| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Young-Sang Kim, Se-Kwon Kim, Sun Joo Par. Apoptotic effect of demethoxyfumitremorgin C from marine fungus Aspergillus fumigatus on PC3 human prostate cancer cells. Chemico-biological interactions. vol 269. 2017-05-09. PMID:28359723. |
demethoxyfumitremorgin c induced apoptosis was associated with downregulation of anti-apoptotic proteins: ras, pi3k, akt, bcl-xl, and bcl-2, and upregulation of pro-apoptotic bax. |
2017-05-09 |
2023-08-13 |
mouse |
| Jingyun Yao, Xing Wei, Yanhua L. Chaetominine reduces MRP1-mediated drug resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells. Biochemical and biophysical research communications. vol 473. issue 4. 2017-05-08. PMID:27038543. |
accordingly, chaetominine induced apoptosis by upregulating ros, pro-apoptotic bax and downregulating anti-apoptotic bcl-2. |
2017-05-08 |
2023-08-13 |
human |
| Chunrong Huang, Haichong Zheng, Wanmei He, Guifang Lu, Xia Li, Yubin Deng, Mian Zen. Ghrelin ameliorates the human alveolar epithelial A549 cell apoptosis induced by lipopolysaccharide. Biochemical and biophysical research communications. vol 474. issue 1. 2017-05-08. PMID:27103436. |
lps exposure impaired cell viability and increased apoptosis of a549 cells significantly in concentration- and time-dependent manners embodied in increased bax and cleaved caspase-3 production, coupled with decreased bcl-2 levels. |
2017-05-08 |
2023-08-13 |
human |
| Norlaily Mohd Ali, M Nadeem Akhtar, Huynh Ky, Kian Lam Lim, Nadiah Abu, Seema Zareen, Wan Yong Ho, Han Kiat Alan-Ong, Sheau Wei Tan, Noorjahan Banu Alitheen, Jamil Bin Ismail, Swee Keong Yeap, Tunku Kamaru. Flavokawain derivative FLS induced G2/M arrest and apoptosis on breast cancer MCF-7 cell line. Drug design, development and therapy. vol 10. 2017-05-08. PMID:27358555. |
the roles of plk-1, wee-1, and phosphorylation of cdc-2 in g2/m arrest and proapoptotic factors (bax, caspase 9, and p53) in promotion of apoptosis of fls against mcf-7 cells were discovered using fluorometric, quantitative real-time polymerase chain reaction, and western blot analysis. |
2017-05-08 |
2023-08-13 |
human |
| Samira Hajiaghalou, Bita Ebrahimi, Abdolhossein Shahverdi, Mina Sharbatoghli, Nasim Beigi Boroujen. Comparison of apoptosis pathway following the use of two protocols for vitrification of immature mouse testicular tissue. Theriogenology. vol 86. issue 8. 2017-05-08. PMID:27492762. |
morphology, cell viability, apoptosis incidence, and apoptosis gene expression (bax, bcl2, caspase 3, fas, fas ligand, p53) were evaluated at 0, 3, and 20 hours of culture by light microscopy, flow cytometry, and real-time polymerase chain reaction, respectively. |
2017-05-08 |
2023-08-13 |
mouse |
| Shweta Shrivastava, Manish Kumar Jeengar, Dinesh Thummuri, Alexey Koval, Vladimir L Katanaev, Srujan Marepally, V G M Naid. Cardamonin, a chalcone, inhibits human triple negative breast cancer cell invasiveness by downregulation of Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition. BioFactors (Oxford, England). vol 43. issue 2. 2017-05-08. PMID:27580587. |
the results show that cd exhibits cytotoxicity by inducing apoptosis and cell cycle arrest in tnbc cells via modulation of bcl-2, bax, cyt-c, cleaved caspase-3, and parp. |
2017-05-08 |
2023-08-13 |
mouse |
| Haolong Cong, Ning Du, Yang Yang, Lei Song, Wenliang Zhang, Po Tie. Enterovirus 71 2B Induces Cell Apoptosis by Directly Inducing the Conformational Activation of the Proapoptotic Protein Bax. Journal of virology. vol 90. issue 21. 2017-05-05. PMID:27558414. |
enterovirus 71 2b induces cell apoptosis by directly inducing the conformational activation of the proapoptotic protein bax. |
2017-05-05 |
2023-08-13 |
Not clear |
