| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yongxia Cheng, Yukuan Feng, Min Zhu, Bin Yan, Songbin Fu, Jin Guo, Jing Hu, Xiandong Song, Sufen Guo, Guibo Li. Synthetic liver X receptor agonist T0901317 attenuates high glucose-induced oxidative stress, mitochondrial damage and apoptosis in cardiomyocytes. Acta histochemica. vol 116. issue 1. 2015-05-14. PMID:23915475. |
however, pretreatment with t0 effectively decreased apoptosis, reduced the levels of ros, abrogated ΔΨm, inhibited cytochrome c release and nf-κb activation, increased bcl-2 and decreased bax expression. |
2015-05-14 |
2023-08-12 |
Not clear |
| Ramanjaneyulu Allam, Kate E Lawlor, Eric Chi-Wang Yu, Alison L Mildenhall, Donia M Moujalled, Rowena S Lewis, Francine Ke, Kylie D Mason, Michael J White, Katryn J Stacey, Andreas Strasser, Lorraine A O'Reilly, Warren Alexander, Benjamin T Kile, David L Vaux, James E Vinc. Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming. EMBO reports. vol 15. issue 9. 2015-05-14. PMID:24990442. |
neither co-deletion of the essential executioners of mitochondrial apoptosis bak and bax, nor removal of the mitochondrial permeability transition pore component cyclophilin d, nor loss of the mitophagy regulator parkin, nor deficiency in mavs affects nlrp3 inflammasome function. |
2015-05-14 |
2023-08-13 |
Not clear |
| Huan-Liang Wang, Li-Ping Peng, Wen-Juan Chen, Shu-Hai Tang, Bao-Zhu Sun, Chun-Ling Wang, Rui Huang, Zhi-Jie Xu, Wei-Fu Le. HMGB1 enhances smooth muscle cell proliferation and migration in pulmonary artery remodeling. International journal of clinical and experimental pathology. vol 7. issue 7. 2015-05-14. PMID:25120760. |
on the contrary, bax, a gen which represented the apoptosis, revealed an absolutely reversed trend to bcl-2 in pulmonary arteries. |
2015-05-14 |
2023-08-13 |
rat |
| Yan Y Sanders, Hui Liu, Xiangyu Zhang, Louise Hecker, Karen Bernard, Leena Desai, Gang Liu, Victor J Thannicka. Histone modifications in senescence-associated resistance to apoptosis by oxidative stress. Redox biology. vol 1. 2015-05-13. PMID:24024133. |
senescent hdfs are more resistant to oxidative stress (exogenous h2o2)-induced apoptosis in comparison to non-senescent (control) hdfs; this is associated with constitutively high levels of the anti-apoptotic gene, bcl-2, and low expression of the pro-apoptotic gene, bax. |
2015-05-13 |
2023-08-12 |
human |
| Naglaa Mohamed Kholoussi, Sobhy E H El-Nabi, Nora Nassef Esmaiel, Naser Mohamed Abd El-Bary, Ahmed F El-Kase. Evaluation of Bax and Bak gene mutations and expression in breast cancer. BioMed research international. vol 2014. 2015-05-13. PMID:24672785. |
genetic analyses have provided evidence to suggest that bax and bak are the essential genes for apoptosis in mammalians cells. |
2015-05-13 |
2023-08-12 |
Not clear |
| Xiao-Ming Yang, Yun-Fei Wang, Yue-Ying Li, Hai-Le M. Thermal stability of ginkgolic acids from Ginkgo biloba and the effects of ginkgol C17:1 on the apoptosis and migration of SMMC7721 cells. Fitoterapia. vol 98. 2015-05-13. PMID:25016955. |
the anticancer action may occur via the induction of apoptosis by the activation of caspases-3, the upregulation of bax expression, and the inhibition migration of smmc7721 cells. |
2015-05-13 |
2023-08-13 |
Not clear |
| Xiuqing Xiao, Hao He, Xuezhi Ding, Qi Yang, Xuemei Liu, Shuang Liu, Jie Rang, Ting Wang, Mingxing Zuo, Liqiu Xi. Purification and cloning of lectin that induce cell apoptosis from Allium chinense. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 22. issue 2. 2015-05-13. PMID:25765828. |
western blot showed that acl upregulated caspase-3 and bax expression during apoptosis and cloned the structural gene of acl with an open reading frame of 456 bp encoding 151 amino acid residues. |
2015-05-13 |
2023-08-13 |
human |
