| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A-M Joseph, L M-D Nguyen, A E Welter, J M Dominguez, B J Behnke, P J Adhihett. Mitochondrial adaptations evoked with exercise are associated with a reduction in age-induced testicular atrophy in Fischer-344 rats. Biogerontology. vol 15. issue 5. 2015-06-22. PMID:25108553. |
no effect was observed in the pro- or anti-apoptotic proteins, bax and bcl-2, respectively, but age increased apoptosis inducing factor levels. |
2015-06-22 |
2023-08-13 |
rat |
| Yanyan Wang, Jingwu Sun, Chengxia Liu, Can Fan. Protective effects of crocetin pretreatment on myocardial injury in an ischemia/reperfusion rat model. European journal of pharmacology. vol 741. 2015-06-22. PMID:25176181. |
crocetin activation also decreases the terminal deoxynucleotidyl transferase-mediated dutp-biotin nick end labeling (tunel) staining positive percentage and bax expression, elevated bcl-2 and endothelial nitric oxide synthase (enos) expression and nitrite (no) production, these indicating that crocetin can suppress the apoptosis damage. |
2015-06-22 |
2023-08-13 |
rat |
| C X Huang, J N Zhao, W H Zou, J J Li, P C Wang, C H Liu, Y B Wan. Reduction of galectin-3 expression reduces pituitary tumor cell progression. Genetics and molecular research : GMR. vol 13. issue 3. 2015-06-22. PMID:25177969. |
inhibition of gal-3 gene expression by rna interference decreased gh3 cell proliferation and increased cell apoptosis; the expression levels of gal-3 protein significantly decreased, along with those of bcl-2, although bax levels did not change. |
2015-06-22 |
2023-08-13 |
Not clear |
| X Y Dong, F Zh. Effect of pinacidil on rat ventricular myocytes during transient hypoxia and reperfusion. Genetics and molecular research : GMR. vol 13. issue 4. 2015-06-22. PMID:25299204. |
the kinetic parameters and electrophysiological properties, including early apoptosis protein expression changes of bax, bcl-2, and fn were examined using the isolated perfusion and patch-clamp technique and immunohistochemistry. |
2015-06-22 |
2023-08-13 |
rat |
| X Y Dong, F Zh. Effect of pinacidil on rat ventricular myocytes during transient hypoxia and reperfusion. Genetics and molecular research : GMR. vol 13. issue 4. 2015-06-22. PMID:25299204. |
the expression of apoptosis proteins (bax, fn) increased during a/r, while bcl-2 protein expression decreased. |
2015-06-22 |
2023-08-13 |
rat |
| Debjani Ghosh, Subrata Kumar Dey, Chabita Sah. Antagonistic effects of black tea against gamma radiation-induced oxidative damage to normal lymphocytes in comparison with cancerous K562 cells. Radiation and environmental biophysics. vol 53. issue 4. 2015-06-19. PMID:24981250. |
the changes in the mrna expression of bax, bcl2, p53 and nrf2 were also followed to evaluate regulation of radiation-induced apoptosis by bte. |
2015-06-19 |
2023-08-13 |
Not clear |
| Hui Han, Sheng Yang, Shun-Guo Lin, Chun-Sen Xu, Zhong-Hua Ha. Effects and mechanism of downregulation of COX‑2 expression by RNA interference on proliferation and apoptosis of human breast cancer MCF‑7 cells. Molecular medicine reports. vol 10. issue 6. 2015-06-19. PMID:25323004. |
rna interference markedly deactivated the cox‑2 gene, suppressed the proliferation of breast cancer mcf‑7 cells, and, to a certain extent, enhanced the induced spontaneous apoptosis, which is regulated by the bax gene. |
2015-06-19 |
2023-08-13 |
human |