| Haolong Cong, Ning Du, Yang Yang, Lei Song, Wenliang Zhang, Po Tie. Enterovirus 71 2B Induces Cell Apoptosis by Directly Inducing the Conformational Activation of the Proapoptotic Protein Bax. Journal of virology. vol 90. issue 21. 2017-05-05. PMID:27558414. |
in this study, we report that ev71 2b protein (2b) localized to the mitochondria and induced cell apoptosis by interacting directly with and activating the proapoptotic protein bax. |
2017-05-05 |
2023-08-13 |
Not clear |
| Haolong Cong, Ning Du, Yang Yang, Lei Song, Wenliang Zhang, Po Tie. Enterovirus 71 2B Induces Cell Apoptosis by Directly Inducing the Conformational Activation of the Proapoptotic Protein Bax. Journal of virology. vol 90. issue 21. 2017-05-05. PMID:27558414. |
importantly, apoptosis in cells with either ev71 infection or 2b expression was dramatically reduced in bax knockdown cells but not in bak knockdown cells, suggesting that bax played a pivotal role in ev71- or 2b-induced apoptosis. |
2017-05-05 |
2023-08-13 |
Not clear |
| Jian Du, Jiyan Leng, Li Zhang, Guangxin Bai, Di Yang, Huan Lin, Junjie Qi. Angiotensin II-Induced Apoptosis of Human Umbilical Vein Endothelial Cells was Inhibited by Blueberry Anthocyanin Through Bax- and Caspase 3-Dependent Pathways. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2017-05-04. PMID:27616275. |
background this study aimed to investigate the inhibitory effect of blueberry anthocyanin (bba) on angiotensin ii (ang ii)-induced apoptosis of human umbilical vein endothelial cells (huvecs), and its regulation mechanisms involving bax and caspase 3. |
2017-05-04 |
2023-08-13 |
human |
| S J Peng, J Li, Y Zhou, M Tuo, X X Qin, Q Yu, H Cheng, Y M L. In vitro effects and mechanisms of lycopene in MCF-7 human breast cancer cells. Genetics and molecular research : GMR. vol 16. issue 2. 2017-05-04. PMID:28407181. |
in conclusion, lycopene inhibits proliferation and facilitates apoptosis of mcf-7 cells in vitro, possibly by regulating the expression of p53 and bax. |
2017-05-04 |
2023-08-13 |
human |
| Jian Xu, Di Xiao, Qing-Hua Lin, Jing-Feng He, Wen-Yuan Liu, Ning Xie, Feng Feng, Wei Q. Cytotoxic Tirucallane and Apotirucallane Triterpenoids from the Stems of Picrasma quassioides. Journal of natural products. vol 79. issue 8. 2017-05-02. PMID:27494664. |
flow cytometry and western blot analysis revealed that 2 induces the apoptosis of mkn-28 cells via activating caspase-3/-9, while increasing bax and bad and decreasing bcl-2 expression levels. |
2017-05-02 |
2023-08-13 |
human |
| Jun-Jie Guo, Lei-Lei Ma, Hong-Tao Shi, Jian-Bing Zhu, Jian Wu, Zhi-Wen Ding, Yi An, Yun-Zeng Zou, Jun-Bo G. Alginate Oligosaccharide Prevents Acute Doxorubicin Cardiotoxicity by Suppressing Oxidative Stress and Endoplasmic Reticulum-Mediated Apoptosis. Marine drugs. vol 14. issue 12. 2017-05-02. PMID:27999379. |
moreover, aos pretreatment significantly decreased the expression of caspase-12, c/ebp homologous protein (chop) (markers for endoplasmic reticulum-mediated apoptosis) and bax (a downstream molecule of chop), while up-regulating the expression of anti-apoptotic protein bcl-2. |
2017-05-02 |
2023-08-13 |
mouse |
| Sakshi Mishra, Prachi Tewari, Bhushan P Chaudhari, Premendra D Dwivedi, Haushila P Pandey, Mukul Da. Deoxynivalenol induced mouse skin tumor initiation: Elucidation of molecular mechanisms in human HaCaT keratinocytes. International journal of cancer. vol 139. issue 9. 2017-05-01. PMID:27389473. |
