| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andresa Borges Soares, Elizabeth Ferreira Martinez, Patricia Fernandes Avila Ribeiro, Icleia Siqueira Barreto, Maria Cássia Aguiar, Cristiane Furuse, Marcelo Sperandio, Victor Angelo Montalli, Ney Soares de Araújo, Vera Cavalcanti de Araúj. Factors that may influence polymorphous low-grade adenocarcinoma growth. Virchows Archiv : an international journal of pathology. vol 470. issue 4. 2017-04-06. PMID:28188441. |
we analyzed 31 cases of plga using immunohistochemistry to antibodies against cd34 and cd105 to detect blood vessels; against d2-40 to detect lymphatic vessels; against bax, bcl-2, and survivin to explore cell apoptosis; and against beclin and lcb3 to investigate autophagy and against p21 and p16 to assess senescence. |
2017-04-06 |
2023-08-13 |
Not clear |
| Néstor Méndez Palacios, María Elena Ayala Escobar, Maximino Méndez Mendoza, Rubén Huerta Crispín, Octavio Guerrero Andrade, Javier Hernández Melández, Andrés Aragón Martíne. Prepubertal male rats with high rates of germ-cell apoptosis present exacerbated rates of germ-cell apoptosis after serotonin depletion. Reproduction, fertility, and development. vol 28. issue 6. 2017-04-05. PMID:25486044. |
bax and shbg mrna levels were higher in rats with high rates of germ-cell apoptosis. |
2017-04-05 |
2023-08-13 |
rat |
| Néstor Méndez Palacios, María Elena Ayala Escobar, Maximino Méndez Mendoza, Rubén Huerta Crispín, Octavio Guerrero Andrade, Javier Hernández Melández, Andrés Aragón Martíne. Prepubertal male rats with high rates of germ-cell apoptosis present exacerbated rates of germ-cell apoptosis after serotonin depletion. Reproduction, fertility, and development. vol 28. issue 6. 2017-04-05. PMID:25486044. |
in rats with high rates of germ-cell apoptosis bax mrna expression remained high after treatment with pca. |
2017-04-05 |
2023-08-13 |
rat |
| Maryam Jalayeri, Afshin Pirnia, Elaheh Poorazizi Najafabad, Ali Mohammad Varzi, Mohammadreza Gholam. Evaluation of alginate hydrogel cytotoxicity on three-dimensional culture of type A spermatogonial stem cells. International journal of biological macromolecules. vol 95. 2017-04-05. PMID:27984148. |
after one month of encapsulation and culture in dmem culture medium containing 10ng/ml gdnf, cells were removed from hydrogel and were examined for viability, cell morphology and structure, cytotoxicity and expression of apoptosis genes fas, p53, bax, bcl2, caspase3 by staining with trypan blue, scanning electron microscopy, ldh test, and real time pcr, respectively. |
2017-04-05 |
2023-08-13 |
mouse |
| Yaqiong Zhang, Zhihua Cheng, Changli Wang, Hongda Ma, Weihong Meng, Qingchun Zha. Neuroprotective Effects of Kukoamine a against Radiation-induced Rat Brain Injury through Inhibition of Oxidative Stress and Neuronal Apoptosis. Neurochemical research. vol 41. issue 10. 2017-04-04. PMID:27241194. |
kua decreased malondialdehyde (mda) level, increased glutathione (gsh) level, superoxide dismutase (sod) and catalase (cat) activities, as well as alleviated neuronal apoptosis by regulating the expression of cleaved caspase-3, cytochrome c, bax and bcl-2. |
2017-04-04 |
2023-08-13 |
rat |
| Nesstor Pilco-Ferreto, Gloria M Cala. Influence of doxorubicin on apoptosis and oxidative stress in breast cancer cell lines. International journal of oncology. vol 49. issue 2. 2017-04-04. PMID:27278553. |
results also indicated that dox induced apoptosis by upregulating bax, caspase-8 and caspase-3 and downregulation of bcl-2 protein expression. |
2017-04-04 |
2023-08-13 |
Not clear |
| Yi Feng, Huaqing Xue, Jie Zhu, Likun Yang, Feng Zhang, Rong Qian, Wei Lin, Yuhai Wan. ESE1 is Associated with Neuronal Apoptosis in Lipopolysaccharide Induced Neuroinflammation. Neurochemical research. vol 41. issue 10. 2017-04-04. PMID:27350582. |