| Bo Zhang, Hongsheng Zhou, Qian Cheng, Lei Lei, Bing H. Low-frequency low energy ultrasound combined with microbubbles induces distinct apoptosis of A7r5 cells. Molecular medicine reports. vol 10. issue 6. 2015-06-19. PMID:25324182. |
low frequency ultrasound combined with microbubbles induced apoptosis in a7r5 cells through the upregulation of bax and the downregulation of the bcl‑2/bax ratio, where the cavitation effect may have an important role. |
2015-06-19 |
2023-08-13 |
rat |
| Yan Jing Li, Peng Huang, Cai Ling Jiang, De Xin Jia, Xiao Xue Du, Jian Hua Zhou, Yu Han, Hong Sui, Xiao Li Wei, Lei Liu, Heng Heng Yuan, Ting Ting Zhang, Wen Jie Zhang, Rui Xie, Xiao Hui Lang, Li Ying Wang, Tao Liu, Yu Xian Bai, Ye Tia. Sonodynamically induced anti-tumor effect of 5-aminolevulinic acid on pancreatic cancer cells. Ultrasound in medicine & biology. vol 40. issue 11. 2015-06-18. PMID:25220273. |
the mechanism underlying the effect of sdt involves, in part, the induction of a conspicuous loss in mitochondrial membrane potential and, in part, the induction of apoptosis through upregulation of bax expression, downregulation of bcl-2 and increased activation of procaspase-3. |
2015-06-18 |
2023-08-13 |
human |
| Jun Han, Jia-Li Xuan, Hao-Ran Hu, Zhi-Wu Che. [Protective effect against myocardial ischemia reperfusion injuries induced by hyperoside preconditioning and its relationship with PI3K/Akt signaling pathway in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 40. issue 1. 2015-06-18. PMID:25993800. |
hyp pretreatment apparently restrained myocardial apoptosis as evidenced by decreasing the level of bax expression, increasing the levels of phosphorylation of akt and bcl-2 expression. |
2015-06-18 |
2023-08-13 |
rat |
| Priyanka Bhatnagar, Soma Patnaik, Amit K Srivastava, Mohan K R Mudiam, Yogeshwer Shukla, Amulya K Panda, Aditya B Pant, Pradeep Kumar, Kailash C Gupt. Anti-cancer activity of bromelain nanoparticles by oral administration. Journal of biomedical nanotechnology. vol 10. issue 12. 2015-06-18. PMID:26000370. |
altered expression of marker proteins associated with apoptosis and cell death (p53, p21, bcl2, bax) also confirmed the enhanced anti-carcinogenic potential of formulated nps. |
2015-06-18 |
2023-08-13 |
mouse |
| J Long, Y X Su, H C Den. Lipoapoptosis pathways in pancreatic β-cells and the anti-apoptosis mechanisms of adiponectin. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 46. issue 10. 2015-06-16. PMID:25028793. |
moreover, adiponectin treatment prevented palmitate-induced apoptosis by inhibition of caspase-9 activation, but not of caspase-8, and induced an upregulation of bcl-2 and a downregulation of bax in protein level. |
2015-06-16 |
2023-08-13 |
Not clear |
| I G Chae, D-H Kim, J Kundu, C-H Jeong, J K Kundu, K-S Chu. Generation of ROS by CAY10598 leads to inactivation of STAT3 signaling and induction of apoptosis in human colon cancer HCT116 cells. Free radical research. vol 48. issue 11. 2015-06-16. PMID:25096910. |
our study revealed that treatment with cay10598 significantly reduced the cell viability and induced apoptosis in hct116 cells, as evidenced by the induction of p53 and bax, release of cytochrome c, cleavage of caspase-9, -7, and -3, and parp, and the inhibition of bcl-2, bcl-xl and survivin expression. |
2015-06-16 |
2023-08-13 |
human |
