| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chen Yang, Xiaojuan Liu, Fangfang Yang, Weixun Zhang, Zihao Chen, Daliang Yan, Qingsheng You, Xiang W. Mitochondrial phosphatase PGAM5 regulates Keap1-mediated Bcl-xL degradation and controls cardiomyocyte apoptosis driven by myocardial ischemia/reperfusion injury. In vitro cellular & developmental biology. Animal. vol 53. issue 3. 2017-03-30. PMID:27815660. |
though pgam5 is known to be required for inducing intrinsic apoptosis through interacting with bcl2 associated x protein (bax) and dynamin-related protein 1 (drp1), the expression and role of pgam5 in cardiomyocyte apoptosis driven by myocardial ischemia/reperfusion injury(miri) has not been studied. |
2017-03-30 |
2023-08-13 |
Not clear |
| Ebrahim Hosseini, Seyed Younes Hosseini, Tayebeh Hashempour, Mohammad-Reza Fattahi, Majid Sadeghizade. Effect of RGD coupled MDA-7/IL-24 on apoptosis induction in a hepatocellular carcinoma cell line. Molecular medicine reports. vol 15. issue 1. 2017-03-30. PMID:27959433. |
the expression level of the pro‑apoptotic dna damage inducible transcript 3 (gadd153) and bcl2 associated x apoptosis regulator (bax) genes in the different groups were compared by reverse transcription-quantitative polymerase chain reaction. |
2017-03-30 |
2023-08-13 |
Not clear |
| Shujun Feng, Ye Jin, Mengjiao Cui, Jianhua Zhen. Lysine-Specific Demethylase 1 (LSD1) Inhibitor S2101 Induces Autophagy via the AKT/mTOR Pathway in SKOV3 Ovarian Cancer Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2017-03-29. PMID:27914215. |
results our results show that the proportion of early apoptotic and late apoptotic cells increased significantly for cells treated with s2101 at a concentration of 100 μm for 48 h. treatment of s2101 in skov3 cells resulted in upregulation of bax and downregulation of bcl-2 in a time-dependent manner, indicating that s2101 can induce apoptosis in skov3. |
2017-03-29 |
2023-08-13 |
Not clear |
| Younan Ren, Shanjun Tao, Shuguo Zheng, Mengqiu Zhao, Yuanmei Zhu, Jieren Yang, Yuanjie W. Salvianolic acid B improves vascular endothelial function in diabetic rats with blood glucose fluctuations via suppression of endothelial cell apoptosis. European journal of pharmacology. vol 791. 2017-03-28. PMID:27614127. |
sal b effectively reduced vascular endothelial cell apoptosis, with bcl-2 protein up-regulated and bax protein down-regulated markedly. |
2017-03-28 |
2023-08-13 |
rat |
| Chunhui Yang, Hong Cai, Xiuxiang Men. Polyphyllin D induces apoptosis and differentiation in K562 human leukemia cells. International immunopharmacology. vol 36. 2017-03-27. PMID:27104314. |
polyphyllin d induced apoptosis via the mitochondrial apoptotic pathway, as evidenced by the decreased bcl-2 and bcr/abl expression levels, the disruption of mmp and increased bax, cytochrome c and cleaved-caspase-3 levels. |
2017-03-27 |
2023-08-13 |
human |
| Lian-Yun Chen, Qin Chen, Xiao-Jing Zhu, De-Song Kong, Li Wu, Jiang-Juan Shao, Shi-Zhong Zhen. Diallyl trisulfide protects against ethanol-induced oxidative stress and apoptosis via a hydrogen sulfide-mediated mechanism. International immunopharmacology. vol 36. 2017-03-27. PMID:27107369. |
additionally, dats inhibited hepatocyte apoptosis via down-regulating bax expression and up-regulating bcl-2 expression, and attenuated alcohol-induced caspase-dependent apoptosis. |
2017-03-27 |
2023-08-13 |
human |