in vitro, ese1 depletion in cortical primary neurons inhibited active caspase-3 and bax expression as well as lactate dehydrogenase (ldh) release with up-regulation of bcl-2, while ese1 overexpression can exert opposite effects, indicating that ese1 promoted neuronal apoptosis induced by lps or lps exposed microglia conditioned media (cm). |
2017-04-04 |
2023-08-13 |
Not clear |
| Magdalena Dziegala, Monika Kasztura, Kamil Kobak, Jacek Bania, Waldemar Banasiak, Piotr Ponikowski, Ewa A Jankowsk. Influence of the availability of iron during hypoxia on the genes associated with apoptotic activity and local iron metabolism in rat H9C2 cardiomyocytes and L6G8C5 skeletal myocytes. Molecular medicine reports. vol 14. issue 4. 2017-04-04. PMID:27599775. |
the mrna expression levels of markers of apoptosis [b‑cell lymphoma‑2 (bcl2; inhibition) and bcl‑2‑activated x protein (bax; induction)], atrophy (atrogin), glycolysis (pyruvate kinase 2; pkm2) and iron metabolism [transferrin receptor 1 (tfr1; iron importer), ferroportin 1 (fpn1; iron exporter), ferritin heavy chain (fth; iron storage protein) and hepcidin (hamp; iron regulator)] were determined using reverse transcription‑quantitative polymerase chain reaction, and cell viability was measured using an tetrazolium reduction assay. |
2017-04-04 |
2023-08-13 |
rat |
| Jun Feng, Shusheng Li, Huawen Che. Tanshinone IIA inhibits myocardial remodeling induced by pressure overload via suppressing oxidative stress and inflammation: Possible role of silent information regulator 1. European journal of pharmacology. vol 791. 2017-04-04. PMID:27693799. |
tan conferred cardioprotective effects by improving cardiac function, reducing apoptosis and myocardial remodeling, upregulating sirt1, bcl-2 expressions, and downregulating bax and caspase-3 expressions. |
2017-04-04 |
2023-08-13 |
rat |
| Qi-Rui Fu, Wei Song, Yi-Tao Deng, Hua-Liang Li, Xiao-Mei Mao, Chen-Lu Lin, Ya-Hui Zheng, Shu-Ming Chen, Qiong-Hua Chen, Qing-Xi Che. ESC-3 induces apoptosis of human ovarian carcinomas through Wnt/β-catenin and Notch signaling in vitro and in vivo. International journal of oncology. vol 50. issue 1. 2017-04-04. PMID:27878242. |
esc-3 could significantly upregulate the expression of bax proteins while bcl-2 protein remained unchanged, resulting in the elevation of bax/bcl-2 ratio, which usually could induce apoptosis. |
2017-04-04 |
2023-08-13 |
human |
| Yong Zhang, Yu-Lin Wen, Ji-Wei Ma, Jie-Cheng Ye, Xiao Wang, Jian-Xian Huang, Chao-Yue Meng, Xiao-Ze Xu, Shao-Xiang Wang, Xue-Yun Zhon. Tetrandrine inhibits glioma stem-like cells by repressing β-catenin expression. International journal of oncology. vol 50. issue 1. 2017-04-04. PMID:27909720. |
importantly, tet treatment significantly repressed the nuclear translocation and expression of β-catenin and induced apoptosis in gslcs, as indicated in part by the upregulation of bax, the cleavage of parp and the downregulation of bcl-2. |
2017-04-04 |
2023-08-13 |
human |
| Bi Liu, Ming Lei, Tao Hu, Fei Yu, De-Ming Xiao, Hao Kan. Inhibitory effects of SRT1720 on the apoptosis of rabbit chondrocytes by activating SIRT1 via p53/bax and NF-κB/PGC-1α pathways. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 36. issue 3. 2017-04-03. PMID:27376802. |
with the srt1720 concentration increasing, the chondrocyte viability increased, the apoptosis rate decreased, the protein expression levels of sirt1 and pgc-1α and the mrna expression levels of type ii collagen and aggrecan increased ({ptp}<0.05), and the expression levels of p53, nf-κb and bax decreased (p<0.05). |
2017-04-03 |
2023-08-13 |
rabbit |
| Dorrah Deeb, Xiaohua Gao, Yongbo Liu, Yiguan Zhang, Jiajiu Shaw, Frederick A Valeriote, Subhash C Gauta. The inhibition of cell proliferation and induction of apoptosis in pancreatic ductal adenocarcinoma cells by verrucarin A, a macrocyclic trichothecene, is associated with the inhibition of Akt/NF-кB/mTOR prosurvival signaling. International journal of oncology. vol 49. issue 3. 2017-04-03. PMID:27573873. |