| Gu Gong, Libang Yuan, Lin Cai, Maorong Ran, Yulan Zhang, Huaqu Gong, Xuemei Dai, Wei Wu, Hailong Don. Tetramethylpyrazine suppresses transient oxygen-glucose deprivation-induced connexin32 expression and cell apoptosis via the ERK1/2 and p38 MAPK pathway in cultured hippocampal neurons. PloS one. vol 9. issue 9. 2015-06-16. PMID:25237906. |
moreover, our study showed that viability was increased in sirna-cx32-treated-neurons, and neuron apoptosis was suppressed by activating bcl-2 expression and inhibiting bax expression. |
2015-06-16 |
2023-08-13 |
Not clear |
| Han Sung Kim, Seung-Il Choi, Eui-Bae Jeung, Yeong-Min Yo. Cyclosporine A induces apoptotic and autophagic cell death in rat pituitary GH3 cells. PloS one. vol 9. issue 10. 2015-06-16. PMID:25299210. |
in contrast, bax levels in both types of cell death were increased in a dose-dependent manner, while bcl-2 levels showed dose-dependent augmentation in autophagy and were decreased in apoptosis. |
2015-06-16 |
2023-08-13 |
rat |
| Cátia dos Santos Branco, Émilin Dreher de Lima, Tiago Selau Rodrigues, Thamiris Becker Scheffel, Gustavo Scola, Claudia Cilene Fernandes Correia Laurino, Sidnei Moura, Mirian Salvado. Mitochondria and redox homoeostasis as chemotherapeutic targets of Araucaria angustifolia (Bert.) O. Kuntze in human larynx HEp-2 cancer cells. Chemico-biological interactions. vol 231. 2015-06-16. PMID:25770932. |
a significant increase in the apoptosis inducing factor (aif), bax, poly-(adp-ribose) polymerase (parp) and caspase-3 cleavage expression were also found. |
2015-06-16 |
2023-08-13 |
human |
| Pabitra Bikash Pal, Krishnendu Sinha, Parames C Si. Mangiferin attenuates diabetic nephropathy by inhibiting oxidative stress mediated signaling cascade, TNFα related and mitochondrial dependent apoptotic pathways in streptozotocin-induced diabetic rats. PloS one. vol 9. issue 9. 2015-06-15. PMID:25233093. |
in addition, oxidative stress also disturbed the proapoptotic-antiapoptotic (bax and bcl-2) balance and activated mitochorndia-dependent apoptosis via caspase 9, caspase 3 and parp cleavage. |
2015-06-15 |
2023-08-13 |
rat |
| Theera Srisawat, Yaowapa Sukpondma, Siriphon Chimplee, Kanyanatt Kanokwiroon, Aman Tedasen, Potchanapond Graidis. Extracts from Vatica diospyroides type SS fruit show low dose activity against MDA-MB-468 breast cancer cell-line via apoptotic action. BioMed research international. vol 2014. 2015-06-15. PMID:25302299. |
the expression of bax increased within 12-48 hours of dosing, confirming apoptosis induced by time-dependent responses. |
2015-06-15 |
2023-08-13 |
Not clear |
| Lauren A Barclay, Thomas E Wales, Thomas P Garner, Franziska Wachter, Susan Lee, Rachel M Guerra, Michelle L Stewart, Craig R Braun, Gregory H Bird, Evripidis Gavathiotis, John R Engen, Loren D Walensk. Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism. Molecular cell. vol 57. issue 5. 2015-06-15. PMID:25684204. |
these data reveal a previously unappreciated binding site for targeted inhibition of bax and suggest that the bcl-2 bh4 domain may participate in apoptosis blockade by a noncanonical interaction mechanism. |
2015-06-15 |
2023-08-13 |
Not clear |
| Mohammad Hassan Naseri, Majid Mahdavi, Jamshid Davoodi, Saeed Hesami Tackallou, Mahdi Goudarzvand, Shima Hallaj Neishabour. Up regulation of Bax and down regulation of Bcl2 during 3-NC mediated apoptosis in human cancer cells. Cancer cell international. vol 15. 2015-06-15. PMID:26074734. |
up regulation of bax and down regulation of bcl2 during 3-nc mediated apoptosis in human cancer cells. |
2015-06-15 |
2023-08-13 |
human |