| Leila H Sayed, Gamal Badr, Hossam M Omar, Ali M Abd El-Rahim, Mohamed H Mahmou. Camel whey protein improves oxidative stress and histopathological alterations in lymphoid organs through Bcl-XL/Bax expression in a streptozotocin-induced type 1 diabetic mouse model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 88. 2017-03-27. PMID:28129627. |
additionally, supplementation of diabetic mice with cwp improvement in the architecture of lymphoid tissues and rescued from apoptosis through direct effects on the bax and bcl-xl proteins. |
2017-03-27 |
2023-08-13 |
mouse |
| Sairong Fan, Junfeng Zhang, Wenjian Nie, Wenyuan Zhou, Liqin Jin, Xiaoming Chen, Jianxin L. Antitumor effects of polysaccharide from Sargassum fusiforme against human hepatocellular carcinoma HepG2 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 102. 2017-03-27. PMID:28131629. |
sfps exerted a stimulatory effect on apoptosis of hepg2 cells, increased the expression of bax, and decreased the expression of bcl-2. |
2017-03-27 |
2023-08-13 |
mouse |
| Zhi Cui, Ye Cui, Shuting Yang, Gan Luo, Yang Wang, Yixin Lou, Xinhua Su. KLK4 silencing inhibits the growth of oral squamous cell carcinoma through Wnt/β-catenin signaling pathway. Cell biology international. vol 41. issue 4. 2017-03-27. PMID:28150891. |
additionally, apoptosis of oscc cells was enhanced by klk4 silencing, with increased protein levels of cleaved parp, cleaved caspase-3, bax and decreased levels of bcl-2. |
2017-03-27 |
2023-08-13 |
Not clear |
| Cuilan Hou, Wenguang Li, Zengyou Li, Jing Gao, Zhenjie Chen, Xiqiong Zhao, Yaya Yang, Xiaoyu Zhang, Yong Son. Synthetic Isoliquiritigenin Inhibits Human Tongue Squamous Carcinoma Cells through Its Antioxidant Mechanism. Oxidative medicine and cellular longevity. vol 2017. 2017-03-27. PMID:28203317. |
the associated regulatory mechanisms were examined using fcm and fluorescence microscopy for intracellular reactive oxygen species (ros) generation, gelatin zymography assay for matrix metalloproteinase (mmp) activities, and western blot for apoptosis regulatory proteins (bcl-2 and bax). |
2017-03-27 |
2023-08-13 |
human |
| Can Chen, Sarah Zingales, Ting Wang, Mingyong Yuan, Dan Wang, Lulu Cai, Qinglin Jian. Synthesis and in vitro evaluation of 4-substituted furano[3,2-c] tetrahydroquinolines as potential anti-cancer agents. Journal of enzyme inhibition and medicinal chemistry. vol 31. issue 5. 2017-03-24. PMID:26207511. |
in addition, 10a induced murine c6 glioma cell apoptosis in a dose-dependent manner by up-regulating the expression of bax, caspase-3, and caspase-9, and by down-regulating bcl-2. |
2017-03-24 |
2023-08-13 |
Not clear |
| Lijian Han, Yaohui Ni, Maohong Cao, Liang Zhu, Aihua Dai, Zhiwei Xu, Xiaorong Liu, Rongrong Chen, Xiaojin Ning, Kaifu K. A New Role Discovered for IGTP: The Protective Effect of IGTP in ICH-Induced Neuronal Apoptosis. Cellular and molecular neurobiology. vol 36. issue 5. 2017-03-24. PMID:26242173. |
finally, in vitro study, knocking down igtp with igtp-specific sirna promoted active-caspase-3, p-gsk-3β, and bax expression, and led to more severe neuronal apoptosis after ich. |
2017-03-24 |
2023-08-13 |
Not clear |
| Kai Yao, Junfeng Wu, Jianfeng Zhang, Jimei Bo, Zhen Hong, Hengbing Z. Protective Effect of DHT on Apoptosis Induced by U18666A via PI3K/Akt Signaling Pathway in C6 Glial Cell Lines. Cellular and molecular neurobiology. vol 36. issue 5. 2017-03-24. PMID:26340949. |
dht may inhibit u18666a-induced apoptosis by regulating downstream apoptosis-related proteins including seladin-1, caspase-3, bcl-xl, and bax through activation of the pi3k/akt signal pathway. |
