| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ziwei Miao, Fei Yu, Yahao Ren, Jun Yan. d,l-Sulforaphane Induces ROS-Dependent Apoptosis in Human Gliomablastoma Cells by Inactivating STAT3 Signaling Pathway. International journal of molecular sciences. vol 18. issue 1. 2017-04-13. PMID:28054986. |
cell viability assays, flow cytometry, immunofluorescence, and western blot results revealed that sfn could induced apoptosis of gbm cells in a dose- and time-dependent manner, via up-regulation of caspase-3 and bax, and down-regulation of bcl-2. |
2017-04-13 |
2023-08-13 |
human |
| Wei Ye, Yuchan Chen, Haohua Li, Weimin Zhang, Hongxin Liu, Zhanghua Sun, Taomei Liu, Saini L. Two Trichothecene Mycotoxins from Myrothecium roridum Induce Apoptosis of HepG-2 Cells via Caspase Activation and Disruption of Mitochondrial Membrane Potential. Molecules (Basel, Switzerland). vol 21. issue 6. 2017-04-11. PMID:27322225. |
the results showed that the two trichothecene mycotoxins induced the apoptosis of cancer cell hepg-2 via activation of caspase-9 and caspase-3, up-regulation of bax gene expression, down-regulation of bcl-2 gene expression, and disruption of the mitochondrial membrane potential of the hepg-2 cell. |
2017-04-11 |
2023-08-13 |
Not clear |
| Xingyi Kuang, Chunmei Wei, Tao Zhang, Zesong Yang, Jianxiang Chi, Li Wan. miR-378 inhibits cell growth and enhances apoptosis in human myelodysplastic syndromes. International journal of oncology. vol 49. issue 5. 2017-04-11. PMID:27633496. |
moreover, apoptosis induced by mir-378 correlated with increased expression of bax and activation of caspase-3, -8 and -9. |
2017-04-11 |
2023-08-13 |
human |
| Zhongyong Jiang, Xi Liu, Kai Chang, Xia Liu, Jie Xion. Allyl Isothiocyanate Inhibits the Proliferation of Renal Carcinoma Cell Line GRC-1 by Inducing an Imbalance Between Bcl2 and Bax. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2017-04-11. PMID:27834342. |
results aitc inhibited grc-1 cell proliferation and induced cell apoptosis in a dose-dependent manner; it also elevated bax while suppressing bcl-2 gene expression at both mrna and protein levels. |
2017-04-11 |
2023-08-13 |
Not clear |
| Zhihong Liu, You Lu, Yingmin Xiao, Yipin L. Upregulation of miR-21 expression is a valuable predicator of advanced clinicopathological features and poor prognosis in patients with renal cell carcinoma through the p53/p21‑cyclin E2‑Bax/caspase-3 signaling pathway. Oncology reports. vol 37. issue 3. 2017-04-11. PMID:28184919. |
meanwhile, the overexpression of mir-21 not only increased cell proliferation, inhibited apoptosis and reduced caspase-3 activity in the a-498 cells, but also suppressed p53, cdkn1a p21, cyclin e2 and bax protein expression in the a-498 cells. |
2017-04-11 |
2023-08-13 |
human |
| Su-Jin Cho, Kyeong-Lim Lee, Yu-Gon Kim, Dong-Hoon Kim, Jae-Gyu Yoo, Byoung-Chul Yang, Jin-Ki Park, Il-Keun Kon. Differential gene-expression profiles from canine cumulus cells of ovulated versus in vitro-matured oocytes. Reproduction, fertility, and development. vol 28. issue 3. 2017-04-10. PMID:25004936. |
genes analysed are related to cell maturation, development and apoptosis, including gdf9, mapk1, ptx3, cx43, bcl2 and bax; mrna expression for all of these genes, except for gdf9, differed (p<0.05) between in vivo- and in vitro-matured ccs. |
2017-04-10 |
2023-08-13 |
Not clear |
| X X Liu, C Sun, X D Jin, P Li, X G Zheng, T Zhao, Q L. Genistein sensitizes sarcoma cells in vitro and in vivo by enhancing apoptosis and by inhibiting DSB repair pathways. Journal of radiation research. vol 57. issue 3. 2017-04-10. PMID:26922091. |
moreover, a significant increase in apoptosis was accompanied by upregulation of bax and downregulation of bcl-2 in the mitochondria, and lots of cytochrome c being transferred to the cytoplasm. |
2017-04-10 |
2023-08-13 |
mouse |
