| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing-Xing Zhang, Rui Wang, Jin Xi, Lin Shen, An-You Zhu, Qi Qi, Qi-Yi Wang, Lun-Jun Zhang, Feng-Chao Wang, He-Zuo Lü, Jian-Guo H. Morroniside protects SK-N-SH human neuroblastoma cells against H2O2-induced damage. International journal of molecular medicine. vol 39. issue 3. 2017-03-15. PMID:28204825. |
thus, morroniside protects human neuroblastoma cells against oxidative damage by inhibiting ros production while suppressing bax and stimulating bcl-2 expression, thereby blocking mitochondrial-mediated apoptosis. |
2017-03-15 |
2023-08-13 |
human |
| Meng Lu, Yi Miao, Lan Qi, Mingzhu Bai, Jiarong Zhang, Youji Fen. RNAi-Mediated Downregulation of FKBP14 Suppresses the Growth of Human Ovarian Cancer Cells. Oncology research. vol 23. issue 6. 2017-03-14. PMID:27131312. |
moreover, knockdown of fkbp14 induced cell apoptosis via increasing the ratio of bax to bcl-2. |
2017-03-14 |
2023-08-13 |
human |
| XinGang Lu, Liu Yang, JingXian Chen, JiAn Zhou, XiaoDan Tang, YingGang Zhu, HongFu Qiu, Jie She. The action and mechanism of myrislignan on A549 cells in vitro and in vivo. Journal of natural medicines. vol 71. issue 1. 2017-03-14. PMID:27491743. |
the apoptosis and anti-cell proliferation was mediated by the activation of mitogen-activated protein kinase and the inhibition of epidermal growth factor receptor signal pathway, change of mitochondrial membrane potential, the releasing of c-myc, the downregulation of the level of the anti-apoptotic protein bcl-2, and the upregulation of the level of the pro-apoptotic protein bax. |
2017-03-14 |
2023-08-13 |
human |
| Yiyan Lei, Yulan Zhen, Wei Zhang, Xiuting Sun, Xiaoxiong Lin, Jianqiang Feng, Honghe Luo, Zhenguang Chen, Chunhua Su, Bo Zeng, Jingfu Che. Exogenous hydrogen sulfide exerts proliferation, anti-apoptosis, angiopoiesis and migration effects via activating HSP90 pathway in EC109 cells. Oncology reports. vol 35. issue 6. 2017-03-13. PMID:27108782. |
in addition, nahs treatment reduced apoptosis, as indicated by the increased bcl-2 expression and decreased cleaved caspase-3 and bax expression. |
2017-03-13 |
2023-08-13 |
Not clear |
| Hye-Sook Seo, Jin Mo Ku, Han-Seok Choi, Youn Kyung Choi, Jong-Kyu Woo, Minsoo Kim, Ilhwan Kim, Chang Hyeok Na, Hansol Hur, Bo-Hyoung Jang, Yong Cheol Shin, Seong-Gyu K. Quercetin induces caspase-dependent extrinsic apoptosis through inhibition of signal transducer and activator of transcription 3 signaling in HER2-overexpressing BT-474 breast cancer cells. Oncology reports. vol 36. issue 1. 2017-03-13. PMID:27175602. |
in contrast, quercetin did not induce apoptosis via intrinsic mitochondrial apoptosis pathway since this compound did not decrease the mitochondrial membrane potential and did not affect the levels of b-cell lymphoma 2 (bcl-2) and bcl-2-associated x protein (bax). |
2017-03-13 |
2023-08-13 |
Not clear |
| Jian-Ying Li, Jun Yu, Xu-Sheng Du, Hui-Min Zhang, Bo Wang, Hua Guo, Jie Bai, Juan-Hong Wang, An Liu, Yi-Li Wan. Safflower polysaccharide induces NSCLC cell apoptosis by inhibition of the Akt pathway. Oncology reports. vol 36. issue 1. 2017-03-13. PMID:27177149. |
results showed that sps suppressed the proliferation of a549 and ytmlc-90 cells and induced apoptosis by increasing mrna levels of bax and caspase-3, and inhibited tumor growth in vivo. |
2017-03-13 |
2023-08-13 |
mouse |