| Tao Shen, Wei Li, Yan-Yan Wang, Qing-Qing Zhong, Shu-Qi Wang, Xiao-Ning Wang, Dong-Mei Ren, Hong-Xiang Lo. Antiproliferative activities of Garcinia bracteata extract and its active ingredient, isobractatin, against human tumor cell lines. Archives of pharmacal research. vol 37. issue 3. 2015-05-12. PMID:23812779. |
additionally, 1 enhanced pc3 cell apoptosis by activations of bax, caspases 3 and 9, and by inhibition of bcl-2. |
2015-05-12 |
2023-08-12 |
human |
| Maria Dolores Sanchez-Niño, Jonay Poveda, Ana Belen Sanz, Susana Carrasco, Marta Ruiz-Ortega, Rafael Selgas, Jesus Egido, Alberto Orti. 3,4-DGE is cytotoxic and decreases HSP27/HSPB1 in podocytes. Archives of toxicology. vol 88. issue 3. 2015-05-12. PMID:24337777. |
antagonism of bax by a ku-70-derived peptide also prevented apoptosis. |
2015-05-12 |
2023-08-12 |
mouse |
| Yi-Jun Shu, Run-Fa Bao, Xiang-Song Wu, Hao Weng, Qian Ding, Yang Cao, Mao-Lan Li, Jia-Sheng Mu, Wen-Guang Wu, Qi-Chen Ding, Tian-Yu Liu, Lin Jiang, Yun-Ping Hu, Zhu-Jun Tan, Peng Wang, Ying-Bin Li. Baicalin induces apoptosis of gallbladder carcinoma cells in vitro via a mitochondrial-mediated pathway and suppresses tumor growth in vivo. Anti-cancer agents in medicinal chemistry. vol 14. issue 8. 2015-05-12. PMID:24568162. |
we observed inhibition of nf-κb nuclear translocation, up-regulation of bax and down-regulation of bcl-2, as well as increased caspase-3 and caspase-9 expression after baicalin treatment in vitro and in vivo, which indicates that the mitochondrial pathway was involved in baicalin-induced apoptosis. |
2015-05-12 |
2023-08-12 |
mouse |
| Hyunji Lee, Hyunjung Lee, Hyunjung Chin, Kyoungmi Kim, Daekee Le. ERBB3 knockdown induces cell cycle arrest and activation of Bak and Bax-dependent apoptosis in colon cancer cells. Oncotarget. vol 5. issue 13. 2015-05-12. PMID:24970817. |
apoptosis was irrelevant to the majority of bh3-only pro-apoptotic proteins and correlated with the transcriptional upregulation of bak and p53-dependent bax translocation. |
2015-05-12 |
2023-08-13 |
Not clear |
| Qiang Yu, Qiaoyu Li, Peisong Lu, Qianxue Che. Polyphyllin D induces apoptosis in U87 human glioma cells through the c-Jun NH2-terminal kinase pathway. Journal of medicinal food. vol 17. issue 9. 2015-05-12. PMID:25045920. |
the apoptosis of u87 glioma cells was detected by flow cytometry, and western blot analysis was used to examine human b-cell leukemia/lymphoma 2 (bcl-2), human bcl-2 associated x protein (bax), caspase-3, total-c-jun nh2-terminal kinase (t-jnk), and phosphorylation-jnk (p-jnk) protein expression in u87 human glioma cells. |
2015-05-12 |
2023-08-13 |
human |
| Qiang Yu, Qiaoyu Li, Peisong Lu, Qianxue Che. Polyphyllin D induces apoptosis in U87 human glioma cells through the c-Jun NH2-terminal kinase pathway. Journal of medicinal food. vol 17. issue 9. 2015-05-12. PMID:25045920. |
pd increased apoptosis and significantly upregulated the expression of bax, caspase-3, and p-jnk associated with apoptosis, but downregulated antiapoptotic bcl-2 expression in u87 human glioma cells. |
2015-05-12 |
2023-08-13 |
human |
| Lei-Lei Ma, Hong-Wei Ge, Fei-Juan Kong, Ling-Bo Qian, Bang-Chuan Hu, Qian Li, Liang Xu, Jing-Quan Liu, Yun-Xiang Xu, Ren-Hua Su. Ventricular hypertrophy abrogates intralipid-induced cardioprotection by alteration of reperfusion injury salvage kinase/glycogen synthase kinase 3β signal. Shock (Augusta, Ga.). vol 41. issue 5. 2015-05-11. PMID:24430545. |
the hemodynamics, infarct size, apoptosis, phosphorylated protein kinase b (p-akt), phosphorylated extracellular regulated protein kinase 1/2 (erk1/2), phosphorylated glycogen synthase kinase 3β (gsk3β), bcl-2, phosphorylated bad, and bax were determined. |
2015-05-11 |
2023-08-12 |
rat |
| Anupam Bishayee, Animesh Manda. Trianthema portulacastrum Linn. exerts chemoprevention of 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis in rats. Mutation research. vol 768. 2015-05-11. PMID:24451939. |