| Hai-Ying Hua, Hua-Qiang Gao, Ai-Ning Sun, Jian-Nong Cen, Li-Li W. Arsenic trioxide and triptolide synergistically induce apoptosis in the SKM‑1 human myelodysplastic syndrome cell line. Molecular medicine reports. vol 14. issue 5. 2017-04-10. PMID:27665715. |
cell viability, cell apoptosis, levels of reactive oxygen species (ros) and the expression of the cell apoptosis‑associated genes, b cell lymphoma‑2 (bcl‑2), bcl‑2‑associated x protein (bax) and caspase‑3, were determined using an mtt assay, flow cytometric analysis of annexin v‑fluorescein isothiocyanate/propidium iodide double‑stained cells, flow cytometic analysis of intracellular 2',7'‑dichlorodihydrofluorescein diacetate fluorescence and reverse transcription‑quantitative polymerase chain reaction analysis, respectively. |
2017-04-10 |
2023-08-13 |
human |
| Hai-Ying Hua, Hua-Qiang Gao, Ai-Ning Sun, Jian-Nong Cen, Li-Li W. Arsenic trioxide and triptolide synergistically induce apoptosis in the SKM‑1 human myelodysplastic syndrome cell line. Molecular medicine reports. vol 14. issue 5. 2017-04-10. PMID:27665715. |
the combination treatment was found to synergistically inhibit mds skm‑1 cell growth, induce cell apoptosis, increase ros levels, upregulate the expression levels of bax and caspase‑3, and downregulate the mrna expression of bcl‑2. |
2017-04-10 |
2023-08-13 |
human |
| Fang Li, Xianjie Zheng, Xiaoxue Fan, Kefeng Zhai, Yisha Tan, Junping Kou, Boyang Y. YiQiFuMai Powder Injection Attenuates Ischemia/Reperfusion-Induced Myocardial Apoptosis Through AMPK Activation. Rejuvenation research. vol 19. issue 6. 2017-04-07. PMID:27072567. |
moreover, yqfm inhibited h9c2 apoptosis, blocked the expression of caspase-3, and modulated bcl-2 and bax proteins, leading to an increased mitochondrial membrane potential and cellular atp content. |
2017-04-07 |
2023-08-13 |
Not clear |
| Guangxian Zhang, Xiancheng Zeng, Ren Zhang, Juan Liu, Weici Zhang, Yujun Zhao, Xiaoyuan Zhang, Zhixue Wu, Yuhui Tan, Yingya Wu, Biaoyan D. Dioscin suppresses hepatocellular carcinoma tumor growth by inducing apoptosis and regulation of TP53, BAX, BCL2 and cleaved CASP3. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 23. issue 12. 2017-04-07. PMID:27765352. |
dioscin suppresses hepatocellular carcinoma tumor growth by inducing apoptosis and regulation of tp53, bax, bcl2 and cleaved casp3. |
2017-04-07 |
2023-08-13 |
Not clear |
| Rui An, Lei Zhao, Jian Xu, Cong Xi, Haixun Li, Guohong Shen, Wei Zhang, Shumiao Zhang, Lijun Su. Resveratrol alleviates sepsis‑induced myocardial injury in rats by suppressing neutrophil accumulation, the induction of TNF‑α and myocardial apoptosis via activation of Sirt1. Molecular medicine reports. vol 14. issue 6. 2017-04-07. PMID:27779675. |
the protein expression levels of sirt1, acetylated (ac)‑forkhead box o1 (foxo1), b cell lymphoma 2 apoptosis regulator (bcl‑2) and bcl‑2 associated protein x apoptosis regulator (bax) were detected by western blot analysis. |
2017-04-07 |
2023-08-13 |
rat |
| Xin Hu, Jing Wang, Yu Xia, Mihereguli Simayi, Syed Ikramullah, Yuanbing He, Shihong Cui, Shuang Li, Qimanguli Wushoue. Resveratrol induces cell cycle arrest and apoptosis in human eosinophils from asthmatic individuals. Molecular medicine reports. vol 14. issue 6. 2017-04-07. PMID:27779703. |
in addition, resveratrol was observed to arrest cell cycle progression in g1/s phase by increasing the protein expression levels of p53 and p21, and concurrently reducing the protein expression levels of cdk2, cyclin a and cyclin e. furthermore, resveratrol treatment significantly induced apoptosis in eosinophils, likely through the upregulation of bim and bax protein expression levels and the downregulation of bcl‑2 protein expression. |
2017-04-07 |
2023-08-13 |
human |
