| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Erbao Song, Shu Tang, Jiao Xu, Bin Yin, Endong Bao, Joerg Hartun. Lenti-siRNA Hsp60 promote bax in mitochondria and induces apoptosis during heat stress. Biochemical and biophysical research communications. vol 481. issue 1-2. 2017-05-22. PMID:27818197. |
lenti-sirna hsp60 promote bax in mitochondria and induces apoptosis during heat stress. |
2017-05-22 |
2023-08-13 |
Not clear |
| Sawinee Aupanun, Patchara Phuektes, Saranya Poapolathep, Samak Sutjarit, Mario Giorgi, Amnart Poapolathe. Apoptosis and gene expression in Jurkat human T cells and lymphoid tissues of fusarenon-X-treated mice. Toxicon : official journal of the International Society on Toxinology. vol 123. 2017-05-18. PMID:27773736. |
these data suggested that treatment with low dosage of fx can induce apoptosis in lymphocytes through an effect on bax, bid, trp53, and caspase-9 and therefore the mitochondrial apoptotic pathway. |
2017-05-18 |
2023-08-13 |
mouse |
| Cagri Bodur, Bahriye Karakas, Ahmet Can Timucin, Tugsan Tezil, Huveyda Basag. AMP-activated protein kinase couples 3-bromopyruvate-induced energy depletion to apoptosis via activation of FoxO3a and upregulation of proapoptotic Bcl-2 proteins. Molecular carcinogenesis. vol 55. issue 11. 2017-05-17. PMID:26373689. |
together, these data suggest that ampk couples 3-bp-induced metabolic disruption to intrinsic apoptosis via modulation of foxo3a-bim axis and bax expression. |
2017-05-17 |
2023-08-13 |
Not clear |
| Mohammed Zeeshan, Anbazhagan Murugadas, Surendra Ghaskadbi, Babu Rajendran Ramaswamy, Mohammad Abdulkader Akbarsh. Ecotoxicological assessment of cobalt using Hydra model: ROS, oxidative stress, DNA damage, cell cycle arrest, and apoptosis as mechanisms of toxicity. Environmental pollution (Barking, Essex : 1987). vol 224. 2017-05-17. PMID:28222982. |
immunoblot analyses revealed that cobalt treatment triggered mitochondria-mediated apoptosis as inferred from the modulation of the key proteins bax, bcl-2, and caspase-3. |
2017-05-17 |
2023-08-13 |
Not clear |
| Danielle D Jandial, Lauren S Krill, Lixia Chen, Chunli Wu, Yu Ke, Jun Xie, Bang H Hoang, Xiaolin Z. Induction of G2M Arrest by Flavokawain A, a Kava Chalcone, Increases the Responsiveness of HER2-Overexpressing Breast Cancer Cells to Herceptin. Molecules (Basel, Switzerland). vol 22. issue 3. 2017-05-17. PMID:28335434. |
in addition, fka induces apoptosis in skbr3 cells by increasing the protein expression of bim and bax and decreasing expression of bcl₂, bcl |
2017-05-17 |
2023-08-13 |
Not clear |
| Ning Yang, Yuying Zhao, Zhipeng Wang, Yu Liu, Yanqiao Zhan. Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway. Molecular medicine reports. vol 15. issue 2. 2017-05-16. PMID:28035355. |
the expression level of the anti‑apoptotic protein, bcl‑2 apoptosis regulator (bcl‑2), was reduced by scutellarin in hct‑116 cells, whereas the expression bcl‑2 associated x apoptosis regulator (bax) and the activation of caspase‑3 protein were increased by scutellarin treatment. |
2017-05-16 |
2023-08-13 |
human |
| Alex R D Delbridge, Stephane Chappaz, Matthew E Ritchie, Benjamin T Kile, Andreas Strasser, Stephanie Grabo. Loss of PUMA (BBC3) does not prevent thrombocytopenia caused by the loss of BCL-XL (BCL2L1). British journal of haematology. vol 174. issue 6. 2017-05-15. PMID:27221652. |
it functions to restrain the pro-apoptotic bcl-2 family members bak (also termed bak1) and bax, the essential mediators of intrinsic apoptosis. |
