| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shanshan Jiang, Qian Wang, Meiqing Feng, Jiyang Li, Zhongbin Guan, Duopeng An, Mengxue Dong, Yuzhe Peng, Kudelaidi Kuerban, Li Y. C2-ceramide enhances sorafenib-induced caspase-dependent apoptosis via PI3K/AKT/mTOR and Erk signaling pathways in HCC cells. Applied microbiology and biotechnology. vol 101. issue 4. 2017-03-08. PMID:27807662. |
sorafenib plus c2-ceramide stimulated significantly the production of reactive oxygen species (ros) and mitochondrial depolarization, which promoted caspases-dependent cell apoptosis as illustrated by related protein expression including caspase 3, caspase 9, bax, bcl-2, and cytochrome c. combination treatment of sorafenib and c2-ceramide inhibited obviously cell growth and proliferation via pi3k/akt/mtor and erk signaling pathways. |
2017-03-08 |
2023-08-13 |
human |
| Cristiane Oliveira, Gustavo Jacob Lourenço, José Augusto Rinck-Junior, Aparecida Machado de Moraes, Carmen Silvia Passos Lim. Polymorphisms in apoptosis-related genes in cutaneous melanoma prognosis: sex disparity. Medical oncology (Northwood, London, England). vol 34. issue 2. 2017-03-08. PMID:28050764. |
cutaneous melanoma (cm) cells are resistant to apoptosis, and steroid hormones are involved in this process through regulation of tp53, mdm2, bax, and bcl2 expression. |
2017-03-08 |
2023-08-13 |
Not clear |
| b' Iva Poto\\xc4\\x8dnjak, Robert Domitrovi\\xc4\\x8. Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K/Akt activation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 98. issue Pt B. 2017-03-07. PMID:27825756.' |
cp intoxication induced apoptosis and inhibition of the cell cycle in kidneys by increasing the expression of p53 and bax and suppressing bcl-2 and cyclin d1 expression. |
2017-03-07 |
2023-08-13 |
mouse |
| Lina Zhang, Jingxi Ma, Xinhao Jin, Gongwei Jia, Ying Jiang, Changqing L. L-PGDS Mediates Vagus Nerve Stimulation-Induced Neuroprotection in a Rat Model of Ischemic Stroke by Suppressing the Apoptotic Response. Neurochemical research. vol 42. issue 2. 2017-03-07. PMID:27900597. |
i/r rats treated with vns showed better neurological deficit scores, reduced infarct volume, and decreased neuronal apoptosis as indicated by the decreased levels of bax and cleaved caspase-3 as well as increased levels of bcl-2. |
2017-03-07 |
2023-08-13 |
rat |
| Meizhu Zheng, Chunming Liu, Yajun Fan, Dongfang Shi, Yuchi Zhan. Protective Effects of Paeoniflorin Against MPP(+)-induced Neurotoxicity in PC12 Cells. Neurochemical research. vol 41. issue 6. 2017-03-06. PMID:27053303. |
our work included examination of cell viability assessment, amounts of released lactic dehydrogenase (ldh), intracellular ca(2+) concentration, cell apoptosis, mitochondrial membrane potential, caspase-3 activity, and expression profiling of two apoptosis-related genes (bcl-2 and bax). |
2017-03-06 |
2023-08-13 |
rat |
| Yidong Cao, Liang Zhang, Shukai Sun, Zhenheng Yi, Xue Jiang, Dong Ji. Neuroprotective effects of syringic acid against OGD/R-induced injury in cultured hippocampal neuronal cells. International journal of molecular medicine. vol 38. issue 2. 2017-03-06. PMID:27278454. |
western blot analysis revealed that ogd/r promoted cell apoptosis with concomitant increases in bax and caspase-3 expression, and reduced bcl-2 expression, which was reversed by pre‑treatment with sa in a dose-dependent manner. |
2017-03-06 |
2023-08-13 |
Not clear |
| Xinsheng Shen, Yaqing Si, Zhao Wang, Jiachen Wang, Yongqiang Guo, Xiefu Zhan. Quercetin inhibits the growth of human gastric cancer stem cells by inducing mitochondrial-dependent apoptosis through the inhibition of PI3K/Akt signaling. International journal of molecular medicine. vol 38. issue 2. 2017-03-06. PMID:27278820. |