| Qiwei Chen, Liang Zhu, Bo Zheng, Jinliang Wang, Xishuang Song, Wei Zheng, Lina Wang, Deyong Yang, Jianbo Wan. Effect of AQP9 Expression in Androgen-Independent Prostate Cancer Cell PC3. International journal of molecular sciences. vol 17. issue 5. 2017-03-13. PMID:27187384. |
in addition, knockdown of aqp9 resulted in a significant decrease in the expression of the bcl-2 and with a notable increase in the expression of bax and cleaved caspase 3, indicated that aqp9 knockdown promoted apoptosis in prostate cancer cells. |
2017-03-13 |
2023-08-13 |
Not clear |
| Yonghuan Mao, Ling Xi, Quan Li, Zeling Cai, Yimei Lai, Xinhua Zhang, Chunzhao Y. Regulation of cell apoptosis and proliferation in pancreatic cancer through PI3K/Akt pathway via Polo-like kinase 1. Oncology reports. vol 36. issue 1. 2017-03-13. PMID:27220401. |
additionally, plk1 inhibition can lead to cancer cell apoptosis through inactivating xiap, activating caspase-3, upregulating bax and downregulating bcl-2. |
2017-03-13 |
2023-08-13 |
human |
| Sumit Kumar, Ramovatar Meena, Paulraj Rajaman. Fabrication of BSA-Green Tea Polyphenols-Chitosan Nanoparticles and Their Role in Radioprotection: A Molecular and Biochemical Approach. Journal of agricultural and food chemistry. vol 64. issue 30. 2017-03-13. PMID:27389300. |
tps reduce radiation-induced oxidative damage and apoptosis by restoring the redox status through the nrf2-erk pathway and reducing bax expression, respectively. |
2017-03-13 |
2023-08-13 |
mouse |
| Xiaohui Yang, Shuai Wang, Yunchuan Mu, Yixiong Zhen. Schisandrin B inhibits cell proliferation and induces apoptosis in human cholangiocarcinoma cells. Oncology reports. vol 36. issue 4. 2017-03-13. PMID:27499090. |
mechanistically, western blot analysis indicated that sch b induced apoptosis by upregulating bax, cleaved caspase-3, cleaved caspase-9 and cleaved parp, and by downregulating cyclin d1, bcl-2 and cdk-4. |
2017-03-13 |
2023-08-13 |
mouse |
| Ge Sheng Cheng, Yu Shun Zhang, Ting Ting Zhang, Lu He, Xing Ye Wan. Bone marrow-derived mesenchymal stem cells modified with IGFBP-3 inhibit the proliferation of pulmonary artery smooth muscle cells. International journal of molecular medicine. vol 39. issue 1. 2017-03-13. PMID:27959432. |
moreover, the igfbp‑3-modified hbm‑mscs promoted apoptosis and downregulated the expression of b-cell lymphoma-2 (bcl-2), but increased the expression of bcl-2 associated x protein (bax) in hpasmcs. |
2017-03-13 |
2023-08-13 |
human |
| Yichao Zhao, Longwei Xu, Zhiqing Qiao, Lingchen Gao, Song Ding, Xiaoying Ying, Yuanyuan Su, Nan Lin, Ben He, Jun P. YiXin-Shu, a ShengMai-San-based traditional Chinese medicine formula, attenuates myocardial ischemia/reperfusion injury by suppressing mitochondrial mediated apoptosis and upregulating liver-X-receptor α. Scientific reports. vol 6. 2017-03-10. PMID:26964694. |
mechanistically, yxs attenuated myocardial apoptosis by inhibiting the mitochondrial mediated apoptosis pathway (as reflected by inhibition of mitochondrial swelling, cytochrome c release and caspase-9 activity, and normalization of bcl-2 and bax levels) without altering the death receptor and endoplasmic reticulum-stress death pathways. |
2017-03-10 |
2023-08-13 |
mouse |
| Fang Zhang, Liang Wang, Jun-Jie Wang, Peng-Fei Luo, Xing-Tong Wang, Zhao-Fan Xi. The caspase-1 inhibitor AC-YVAD-CMK attenuates acute gastric injury in mice: involvement of silencing NLRP3 inflammasome activities. Scientific reports. vol 6. 2017-03-10. PMID:27053298. |
