| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Milo\\xc5\\xa1 Stanojlovi\\xc4\\x87, Ivana Gu\\xc5\\xa1evac, Ivana Grkovi\\xc4\\x87, Nata\\xc5\\xa1a Mitrovi\\xc4\\x87, Jelena Zlatkovi\\xc4\\x87, Anica Horvat, Dunja Drakuli\\xc4\\x8. Repeated Estradiol Treatment Attenuates Chronic Cerebral Hypoperfusion-Induced Neurodegeneration in Rat Hippocampus. Cellular and molecular neurobiology. vol 36. issue 6. 2017-03-22. PMID:26689702.' |
the present study attempted to verify whether post-ischemic estradiol treatment (33.3 μg/kg for seven consecutive days) affects previously reported number of hippocampal apoptotic cells and amount of dna fragmentation characteristic for apoptosis as well as the expression of key elements within synaptosomal akt and erk signal transduction pathways (nf-κb, bax, bcl-2, cytochrome c, caspase 3, and parp). |
2017-03-22 |
2023-08-13 |
rat |
| Haidan Ni, Jiabing Shen, Yan Song, Maohong Cao, Xiaorong Liu, Jie Huang, Weidong Zhang, Lili Xie, Xiaojin Ning, Kaifu K. EP3, Prostaglandin E2 Receptor Subtype 3, Associated with Neuronal Apoptosis Following Intracerebral Hemorrhage. Cellular and molecular neurobiology. vol 36. issue 6. 2017-03-22. PMID:26718710. |
furthermore, the expression of these three proteins reduced active caspase-3 and bax expression, while increased bcl-2 were changed after knocking down ep3 by rna interference in pc12 cells, further confirmed that ep3 might exert its pro-apoptotic function on neuronal apoptosis. |
2017-03-22 |
2023-08-13 |
Not clear |
| Lei Yu, Jinghui Yang, Xin Wang, Bo Jiang, Yongxue Sun, Yubin J. Antioxidant and antitumor activities of Capparis spinosa L. and the related mechanisms. Oncology reports. vol 37. issue 1. 2017-03-22. PMID:27878299. |
the regulatory mechanism of hepg2 cell apoptosis induced by csqah involved the increase in ca2+ concentration and ros levels, a decrease in ca2+-mg2+-atpase activity in the hepg2 cells, and downregulation of anti-apoptotic bcl-2 expression, and upregulation of apoptotic bax expression. |
2017-03-22 |
2023-08-13 |
Not clear |
| b' Matja\\xc5\\xbe Novak, Bojana \\xc5\\xbdegura, \\xc5\\xa0pela Baebler, Alja \\xc5\\xa0tern, Ana Rotter, Katja Stare, Metka Filipi\\xc4\\x8. Influence of selected anti-cancer drugs on the induction of DNA double-strand breaks and changes in gene expression in human hepatoma HepG2 cells. Environmental science and pollution research international. vol 23. issue 15. 2017-03-21. PMID:26392091.' |
the analysis of the changes in the expression of genes involved in the response to dna damage (cdkn1a, gadd45a, mdm2), apoptosis (bax, bcl2) and oncogenesis (myc, jun) showed that 5-fu, cddp and et upregulated the genes involved in dna damage response, while the anti-apoptotic gene bcl2 and oncogene myc were downregulated. |
2017-03-21 |
2023-08-13 |
human |
| Zhan Shi, Ding Wu, Run Tang, Xiang Li, Renfu Chen, Song Xue, Chengjing Zhang, Xiaoqing Su. Silencing of HMGA2 promotes apoptosis and inhibits migration and invasion of prostate cancer cells. Journal of biosciences. vol 41. issue 2. 2017-03-21. PMID:27240983. |
our results showed that knockdown of hmga2 markedly inhibited cell proliferation; this reduced cell proliferation was due to the promotion of cell apoptosis as the bcl-xl was decreased, whereas bax was up-regulated. |
2017-03-21 |
2023-08-13 |
human |
| Yudan Cao, Fangfang Cheng, Weifeng Yao, Beihua Bao, Kaicheng Zhang, Li Zhang, Anwei Din. Toxicity of Pekinenin C from Euphorbia Pekinensis Radix on Rat Small Intestinal Crypt Epithelial Cell and Its Apoptotic Mechanism. International journal of molecular sciences. vol 17. issue 6. 2017-03-21. PMID:27271594. |