moreover, quercetin induced cell apoptosis in a mitochondrial-dependent manner, as shown by the reduction in mitochondrial membrane potential, the activation of caspase-3 and -9, and the downregulation of bcl-2, as well as the upregulation of bax and cytochrome c (cyt-c). |
2017-03-06 |
2023-08-13 |
human |
| Jianlin Liu, Lin Yang, Hongyan Tian, Qiang M. Cathepsin D is involved in the oxygen and glucose deprivation/reperfusion-induced apoptosis of astrocytes. International journal of molecular medicine. vol 38. issue 4. 2017-03-06. PMID:27573911. |
cat d overexpression enhanced cell apoptosis and the levels of apoptogenic proteins, including bax and caspase-3, whereas cat d sirna transfection had an inhibitory effect on cell apoptosis and the expression of proapoptotic proteins. |
2017-03-06 |
2023-08-13 |
Not clear |
| Zhen Zhang, Lei Yang, Lei Lei, Rongping Chen, Hong Chen, Hua Zhan. Glucagon-like peptide-1 attenuates advanced oxidation protein product-mediated damage in islet microvascular endothelial cells partly through the RAGE pathway. International journal of molecular medicine. vol 38. issue 4. 2017-03-06. PMID:27574116. |
apoptosis, cell viability and reactive oxygen species (ros) production were examined, the expression levels of p53, bax, receptor for advanced glycation end-products (rage) and nad(p)h oxidase subunit were determined, and the activity of nad(p)h oxidase, caspase-9 and caspase-3 was also determined. |
2017-03-06 |
2023-08-13 |
Not clear |
| Zhen Zhang, Lei Yang, Lei Lei, Rongping Chen, Hong Chen, Hua Zhan. Glucagon-like peptide-1 attenuates advanced oxidation protein product-mediated damage in islet microvascular endothelial cells partly through the RAGE pathway. International journal of molecular medicine. vol 38. issue 4. 2017-03-06. PMID:27574116. |
the results revealed that aopps increased the expression of rage, p47phox and p22phox; induced nad(p)h oxidase-dependent ros generation, increased p53 and bax expression, enhanced the activity of caspase-9 and caspase-3, and induced cell apoptosis. |
2017-03-06 |
2023-08-13 |
Not clear |
| Jiming Liu, Qiang Li, Zhilong Liu, Liuming Lin, Xiangqiang Zhang, Mingrong Cao, Jianwei Jian. Harmine induces cell cycle arrest and mitochondrial pathway-mediated cellular apoptosis in SW620 cells via inhibition of the Akt and ERK signaling pathways. Oncology reports. vol 35. issue 6. 2017-03-03. PMID:27004568. |
the apoptosis of sw620 cells was also detected by western blot analysis, showing caspase-3 and -9, and parp activation; the downregulation of bcl-2, mcl-1, bcl-xl; and the upregulation of bax. |
2017-03-03 |
2023-08-13 |
human |
| Jia Li, Zhiming Zhang, Lianjie Lv, Haibo Qiao, Xiuju Chen, Changlin Zo. (-)-Epigallocatechin Gallate Inhibits Asymmetric Dimethylarginine-Induced Injury in Human Brain Microvascular Endothelial Cells. Neurochemical research. vol 41. issue 8. 2017-03-03. PMID:27038929. |
at the same time, we found that pretreatment with egcg attenuated the upregulation of bax and the downregulation of bcl-2, thus confirming the cellular protective properties of egcg against adma-induced apoptosis. |
2017-03-03 |
2023-08-13 |
human |
| Hao Wang, Libo He, Yongyan Pei, Pengfei Chu, Rong Huang, Yongming Li, Lanjie Liao, Zuoyan Zhu, Yaping Wan. Cloning and characterization of Bax1 and Bax2 genes of Ctenopharyngodon idellus and evaluation of transcript expression in response to grass carp reovirus infection. Fish physiology and biochemistry. vol 42. issue 5. 2017-03-03. PMID:27048597. |
multidomain proapoptotic bcl-2-associated x (bax) protein is an essential effector responsible for mitochondrial outer membrane permeabilization, resulting in cell death via apoptosis. |
2017-03-03 |
2023-08-13 |
zebrafish |
