| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiang-Hua Ding, Li-Ya Yuan, Rui-Bin Huang, Guo-An Che. Aspirin inhibits proliferation and induces apoptosis of multiple myeloma cells through regulation of Bcl-2 and Bax and suppression of VEGF. European journal of haematology. vol 93. issue 4. 2015-05-28. PMID:24766194. |
aspirin inhibits proliferation and induces apoptosis of multiple myeloma cells through regulation of bcl-2 and bax and suppression of vegf. |
2015-05-28 |
2023-08-13 |
Not clear |
| Zihao Qi, Mingming Liu, Yang Liu, Meiqin Zhang, Gong Yan. Tetramethoxychalcone, a chalcone derivative, suppresses proliferation, blocks cell cycle progression, and induces apoptosis of human ovarian cancer cells. PloS one. vol 9. issue 9. 2015-05-28. PMID:25180593. |
we demonstrated that tmoc might induce cell apoptosis through suppressing bcl-2 and bcl-xl, but enhancing the expression of bax and the cleavage of parp-1. |
2015-05-28 |
2023-08-13 |
human |
| Ming-Che Shen, Xiangmin Zhao, Gene P Siegal, Renee Desmond, Robert W Hard. Dietary stearic acid leads to a reduction of visceral adipose tissue in athymic nude mice. PloS one. vol 9. issue 9. 2015-05-28. PMID:25222131. |
the apoptosis was, at least in part, due to increased caspase-3 activity and was associated with decreased cellular inhibitor of apoptosis protein-2 (ciap2) and increased bax gene expression. |
2015-05-28 |
2023-08-13 |
mouse |
| Lili Wei, Dave Hoole, Baojian Su. Identification of apoptosis-related genes and transcription variations in response to microcystin-LR in zebrafish liver. Toxicology and industrial health. vol 30. issue 9. 2015-05-27. PMID:23064767. |
the messenger rna abundance of some apoptosis-related genes was found to be increased, including five tumor necrosis factor (tnf)-related members (apoptosis regulatory protein siva, tumor necrosis factor-α (tnfa) tnf (ligand) superfamily member 10 (tnfsf10), tnf-inducible protein 6 (tnfaip6) and tnf receptor associated factor 2 binding protein (traf2bp)), three p53-related genes (tumor protein p53 inducible nuclear protein 1 (tp53inp1), p53-induced protein phosphatase 1 (ppm1d) and a novel apoptosis stimulating protein of p53 (aspp2)), bcl 2 family members (proapoptosis gene bax and antiapoptosis gene mcl 1), caspases (caspase y (caspy) and a pyd and card domain-containing protein (pycard)) and the transforming growth factor beta (tgf-β) induced apoptosis protein 2 (taip2). |
2015-05-27 |
2023-08-12 |
zebrafish |
| Guiping Yuan, Shujun Dai, Zhongqiong Yin, Hongke Lu, Renyong Jia, Jiao Xu, Xu Song, Li Li, Yang Shu, Xinghong Zhao, Zhenzhen Chen, Qiaojia Fan, Xiaoxia Liang, Changliang He, Lizi Yin, Cheng Lv, Qiaobo Lei, Liang Wang, Yong Mi, Xiaolong Yu, Min Zhan. Sub-chronic lead and cadmium co-induce apoptosis protein expression in liver and kidney of rats. International journal of clinical and experimental pathology. vol 7. issue 6. 2015-05-26. PMID:25031709. |
hepatic and renal apoptosis induced by low-dose exposure is associated with mitochondrial injury and changes in levels of apoptogenic proteins, such as bcl-2, bax, and caspase-3. |
2015-05-26 |
2023-08-13 |
rat |
| Jessie Colin, Julie Garibal, Amandine Clavier, Aurore Rincheval-Arnold, Sébastien Gaumer, Bernard Mignotte, Isabelle Guéna. The drosophila Bcl-2 family protein Debcl is targeted to the proteasome by the β-TrCP homologue slimb. Apoptosis : an international journal on programmed cell death. vol 19. issue 10. 2015-05-26. PMID:25208640. |
we then demonstrated that uba1 also regulates apoptosis induced by debcl, the only counterpart of bax in drosophila. |
2015-05-26 |
2023-08-13 |
drosophila_melanogaster |
| Tong Li, Ze-Lin Sun, Qi Ying Xi. Protective effect of microRNA-30b on hypoxia/reoxygenation-induced apoptosis in H9C2 cardiomyocytes. Gene. vol 561. issue 2. 2015-05-26. PMID:25701595. |
h/r induced apoptosis was detected by flow cytometry and the pathways involved in mir-30b-mediated protection were examined by analyzing the expression of mir-30b, bcl-2, bax, caspase-3, kras, p-akt and total akt in h9c2 cells. |
