| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaonan Qi, Huatao Li, Xia Cong, Xin Wang, Zhongling Jiang, Rongfeng Cao, Wenru Tia. Baicalin increases developmental competence of mouse embryos in vitro by inhibiting cellular apoptosis and modulating HSP70 and DNMT expression. The Journal of reproduction and development. vol 62. issue 6. 2017-06-06. PMID:27478062. |
moreover, baicalin increased the expression of gja1, cdh1, bcl-2, and dnmt3a genes, decreased the expression of dnmt1 gene, and decreased cellular stress and apoptosis as it decreased the expression of hsp70, casp3, and bax and increased bcl-2 expression in blastocysts cultured in vitro. |
2017-06-06 |
2023-08-13 |
mouse |
| Tuanjie Wang, Jian Zhang, Aiju Xiao, Weiqing Liu, Yun Shang, Jindou A. Melittin ameliorates CVB3-induced myocarditis via activation of the HDAC2-mediated GSK-3β/Nrf2/ARE signaling pathway. Biochemical and biophysical research communications. vol 480. issue 1. 2017-06-06. PMID:27693786. |
flow cytometry showed that melittin inhibited myocardial cell apoptosis; in addition, real-time pcr showed that melittin decreased the expression of bax and caspase-3, and increased the expression of bcl-2. |
2017-06-06 |
2023-08-13 |
mouse |
| Chuan Li, Masahiko Imai, Shinya Hasegawa, Masahiro Yamasaki, Noriko Takahash. Growth Inhibition of Refractory Human Gallbladder Cancer Cells by Retinol, and Its Mechanism of Action. Biological & pharmaceutical bulletin. vol 40. issue 4. 2017-06-06. PMID:28100868. |
retinol did not affect caspase-3 activity or mrna expression of bax and bcl-2, which are associated with apoptosis. |
2017-06-06 |
2023-08-13 |
human |
| Chongshan Wang, Qiongren Wang, Xiezhao Li, Zhong Jin, Peng Xu, Naijin Xu, Abai Xu, Yawen Xu, Shaobo Zheng, Junxia Zheng, Chunxiao Liu, Peng Huan. Lycorine induces apoptosis of bladder cancer T24 cells by inhibiting phospho-Akt and activating the intrinsic apoptotic cascade. Biochemical and biophysical research communications. vol 483. issue 1. 2017-06-01. PMID:28042037. |
in this study, we demonstrated that lycorine induced apoptosis in human bladder cancer t24 cells, an effect that is mediated via inhibition of phospho-akt expression and the consequent activation of caspase-3 and bax in vitro. |
2017-06-01 |
2023-08-13 |
mouse |
| Pihong Li, Xiang Zhou, Weijian Sun, Weiwei Sheng, Yangyang Tu, Yaojun Yu, Jianda Dong, Bing Ye, Zhiqiang Zheng, Mingdong L. Elemene Induces Apoptosis of Human Gastric Cancer Cell Line BGC-823 via Extracellular Signal-Regulated Kinase (ERK) 1/2 Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2017-06-01. PMID:28196062. |
conclusions elemene can inhibit the proliferation and induce the apoptosis of gastric cancer cells associated with the erk 1/2 signaling pathway and expression levels of bax mrna and bcl-2 mrna. |
2017-06-01 |
2023-08-13 |
mouse |
| Liza J Burton, Mariela Rivera, Ohuod Hawsawi, Jin Zou, Tamaro Hudson, Guangdi Wang, Qiang Zhang, Luis Cubano, Nawal Boukli, Valerie Odero-Mara. Muscadine Grape Skin Extract Induces an Unfolded Protein Response-Mediated Autophagy in Prostate Cancer Cells: A TMT-Based Quantitative Proteomic Analysis. PloS one. vol 11. issue 10. 2017-05-31. PMID:27755556. |
the up-regulation of pro-apoptotic markers parp, caspase-12, cleaved caspase-3, -7, bax and down-regulation of anti-apoptotic marker bcl2 was confirmed by western blot analysis and apoptosis was visualized by increased tunel/annexin v staining upon mske treatment. |
2017-05-31 |
2023-08-13 |
Not clear |
| Fabiana Ourique, Maicon R Kviecinski, Guilherme Zirbel, Luiza S E P W Castro, Allisson Jhonatan Gomes Castro, Fátima Regina Mena Barreto Silva, Jaime A Valderrama, David Rios, Julio Benites, Pedro Buc Calderon, Rozangela Curi Pedros. In vivo inhibition of tumor progression by 5 hydroxy-1,4-naphthoquinone (juglone) and 2-(4-hydroxyanilino)-1,4-naphthoquinone (Q7) in combination with ascorbate. Biochemical and biophysical research communications. vol 477. issue 4. 2017-05-29. PMID:27346131. |