2017-03-24 |
2023-08-13 |
Not clear |
| Monika Bhardwaj, Na-Hyung Kim, Souren Paul, Rekha Jakhar, Jaehong Han, Sun Chul Kan. 5-Hydroxy-7-Methoxyflavone Triggers Mitochondrial-Associated Cell Death via Reactive Oxygen Species Signaling in Human Colon Carcinoma Cells. PloS one. vol 11. issue 4. 2017-03-24. PMID:27116119. |
treatment of hct-116 cells with hmf caused dna damage and triggered mitochondrial membrane perturbation accompanied by cyt c release, down-regulation of bcl-2, activation of bid and bax, and caspase-3-mediated apoptosis. |
2017-03-24 |
2023-08-13 |
human |
| Manel Boussabbeh, Intidhar Ben Salem, Faicel Belguesmi, Fadwa Neffati, Mohamed Fadhel Najjar, Salwa Abid-Essefi, Hassen Bach. Crocin protects the liver and kidney from patulin-induced apoptosis in vivo. Environmental science and pollution research international. vol 23. issue 10. 2017-03-23. PMID:26856859. |
the analysis of the protein expression in these organs revealed that pat-induced toxicity promotes the induction of apoptosis via the increase in p53, bax, and cytochrome c and the decrease in bcl2 expressions. |
2017-03-23 |
2023-08-13 |
mouse |
| Myoung-Sun Lee, Seon-Ok Lee, Sung-Hoon Kim, Eun-Ok Lee, Hyo-Jeong Le. Anti-Cancer Effect of Lambertianic Acid by Inhibiting the AR in LNCaP Cells. International journal of molecular sciences. vol 17. issue 7. 2017-03-23. PMID:27399684. |
la induced apoptosis and the expression of related proteins, including cleaved caspase-9 and -3, c-parp and bax, and inhibited bcl-2. |
2017-03-23 |
2023-08-13 |
Not clear |
| Nehal M Elsherbiny, Nahla N Younis, Mohamed A Shaheen, Mohamed M Elseweid. The synergistic effect between vanillin and doxorubicin in ehrlich ascites carcinoma solid tumor and MCF-7 human breast cancer cell line. Pathology, research and practice. vol 212. issue 9. 2017-03-23. PMID:27493101. |
it also offered an in-vitro growth inhibitory effect and cytotoxicity mediated by apoptosis (increased caspase-9 and bax:bcl-2 ratio) along with anti-metasasis effect. |
2017-03-23 |
2023-08-13 |
mouse |
| Qiao-Li Lv, Lei Hu, Shu-Hui Chen, Bao Sun, Meng-Long Fu, Chong-Zhen Qin, Qiang Qu, Gui-Hua Wang, Chen-Jie He, Hong-Hao Zho. A Long Noncoding RNA ZEB1-AS1 Promotes Tumorigenesis and Predicts Poor Prognosis in Glioma. International journal of molecular sciences. vol 17. issue 9. 2017-03-23. PMID:27589728. |
additionally, forced down-regulation of zeb1-as1 could dramatically promote apoptosis by increasing the expression level of bax and reducing bcl-2 expression in glioma. |
2017-03-23 |
2023-08-13 |
Not clear |
| Bo Wang, Xin-Huai Zha. Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells. Oncology reports. vol 37. issue 2. 2017-03-23. PMID:27959417. |
with this mechanism, apigenin resulted in the hct-116 cells with enhanced intracellular ros generation and ca2+ release together with damaged mitochondrial membrane, and upregulated protein expression of chop, dr5, cleaved bid, bax, cytochrome c, cleaved caspase-3, cleaved caspase-8 and cleaved caspase-9, which triggered apoptosis of the cells. |
2017-03-23 |
2023-08-13 |
human |
| Chen Zhang, Ping Gong, Pengfei Liu, Ning Zhou, Yulai Zhou, Yi Wan. Thioridazine elicits potent antitumor effects in colorectal cancer stem cells. Oncology reports. vol 37. issue 2. 2017-03-23. PMID:28000884. |
the expression of some apoptosis genes (bax and caspase-3) was upregulated after treatment with thio, while that of the anti-apoptosis gene bcl-2 was downregulated. |
2017-03-23 |
2023-08-13 |
human |