2015-05-26 |
2023-08-13 |
rat |
| Bo Wei, Ye Cui, Yuefeng Huang, Heng Liu, Lin Li, Mi Li, Kang-Cheng Ruan, Qin Zhou, Chen Wan. Tom70 mediates Sendai virus-induced apoptosis on mitochondria. Journal of virology. vol 89. issue 7. 2015-05-21. PMID:25609812. |
consequently, the relocation of bax onto mitochondria induces the leakage of cytochrome c into the cytosol and initiates the corresponding apoptosis. |
2015-05-21 |
2023-08-13 |
Not clear |
| Jiao Liu, Ying Liang, Ting Liu, Dengke Li, Xingsheng Yan. Anti-EGFR-Conjugated Hollow Gold Nanospheres Enhance Radiocytotoxic Targeting of Cervical Cancer at Megavoltage Radiation Energies. Nanoscale research letters. vol 10. 2015-05-21. PMID:25995714. |
anti-egfr/hgns remarkably increased the ratio of hela cells in the g2/m phase and induced more apoptosis by an obvious deregulation of bcl-2 and upregulation of bax, bad, and caspase 3 when combined with radiation. |
2015-05-21 |
2023-08-13 |
Not clear |
| Ali Roohbakhsh, Hamideh Parhiz, Fatemeh Soltani, Ramin Rezaee, Mehrdad Iranshah. Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases. Life sciences. vol 124. 2015-05-19. PMID:25625242. |
unlike conventional anti-cancer drugs, hsd and hst inhibit tumor growth by targeting multiple cellular protein targets at the same time, including caspases, bcl-2 (b-cell lymphoma 2) and bax (bcl-2 associated x protein) for the induction of apoptosis, and cox-2 (cyclooxygenase-2), mmp-2 (matrix metalloproteinase-2) and mmp-9 for the inhibition of angiogenesis and metastasis. |
2015-05-19 |
2023-08-13 |
Not clear |
| Le Yang, Qi Yang, Kun Zhang, Yu-Jiao Li, Yu-Mei Wu, Shui-Bing Liu, Lian-He Zheng, Ming-Gao Zha. Neuroprotective effects of daphnetin against NMDA receptor-mediated excitotoxicity. Molecules (Basel, Switzerland). vol 19. issue 9. 2015-05-18. PMID:25225718. |
dap significantly inhibited the neuronal apoptosis by regulating balance of bcl-2 and bax expression. |
2015-05-18 |
2023-08-13 |
mouse |
| Jun-Yi Chen, Xiao-Xia Li, Ya-Kun Xu, Hua Wu, Jun-Jun Zheng, Xue-Li Y. Developmental competence and gene expression of immature oocytes following liquid helium vitrification in bovine. Cryobiology. vol 69. issue 3. 2015-05-18. PMID:25307439. |
moreover, the expression of gdf9 (growth/differentiation factor-9), bax (apoptosis factor) and zar1 (zygote arrest 1) was analyzed by quantitative real-time polymerase chain reaction (qrt-pcr) when the vitrified-thawed oocytes were matured 24h. |
2015-05-18 |
2023-08-13 |
cattle |
| Sarah Neidel, Carlos Maluquer de Motes, Daniel S Mansur, Pavla Strnadova, Geoffrey L Smith, Stephen C Graha. Vaccinia virus protein A49 is an unexpected member of the B-cell Lymphoma (Bcl)-2 protein family. The Journal of biological chemistry. vol 290. issue 10. 2015-05-18. PMID:25605733. |
whereas bcl-2 family members characteristically modulate cellular apoptosis, a49 lacks a surface groove suitable for binding bh3 peptides and does not bind proapoptotic bcl-2 family proteins bax or bak. |
2015-05-18 |
2023-08-13 |
Not clear |
| Yoona Park, Jiyeon Choi, Joo Weon Lim, Hyeyoung Ki. β-Carotene-induced apoptosis is mediated with loss of Ku proteins in gastric cancer AGS cells. Genes & nutrition. vol 10. issue 4. 2015-05-18. PMID:25981694. |
in the present study, we investigated the mechanism of β-carotene-induced apoptosis of gastric cancer ags cells by determining cell viability, dna fragmentation, apoptotic indices (increases in cytochrome c and bax, decrease in bcl-2), ros levels, mitochondrial membrane potential, caspase-3 activity, ku70/80 levels, and ku-dna-binding activity of the cells treated with or without antioxidant n-acetyl cysteine and caspase-3 inhibitor z-deved-fmk. |
2015-05-18 |
2023-08-13 |
Not clear |