hypoxia inducible factor hif-1α, glut1, proteins driving cell cycle (p53, p16 and cyclin a) and apoptosis (poly-adp-polymerase parp, bax and bcl-xl) were assessed by western blot. |
2017-05-29 |
2023-08-13 |
mouse |
| Fabiana Ourique, Maicon R Kviecinski, Guilherme Zirbel, Luiza S E P W Castro, Allisson Jhonatan Gomes Castro, Fátima Regina Mena Barreto Silva, Jaime A Valderrama, David Rios, Julio Benites, Pedro Buc Calderon, Rozangela Curi Pedros. In vivo inhibition of tumor progression by 5 hydroxy-1,4-naphthoquinone (juglone) and 2-(4-hydroxyanilino)-1,4-naphthoquinone (Q7) in combination with ascorbate. Biochemical and biophysical research communications. vol 477. issue 4. 2017-05-29. PMID:27346131. |
apoptosis was induced mostly when treatments were done with ascorbate, causing parp and bax cleavage, and increased bax/bcl-xl ratio. |
2017-05-29 |
2023-08-13 |
mouse |
| Jan L Lyche, Irena M Grześ, Camilla Karlsson, Rasoul Nourizadeh-Lillabadi, Peter Aleström, Erik Ropsta. Parental exposure to natural mixtures of persistent organic pollutants (POP) induced changes in transcription of apoptosis-related genes in offspring zebrafish embryos. Journal of toxicology and environmental health. Part A. vol 79. issue 13-15. 2017-05-26. PMID:27484141. |
in both exposure groups the main executors of apoptosis p53, casp 2, casp 6, cassp 8, and bax displayed upregulation compared to controls, suggesting that these pop induce apoptosis via a p53-dependent mechanism. |
2017-05-26 |
2023-08-13 |
zebrafish |
| Minghong Wu, Chenyuan Pan, Zhong Chen, Lihui Jiang, Penghui Lei, Ming Yan. Bioconcentration pattern and induced apoptosis of bisphenol A in zebrafish embryos at environmentally relevant concentrations. Environmental science and pollution research international. vol 24. issue 7. 2017-05-26. PMID:28083739. |
in addition, the expression patterns of four genes related to apoptosis including caspase-3, bax, p53, and c-jun were significantly up-regulated (p < 0.05) in fish embryos/larvae upon bpa exposure at 72 and 168 hpf. |
2017-05-26 |
2023-08-13 |
zebrafish |
| Fangyi Long, Ting Wang, Ping Jia, Huafei Wang, Yi Qing, Tingting Xiong, Mengjie He, Xiaoli Wan. Anti-Tumor Effects of Atractylenolide-I on Human Ovarian Cancer Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2017-05-26. PMID:28141785. |
in addition, the treatment induced apoptosis, as shown by up-regulation of bax, cleaved caspase-9, cleaved caspase-3, and cytosolic release of cytochrome c and aif, and down-regulation of bcl-2, in a dose-dependent manner. |
2017-05-26 |
2023-08-13 |
human |
| Xiaoling Guo, Deliang Zhu, Ruiling Lian, Yuting Han, Yonglong Guo, Zhijie Li, Shibo Tang, Jiansu Che. Matrigel and Activin A promote cell-cell contact and anti-apoptotic activity in cultured human retinal pigment epithelium cells. Experimental eye research. vol 147. 2017-05-25. PMID:27130547. |
moreover, ma treatment decreased apoptotic cells, ros and bax and increased △Ψ m and bcl2 in hrpe cells under serum withdrawal-induced apoptosis. |
2017-05-25 |
2023-08-13 |
human |
| Dan Li, Nan Liu, Liang Zhao, Lei Tong, Hitoshi Kawano, Hong-Jing Yan, Hong-Peng L. Protective effect of resveratrol against nigrostriatal pathway injury in striatum via JNK pathway. Brain research. vol 1654. issue Pt A. 2017-05-24. PMID:27769789. |
the study assessed modified improved neurological function score (mnss) and beam/walking test, the level of inflammatory cytokines il-1β, il-6 and tnf-α, and striatal expression of bax and bcl-2 proteins associated with neuronal apoptosis. |
2017-05-24 |
2023-08-13 |
mouse |