the apoptosis mechanism of pekinenin c on iec-6 was investigated through assaying the activities of caspase-3, 8, 9 by enzyme-linked immunosorbent assay (elisa), protein expression of bax, bcl-2, apoptosis-inducing factor (aif), apaf-1, fas-associated death domain (fadd) and type 1-associated death domain (tradd) by western-blot, mrna expression of fas receptor (fasr), fas ligand (fasl), tumor necrosis factor receptor (tnfr1) and nf-κb by rt-pcr. |
2017-03-21 |
2023-08-13 |
rat |
| Yudan Cao, Fangfang Cheng, Weifeng Yao, Beihua Bao, Kaicheng Zhang, Li Zhang, Anwei Din. Toxicity of Pekinenin C from Euphorbia Pekinensis Radix on Rat Small Intestinal Crypt Epithelial Cell and Its Apoptotic Mechanism. International journal of molecular sciences. vol 17. issue 6. 2017-03-21. PMID:27271594. |
additionally, pekinenin c could increase the expressions of bax, aif, apaf-1, fasr, fasl, tnfr1 and nf-κb, suppress the expression of bcl-2, fadd and tradd, then activate caspase-3, 8, 9 cascades, and at last result in apoptosis. |
2017-03-21 |
2023-08-13 |
rat |
| Hongxia Li, Li Juan, Leiming Xia, Yi Wang, Yangyi Bao, Guoping Su. Thioridazine Sensitizes Esophageal Carcinoma Cell Lines to Radiotherapy-Induced Apoptosis In Vitro and In Vivo. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2017-03-21. PMID:27453171. |
in addition, thioridazine and irradiation treatment induced apoptosis through up-regulation of cleaved capase-3 and 9, as well as an increase in the expression of bax and bak and a decrease in the expression of bcl-2 and bcl-xl. |
2017-03-21 |
2023-08-13 |
mouse |
| Y B Ji, G S Xin, Z Y Qu, X Zou, M Y. Mechanism of juglone-induced apoptosis of MCF-7 cells by the mitochondrial pathway. Genetics and molecular research : GMR. vol 15. issue 3. 2017-03-21. PMID:27525860. |
the results suggest that the mechanism of juglone-induced apoptosis in mcf-7 cells is characterized by elevated ros levels, reduced bcl-2 expression, increased bax expression, decreased mitochondrial membrane potential, increased intracellular ca(2+) concentration, outer mitochondrial-membrane rupture, cytochrome c release, and caspase-3 activation. |
2017-03-21 |
2023-08-13 |
human |
| T V Ilchibaeva, A S Tsybko, R V Kozhemyakina, V S Naumenk. [Expression of apoptosis genes in the brain of rats with genetically defined fear-induced aggression]. Molekuliarnaia biologiia. vol 50. issue 5. 2017-03-21. PMID:27830683. |
in the present work, the expression of the genes that encode main pro- and antiapoptotic bax and bcl-xl proteins, as well as caspase 3 (the main effector of apoptosis), in different brain structures of rats that were selected on a high aggression towards human (or its absence) was studied. |
2017-03-21 |
2023-08-13 |
human |
| T V Ilchibaeva, A S Tsybko, R V Kozhemyakina, V S Naumenk. [Expression of apoptosis genes in the brain of rats with genetically defined fear-induced aggression]. Molekuliarnaia biologiia. vol 50. issue 5. 2017-03-21. PMID:27830683. |
it is assumed that an increase in the bcl-xl gene expression (accompanied by a decrease in the bax gene expression) can indicate an increase in the threshold of neuronal apoptosis in highly aggressive rats. |
2017-03-21 |
2023-08-13 |
human |
| Eun Gyeong Lim, Guen Tae Kim, Se Hee Lee, Sang-Yong Kim, Young Min Ki. Apoptotic effects of extract from Cnidium monnieri (L.) Cusson by adenosine monosphosphate-activated protein kinase-independent pathway in HCT116 colon cancer cells. Molecular medicine reports. vol 13. issue 6. 2017-03-20. PMID:27082059. |
the present study demonstrated that cme induced the release of ldh and apoptosis through its inhibition of p‑akt to control bcl‑2 and activate bax and bak. |
2017-03-20 |
2023-08-13 |
Not clear |
| Jeyce K F Andrade, Márcia I F Souza, Manoel A Gomes Filho, Diogo M F Silva, André L S Barros, Maria D Rodrigues, Paulo B N Silva, Silene C Nascimento, Jaciana S Aguiar, Dalci J Brondani, Gardênia C G Militão, Teresinha G Silv. N-pentyl-nitrofurantoin induces apoptosis in HL-60 leukemia cell line by upregulating BAX and downregulating BCL-xL gene expression. Pharmacological reports : PR. vol 68. issue 5. 2017-03-20. PMID:27505854. |