inhibiting caspase-1 activity in the nlrp3 inflammasome decreased gastric cell apoptosis, and the expression of bax and cleaved caspase-3. |
2017-03-10 |
2023-08-13 |
mouse |
| Edwin O Quisbert-Valenzuela, Gloria M Cala. Apoptotic effect of noscapine in breast cancer cell lines. International journal of oncology. vol 48. issue 6. 2017-03-10. PMID:27081867. |
bax is a protein pro-apoptotic enhancer of apoptosis in contrast to bcl-2 with antiapoptotic properties. |
2017-03-10 |
2023-08-13 |
Not clear |
| Edwin O Quisbert-Valenzuela, Gloria M Cala. Apoptotic effect of noscapine in breast cancer cell lines. International journal of oncology. vol 48. issue 6. 2017-03-10. PMID:27081867. |
our results showed that noscapine had lower toxicity in normal cells and was an effective anticancer agent that induced apoptosis in breast cancer cells because it increases bax gene and protein expression in three cell lines, while decreases bcl-xl gene expression, and bcl-2 protein expression decreased in breast cancer cell lines. |
2017-03-10 |
2023-08-13 |
Not clear |
| Shiyong Gao, Huixin Tan, Nan Zhu, Haiyu Gao, Chunyu Lv, Jian Gang, Yubin J. Oridonin induces apoptosis through the mitochondrial pathway in human gastric cancer SGC-7901 cells. International journal of oncology. vol 48. issue 6. 2017-03-10. PMID:27082253. |
apoptosis pathway was analyzed by western blot analysis of bcl-2, bax, cytochrome c and caspase-3 expression. |
2017-03-10 |
2023-08-13 |
human |
| Lili Wen, Fang Han, Yuxiu Shi, Xiaoyan L. Role of the Endoplasmic Reticulum Pathway in the Medial Prefrontal Cortex in Post-Traumatic Stress Disorder Model Rats. Journal of molecular neuroscience : MN. vol 59. issue 4. 2017-03-09. PMID:27112439. |
in addition, the er molecular chaperone 78-kda glucose-regulated protein (grp78) and the er-related apoptosis factors caspase family and bax also were examined. |
2017-03-09 |
2023-08-13 |
rat |
| Xi Peng, Kejie Chen, Jin Chen, Jing Fang, Hengmin Cui, Zhicai Zuo, Junliang Deng, Zhengli Chen, Yi Geng, Weimin La. Aflatoxin B1 affects apoptosis and expression of Bax, Bcl-2, and Caspase-3 in thymus and bursa of fabricius in broiler chickens. Environmental toxicology. vol 31. issue 9. 2017-03-08. PMID:25736028. |
aflatoxin b1 affects apoptosis and expression of bax, bcl-2, and caspase-3 in thymus and bursa of fabricius in broiler chickens. |
2017-03-08 |
2023-08-13 |
Not clear |
| Wanyun Zhao, Xiaoqi Pan, Tao Li, Changchun Zhang, Nian Sh. Lycium barbarum Polysaccharides Protect against Trimethyltin Chloride-Induced Apoptosis via Sonic Hedgehog and PI3K/Akt Signaling Pathways in Mouse Neuro-2a Cells. Oxidative medicine and cellular longevity. vol 2016. 2017-03-08. PMID:27143997. |
results showed that tmt treatment significantly enhanced apoptosis, upregulated proapoptotic bax, downregulated antiapoptotic bcl-2 expression, and increased caspase-3 activity in a dose-dependent manner in n2a cells. |
2017-03-08 |
2023-08-13 |
mouse |
| Hongmei Xu, Jihong Zhu, Cong Hu, Hua Song, Yiyang L. Inhibition of microRNA-181a may suppress proliferation and invasion and promote apoptosis of cervical cancer cells through the PTEN/Akt/FOXO1 pathway. Journal of physiology and biochemistry. vol 72. issue 4. 2017-03-08. PMID:27534652. |
in addition, inhibition of mir-181a promoted apoptosis of hela and caski cells due to increasing bax expression and decreasing bcl-2 expression. |
2017-03-08 |
2023-08-13 |
Not clear |