2017-05-15 |
2023-08-13 |
Not clear |
| Alex R D Delbridge, Stephane Chappaz, Matthew E Ritchie, Benjamin T Kile, Andreas Strasser, Stephanie Grabo. Loss of PUMA (BBC3) does not prevent thrombocytopenia caused by the loss of BCL-XL (BCL2L1). British journal of haematology. vol 174. issue 6. 2017-05-15. PMID:27221652. |
it therefore remains to be established whether other bh3-only proteins play a critical role in induction of apoptosis in platelets or whether their death is controlled solely by the interactions between bcl-xl with bak and bax. |
2017-05-15 |
2023-08-13 |
Not clear |
| Yilin Pang, Guiqi Qin, Liping Wu, Xiaoping Wang, Tongsheng Che. Artesunate induces ROS-dependent apoptosis via a Bax-mediated intrinsic pathway in Huh-7 and Hep3B cells. Experimental cell research. vol 347. issue 2. 2017-05-15. PMID:27327234. |
in addition, ars induced translocation and activation of the proapoptotic bax, and silencing bax remarkably inhibited ars-induced apoptosis and ΔΨm collapse in huh-7 and hep3b cells, demonstrating the key role of bax in ars-induced apoptosis. |
2017-05-15 |
2023-08-13 |
human |
| Jie Zan, Juan Liu, Jian-Wei Zhou, Hai-Long Wang, Kai-Kun Mo, Yan Yan, Yun-Bin Xu, Min Liao, Shuo Su, Rong-Liang Hu, Ji-Yong Zho. Rabies virus matrix protein induces apoptosis by targeting mitochondria. Experimental cell research. vol 347. issue 1. 2017-05-15. PMID:27426727. |
cvs blocks bax activation at the early stages of infection; while m protein partially targets mitochondria and induces mitochondrial apoptosis at the late stages of infection. |
2017-05-15 |
2023-08-13 |
Not clear |
| Xian-Xiang Xu, Xiao-Hong Zhang, Yong Diao, Yu-Xiang Huan. Achyranthes bidentate saponins protect rat articular chondrocytes against interleukin-1β-induced inflammation and apoptosis in vitro. The Kaohsiung journal of medical sciences. vol 33. issue 2. 2017-05-15. PMID:28137413. |
abs suppressed il-1β-induced apoptosis by suppressing the activation of caspase-3, inhibiting levels of proapoptotic proteins bax and bad, decreasing p53 protein phosphorylation, and promoting the expression of antiapoptotic protein bcl-x |
2017-05-15 |
2023-08-13 |
rat |
| Hongxia Che, Lei Du, Peixu Cong, Suyuan Tao, Ning Ding, Fengjuan Wu, Changhu Xue, Jie Xu, Yuming Wan. Cerebrosides from Sea Cucumber Protect Against Oxidative Stress in SAMP8 Mice and PC12 Cells. Journal of medicinal food. vol 20. issue 4. 2017-05-15. PMID:28406733. |
the neuroprotective effect of sea cucumber cerebrosides (scc) was also verified in vitro: the cerebrosides increased the survival rate of pc12 cells, recovered the cellular morphology, downregulated the protein levels of caspase-9, cleaved caspase-3, total caspase-3, and bax, and upregulated the protein level of bcl-2, revealing that cerebrosides could inhibit aβ-induced cell apoptosis. |
2017-05-15 |
2023-08-13 |
mouse |
| Hongbing Gui, Zanming She. Concentrate diet modulation of ruminal genes involved in cell proliferation and apoptosis is related to combined effects of short-chain fatty acid and pH in rumen of goats. Journal of dairy science. vol 99. issue 8. 2017-05-12. PMID:27236768. |
the gene expression of apoptosis genes (caspase 3, caspase 8, caspase 9, p53, and bax) was significantly higher, and the ratio of bcl-2 to bax (bcl-2/bax) expression was lower in the mc group than in the lc group. |
2017-05-12 |
2023-08-13 |
Not clear |
