| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhuang Song, Cai-Ping Chen, Jun Liu, Xiaoan Wen, Hongbin Sun, Haoliang Yua. Design, synthesis, and biological evaluation of (2E)-(2-oxo-1, 2-dihydro-3H-indol-3-ylidene)acetate derivatives as anti-proliferative agents through ROS-induced cell apoptosis. European journal of medicinal chemistry. vol 124. 2017-02-28. PMID:27643639. |
mechanistic study revealed that compound 8c enhanced reactive oxygen species level by inhibiting trxr and then induced apoptosis by activating apoptosis proteins, bax and cleaved-caspase 3 in hct116 cells. |
2017-02-28 |
2023-08-13 |
Not clear |
| Seojeong Park, Til Bahadur Thapa Magar, Tara Man Kadayat, Hwa Jong Lee, Ganesh Bist, Aarajana Shrestha, Eung-Seok Lee, Youngjoo Kwo. Rational design, synthesis, and evaluation of novel 2,4-Chloro- and Hydroxy-Substituted diphenyl Benzofuro[3,2-b]Pyridines: Non-intercalative catalytic topoisomerase I and II dual inhibitor. European journal of medicinal chemistry. vol 127. 2017-02-28. PMID:28068603. |
in addition, compound 14 induced apoptosis in hct15 cells through increase of bax, decrease of bcl-2 and increase of parp cleavage. |
2017-02-28 |
2023-08-13 |
human |
| Zhenyan Jiang, Hansi Zhang, Rainer A Böckman. Allostery in BAX protein activation. Journal of biomolecular structure & dynamics. vol 34. issue 11. 2017-02-24. PMID:26578184. |
bax is a member of the proapoptotic bcl-2 family of proteins, which is involved in the regulation of the intrinsic pathway of apoptosis. |
2017-02-24 |
2023-08-13 |
Not clear |
| Zhenyan Jiang, Hansi Zhang, Rainer A Böckman. Allostery in BAX protein activation. Journal of biomolecular structure & dynamics. vol 34. issue 11. 2017-02-24. PMID:26578184. |
in the process of apoptosis, bh3-only molecules activate cytosolic bax. |
2017-02-24 |
2023-08-13 |
Not clear |
| Zhenyan Jiang, Hansi Zhang, Rainer A Böckman. Allostery in BAX protein activation. Journal of biomolecular structure & dynamics. vol 34. issue 11. 2017-02-24. PMID:26578184. |
for a molecular understanding of the activation of bax, and thus the first steps in apoptosis, we performed microsecond atomistic molecular dynamics simulations both of the bax protein and of the bax:bim sahb complex in aqueous solution. |
2017-02-24 |
2023-08-13 |
Not clear |
| Jun Wang, Rongrong Chen, Xiaojuan Liu, Jianhong Shen, Yaohua Yan, Yilu Gao, Tao Tao, Jiansheng Sh. Hck Promotes Neuronal Apoptosis Following Intracerebral Hemorrhage. Cellular and molecular neurobiology. vol 37. issue 2. 2017-02-23. PMID:27053350. |
in addition, the temporary raise of hck expression was paralleled with the expression of p53, bax, and active caspase-3, suggesting that hck was involved in neuronal apoptosis. |
2017-02-23 |
2023-08-13 |
Not clear |
| Sun-Hyung Ha, Ji-Min Lee, Kyung-Min Kwon, Choong-Hwan Kwak, Fukushi Abekura, Jun-Young Park, Seung-Hak Cho, Kichoon Lee, Young-Chae Chang, Young-Choon Lee, Hee-Jung Choi, Tae-Wook Chung, Ki-Tae Ha, Hyeun-Wook Chang, Cheorl-Ho Ki. Exogenous and Endogeneous Disialosyl Ganglioside GD1b Induces Apoptosis of MCF-7 Human Breast Cancer Cells. International journal of molecular sciences. vol 17. issue 5. 2017-02-22. PMID:27144558. |
treatment of mcf-7 cells with gd1b activated apoptotic molecules such as processed forms of caspase-8, -7 and parp (poly(adp-ribose) polymerase), without any change in the expression of mitochondria-mediated apoptosis molecules such as bax and bcl-2. |
2017-02-22 |
2023-08-13 |
human |
