| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' \\xc3\\x89va Csatl\\xc3\\xb3s, Szabolcs M\\xc3\\xa1t\\xc3\\xa9, Marcella Laky, J\\xc3\\xa1nos Rig\\xc3\\xb3, J\\xc3\\xb3zsef G\\xc3\\xa1bor Jo\\xc3\\xb. Role of Apoptosis in the Development of Uterine Leiomyoma: Analysis of Expression Patterns of Bcl-2 and Bax in Human Leiomyoma Tissue With Clinical Correlations. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. vol 34. issue 4. 2017-04-20. PMID:25851703.' |
role of apoptosis in the development of uterine leiomyoma: analysis of expression patterns of bcl-2 and bax in human leiomyoma tissue with clinical correlations. |
2017-04-20 |
2023-08-13 |
human |
| Qing-Sheng Zhao, Ling-Ling Hu, Zhi-Dong Wang, Zhao-Pei Li, Ai-Wen Wang, Jing Li. Resveratrol-loaded folic acid-grafted dextran stearate submicron particles exhibits enhanced antitumor efficacy in non-small cell lung cancers. Materials science & engineering. C, Materials for biological applications. vol 72. 2017-04-20. PMID:28024576. |
we have found that apoptosis induced by rsv-df was associated with the higher expression of p53, caspase-3, and bax than the free rsv. |
2017-04-20 |
2023-08-13 |
Not clear |
| Qing-Sheng Zhao, Ling-Ling Hu, Zhi-Dong Wang, Zhao-Pei Li, Ai-Wen Wang, Jing Li. Resveratrol-loaded folic acid-grafted dextran stearate submicron particles exhibits enhanced antitumor efficacy in non-small cell lung cancers. Materials science & engineering. C, Materials for biological applications. vol 72. 2017-04-20. PMID:28024576. |
the higher level of bax and caspase-3 further indicates the involvement of mitochondria-dependent apoptosis in the anticancer efficacy of formulations. |
2017-04-20 |
2023-08-13 |
Not clear |
| Jiangyong Miao, Lina Wang, Xiangjian Zhang, Chunhua Zhu, Lili Cui, Hui Ji, Ying Liu, Xiaolu Wan. Protective Effect of Aliskiren in Experimental Ischemic Stroke: Up-Regulated p-PI3K, p-AKT, Bcl-2 Expression, Attenuated Bax Expression. Neurochemical research. vol 41. issue 9. 2017-04-17. PMID:27180190. |
furthermore, the protection of alk was also related to decreased levels of apoptosis in mice by enhanced activation of phosphatidylinositol 3-kinase (pi3k)/akt pathway, increased level of bcl-2 and reduced bax expression (p < 0.05). |
2017-04-17 |
2023-08-13 |
mouse |
| Li-Yan Wang, Zhi-Jun Tang, Yu-Zeng Ha. Neuroprotective effects of caffeic acid phenethyl ester against sevoflurane‑induced neuronal degeneration in the hippocampus of neonatal rats involve MAPK and PI3K/Akt signaling pathways. Molecular medicine reports. vol 14. issue 4. 2017-04-17. PMID:27498600. |
cape significantly reduced sevoflurane‑induced apoptosis, downregulated the expression levels of caspases and pro‑apoptotic proteins (bax and bad) and elevated the expression levels of bcl‑2 and bcl‑xl when compared with sevoflurane treatment. |
2017-04-17 |
2023-08-13 |
rat |
| Letteria Minutoli, Mariagrazia Rinaldi, Herbert Marini, Natasha Irrera, Giovanni Crea, Cesare Lorenzini, Domenico Puzzolo, Andrea Valenti, Antonina Pisani, Elena B Adamo, Domenica Altavilla, Francesco Squadrito, Antonio Mical. Apoptotic Pathways Linked to Endocrine System as Potential Therapeutic Targets for Benign Prostatic Hyperplasia. International journal of molecular sciences. vol 17. issue 8. 2017-04-17. PMID:27529214. |
increased levels of the glycoprotein dickkopf-related protein 3 in bph cause an inhibition of the apoptosis machinery through a reduction in b cell lymphoma (bcl)-2 associated x protein (bax) expression. |
2017-04-17 |
2023-08-13 |
Not clear |
| Shaobing Cheng, Xu Jiang, Chaofeng Ding, Chengli Du, Kwabena Gyabaah Owusu-Ansah, Xiaoyu Weng, Wendi Hu, Chuanhui Peng, Zhen Lv, Rongliang Tong, Heng Xiao, Haiyang Xie, Lin Zhou, Jian Wu, Shusen Zhen. Expression and Critical Role of Interleukin Enhancer Binding Factor 2 in Hepatocellular Carcinoma. International journal of molecular sciences. vol 17. issue 8. 2017-04-17. PMID:27556459. |
expression of ilf2 may regulate cell growth and apoptosis in liver cancer cells via regulation of b-cell lymphoma 2 (bcl-2), bcl-2 related ovarian killer (bok), bcl-2-associated x protein (bax), and cellular inhibitor of apoptosis 1 (ciap1). |