| Fan Zeng, Rui-Jun Ju, Lei Liu, Hong-Jun Xie, Li-Min Mu, Yao Zhao, Yan Yan, Ying-Jie Hu, Jia-Shuan Wu, Wan-Liang L. Application of functional vincristine plus dasatinib liposomes to deletion of vasculogenic mimicry channels in triple-negative breast cancer. Oncotarget. vol 6. issue 34. 2017-03-02. PMID:26429872. |
the liposomes exhibited the superior performances in the following aspects: the enhancement of cellular uptake via targeted action; the induction of apoptosis via activation of caspase 8, 9, and 3, increased expression of bax, decreased expression of mcl-1, and generation of reactive oxygen species (ros); and the deletion of vm channels via inhibitions on the vm channel indicators, which consisted of vascular endothelial-cadherin (ve-cad), focal adhesion kinase (fak), phosphatidylinositide 3-kinase (pi3k), and matrix metallopeptidases (mmp-2, and mmp-9). |
2017-03-02 |
2023-08-13 |
mouse |
| Georg Karpel-Massler, Maïmouna Bâ, Chang Shu, Marc-Eric Halatsch, Mike-Andrew Westhoff, Jeffrey N Bruce, Peter Canoll, Markus D Siegeli. TIC10/ONC201 synergizes with Bcl-2/Bcl-xL inhibition in glioblastoma by suppression of Mcl-1 and its binding partners in vitro and in vivo. Oncotarget. vol 6. issue 34. 2017-03-02. PMID:26474387. |
consistently, the combination treatment of tic10/onc201 and abt263 required the presence of functional bax and bak to drive intrinsic apoptosis, but is surprisingly independent of the extrinsic apoptotic pathway. |
2017-03-02 |
2023-08-13 |
Not clear |
| Rajib Majumder, Samudra Prosad Banik, Suman Khowal. AkP from mushroom Termitomyces clypeatus is a proteoglycan specific protease with apoptotic effect on HepG2. International journal of biological macromolecules. vol 91. 2017-03-02. PMID:27180294. |
augmentation of apoptosis was attributed to up-regulation of p53 and bax protein expression succeeded by caspase-3 activation. |
2017-03-02 |
2023-08-13 |
Not clear |
| Wei Chang, Wei He, Pei-Pei Li, Sha-Sha Song, Ping-Fan Yuan, Jing-Tao Lu, Wei We. Protective effects of Celastrol on diethylnitrosamine-induced hepatocellular carcinoma in rats and its mechanisms. European journal of pharmacology. vol 784. 2017-03-02. PMID:27181068. |
meanwhile, celastrol suppressed the expression of the protein mdm2, activated the intrinsic mitochondrial apoptosis pathway induced by p53, inhibited anti-apoptotic bcl-2 and bcl-xl, induced the pro-apoptotic bax, cytochrome c, parp and caspases. |
2017-03-02 |
2023-08-13 |
rat |
| Moudan Lin, Tian Wu, Lingbin Sun, Jackie Jin Lin, Zhenghong Zuo, Chonggang Wan. Aroclor 1254 causes atrophy of exocrine pancreas in mice and the mechanism involved. Environmental toxicology. vol 31. issue 6. 2017-03-01. PMID:25409620. |
tunel-positive apoptotic cells as well as the expression of bcl2, bclxl, bax, and bad of exocrine pancreas did not show significant changes in the treated mice, indicating that aroclor 1254 has no effect on apoptosis. |
2017-03-01 |
2023-08-13 |
mouse |
| Nan Liu, Chen Wang, Libing Wang, Lei Gao, Hui Cheng, Gusheng Tang, Xiaoxia Hu, Jianmin Wan. Valproic acid enhances the antileukemic effect of cytarabine by triggering cell apoptosis. International journal of molecular medicine. vol 37. issue 6. 2017-02-28. PMID:27082972. |
using rt-qpcr, we noted that the combination of vpa and ara‑c significantly upregulated bax expression and led to the arrest of leukemia cell proliferation, sub-g1 dna accumulation and cell apoptosis, as demonstrated by flow cytometric analysis. |
2017-02-28 |
2023-08-13 |
human |
| Nan Liu, Chen Wang, Libing Wang, Lei Gao, Hui Cheng, Gusheng Tang, Xiaoxia Hu, Jianmin Wan. Valproic acid enhances the antileukemic effect of cytarabine by triggering cell apoptosis. International journal of molecular medicine. vol 37. issue 6. 2017-02-28. PMID:27082972. |
significantly, further experiments revealed that knockdown of bax expression prevented vpa and ara‑c‑induced cell apoptosis in thp-1 cells. |
2017-02-28 |
2023-08-13 |
human |