| Yanyan Zhu, Yameng Jiang, Lei Shi, Linying Du, Xiaodong Xu, Enxia Wang, Yong Sun, Xin Guo, Boyang Zou, Huaxin Wang, Changyuan Wang, Lidan Sun, Yuhong Zhe. 7-O-Geranylquercetin induces apoptosis in gastric cancer cells via ROS-MAPK mediated mitochondrial signaling pathway activation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 87. 2017-02-22. PMID:28076833. |
mechanism study showed that gq triggered generation of reactive oxygen species (ros), then activated p38 and jnk signaling pathways, subsequently led to mitochondrial impairment by regulating the expression of bcl-2, bcl-xl and bax, and finally promoted the release of cytochrome c and the activation of caspases to induce apoptosis. |
2017-02-22 |
2023-08-13 |
human |
| Caihong Bai, Xiaojiao Yang, Kun Zou, Haibo He, Junzhi Wang, Huilin Qin, Xiaoqin Yu, Chengxiong Liu, Juyan Zheng, Fan Cheng, Jianfeng Che. Anti-proliferative effect of RCE-4 from Reineckia carnea on human cervical cancer HeLa cells by inhibiting the PI3K/Akt/mTOR signaling pathway and NF-κB activation. Naunyn-Schmiedeberg's archives of pharmacology. vol 389. issue 6. 2017-02-21. PMID:26935715. |
the results indicated that the hela cell was the most sensitive with an ic50 of 7.01 μm; rce-4 significantly promoted the release of cellular lactate dehydrogenase (ldh); increased dna fragmentation and apoptosis; reduced pi3k, akt, mtor, and nf-κbp65 phosphorylation levels; increased the bax and cleaved poly (adp-ribose) polymerase (parp) protein levels; suppressed bcl-2 protein expression; elevated the bax/bcl-2 expression ratio; and decreased the interleukin-1 beta (il-1β) and interleukin-6 (il-6) mrna expressions in hela cells in a concentration-dependent manner. |
2017-02-21 |
2023-08-13 |
human |
| Zhengxing Xie, Ping Han, Zhenwen Cui, Baofeng Wang, Zhihong Zhong, Yuhao Sun, Guoyuan Yang, Qingfang Sun, Liuguan Bia. Pretreatment of Mouse Neural Stem Cells with Carbon Monoxide-Releasing Molecule-2 Interferes with NF-κB p65 Signaling and Suppresses Iron Overload-Induced Apoptosis. Cellular and molecular neurobiology. vol 36. issue 8. 2017-02-21. PMID:26961543. |
tunel staining showed that preconditioning c17.2 cells with corm-2 enhanced their resistance to apoptosis induced by iron overload, which was concomitant with down-regulation of the pro-apoptotic proteins (bax and cleaved caspase-3) and up-regulation of the anti-apoptotic protein bcl2. |
2017-02-21 |
2023-08-13 |
mouse |
| Yuan Wang, Peng-Cheng He, Yan-Feng Liu, Jun Qi, Mei Zhan. Construction of SET overexpression vector and its effects on the proliferation and apoptosis of 293T cells. Molecular medicine reports. vol 13. issue 5. 2017-02-21. PMID:27035430. |
an increase in b‑cell lymphoma 2 (bcl‑2) and a decrease in bcl‑2‑associated x (bax) protein expression was observed in the pegfp‑n1‑set‑transfected cells compared with that in the controls, and their susceptibility to as4s4‑induced apoptosis was decreased. |
2017-02-21 |
2023-08-13 |
human |
| Rui Hu, Fengqing Hu, Xiao Xie, Lei Wang, Guoqing Li, Tong Qiao, Mingsong Wang, Haibo Xia. TMEM45B, up-regulated in human lung cancer, enhances tumorigenicity of lung cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 9. 2017-02-21. PMID:27225290. |
moreover, knockdown of tmem45b significantly suppressed g1/s transition, induced cell apoptosis, and inhibited cell invasion via regulating the expression of cell cycle-related proteins (cdk2, cdc25a, and pcna), cell apoptosis-related proteins (bcl2, bax, and cleaved caspase 3), and metastasis-related proteins (mmp-9, twist, and snail), respectively. |
2017-02-21 |
2023-08-13 |
mouse |
| Junguo Ma, Yiyi Feng, Yang Liu, Xiaoyu L. PUMA and survivin are involved in the apoptosis of HepG2 cells induced by microcystin-LR via mitochondria-mediated pathway. Chemosphere. vol 157. 2017-02-21. PMID:27235693. |