2017-04-17 |
2023-08-13 |
mouse |
| Shouzhu Xu, Yanying Lv, Jing Zhao, Junping Wang, Xing Zhao, Siwang Wan. Inhibitory effects of Shenkang injection and its main component emodin on the proliferation of high glucose‑induced renal mesangial cells through cell cycle regulation and induction of apoptosis. Molecular medicine reports. vol 14. issue 4. 2017-04-17. PMID:27572472. |
transmission electron microscopy revealed morphological characteristics of apoptosis and western blot analysis demonstrated the upregulation of b‑cell lymphoma 2‑associated x protein (bax) and activation of caspases in rmcs following treatment with ski or em under high‑glucose conditions. |
2017-04-17 |
2023-08-13 |
rat |
| Shouzhu Xu, Yanying Lv, Jing Zhao, Junping Wang, Xing Zhao, Siwang Wan. Inhibitory effects of Shenkang injection and its main component emodin on the proliferation of high glucose‑induced renal mesangial cells through cell cycle regulation and induction of apoptosis. Molecular medicine reports. vol 14. issue 4. 2017-04-17. PMID:27572472. |
in conclusion, ski and its major active component em were shown to inhibit high‑glucose‑induced proliferation of rmcs via inducing cell cycle arrest at g1 phase as well as cellular apoptosis via upregulation of pro‑apoptotic mediators bax and caspase activation, and may therefore be suitable for the treatment of dn. |
2017-04-17 |
2023-08-13 |
rat |
| Qiufa Hao, Xiaoyan Xiao, Junhui Zhen, Jinbo Feng, Chun Song, Bei Jiang, Zhao H. Resveratrol attenuates acute kidney injury by inhibiting death receptor‑mediated apoptotic pathways in a cisplatin‑induced rat model. Molecular medicine reports. vol 14. issue 4. 2017-04-17. PMID:27600998. |
furthermore, compared with untreated control animals, cisplatin lead to significantly increased expression of fas ligand, tumor necrosis factor‑α (tnf‑α), caspase‑8 and bcl‑2 associated protein x apoptosis regulator (bax), and decreased expression of anti‑apoptosis regulators, bh3 interacting domain death agonist (bid) and b cell lymphoma 2 apoptosis regulator (bcl‑2). |
2017-04-17 |
2023-08-13 |
rat |
| Su Jung Hwang, Hyeung-Geun Park, Yohan Park, Hyo-Jong Le. An α-quaternary chiral latam derivative, YH-304 as a novel broad-spectrum anticancer agent. International journal of oncology. vol 49. issue 6. 2017-04-17. PMID:27748805. |
proapoptotic activity of yh-304 was determined by tunel assay and cleaved parp, cleaved caspase-9, and bax as markers for apoptosis. |
2017-04-17 |
2023-08-13 |
human |
| Ai-Shun Guo, Yi-Qun Huang, Xu-Dong Ma, Rui-Sheng Li. Mechanism of G9a inhibitor BIX‑01294 acting on U251 glioma cells. Molecular medicine reports. vol 14. issue 5. 2017-04-17. PMID:27748874. |
in addition, the apoptosis percentage of u251 cells was analyzed by tunel assay and the expression levels of apoptosis‑associated proteins, including b‑cell lymphoma 2 (bcl‑2), bcl‑2‑associated x protein (bax), caspase‑9 and caspase‑3, and the acetylation of histones, including h3k27me1, h3k27me2 and h3 in u251 were analyzed by western blot following bix‑01294 treatment. |
2017-04-17 |
2023-08-13 |
human |
| Ai-Shun Guo, Yi-Qun Huang, Xu-Dong Ma, Rui-Sheng Li. Mechanism of G9a inhibitor BIX‑01294 acting on U251 glioma cells. Molecular medicine reports. vol 14. issue 5. 2017-04-17. PMID:27748874. |
bix‑01294 inhibited the proliferation of u251, downregulated expression of bcl‑2, and upregulated expression of bax, caspase‑3 and caspase‑9, and induced apoptosis of u251. |
2017-04-17 |
2023-08-13 |
human |
| Qi Jiang, Qingwei Li, Jianmei Han, Meng Gou, Yuanyuan Zheng, Bowen Li, Rong Xiao, Jihong Wan. rLj-RGD3 induces apoptosis via the mitochondrial-dependent pathway and inhibits adhesion, migration and invasion of human HeyA8 cells via FAK pathway. International journal of biological macromolecules. vol 96. 2017-04-17. PMID:28038913. |