| Jin-Song Liu, Jian-Feng Ma, Qi Wang, Da-Feng Zhang, Chuan-Tong Liu, Xing Lian. [Effects of fluid shear stress on apoptosis of osteoblasts and expression of bcl-2,Bax and caspase-3]. Shanghai kou qiang yi xue = Shanghai journal of stomatology. vol 17. issue 5. 2015-05-17. PMID:18989592. |
[effects of fluid shear stress on apoptosis of osteoblasts and expression of bcl-2,bax and caspase-3]. |
2015-05-17 |
2023-08-12 |
Not clear |
| Lin Yang, Jian-Min Luo, Xiao-Jun Liu, Shu-Peng Wen, Xing-Yan Du, Li Yao, Jing-Ci Yan. [The mechanism for SHIP gene to induce the apoptosis of human leukemia cell line K562.]. Sheng li xue bao : [Acta physiologica Sinica]. vol 61. issue 2. 2015-05-16. PMID:19377826. |
the results are as follows: (1) human leukemia cell line k562 was ship-negative; (2) transfection with ship gene led to the re-expression of ship mrna and protein in k562, as shown by fq-pcr and western blot; (3) the expression of ship protein inhibited cell growth and significantly increased apoptosis in k562 cells; (4) compared to that in control group, the expression level of p-akt-308 and p-akt-473 in ship-expressing cell group decreased significantly (p<0.01); ship activated caspase-9, caspase-3, up-regulated protein levels of bad, p27, down-regulated expression of bcl-xl, while it had no effect on the expression of bcl-2 and bax. |
2015-05-16 |
2023-08-12 |
human |
| Zhen-Ying Zhang, Xiu-Hua Liu, Yong-Jun Ye, Sheng Sun, Fei Rong, Xiao-Sun Guo, Wei-Cheng H. [C/EBP homologous protein-mediated endoplasmic reticulum stress-related apoptosis pathway is involved in abdominal aortic constriction-induced myocardium hypertrophy in rats.]. Sheng li xue bao : [Acta physiologica Sinica]. vol 61. issue 2. 2015-05-16. PMID:19377828. |
prolonged ers triggered myocyte apoptosis, as both the mrna and protein level of chop in model group increased by 22.2% (p<0.01) and 76.0% (p<0.01) respectively compared with control on 7 d after hypertrophy (14 d after surgery), and meanwhile, the protein expression of pro-apoptotic bax increased by 41.1% (p<0.01) and anti-apoptotic bcl-2 protein expression decreased by 25.5% (p<0.01). |
2015-05-16 |
2023-08-12 |
rat |
| WenLi Mu, QingJun Zhang, XiaoQiang Tang, WenYan Fu, Wei Zheng, YunBiao Lu, HongLiang Li, YuSheng Wei, Li Li, ZhiGang She, HouZao Chen, DePei Li. Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure. Science China. Life sciences. vol 57. issue 9. 2015-05-15. PMID:25104317. |
furthermore, we show that cardiomyocyte apoptosis caused by suppression of sirt1 activity is, at least in part, due to increased p53 acetylation and upregulated bax expression. |
2015-05-15 |
2023-08-13 |
mouse |
| Qi Xiong, Qin Ru, Lin Chen, Kai Yue, Xiang Tian, Baomiao Ma, Lu Liu, Rihui Wu, Congyue Xu, Mingshan Pi, Chaoying L. Combined effects of fine particulate matter and lipopolysaccharide on apoptotic responses in NR8383 macrophages. Journal of toxicology and environmental health. Part A. vol 78. issue 7. 2015-05-15. PMID:25785558. |
data showed that srm 2786 alone induced damage and apoptosis in nr8383 cells in a concentration-dependent manner as demonstrated by significant decrease in expression of bcl-2 and increase in expression of bax, suggesting fine pm might trigger apoptosis involving a mitochondria-mediated apoptotic pathway. |
2015-05-15 |
2023-08-13 |
rat |
| Yongxia Cheng, Yukuan Feng, Min Zhu, Bin Yan, Songbin Fu, Jin Guo, Jing Hu, Xiandong Song, Sufen Guo, Guibo Li. Synthetic liver X receptor agonist T0901317 attenuates high glucose-induced oxidative stress, mitochondrial damage and apoptosis in cardiomyocytes. Acta histochemica. vol 116. issue 1. 2015-05-14. PMID:23915475. |
exposure of h9c2 cells to high glucose alone, not only caused a significant increase in apoptosis and reactive oxygen species (ros) generation, but also led to a decrease in mitochondrial membrane potential (ΔΨm), release of cytochrome c, decrease in bcl-2, increase in bax expression and the activation of caspase-3, caspase-9, poly (adp-ribose) polymerase (parp) and nuclear factor (nf)-κb. |
2015-05-14 |
2023-08-12 |
Not clear |