moreover, we also found that p53 and bax might play an important role in mc-lr-induced apoptosis in hepg2 cells in which puma and survivin were involved. |
2017-02-21 |
2023-08-13 |
human |
| Jing Wu, Xia Xue, Bin Zhang, Hongmei Cao, Feng Kong, Wen Jiang, Juan Li, Deqing Sun, Ruichen Gu. Enhanced antitumor activity and attenuated cardiotoxicity of Epirubicin combined with Paeonol against breast cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 9. 2017-02-21. PMID:27272157. |
increased apoptosis was associated with the activation of apoptosis-related proteins including parp, bax, caspase 3, and inhibition of p38/jnk/erk mapks. |
2017-02-21 |
2023-08-13 |
mouse |
| Hao Zhou, Wu-Shuang Yang, Ying Li, Tong Ren, Lu Peng, Han Guo, Jin-Feng Liu, Yu Zhou, Yun Zhao, Li-Chao Yang, Xin Ji. Oleoylethanolamide attenuates apoptosis by inhibiting the TLR4/NF-κB and ERK1/2 signaling pathways in mice with acute ischemic stroke. Naunyn-Schmiedeberg's archives of pharmacology. vol 390. issue 1. 2017-02-21. PMID:27738712. |
our data showed that oea treatment alleviated cell apoptosis in a mouse model of ischemic stroke, accompanied by suppression of bax, as well as upregulation of antiapoptotic protein bcl-2 level. |
2017-02-21 |
2023-08-13 |
mouse |
| Wenping Xu, Bo Wang, Mingjun Yang, Yang Zhang, Zhiping Xu, Yun Yang, Haijing Cao, Liming Ta. Tebufenozide induces G1/S cell cycle arrest and apoptosis in human cells. Environmental toxicology and pharmacology. vol 49. 2017-02-21. PMID:27960113. |
in addition, western blotting showed apoptosis was associated with the upregulation of p53, bax and cleaved-parp, as well as downregulation of bcl-2 and parp. |
2017-02-21 |
2023-08-13 |
human |
| Cheng-Cheng Zhu, Yue Zhang, Xing Duan, Jun Han, Shao-Chen Su. Toxic effects of HT-2 toxin on mouse oocytes and its possible mechanisms. Archives of toxicology. vol 90. issue 6. 2017-02-20. PMID:26138683. |
ht-2 toxin exposure also induced oxidative stress and resulted in oocyte apoptosis, as shown by ros accumulation, increased sod mrna level, and the expression of the early apoptosis marker annexin v and increased caspase-3 and bax mrna levels. |
2017-02-20 |
2023-08-13 |
mouse |
| Bingyan Zhu, Boyang Shang, Yi Li, Yongsu Zhe. Inhibition of histone deacetylases by trans-cinnamic acid and its antitumor effect against colon cancer xenografts in athymic mice. Molecular medicine reports. vol 13. issue 5. 2017-02-17. PMID:27035417. |
apoptosis was shown by the activation of cleavage of poly adp ribose polymerase and the increased expression of bax. |
2017-02-17 |
2023-08-13 |
mouse |
| Zhi-Qiang d. BAX, a novel cell pro-apoptotic protein, involved in hemocytes early antiviral immune response in fresh water crayfish, Procambarus clarkii. Fish & shellfish immunology. vol 55. 2017-02-17. PMID:27291352. |
taken together, these results revealed that crayfish hemocytes apoptosis scale was enhanced to suppress wssv replication by up-regulating bax protein expression level after wssv infection. |
2017-02-17 |
2023-08-13 |
Not clear |
| Xing-Mei Yao, Yu-Jun Liu, Yun-Man Wang, Hao Wang, Bing-Bing Zhu, Yong-Ping Liang, Wei-Guo Yao, Hui Yu, Nian-Song Wang, Xue-Mei Zhang, Wen Pen. Astragaloside IV prevents high glucose-induced podocyte apoptosis via downregulation of TRPC6. Molecular medicine reports. vol 13. issue 6. 2017-02-16. PMID:27109610. |
apoptosis, cell viability, expression of trpc6, nuclear factor of activated t cells (nfat2) and b‑cell lymphoma 2‑associated x protein (bax), as well as the intracellular ca2+ concentration were subsequently analyzed. |
2017-02-16 |
2023-08-13 |
Not clear |