| Dandan Zhang, Xue Liu, Jiujiao Gao, Yan Sun, Tingjiao Liu, Qiu Yan, Xuesong Yan. The role of epithelial cell adhesion molecule N-glycosylation on apoptosis in breast cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 3. 2017-04-07. PMID:28349835. |
deglycosylation of epithelial cell adhesion molecule enhanced the cytotoxic effect of 5-fluorouracil, promoting apoptosis by downregulating the expression of the anti-apoptotic protein bcl-2 and upregulating the expression of the pro-apoptotic proteins bax and caspase 3 via the extracellular-signal-regulated kinase 1/2 and c-jun n-terminal kinase mitogen-activated protein kinase signaling pathways in mcf-7 and mda-mb-231 cells. |
2017-04-07 |
2023-08-13 |
Not clear |
| Xiaoxiao Yao, Xiaoning Li, Dan Zhang, Yingjun Xie, Baozhen Sun, Hang Li, Liankun Sun, Xuewen Zhan. B-cell lymphoma 2 inhibitor ABT-737 induces Beclin1- and reactive oxygen species-dependent autophagy in Adriamycin-resistant human hepatocellular carcinoma cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 3. 2017-04-07. PMID:28351336. |
abt-737, a b-cell lymphoma 2 homology 3 mimetic, not only induces cell apoptosis by inhibiting the interaction of b-cell lymphoma 2 and bax but also induces cell autophagy by interrupting the interaction of b-cell lymphoma 2 and beclin1. |
2017-04-07 |
2023-08-13 |
human |
| Zhen-Zhong Ji, Yan-Cheng X. Melatonin protects podocytes from angiotensin II-induced injury in an in vitro diabetic nephropathy model. Molecular medicine reports. vol 14. issue 1. 2017-04-06. PMID:27220903. |
based on an in vitro podocyte injury model, the present study found that the application of melatonin significantly reduced angii‑induced apoptosis and increased the proliferative rate of cells, as evidenced by decreased expression levels of apoptotic proteins, including caspase‑3 and bax, and a change in the ratio of bax/bcl‑2. |
2017-04-06 |
2023-08-13 |
Not clear |
| Qinglin Li, Xiaopei Yan, Hui Kong, Weiping Xie, Hong Wan. Iptakalim influences the proliferation and apoptosis of human pulmonary artery smooth muscle cells. Molecular medicine reports. vol 14. issue 1. 2017-04-06. PMID:27221642. |
cell viability was evaluated using a cck-8 assay, cell proliferation by 5-ethynyl-2'-deoxyuridine (edu) incorporation assay, and cell apoptosis via the expression of apoptosis-related proteins, i.e., bcl-2-associated x protein (bax) and b-cell lymphoma 2 (bcl-2) using western blotting. |
2017-04-06 |
2023-08-13 |
human |
| Xin Ren, Hao Liu, Mingjie Zhang, Mengjun Wang, Shiyin M. Co-expression of ING4 and P53 enhances hypopharyngeal cancer chemosensitivity to cisplatin in vivo. Molecular medicine reports. vol 14. issue 3. 2017-04-06. PMID:27484725. |
this suggested that the enhanced cisplatin chemosensitivity with ad-ing4-p53 gene therapy in hypopharyngeal cancer xenografts may be associated with apoptosis induction through upregulation of bax expression and downregulation of bcl‑2. |
2017-04-06 |
2023-08-13 |
mouse |
| Jae-Yun Ju, Kyung-Sook Chung, Se-Yun Cheon, Hyo-Jin A. Musulju improves benign prostatic hyperplasia by regulating inflammatory and apoptotic proteins. Molecular medicine reports. vol 14. issue 5. 2017-04-06. PMID:27748836. |
furthermore, msj induced apoptosis by regulating b‑cell lymphoma (bcl)‑2 protein expression and the bcl‑2:bax ratio, leading to caspase 3 activation. |
2017-04-06 |
2023-08-13 |
rat |
| Tao Lin, Jae Eun Lee, Reza K Oqani, So Yeon Kim, Eun Seok Cho, Yong Dae Jeong, Jun Jong Baek, Dong Il Ji. Tauroursodeoxycholic acid improves pre-implantation development of porcine SCNT embryo by endoplasmic reticulum stress inhibition. Reproductive biology. vol 16. issue 4. 2017-04-06. PMID:27765486. |
tunel assay showed that tudca treatment significantly reduced apoptosis in porcine scnt blastocysts confirmed by decreased pro-apoptotic bax and increased anti-apoptotic bcl2 mrna levels. |
2017-04-06 |
2023-08-13 |
Not clear |