| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dana Westphal, Grant Dewson, Marie Menard, Paul Frederick, Sweta Iyer, Ray Bartolo, Leonie Gibson, Peter E Czabotar, Brian J Smith, Jerry M Adams, Ruth M Kluc. Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 39. 2015-04-30. PMID:25228770. |
the pivotal step on the mitochondrial pathway to apoptosis is permeabilization of the mitochondrial outer membrane (mom) by oligomers of the b-cell lymphoma-2 (bcl-2) family members bak or bax. |
2015-04-30 |
2023-08-13 |
Not clear |
| Xian Jiang, Hui Jiang, Zhirong Shen, Xiaodong Wan. Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 41. 2015-04-30. PMID:25275009. |
activation of mitochondrial protease oma1 by bax and bak promotes cytochrome c release during apoptosis. |
2015-04-30 |
2023-08-13 |
Not clear |
| Xian Jiang, Hui Jiang, Zhirong Shen, Xiaodong Wan. Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 41. 2015-04-30. PMID:25275009. |
thus it is clear that oligomerized bax and bak trigger apoptosis by causing both the permeabilization of the mitochondrial outer membrane and activation oma1. |
2015-04-30 |
2023-08-13 |
Not clear |
| Zhiyi Luo, Yu Fang, Lu Zhan. The effects of antiepileptic drug valproic acid on apoptosis of hippocampal neurons in epileptic rats. Pakistan journal of pharmaceutical sciences. vol 28. issue 1 Suppl. 2015-04-30. PMID:25631498. |
based on the experiment, we reached the conclusion that, vpa showed no harm to epileptic rats and the hippocampal neuronal apoptosis after epilepsy and anti-epileptic drug was probably resulted from the decrease of bcl-2 expression and increase of bax expression. |
2015-04-30 |
2023-08-13 |
rat |
| Hsin-I Hu, Hsin-Hou Chang, Der-Shan Su. Differential regulation of caspase-2 in MPP⁺-induced apoptosis in primary cortical neurons. Experimental cell research. vol 332. issue 1. 2015-04-24. PMID:25645943. |
previous reports have indicated those knockout mice with bcl-2 associated protein x (bax) or caspase-2, two mitochondrial outer membrane permeabilization inducers, are resistant to mptp administration, suggesting that mitochondria are involved in mpp(+)-triggered apoptosis. |
2015-04-24 |
2023-08-13 |
mouse |
| Hsin-I Hu, Hsin-Hou Chang, Der-Shan Su. Differential regulation of caspase-2 in MPP⁺-induced apoptosis in primary cortical neurons. Experimental cell research. vol 332. issue 1. 2015-04-24. PMID:25645943. |
we demonstrated that caspase-2 activation is specific to mpp(+)-induced apoptosis and occurs before bax translocation to the mitochondria. |
2015-04-24 |
2023-08-13 |
mouse |
| Xiaobei Deng, Fang Zhang, Lijuan Wang, Wei Rui, Fang Long, Yong Zhao, Deliang Chen, Wenjun Din. Airborne fine particulate matter induces multiple cell death pathways in human lung epithelial cells. Apoptosis : an international journal on programmed cell death. vol 19. issue 7. 2015-04-22. PMID:24722831. |
much to our surprise, we found that pm2.5-exposure caused oxidative stress, resulting in activation of multiple cell death pathways in a549 cells, that is, the tumor necrosis factor-alpha (tnf-α)-induced pathway as evidenced by tnf-α secretion and activation of caspase-8 and -3, the intrinsic apoptosis pathway as evidenced by increased expression of pro-apoptotic protein bax, decreased expression of anti-apoptotic protein bcl-2, disruption of mitochondrial membrane potential, and activation of caspase-9 and -3, and autophagy as evidenced by an increased number of double-membrane vesicles, accompanied by increases of conversion and punctuation of microtubule-associated proteins light chain 3 (lc3) and expression of beclin 1. |
2015-04-22 |
2023-08-13 |
human |
