cerebellum. |
2015-04-07 |
2023-08-12 |
Not clear |
| Carlos Hedman, Jaber Lyahyai, Hicham Filali, Belén Marín, Carmen Serrano, Eva Monleón, Bernardino Moreno, Pilar Zaragoza, Juan José Badiola, Inmaculada Martín-Burriel, Rosa Bole. Differential gene expression and apoptosis markers in presymptomatic scrapie affected sheep. Veterinary microbiology. vol 159. issue 1-2. 2015-04-07. PMID:22482719. |
finally, the gene expression profiles indicated that the mitochondrial pathway of apoptosis was activated with higher intensity in presymptomatic animals than in symptomatic sheep and confirmed the implication of genes such as bax or aif in the disease. |
2015-04-07 |
2023-08-12 |
Not clear |
| Mei-Juan Xie, Yi-Hua Ma, Lin Miao, Yan Wang, Hai-Zhen Wang, Ying-Ying Xing, Tao Xi, Yuan-Yuan L. Emodin-provoked oxidative stress induces apoptosis in human colon cancer HCT116 cells through a p53-mitochondrial apoptotic pathway. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 13. 2015-04-07. PMID:25040975. |
transfecting p53 sirna also attenuated apoptosis induced by emodin, bax expression and mitochondrial translocation being reduced compared to treatment with emodin alone. |
2015-04-07 |
2023-08-13 |
human |