according to the confocal microscope, flow cytometry and western blot analysis, rlj-rgd3 could trigger heya8 cells apoptosis by changing mitochondrial membrane potential, arrangement of f-actin, protein level of bcl2, bax, caspase 3, and cleaved caspase 3, concentration of cytoplasmic calcium, as well as phosphorylation level of erk/jnk/p38. |
2017-04-17 |
2023-08-13 |
human |
| Nagwa I Abdel-Hamid, Mona F El-Azab, Yasser M Moustaf. Macrolide antibiotics differentially influence human HepG2 cytotoxicity and modulate intrinsic/extrinsic apoptotic pathways in rat hepatocellular carcinoma model. Naunyn-Schmiedeberg's archives of pharmacology. vol 390. issue 4. 2017-04-17. PMID:28070612. |
in vivo, chemically-induced hcc rat model proved that clarithromycin suppressed hcc via induction of apoptosis through up-regulation of both extrinsic/intrinsic apoptotic pathways' proteins (tnfr1, cleaved caspase-3, and bax with an increased bax/bcl-2 ratio) along with mmp-9 normalization. |
2017-04-17 |
2023-08-13 |
human |
| Shuyun Zhang, Baolin Sh. Erythropoietin Modification Enhances the Protection of Mesenchymal Stem Cells on Diabetic Rat-Derived Schwann Cells: Implications for Diabetic Neuropathy. BioMed research international. vol 2017. 2017-04-17. PMID:28299330. |
in normal glucose culture condition, the overexpression of epo in msc promoted the msc-induced restoration of sc from diabetic rats, including increases in gsh level and cell viability, decrease in tunel apoptosis, upregulation of antiapoptotic proteins, p-akt, and bcl-2, and downregulation of proapoptotic proteins, cleaved caspase-3, and bax. |
2017-04-17 |
2023-08-13 |
rat |
| V M Paes, L A Vieira, H H V Correia, N A R Sa, A A A Moura, A D Sales, A P R Rodrigues, D M Magalhães-Padilha, F W Santos, G A Apgar, C C Campello, L S A Camargo, J R Figueired. Effect of heat stress on the survival and development of in vitro cultured bovine preantral follicles and on in vitro maturation of cumulus-oocyte complex. Theriogenology. vol 86. issue 4. 2017-04-14. PMID:27125691. |
furthermore, the following end points were evaluated in all experiments: follicle/oocyte survival, reactive oxygen species (ros), estradiol (e2) and progesterone (p4) production, as well as mrna expression for select genes related to stress (hsp70) and apoptosis (mcl1 and bax). |
2017-04-14 |
2023-08-13 |
cattle |
| Guicheng Li, Tao Li, Yunfeng Li, Shumin Cai, Zhiming Zhang, Zhenhua Zeng, Xingmin Wang, Youguang Gao, Yunfeng Li, Zhongqing Che. Ulinastatin inhibits oxidant-induced endothelial hyperpermeability and apoptotic signaling. International journal of clinical and experimental pathology. vol 7. issue 11. 2017-04-13. PMID:25550770. |
monolayer permeability was determined by transendothelial electrical resistance (ter); mitochondrial release of cytochrome c was determined by enzyme-linked immunosorbent assay; caspase-3 activity was measured by fluorometric assay; adherens junction protein β-catenin was detected by immunofluorescense staining; ratio of cell apoptosis was evaluated by annexin-v/pi double stain assay; mitochondrial membrane potential (Δψm) was determined with jc-1; intracellular atp content was assayed by a commercial kit; bax and bcl-2 expression were estimated by western blotting; intracellular reactive oxygen species (ros) level was measured by dcfh-da. |
2017-04-13 |
2023-08-13 |
Not clear |
| Yang Mu, Wen-Jie Yan, Tai-Lang Yin, Jing Yan. Curcumin ameliorates high‑fat diet‑induced spermatogenesis dysfunction. Molecular medicine reports. vol 14. issue 4. 2017-04-13. PMID:27600729. |
in addition, the expression levels of apoptosis associated proteins, fas, b‑cell lymphoma (bcl)‑xl, bcl‑associated x protein (bax) and cleaved‑caspase 3, were determined in the testis. |
2017-04-13 |
2023-08-13 |
rat |
| Yang Mu, Wen-Jie Yan, Tai-Lang Yin, Jing Yan. Curcumin ameliorates high‑fat diet‑induced spermatogenesis dysfunction. Molecular medicine reports. vol 14. issue 4. 2017-04-13. PMID:27600729. |
in addition, curcumin treatment reduced apoptosis in the testis, and decreased expression of fas, bax and cleaved‑caspase 3, as well as increased expression of bcl‑xl. |
2017-04-13 |
2023-08-13 |
rat |