| Radoslava Vlčková, Drahomíra Sopková, Zuzana Andrejčáková, Igor Valocký, Attila Kádasi, Abdel Halim Harrath, Vladimír Petrilla, Alexander V Sirotki. Dietary supplementation of yucca (Yucca schidigera) affects ovine ovarian functions. Theriogenology. vol 88. 2017-05-12. PMID:27746005. |
yucca supplementation significantly decreased the size of small antral follicles (2 to <5 mm in diameter), increased accumulation of the apoptosis marker bax, and decreased serum progesterone (p4) and estradiol (e2) levels. |
2017-05-12 |
2023-08-13 |
human |
| Xingyu Guo, Xiaodong Zhang, Tingan Wang, Shulin Xian, Yunfei L. 3-Bromopyruvate and sodium citrate induce apoptosis in human gastric cancer cell line MGC-803 by inhibiting glycolysis and promoting mitochondria-regulated apoptosis pathway. Biochemical and biophysical research communications. vol 475. issue 1. 2017-05-09. PMID:27163639. |
furthermore, bp and sct can induce the characteristic manifestations of mitochondria-regulated apoptosis, such as down-regulation of anti-apoptosis proteins bcl-2 and survivin, up-regulation of pro-apoptosis protein bax, activation of caspase-3, as well as leakage of cytochrome c (cyt-c). |
2017-05-09 |
2023-08-13 |
human |
| J Jaworek, J Szklarczyk, J Bonior, M Kot, M Goralska, P Pierzchalski, R J Reiter, U Czech, R Tomaszewsk. Melatonin metabolite, N(1)-acetyl-N(1)-formyl-5-methoxykynuramine (AFMK), attenuates acute pancreatitis in the rat: in vivo and in vitro studies. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 67. issue 3. 2017-05-09. PMID:27512002. |
gpx, tnf-α, proapoptotic bax protein, antiapoptotic bcl-2 protein and the executor of apoptosis, caspase-3, were determined by western blot in ar42j cells subjected to afmk or to melatonin (both used at 10(-12), 10(-10), or 10(-8)m), without or with addition of caerulein (10(-8)m). |
2017-05-09 |
2023-08-13 |
rat |
| Xiaodong Han, Haolong Con. Enterovirus 71 induces apoptosis by directly modulating the conformational activation of pro-apoptotic protein Bax. The Journal of general virology. vol 98. issue 3. 2017-05-09. PMID:28073399. |
enterovirus 71 induces apoptosis by directly modulating the conformational activation of pro-apoptotic protein bax. |
2017-05-09 |
2023-08-13 |
Not clear |
| Xiaodong Han, Haolong Con. Enterovirus 71 induces apoptosis by directly modulating the conformational activation of pro-apoptotic protein Bax. The Journal of general virology. vol 98. issue 3. 2017-05-09. PMID:28073399. |
importantly, cells with bax but not bak or caspase-8 knockdown show resistance to apoptosis induced by eva71 infection. |
2017-05-09 |
2023-08-13 |
Not clear |
| Young-Sang Kim, Se-Kwon Kim, Sun Joo Par. Apoptotic effect of demethoxyfumitremorgin C from marine fungus Aspergillus fumigatus on PC3 human prostate cancer cells. Chemico-biological interactions. vol 269. 2017-05-09. PMID:28359723. |
demethoxyfumitremorgin c induced apoptosis was associated with downregulation of anti-apoptotic proteins: ras, pi3k, akt, bcl-xl, and bcl-2, and upregulation of pro-apoptotic bax. |
2017-05-09 |
2023-08-13 |
mouse |
| Jingyun Yao, Xing Wei, Yanhua L. Chaetominine reduces MRP1-mediated drug resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells. Biochemical and biophysical research communications. vol 473. issue 4. 2017-05-08. PMID:27038543. |
accordingly, chaetominine induced apoptosis by upregulating ros, pro-apoptotic bax and downregulating anti-apoptotic bcl-2. |
2017-05-08 |
2023-08-13 |
human |