vc-a also induced mitochondrial depolarization and release of cytochrome c and it inhibited bcl-2 family proteins that regulate apoptosis (bcl-2, bcl-xl, bax and bad). |
2017-04-03 |
2023-08-13 |
Not clear |
| Arijit Mondal, Tanmoy Guria, Tapan Kumar Maity, Anupam Bishaye. A Novel Tetraenoic Fatty Acid Isolated from Amaranthus spinosus Inhibits Proliferation and Induces Apoptosis of Human Liver Cancer Cells. International journal of molecular sciences. vol 17. issue 10. 2017-04-03. PMID:27669220. |
the novel fatty acid also induced apoptosis mediated by downregulation of cyclin b1, upregulation of bax, and downregulation of bcl-2, resulting in the g₂/m transition arrest. |
2017-04-03 |
2023-08-13 |
human |
| Lei Wang, Wanhai Qin, Jing Zhang, Chuntong Bao, Hu Zhang, Yanyi Che, Changjiang Sun, Jingmin Gu, Xin Feng, Chongtao Du, Wenyu Han, Paul Langford Richard, Liancheng Le. Adh enhances Actinobacillus pleuropneumoniae pathogenicity by binding to OR5M11 and activating p38 which induces apoptosis of PAMs and IL-8 release. Scientific reports. vol 6. 2017-03-31. PMID:27046446. |
subsequently, pams apoptosis via the activation of the fax and bax signaling pathways was observed, followed by activation of caspases 8, 9, and 3. |
2017-03-31 |
2023-08-13 |
Not clear |
| Ju-Fang Liu, Chien-Yu Chen, Hsien-Te Chen, Chih-Shiang Chang, Chih-Hsin Tan. BL-038, a Benzofuran Derivative, Induces Cell Apoptosis in Human Chondrosarcoma Cells through Reactive Oxygen Species/Mitochondrial Dysfunction and the Caspases Dependent Pathway. International journal of molecular sciences. vol 17. issue 9. 2017-03-31. PMID:27618007. |
furthermore, bl-038 decreased mitochondrial membrane potential (mmp) and changed mitochondrial-related apoptosis, by downregulating the anti-apoptotic activity members (bcl-2, bcl-xl) and upregulating pro-apoptotic members (bax, bak) of the b-cell lymphoma 2 (bcl-2) family of proteins, key regulators of the apoptotic machinery in cells. |
2017-03-31 |
2023-08-13 |
human |
| Congpin Wang, Bin Wan. Ginkgo Biloba Extract Attenuates Oxidative Stress and Apoptosis in Mouse Cochlear Neural Stem Cells. Phytotherapy research : PTR. vol 30. issue 5. 2017-03-30. PMID:26799058. |
moreover, the anti-apoptotic role of gbe was mediated by antagonizing the intrinsic mitochondrial apoptotic pathway, where gbe could reverse the changes in key intrinsic apoptosis pathway factors including bcl-2, bax, and caspase-3. |
2017-03-30 |
2023-08-13 |
mouse |
| Meijuan Chen, Yuanyuan Guo, Ruolin Zhao, Xiaoxia Wang, Miao Jiang, Haian Fu, Xu Zhan. Ophiopogonin B induces apoptosis, mitotic catastrophe and autophagy in A549 cells. International journal of oncology. vol 49. issue 1. 2017-03-30. PMID:27175570. |
detection by high content screening (hcs) and tunel assay verified that op-b induced apoptosis in this cell line, while detection of caspase-3, bcl-2 and bax showed that op-b induced cell death was caspase and mitochondrial independent. |
2017-03-30 |
2023-08-13 |
Not clear |
| Seong-Kyu Kim, Jung-Yoon Choe, Ki-Yeun Par. Enhanced p62 Is Responsible for Mitochondrial Pathway-Dependent Apoptosis and Interleukin-1β Production at the Early Phase by Monosodium Urate Crystals in Murine Macrophage. Inflammation. vol 39. issue 5. 2017-03-30. PMID:27271513. |
the induction of mitochondrial apoptosis in raw 264.7 murine macrophages by msu crystals was measured using western blotting and quantitative real-time polymerase chain reaction for bax, caspase-3, caspase-9, or parp1, and by flow cytometric analysis. |
2017-03-30 |
2023-08-13 |
Not clear |
| Néstor Prieto-Domínguez, Raquel Ordóñez, Anna Fernández, Carolina Méndez-Blanco, Anna Baulies, Carmen Garcia-Ruiz, José C Fernández-Checa, José L Mauriz, Javier González-Galleg. Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy. Journal of pineal research. vol 61. issue 3. 2017-03-30. PMID:27484637. |
co-administration of 2.5 μmol/l sorafenib and 1 mmol/l melatonin induced apoptosis in hep3b cells, increasing parp hydrolysis and bax expression. |
2017-03-30 |
2023-08-13 |
human |