| Jia-Xin Fan, Ying-Jian Zeng, Guang-Yang Weng, Jian-Wei Wu, Zhang-Qiu Li, Yuan-Ming Li, Rong Zheng, Kun-Yuan Gu. [Effect of honokiol on proliferation and apoptosis in HL-60 cells and its potential mechanism]. Zhongguo shi yan xue ye xue za zhi. vol 22. issue 6. 2015-04-22. PMID:25543478. |
after 24 h treatment with hnk, hl-60 cell apoptosis increased significantly with the upregulation of activated caspase-3, -9, bax expression and the downregulation of bcl-2, bcl-xl expression. |
2015-04-22 |
2023-08-13 |
Not clear |
| Fei Xin, Wu We. [Research advances on caspase-independent cell death of K562 cells]. Zhongguo shi yan xue ye xue za zhi. vol 22. issue 6. 2015-04-22. PMID:25543516. |
caspase independent cell death (cicd) is defined as death that ensues when a signal that normally induces apoptosis fails to activate caspases,it can be activated by parp-1, calpains, bax and aif, possessing distinctive biologic characteristic differed from apoptosis and necrosis. |
2015-04-22 |
2023-08-13 |
Not clear |
| Yonghong Wang, Daliang Kong, Xinwei Wang, Xiaoxiong Dong, Yingying Tao, Haiyang Gon. Molecular mechanisms of luteolin induced growth inhibition and apoptosis of human osteosarcoma cells. Iranian journal of pharmaceutical research : IJPR. vol 14. issue 2. 2015-04-22. PMID:25901161. |
luteolin can inhibit osteosarcoma cell proliferation and induce apoptosis effectively in a dose dependent manner through down-regulating the expression of bcl-2, caspase-3 and survivin proteins levels and up-regulating the expression of bax protein level. |
2015-04-22 |
2023-08-13 |
human |
| Li-Ping Zhang, Hui-Jie Ma, Hui-Min Bu, Mei-Ling Wang, Qian Li, Zhao Qi, Yi Zhan. Polydatin attenuates ischemia/reperfusion-induced apoptosis in myocardium of the rat. Sheng li xue bao : [Acta physiologica Sinica]. vol 61. issue 4. 2015-04-21. PMID:19701589. |
tunel labeling and flow cytometric techniques were used for the measurement of apoptosis and the expression of bcl-2 and bax protein in cardiomyocytes of rat. |
2015-04-21 |
2023-08-12 |
rat |
| Li-Ping Zhang, Hui-Jie Ma, Hui-Min Bu, Mei-Ling Wang, Qian Li, Zhao Qi, Yi Zhan. Polydatin attenuates ischemia/reperfusion-induced apoptosis in myocardium of the rat. Sheng li xue bao : [Acta physiologica Sinica]. vol 61. issue 4. 2015-04-21. PMID:19701589. |
the results showed: (1) compared with those in the control group, the number of tunel-positive cells and apoptosis rate were increased in i/r group; (2) compared with that in the i/r group, the number of tunel-positive cells was significantly decreased in the polydatin group [(18.1+/-4.0)% vs (35.1+/-5.4)%, p<0.01]; (3) apoptosis rate assayed by flow cytometry in i/r group was significantly higher than that in polydatin group [(15.43+/-4.55)% vs (8.66+/-3.18)%, p<0.01]; (4) expression level of bax protein was higher in i/r group than that in polydatin group (p<0.05), while the level of bcl-2 protein and bcl-2/bax ratio were higher in polydatin group than those in i/r group (p<0.05, p<0.01), respectively. |
2015-04-21 |
2023-08-12 |
rat |
| Li-Ping Zhang, Hui-Jie Ma, Hui-Min Bu, Mei-Ling Wang, Qian Li, Zhao Qi, Yi Zhan. Polydatin attenuates ischemia/reperfusion-induced apoptosis in myocardium of the rat. Sheng li xue bao : [Acta physiologica Sinica]. vol 61. issue 4. 2015-04-21. PMID:19701589. |
the results obtained suggest that polydatin exerts an inhibitory effect on i/r-induced apoptosis through increasing bcl-2 protein expression and decreasing bax protein expression in myocardium of the rat. |
2015-04-21 |
2023-08-12 |
rat |
| Jie Zhang, Yang Liu, Hong-Wang Yang, Hai-Yan Xu, Yan Men. [Molecular mechanism of beta cell apoptosis induced by p58 in high glucose medium]. Sheng li xue bao : [Acta physiologica Sinica]. vol 61. issue 4. 2015-04-21. PMID:19701591. |