n-pentyl-nitrofurantoin induces apoptosis in hl-60 leukemia cell line by upregulating bax and downregulating bcl-xl gene expression. |
2017-03-20 |
2023-08-13 |
Not clear |
| Chunling Fu, Yanqing Gong, Xuanxuan Shi, Zengtian Sun, Mingshan Niu, Wei Sang, Linyan Xu, Feng Zhu, Ying Wang, Kailin X. Plumbagin reduces chronic lymphocytic leukemia cell survival by downregulation of Bcl-2 but upregulation of the Bax protein level. Oncology reports. vol 36. issue 3. 2017-03-17. PMID:27461100. |
molecularly, plumbagin markedly induced cll cell apoptosis through reduction of bcl-2, but through an increase in the bax protein level. |
2017-03-17 |
2023-08-13 |
Not clear |
| Jianwei Zhu, Ya Yang, Sihong Liu, Huihua Xu, Yong Wu, Guiqiang Zhang, Yuxuan Wang, Yan Wang, Yamin Liu, Qifeng Gu. Anticancer effect of thalidomide in vitro on human osteosarcoma cells. Oncology reports. vol 36. issue 6. 2017-03-17. PMID:27748909. |
thalidomide was added to osteosarcoma cells and studied by cytotoxicity assay, evaluating apoptosis, cell cycle arrest, mitochondrial membrane potential (ΔΨm), and reactive oxygen species (ros) levels and the expression of bcl‑2, bax, caspase‑3 and nf‑κb. |
2017-03-17 |
2023-08-13 |
human |
| Yali Chen, Qianxiang Zhou, Lei Zhang, Ran Wang, Meihua Jin, Yuling Qiu, Dexin Kon. Idelalisib induces G1 arrest and apoptosis in chronic myeloid leukemia K562 cells. Oncology reports. vol 36. issue 6. 2017-03-17. PMID:27748929. |
furthermore, idelalisib induced apoptosis in the k562 cells, with increased expression of pro-apoptotic molecules such as bad and bax, cleavage of caspase-9, -8 and -3, and parp, in contrast to downregulation of anti-apoptotic protein bcl-2. |
2017-03-17 |
2023-08-13 |
Not clear |
| Lin Xu, Zhu Wang, Shan-Yang He, Su-Fen Zhang, Hong-Jiao Luo, Kai Zhou, Xiao-Fei Li, Shao-Peng Qiu, Kai-Yuan Ca. Bax-interacting factor-1 inhibits cell proliferation and promotes apoptosis in prostate cancer cells. Oncology reports. vol 36. issue 6. 2017-03-17. PMID:27748942. |
bax-interacting factor-1 (bif-1) is a member of endophilin family, which binds to and activates the bax protein in response to the apoptosis signaling pathway. |
2017-03-17 |
2023-08-13 |
Not clear |
| Yongsheng Yang, Qiumei Dong, Rongheng L. Matrine induces the apoptosis of fibroblast-like synoviocytes derived from rats with collagen-induced arthritis by suppressing the activation of the JAK/STAT signaling pathway. International journal of molecular medicine. vol 39. issue 2. 2017-03-16. PMID:28035365. |
the effects of matrine on apoptosis induction were further confirmed by observations that bcl-2 levels were decreased, whereas bax and caspase-3 levels were increased in the matrine-treated synovial tissues and fls. |
2017-03-16 |
2023-08-13 |
rat |
| K F Liu, Y X Sha. Effects of siRNA-mediated silencing of Sal-like 4 expression on proliferation and apoptosis of prostate cancer C4-2 cells. Genetics and molecular research : GMR. vol 15. issue 2. 2017-03-15. PMID:27323021. |
the influence of sall4 on apoptosis was assessed with flow cytometry, and the expression of apoptosis-related proteins b-cell lymphoma 2 (bcl-2) and bcl-like-protein 4 (bax) were detected by western blot. |
2017-03-15 |
2023-08-13 |
Not clear |
| K F Liu, Y X Sha. Effects of siRNA-mediated silencing of Sal-like 4 expression on proliferation and apoptosis of prostate cancer C4-2 cells. Genetics and molecular research : GMR. vol 15. issue 2. 2017-03-15. PMID:27323021. |
silencing sall4 expression by using sirna technology inhibited the proliferation and colony formation of c4-2 cells, and promoted apoptosis likely mediated by bcl-2 and bax expression. |
2017-03-15 |
2023-08-13 |
Not clear |