further, the elucidation of molecular mechanisms of tumor initiation by don (0.42-3.37 nmol/ml) in hacat keratinocytes, revealed (i) enhanced ros generation with cell cycle phase arrest in g0/g1 phase, (ii) increase in levels of 8-oxog (6-24 hr) and γh2ax protein, (iii) significant enhancement in oxidative stress marker enzymes lpo, gsh, gr with concomitant decrease in antioxidant enzymes catalase, gpx, gst, sod and mitochondrial membrane potential after don (1.68 nmol) treatment, (iv) suppression of nrf2 translocation to nucleus, enhanced phosphorylation with subsequent activation erk1/2, p38 and jnk mapk's following don (1.68 nmol) treatment, (v) overexpression of c-jun, c-fos proteins, upregulation of bax along with downregulation of bcl-2 proteins, (vi) increase in cytochrome-c, caspase-9, caspase-3 and poly adp ribose polymerase levels leads to apoptosis. |
2017-05-01 |
2023-08-13 |
mouse |
| Yanping Zhu, Yanxia Fu, Hairong Li. Baicalin Inhibits Renal Cell Apoptosis and Protects Against Acute Kidney Injury in Pediatric Sepsis. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2017-04-28. PMID:28013315. |
mouse sepsis models were constructed by cecal ligation and puncture (clp) and treated with baicalin intragastrically, after which bun and cr examination, tunel apoptosis assay, and expression analyses of bax and bcl2 were performed. |
2017-04-28 |
2023-08-13 |
mouse |
| Yanping Zhu, Yanxia Fu, Hairong Li. Baicalin Inhibits Renal Cell Apoptosis and Protects Against Acute Kidney Injury in Pediatric Sepsis. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2017-04-28. PMID:28013315. |
it inhibited bax and promoted bcl2 in the renal tissue, which was consistent with cell apoptosis changes. |
2017-04-28 |
2023-08-13 |
mouse |
| Ulrike B Hendgen-Cotta, Sonja Esfeld, Katharina Rudi, Ilkka Miinalainen, Johann P Klare, Tienush Rassa. Cytosolic BNIP3 Dimer Interacts with Mitochondrial BAX Forming Heterodimers in the Mitochondrial Outer Membrane under Basal Conditions. International journal of molecular sciences. vol 18. issue 4. 2017-04-28. PMID:28333095. |
we investigated the basal distribution of cardiac bnip3 in vivo and its physical interaction with the pro-death protein bcl2 associated x, apoptosis regulator (bax) and with mitochondria using immunoblot analysis, co-immunoprecipitation, and continuous wave and pulsed electron paramagnetic resonance spectroscopy techniques. |
2017-04-28 |
2023-08-13 |
Not clear |
| Jinkai Xu, Zongyu Li, Qinghua Su, Jun Zhao, Jiancang M. TRIM29 promotes progression of thyroid carcinoma via activating P13K/AKT signaling pathway. Oncology reports. vol 37. issue 3. 2017-04-25. PMID:28098872. |
knockdown of trim29 obviously suppressed cell proliferation; enhanced chemosensitivity to cisplatin; inhibited cell invasion and migration; caused cell cycle arrest at g0/g1 phase by decreasing cyclin b1, cyclin d1 and cdk2, while increasing p21 and p27; and induced cell apoptosis by enhancing the activities of caspase-3, caspase-9, and bax, while decreased bcl-2. |
2017-04-25 |
2023-08-13 |
human |
| Piaoting Guo, Songpo Wang, Wei Liang, Wenjing Wang, Huijun Wang, Miaomiao Zhao, Xiaowei Li. Salvianolic acid B reverses multidrug resistance in HCT‑8/VCR human colorectal cancer cells by increasing ROS levels. Molecular medicine reports. vol 15. issue 2. 2017-04-21. PMID:28000873. |
in addition, salb significantly increased ros levels, which may have accelerated the apoptosis of hct‑8/vcr cells by downregulating bcl‑2 and increasing bax protein expression. |
2017-04-21 |
2023-08-13 |
human |
| Xue-Shan Zhao, Qi Wu, Juan Peng, Li-Hong Pan, Zhong Ren, Hui-Ting Liu, Zhi-Sheng Jiang, Gui-Xue Wang, Zhi-Han Tang, Lu-Shan Li. Hyperlipidemia-induced apoptosis of hippocampal neurons in apoE(-/-) mice may be associated with increased PCSK9 expression. Molecular medicine reports. vol 15. issue 2. 2017-04-21. PMID:28000893. |
in addition, ca3 neurons in the hfd group indicated apparent injuries and increased neuronal apoptosis, which are associated with the expression of bcl‑2, bax, and caspase‑3. |
2017-04-21 |
2023-08-13 |
mouse |