the above results suggest that in high glucose condition, p58 may induce ins-1 cell apoptosis through up-regulating the expression of bax and down-regulating the expression of bcl-2, since both of them could promote the release of cytochrome c into cytoplasm, and finally activate caspase-3. |
2015-04-21 |
2023-08-12 |
Not clear |
| Ruyi Li, Leilei Zhang, Lijing Zhang, Dan Chen, Jingkui Tian, Li Cao, Lin Zhan. Capilliposide C derived from Lysimachia capillipes Hemsl inhibits growth of human prostate cancer PC3 cells by targeting caspase and MAPK pathways. International urology and nephrology. vol 46. issue 7. 2015-04-21. PMID:24554216. |
observations using optical and electron microscope suggested the cytotoxicity of cps-c. cps-c-induced apoptosis was confirmed by the activation of caspases, down-regulation of bcl-2, jnk, and p38α/β, and up-regulation of bax, p-jnk, and p-p38. |
2015-04-21 |
2023-08-12 |
mouse |
| Xin Zhao, Yu Qian, Ya-Lin Zhou, Rui Wang, Qiang Wang, Gui-Jie L. Pu-erh tea has in vitro anticancer activity in TCA8113 cells and preventive effects on buccal mucosa cancer in U14 cells injected mice in vivo. Nutrition and cancer. vol 66. issue 6. 2015-04-21. PMID:24945996. |
pu-erh tea also significantly induced apoptosis in tissues of mice (p < 0.05) by upregulating bax and downregulating bcl-2. |
2015-04-21 |
2023-08-13 |
mouse |
| Katherine Williams, Kuppan Gokulan, Diamond Shelman, Tatsuya Akiyama, Ashraf Khan, Sangeeta Khar. Cytotoxic mechanism of cytolethal distending toxin in nontyphoidal Salmonella serovar (Salmonella Javiana) during macrophage infection. DNA and cell biology. vol 34. issue 2. 2015-04-21. PMID:25389664. |
the mrna expression of genes involved in the induction of autophagy in response to toxin (esr1 and pik3c3) and coregulators of autophagy and apoptosis (bax and cyld) were significantly upregulated in cdtb(+)wt s. javiana-infected macrophages. |
2015-04-21 |
2023-08-13 |
Not clear |
| Donghern Kim, Jin Dai, Leonard Yenwong Fai, Hua Yao, Young-Ok Son, Lei Wang, Poyil Pratheeshkumar, Kazuya Kondo, Xianglin Shi, Zhuo Zhan. Constitutive activation of epidermal growth factor receptor promotes tumorigenesis of Cr(VI)-transformed cells through decreased reactive oxygen species and apoptosis resistance development. The Journal of biological chemistry. vol 290. issue 4. 2015-04-21. PMID:25477514. |
these transformed cells exhibit apoptosis resistance with reduced poly adp-ribose polymerase cleavage (c-parp) and bax expression and enhanced expressions of bcl-2 and bcl-xl. |
2015-04-21 |
2023-08-13 |
mouse |
| Donghern Kim, Jin Dai, Leonard Yenwong Fai, Hua Yao, Young-Ok Son, Lei Wang, Poyil Pratheeshkumar, Kazuya Kondo, Xianglin Shi, Zhuo Zhan. Constitutive activation of epidermal growth factor receptor promotes tumorigenesis of Cr(VI)-transformed cells through decreased reactive oxygen species and apoptosis resistance development. The Journal of biological chemistry. vol 290. issue 4. 2015-04-21. PMID:25477514. |
inhibition of egfr or areg increased bax expression and reduced bcl-2 expression, resulting in reduced apoptosis resistance. |
2015-04-21 |
2023-08-13 |
mouse |
| Donghern Kim, Jin Dai, Leonard Yenwong Fai, Hua Yao, Young-Ok Son, Lei Wang, Poyil Pratheeshkumar, Kazuya Kondo, Xianglin Shi, Zhuo Zhan. Constitutive activation of epidermal growth factor receptor promotes tumorigenesis of Cr(VI)-transformed cells through decreased reactive oxygen species and apoptosis resistance development. The Journal of biological chemistry. vol 290. issue 4. 2015-04-21. PMID:25477514. |
inhibition of pi3k/akt increased ros generation and reduced sod2 expression, resulting in reduced apoptosis resistance with commitment increase in bax expression and reduction of bcl-2 expression. |
2015-04-21 |
2023-08-13 |
mouse |