tpe dose-dependently suppressed proliferating cell nuclear antigen and cyclin d1 expression, induced apoptosis, upregulated proapoptotic protein bax, downregulated antiapoptotic protein bcl-2 and diminished the expression of nuclear and cytosolic β-catenin in mammary tumors. |
2015-05-11 |
2023-08-12 |
human |
| Liang Shen, Ci Chen, Xuan Wei, Xixian Li, Guangjin Luo, Jingwen Zhang, Jianping Bin, Xiaobo Huang, Shiping Cao, Guofeng Li, Yulin Lia. Overexpression of ankyrin repeat domain 1 enhances cardiomyocyte apoptosis by promoting p53 activation and mitochondrial dysfunction in rodents. Clinical science (London, England : 1979). vol 128. issue 10. 2015-05-09. PMID:25511237. |
in the presence of angii in nrcs, infection with a recombinant adenovirus containing rat ankrd1 cdna (ad-ankrd1) enhanced the mitochondrial translocation of bax and phosphorylated p53, increased mitochondrial permeability and cardiomyocyte apoptosis, and reduced cell viability, whereas these effects were antagonized by silencing of ankrd1. |
2015-05-09 |
2023-08-13 |
mouse |
| Haijing Zhao, Qianqian Ji, Guangyin Zhao, Zhenwei Song, Baozhu Du, Yu Nie, Yaosheng Chen, Peiqing Con. Damage of zona pellucida reduces the developmental potential and quality of porcine circovirus type 2-infected oocytes after parthenogenetic activation. Theriogenology. vol 82. issue 6. 2015-05-07. PMID:25062959. |
compared with the one in pozi group, the ratio of antiapoptotic bcl-xl gene to proapoptotic bax gene, an indicator of the ability to resist apoptosis, was lower in pozd group at the one-cell stage, but higher at the two- and four-cell stages. |
2015-05-07 |
2023-08-13 |
Not clear |
| M Gupta, S S Dangi, G Singh, M Sarka. Expression and localization of ghrelin and its receptor in ovarian follicles during different stages of development and the modulatory effect of ghrelin on granulosa cells function in buffalo. General and comparative endocrinology. vol 210. 2015-05-07. PMID:25275756. |
the aim of our study was to investigate the expression and localization of ghrelin and its active receptor, growth hormone secretagogue receptor type 1a (ghs-r1a) in buffalo ovarian follicles of different follicular size and to investigate role of ghrelin on estradiol (e2) secretion, aromatase (cyp19a1), proliferating cell nuclear antigen (pcna) and apoptosis regulator bax gene expression on granulosa cell culture. |
2015-05-07 |
2023-08-13 |
Not clear |
| Nan Wu, Xiaowen Zhang, Pengyu Jia, Dalin Ji. Hypercholesterolemia abrogates the protective effect of ischemic postconditioning by induction of apoptosis and impairment of activation of reperfusion injury salvage kinase pathway. Biochemical and biophysical research communications. vol 458. issue 1. 2015-05-06. PMID:25637532. |
moreover, we also found that hc inhibited the phosphorylation of akt and erk1/2 which usually activated by ipoc in normal heart, induced excessive apoptosis by down-regulating bcl-2 and up-regulating bax, cytochrome c, caspase 9 and caspase 3 when compared with that in normal heart. |
2015-05-06 |
2023-08-13 |
Not clear |
| Azucena Bermejo-Nogales, Marit Nederlof, Laura Benedito-Palos, Gabriel F Ballester-Lozano, Ole Folkedal, Rolf Eric Olsen, Ariadna Sitjà-Bobadilla, Jaume Pérez-Sánche. Metabolic and transcriptional responses of gilthead sea bream (Sparus aurata L.) to environmental stress: new insights in fish mitochondrial phenotyping. General and comparative endocrinology. vol 205. 2015-05-04. PMID:24792819. |
a strong down-regulation of pgc1α, nrf1, nrf2, cpt1a, cs and markers of mitochondrial dynamics and apoptosis (bax, bclx, mfn2, miro2) occurred in m-st fish in association with the greatest circulating cortisol concentration and a reduced lactate production and feed efficiency, which represents a metabolic condition with the highest allostatic load score. |
2015-05-04 |
2023-08-13 |
Not clear |