| Do-Hee Kim, Ki-Woong Park, In Gyeong Chae, Juthika Kundu, Eun-Hee Kim, Joydeb Kumar Kundu, Kyung-Soo Chu. Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells. Molecular carcinogenesis. vol 55. issue 6. 2017-05-23. PMID:26152521. |
treatment with ca induced apoptosis, which was associated with the induction of p53 and bax, inhibition of mdm2, bcl-2, and bcl-xl expression, activation of caspase-9, and -3, and the cleavage of parp in hct116 cells. |
2017-05-23 |
2023-08-13 |
human |
| Lei Ji, Yingying Liu, Ying Zhang, Wenguang Chang, Junli Gong, Shengnan Wei, Xudong Li, Ling Qi. The antioxidant edaravone prevents cardiac dysfunction by suppressing oxidative stress in type 1 diabetic rats and in high-glucose-induced injured H9c2 cardiomyoblasts. Canadian journal of physiology and pharmacology. vol 94. issue 9. 2017-05-23. PMID:27376621. |
in addition, the treatment of high-glucose-incubated h9c2 cells by edaravone increased the activity of antioxidative stress by increasing sirt-1, pgc-1α, and nrf-2, and this treatment also reduced apoptosis by increasing bcl-2 expression and reducing bax and caspase-3 expressions. |
2017-05-23 |
2023-08-13 |
rat |
| Summya Rashid, Sana Nafees, Abul Vafa, Shekh Muhammad Afzal, Nemat Ali, Muneeb U Rehman, Syed Kazim Hasan, Aisha Siddiqi, Preeti Barnwal, Ferial Majed, Sarwat Sultan. Inhibition of precancerous lesions development in kidneys by chrysin via regulating hyperproliferation, inflammation and apoptosis at pre clinical stage. Archives of biochemistry and biophysics. vol 606. 2017-05-23. PMID:27403965. |
ch up regulated intrinsic apoptotic pathway proteins like bax, caspase-9 and caspase-3 along with down regulation of bcl-2 triggering apoptosis. |
2017-05-23 |
2023-08-13 |
rat |
| Weicheng Wang, Wenjie Guo, Lele Li, Zan Fu, Wen Liu, Jian Gao, Yongqian Shu, Qiang Xu, Yang Sun, Yanhong G. Andrographolide reversed 5-FU resistance in human colorectal cancer by elevating BAX expression. Biochemical pharmacology. vol 121. 2017-05-23. PMID:27693317. |
mechanism analysis showed that andrographolide/5-fu co-treatment elevated apoptosis level of hct116/5-fur cells with highly increased level of bax. |
2017-05-23 |
2023-08-13 |
human |
| Weicheng Wang, Wenjie Guo, Lele Li, Zan Fu, Wen Liu, Jian Gao, Yongqian Shu, Qiang Xu, Yang Sun, Yanhong G. Andrographolide reversed 5-FU resistance in human colorectal cancer by elevating BAX expression. Biochemical pharmacology. vol 121. 2017-05-23. PMID:27693317. |
andrographolide-bax interaction prevented bax degradation, enhancing mitochondria-mediated apoptosis thus reversed 5-fu resistance while bax silence diminished this effect. |
2017-05-23 |
2023-08-13 |
human |
| T P Smina, B Nitha, T P A Devasagayam, K K Janardhana. Ganoderma lucidum total triterpenes induce apoptosis in MCF-7 cells and attenuate DMBA induced mammary and skin carcinomas in experimental animals. Mutation research. Genetic toxicology and environmental mutagenesis. vol 813. 2017-05-23. PMID:28010928. |
total triterpenes induced apoptosis in mcf-7 cells by down-regulating the levels of cyclin d1, bcl-2, bcl-xl and also by up-regulating the levels of bax and caspase-9. |
2017-05-23 |
2023-08-13 |
mouse |
| Haihua Ruan, Zhen Zhang, Li Tian, Suying Wang, Shuangyan Hu, Jian-Jun Qia. The Salmonella effector SopB prevents ROS-induced apoptosis of epithelial cells by retarding TRAF6 recruitment to mitochondria. Biochemical and biophysical research communications. vol 478. issue 2. 2017-05-22. PMID:27473656. |
by studying the response of traf6(+/+) and traf6(-/-)mouse embryonic fibroblasts to s. typhimurium infection, we found that traf6 promoted apoptosis by increasing ros accumulation, which led to increased bax/bcl-2 ratio, bax recruitment to mitochondrial membrane, and release of cyt c into the cytoplasm. |
2017-05-22 |
2023-08-13 |
mouse |